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List of works by Kevin M. Prise

1st L. H. Gray Workshop. Measurement of radiation-induced damage

scientific article

A charged-particle microbeam: I. Development of an experimental system for targeting cells individually with counted particles

article

A charged-particle microbeam: II. A single-particle micro-collimation and detection system

scientific article published on 01 October 1997

A comparison of the chemical repair rates of free radical precursors of DNA damage and cell killing in Chinese hamster V79 cells

scientific article

A comparison of the radiosensitivity of relaxed and supercoiled plasmid DNA

scientific article published on 01 January 1999

A computational model of cellular response to modulated radiation fields.

scientific article published on 26 January 2012

A focused ultrasoft x-ray microbeam for targeting cells individually with submicrometer accuracy

scientific article published on 01 December 2001

A general mechanistic model enables predictions of the biological effectiveness of different qualities of radiation

scientific article published on 7 September 2017

A kinetic-based model of radiation-induced intercellular signalling

scientific article

A mechanistic study of gold nanoparticle radiosensitisation using targeted microbeam irradiation.

scientific article published on 16 March 2017

A model for radiation-induced bystander effects, with allowance for spatial position and the effects of cell turnover

scientific article published in February 2005

A multiple-radical model for radiation action on DNA and the dependence of OER on LET.

scientific article published in March 1996

A proliferation-dependent bystander effect in primary porcine and human urothelial explants in response to targeted irradiation.

scientific article

A review of dsb induction data for varying quality radiations ⬇️

scientific article published on August 1, 1998

A review of the bystander effect and its implications for low-dose exposure ⬇️

scientific article published on January 1, 2003

A scanning focussed vertical ion nanobeam: A new UK facility for cell irradiation and analysis

A study of endonuclease III-sensitive sites in irradiated DNA: detection of alpha-particle-induced oxidative damage

scientific article published on 01 May 1999

A study of the biological effects of modulated 6 MV radiation fields.

scientific article published on 17 February 2010

ATM Kinase Inhibition Preferentially Sensitises PTEN-Deficient Prostate Tumour Cells to Ionising Radiation

scientific article published on 30 December 2020

ATM acts downstream of ATR in the DNA damage response signaling of bystander cells

scientific article published on September 2008

Acute radiation impacts contractility of guinea-pig bladder strips affecting mucosal-detrusor interactions.

scientific article published on 7 March 2018

Akt/mTOR mediated induction of bystander effect signaling in a nucleus independent manner in irradiated human lung adenocarcinoma epithelial cells.

scientific article

Alpha particles induce pan-nuclear phosphorylation of H2AX in primary human lymphocytes mediated through ATM.

scientific article published on 25 June 2015

An arrangement for irradiating cultured mammalian cells with aluminium characteristic ultrasoft X-rays

scientific article published on 01 December 1987

An improved method for the treatment of data from DNA strand break measurements using filter elution techniques with an internal standard.

scientific article

An in vitro study of the radiobiological effects of flattening filter free radiotherapy treatments.

scientific article published on 11 February 2013

An overview of current practice in external beam radiation oncology with consideration to potential benefits and challenges for nanotechnology.

scientific article published on 3 February 2017

Antiproton induced DNA damage: proton like in flight, carbon-ion like near rest.

scientific article published on January 2013

Application of an Ex Vivo Tissue Model to Investigate Radiobiological Effects on Spermatogenesis

scientific article published on 29 March 2018

Assessing software upgrades, plan properties and patient geometry using intensity modulated radiation therapy (IMRT) complexity metrics

scientific article published on 01 April 2011

Assessment of DNA double-strand breaks induced by intravascular iodinated contrast media following in vitro irradiation and in vivo, during paediatric cardiac catheterization

scientific article published on 8 November 2015

BJR radiobiology special feature.

scientific article published on 3 February 2014

BRCA1 deficiency exacerbates estrogen-induced DNA damage and genomic instability

scientific article

BRCA1, FANCD2 and Chk1 are potential molecular targets for the modulation of a radiation-induced DNA damage response in bystander cells.

scientific article published on 7 October 2014

Biological consequences of nanoscale energy deposition near irradiated heavy atom nanoparticles

scientific article published on 20 June 2011

Biological mechanisms of gold nanoparticle radiosensitization.

scientific article

Bystander Signalling: Exploring Clinical Relevance Through New Approaches and New Models ⬇️

scientific article published on July 10, 2013

Bystander effects induced by diffusing mediators after photodynamic stress

scientific article

Bystander responses induced by low LET radiation.

scientific article published on October 2003

Bystander signaling between glioma cells and fibroblasts targeted with counted particles.

scientific article

Bystander-induced differentiation: a major response to targeted irradiation of a urothelial explant model

scientific article

Cell survival responses after exposure to modulated radiation fields.

