List of works - Yoichi Maekawa

A mutation in the immunoproteasome subunit PSMB8 causes autoinflammation and lipodystrophy in humans

scientific article

Abrogation of Rbpj attenuates experimental autoimmune uveoretinitis by inhibiting IL-22-producing CD4+ T cells

scientific article published on 28 February 2014

Antigen-driven T-cell repertoire selection.

scientific article

Antigen-specific B cells are required for the secondary response of T cells but not for their priming

scientific article published on 01 July 1996

Breakdown of peripheral T-cell tolerance by chronic interleukin-15 elevation

scientific article published on 01 July 2003

CD98 Heavy Chain Is a Potent Positive Regulator of CD4+ T Cell Proliferation and Interferon-γ Production In Vivo

scientific article

Cathepsin L is crucial for a Th1-type immune response during Leishmania major infection.

scientific article published in April 2004

Cbl-b is a critical regulator of macrophage activation associated with obesity-induced insulin resistance in mice.

scientific article published on 24 January 2013

Clinical roles of increased populations of Foxp3+CD4+ T cells in peripheral blood from advanced pancreatic cancer patients

scientific article published on 01 November 2006

DNA immunization with Plasmodium falciparum serine repeat antigen: regulation of humoral immune response by coinoculation of cytokine expression plasmid

scientific article published in March 1999

Defective clearance of nucleosomes and systemic lupus erythematosus

scientific article published on 01 December 2001

Delta1-Notch3 interactions bias the functional differentiation of activated CD4+ T cells

scientific article

Dendritic cell-mediated NK cell activation is controlled by Jagged2-Notch interaction.

scholarly article

Different cytokines are required for induction and maintenance of the Th2 type response in DBA/2 mice resistant to infection with Leishmania major

scientific article published on 01 October 2000

Dll4-Fc, an inhibitor of Dll4-notch signaling, suppresses liver metastasis of small cell lung cancer cells through the downregulation of the NF-κB activity

scientific article published on 18 September 2012

Escape of malaria parasites from host immunity requires CD4+ CD25+ regulatory T cells

scientific article

Expression and function of Fas antigen on activated murine B cells.

scientific article

Gene gun-based co-immunization of merozoite surface protein-1 cDNA with IL-12 expression plasmid confers protection against lethal Plasmodium yoelii in A/J mice.

scientific article published in March 2003

Gene gun-mediated delivery of an interleukin-12 expression plasmid protects against infections with the intracellular protozoan parasites Leishmania major and Trypanosoma cruzi in mice

scientific article published in April 2000

Granule-dependent killing of Toxoplasma gondii by CD8+ T cells

scientific article

High phosphate diet reduces atherosclerosis formation in apolipoprotein E-deficient mice.

scientific article published on 25 May 2011

How does spaceflight affect the acquired immune system?

scientific article published on 07 May 2020

Inhibition of intracellular cathepsin activities and suppression of immune responses mediated by helper T lymphocyte type-2 by peroral or intraperitoneal administration of vitamin B6

scientific article published on 01 May 2000

Jagged1 suppresses collagen-induced arthritis by indirectly providing a negative signal in CD8+ T cells.

scientific article

Lysosomal cathepsin B plays an important role in antigen processing, while cathepsin D is involved in degradation of the invariant chain inovalbumin-immunized mice.

scientific article published in May 2000

Manipulation of CD98 resolves type 1 diabetes in nonobese diabetic mice.

scientific article published on 30 January 2012

Milk fat globule epidermal growth factor 8 serves a novel biomarker of opisthorchiasis-associated cholangiocarcinoma

scientific article published on March 2014

Nonencapsulated Trichinella pseudospiralis Infection Impairs Follicular Helper T Cell Differentiation with Subclass-Selective Decreases in Antibody Responses.

scientific article published on 10 October 2016

Notch controls the survival of memory CD4+ T cells by regulating glucose uptake

scientific article published on 15 December 2014

Notch signaling drives IL-22 secretion in CD4+ T cells by stimulating the aryl hydrocarbon receptor.

scientific article

Notch signaling regulates the development of a novel type of Thy1-expressing dendritic cell in the thymus.

scientific article

Notch2 integrates signaling by the transcription factors RBP-J and CREB1 to promote T cell cytotoxicity.

scientific article published on 24 August 2008

Notch2 regulates the development of marginal zone B cells through Fos.

scientific article published on 24 January 2012

Notch2 signaling is required for potent antitumor immunity in vivo.

scientific article published on 29 March 2010

Pepstatin A-sensitive aspartic proteases in lysosome are involved in degradation of the invariant chain and antigen-processing in antigen presenting cells of mice infected with Leishmania major.

scientific article published in September 2000

Protein-tyrosine phosphatase-kappa regulates CD4+ T cell development through ERK1/2-mediated signaling.

scientific article

Regulation of membrane phospholipid asymmetry by Notch-mediated flippase expression controls the number of intraepithelial TCRαβ+CD8αα+ T cells.

scientific article

Restoration of surface IgM-mediated apoptosis in an anti-IgM-resistant variant of WEHI-231 lymphoma cells by HS1, a protein-tyrosine kinase substrate ⬇️

scientific article published on August 1, 1995

Roles of NKT cells in resistance against infection with Toxoplasma gondii and in expression of heat shock protein 65 in the host macrophages.