scientific article

Cell type-dependent uptake, localization, and cytotoxicity of 1.9 nm gold nanoparticles.

scientific article

Cell-Specific Radiosensitization by Gold Nanoparticles at Megavoltage Radiation Energies ⬇️

scientific article published on November 20, 2010

Cellular signalling effects in high precision radiotherapy

scientific article published on 20 May 2015

Combined analysis of gamma-H2AX/53BP1 foci and caspase activation in lymphocyte subsets detects recent and more remote radiation exposures

scientific article

Comment on 'implications on clinical scenario of gold nanoparticle radiosensitization in regard to photon energy, nanoparticle size, concentration and location'.

scientific article published in January 2012

Concise Review: Stem Cell Effects in Radiation Risk ⬇️

scientific article published on September 1, 2011

Conventional in vivo irradiation procedures are insufficient to accurately determine tumor responses to non-uniform radiation fields.

scientific article

Cytoplasmic irradiation induces mitochondrial-dependent 53BP1 protein relocalization in irradiated and bystander cells.

scientific article published on June 2007

DNA DSB Repair Dynamics following Irradiation with Laser-Driven Protons at Ultra-High Dose Rates

scientific article published on 14 March 2019

DNA Double Strand Break Repair: A Radiation Perspective ⬇️

scientific article published on March 21, 2013

DNA damage responses following exposure to modulated radiation fields

scientific article (publication date: 2012)

Deficiencies of double-strand break repair factors and effects on mutagenesis in directly gamma-irradiated and medium-mediated bystander human lymphoblastoid cells.

scientific article published on February 2008

Delayed lethality, apoptosis and micronucleus formation in human fibroblasts irradiated with X-rays or alpha-particles.

scientific article

Delivering a research-enabled multistakeholder partnership for enhanced patient care at a population level: The Northern Ireland Comprehensive Cancer Program

scientific article published on 22 December 2015

Development of a novel experimental model to investigate radiobiological implications of respiratory motion in advanced radiotherapy

scientific article

Direct evidence for a bystander effect of ionizing radiation in primary human fibroblasts

scientific article published on March 2001

Dose response and kinetics of foci disappearance following exposure to high- and low-LET ionizing radiation.

scientific article published on January 2009

Dose, dose-rate and field size effects on cell survival following exposure to non-uniform radiation fields.

scientific article published on May 2012

Down-regulation of PERK enhances resistance to ionizing radiation

scientific article published on 5 October 2013

Dual effects of radiation bystander signaling in urothelial cancer: purinergic-activation of apoptosis attenuates survival of urothelial cancer and normal urothelial cells.

scientific article published on 24 October 2017

ESTRO ACROP: Technology for precision small animal radiotherapy research: Optimal use and challenges.

scientific article published on 18 December 2017

Editorial-nanoparticles for diagnostic imaging and radiotherapy.

scientific article published on 21 August 2015

Editorial. Non-DNA targeted effects

scientific article published on 25 January 2010

Effect of radiation quality on lesion complexity in cellular DNA

scientific article published on 01 November 1994

Effective suppression of bystander effects by DMSO treatment of irradiated CHO cells

scientific article published on 23 June 2007

Erratum: CORRIGENDUM: Biological consequences of nanoscale energy deposition near irradiated heavy atom nanoparticles

scientific article published in Scientific Reports

Estrogen enhanced cell-cell signalling in breast cancer cells exposed to targeted irradiation.

scientific article

Evaluating Iodine-125 DNA Damage Benchmarks of Monte Carlo DNA Damage Models

scientific article published in 2022

Evaluation of a Novel Liquid Fiducial Marker, BioXmark®, for Small Animal Image-Guided Radiotherapy Applications

scientific article published on 18 May 2020

Evidence for a hypoxic fixation reaction leading to the induction of ssb and dsb in irradiated DNA

article

Evidence for complexity at the nanometer scale of radiation-induced DNA DSBs as a determinant of rejoining kinetics

article

Evidence for induction of DNA double strand breaks in the bystander response to targeted soft X-rays in CHO cells

scientific article

Evidence for induction of DNA double-strand breaks at paired radical sites

article

FLIP: A Targetable Mediator of Resistance to Radiation in Non-Small Cell Lung Cancer.

scientific article published on 29 July 2016

Further evidence for double-strand breaks originating from a paired radical precursor from studies of oxygen fixation processes

article

Genomic instability after targeted irradiation of human lymphocytes: evidence for inter-individual differences under bystander conditions.

scientific article published on 27 March 2010

Genomic instability in human lymphocytes irradiated with individual charged particles: involvement of tumor necrosis factor alpha in irradiated cells but not bystander cells

scientific article published on 01 February 2005

Gold nanoparticle cellular uptake, toxicity and radiosensitisation in hypoxic conditions.