scientific article

Significance of S100P as a biomarker in diagnosis, prognosis and therapy of opisthorchiasis-associated cholangiocarcinoma

scientific article published on 8 August 2015

Splenic cathepsin L is maturated from the proform by interferon-gamma after immunization with exogenous antigens

scientific article published in May 2001

Stage-specific expression of heat shock protein 90 in murine malaria parasite Plasmodium yoelii

scientific article published in October 1999

The ARNT-STAT3 axis regulates the differentiation of intestinal intraepithelial TCRαβ⁺CD8αα⁺ cells.

scientific article published in January 2013

The lifestyle of the segmented filamentous bacterium: a non-culturable gut-associated immunostimulating microbe inferred by whole-genome sequencing

scientific article

Vdelta1+ T cells are crucial for repertoire formation of gammadelta T cells in the lung

scientific article published on 05 November 2007

List of works by Yoichi Maekawa

A mutation in the immunoproteasome subunit PSMB8 causes autoinflammation and lipodystrophy in humans

Abrogation of Rbpj attenuates experimental autoimmune uveoretinitis by inhibiting IL-22-producing CD4+ T cells

Antigen-driven T-cell repertoire selection.

Antigen-specific B cells are required for the secondary response of T cells but not for their priming

Breakdown of peripheral T-cell tolerance by chronic interleukin-15 elevation

CD98 Heavy Chain Is a Potent Positive Regulator of CD4+ T Cell Proliferation and Interferon-γ Production In Vivo

Cathepsin L is crucial for a Th1-type immune response during Leishmania major infection.

Cbl-b is a critical regulator of macrophage activation associated with obesity-induced insulin resistance in mice.

Clinical roles of increased populations of Foxp3+CD4+ T cells in peripheral blood from advanced pancreatic cancer patients

DNA immunization with Plasmodium falciparum serine repeat antigen: regulation of humoral immune response by coinoculation of cytokine expression plasmid

Defective clearance of nucleosomes and systemic lupus erythematosus

Delta1-Notch3 interactions bias the functional differentiation of activated CD4+ T cells

Dendritic cell-mediated NK cell activation is controlled by Jagged2-Notch interaction.

Different cytokines are required for induction and maintenance of the Th2 type response in DBA/2 mice resistant to infection with Leishmania major

Dll4-Fc, an inhibitor of Dll4-notch signaling, suppresses liver metastasis of small cell lung cancer cells through the downregulation of the NF-κB activity

Escape of malaria parasites from host immunity requires CD4+ CD25+ regulatory T cells

Expression and function of Fas antigen on activated murine B cells.

Gene gun-based co-immunization of merozoite surface protein-1 cDNA with IL-12 expression plasmid confers protection against lethal Plasmodium yoelii in A/J mice.

Gene gun-mediated delivery of an interleukin-12 expression plasmid protects against infections with the intracellular protozoan parasites Leishmania major and Trypanosoma cruzi in mice

Granule-dependent killing of Toxoplasma gondii by CD8+ T cells

High phosphate diet reduces atherosclerosis formation in apolipoprotein E-deficient mice.

How does spaceflight affect the acquired immune system?

Inhibition of intracellular cathepsin activities and suppression of immune responses mediated by helper T lymphocyte type-2 by peroral or intraperitoneal administration of vitamin B6

Jagged1 suppresses collagen-induced arthritis by indirectly providing a negative signal in CD8+ T cells.

Lysosomal cathepsin B plays an important role in antigen processing, while cathepsin D is involved in degradation of the invariant chain inovalbumin-immunized mice.

Manipulation of CD98 resolves type 1 diabetes in nonobese diabetic mice.

Milk fat globule epidermal growth factor 8 serves a novel biomarker of opisthorchiasis-associated cholangiocarcinoma

Nonencapsulated Trichinella pseudospiralis Infection Impairs Follicular Helper T Cell Differentiation with Subclass-Selective Decreases in Antibody Responses.

Notch controls the survival of memory CD4+ T cells by regulating glucose uptake

Notch signaling drives IL-22 secretion in CD4+ T cells by stimulating the aryl hydrocarbon receptor.

Notch signaling regulates the development of a novel type of Thy1-expressing dendritic cell in the thymus.

Notch2 integrates signaling by the transcription factors RBP-J and CREB1 to promote T cell cytotoxicity.

Notch2 regulates the development of marginal zone B cells through Fos.

Notch2 signaling is required for potent antitumor immunity in vivo.

Pepstatin A-sensitive aspartic proteases in lysosome are involved in degradation of the invariant chain and antigen-processing in antigen presenting cells of mice infected with Leishmania major.

Protein-tyrosine phosphatase-kappa regulates CD4+ T cell development through ERK1/2-mediated signaling.

Regulation of membrane phospholipid asymmetry by Notch-mediated flippase expression controls the number of intraepithelial TCRαβ+CD8αα+ T cells.

Restoration of surface IgM-mediated apoptosis in an anti-IgM-resistant variant of WEHI-231 lymphoma cells by HS1, a protein-tyrosine kinase substrate ⬇️

Roles of NKT cells in resistance against infection with Toxoplasma gondii and in expression of heat shock protein 65 in the host macrophages.

Significance of S100P as a biomarker in diagnosis, prognosis and therapy of opisthorchiasis-associated cholangiocarcinoma

Splenic cathepsin L is maturated from the proform by interferon-gamma after immunization with exogenous antigens

Stage-specific expression of heat shock protein 90 in murine malaria parasite Plasmodium yoelii

The ARNT-STAT3 axis regulates the differentiation of intestinal intraepithelial TCRαβ⁺CD8αα⁺ cells.

The lifestyle of the segmented filamentous bacterium: a non-culturable gut-associated immunostimulating microbe inferred by whole-genome sequencing

Vdelta1+ T cells are crucial for repertoire formation of gammadelta T cells in the lung