scientific article published on 17 January 2014

Gold nanoparticles for cancer radiotherapy: a review

scientific article

High dose bystander effects in spatially fractionated radiation therapy

scientific article

High-precision microbeam radiotherapy reveals testicular tissue-sparing effects for male fertility preservation

scientific article published on 01 October 2019

Histone H2AX phosphorylation as a molecular pharmacological marker for DNA interstrand crosslink cancer chemotherapy.

scientific article

Histone H2AX phosphorylation in normal human cells irradiated with focused ultrasoft X rays: evidence for chromatin movement during repair

scientific article published on July 2006

Identification of RBCK1 as a novel regulator of FKBPL: implications for tumor growth and response to tamoxifen.

scientific article published on 5 August 2013

Imaging and radiation effects of gold nanoparticles in tumour cells

scientific article published on 20 January 2016

Immune modulation in advanced radiotherapies: Targeting out-of-field effects

scientific article published on 16 April 2015

Impact of fractionation on out-of-field survival and DNA damage responses following exposure to intensity modulated radiation fields

scientific article published on 18 December 2015

Implications of intercellular signaling for radiation therapy: a theoretical dose-planning study

scientific article

In-vitro investigation of out-of-field cell survival following the delivery of conformal, intensity-modulated radiation therapy (IMRT) and volumetric modulated arc therapy (VMAT) plans

scientific article

Increased protein ADPribosylation in HeLa cells exposed to the anti-cancer drug methotrexate

scientific article

Increased susceptibility to delayed genetic effects of low dose X-irradiation in DNA repair deficient cells.

scientific article published on 17 December 2012

Inhibition of ataxia telangiectasia related-3 (ATR) improves therapeutic index in preclinical models of non-small cell lung cancer (NSCLC) radiotherapy.

scientific article

Intensity Modulated Radiation Fields Induce Protective Effects and Reduce Importance of Dose-Rate Effects

scientific article published on 01 July 2019

Investigating the Implications of a Variable RBE on Proton Dose Fractionation Across a Clinical Pencil Beam Scanned Spread-Out Bragg Peak

scientific article published on 13 February 2016

Investigating the cellular effects of isolated radiation tracks using microbeam techniques

scientific article published on 01 January 2002

Investigating the influence of respiratory motion on the radiation induced bystander effect in modulated radiotherapy

scientific article published on 11 November 2013

Investigating the potential impact of four-dimensional computed tomography (4DCT) on toxicity, outcomes and dose escalation for radical lung cancer radiotherapy.

scientific article published on 9 December 2013

Investigation into the radiobiological consequences of pre-treatment verification imaging with megavoltage X-rays in radiotherapy

scientific article

Investigation of dose-rate effects and cell-cycle distribution under protracted exposure to ionizing radiation for various dose-rates.

scientific article

Ionizing radiation-induced bystander mutagenesis and adaptation: quantitative and temporal aspects.

scientific article published on 18 August 2009

KNK437, abrogates hypoxia-induced radioresistance by dual targeting of the AKT and HIF-1α survival pathways ⬇️

scientific article published on April 13, 2012

LET-weighted doses effectively reduce biological variability in proton radiotherapy planning

scientific article published on 09 November 2018

Local DNA damage by proton microbeam irradiation induces poly(ADP-ribose) synthesis in mammalian cells

scientific article published on 01 September 2003

Low dose effects of ionizing radiation on normal tissue stem cells

scientific article published on 22 February 2014

Low-dose binary behavior of bystander cell killing after microbeam irradiation of a single cell with focused c(k) x rays.

scientific article published on March 2005

Low-dose hypersensitivity in Chinese hamster V79 cells targeted with counted protons using a charged-particle microbeam

scientific article

Low-dose radiation-induced risk in spermatogenesis.

scientific article

Low-dose studies of bystander cell killing with targeted soft X rays

scientific article

Mechanisms of DNA damage response to targeted irradiation in organotypic 3D skin cultures

scientific article

Mechanistic Modeling of Radium-223 Treatment of Bone Metastases

scientific article published on 14 December 2018

Mechanistic Modelling of DNA Repair and Cellular Survival Following Radiation-Induced DNA Damage.

scientific article published on 14 September 2016

Mechanistic Rationale to Target PTEN-Deficient Tumor Cells with Inhibitors of the DNA Damage Response Kinase ATM.

scientific article published on 13 April 2015

Microbeam evolution: from single cell irradiation to pre-clinical studies

scientific article

Microbeam studies of the bystander response

scientific article

Microsatellite analysis for determination of the mutagenicity of extremely low-frequency electromagnetic fields and ionising radiation in vitro.

scientific article published on 20 September 2006

Modelling responses to spatially fractionated radiation fields using preclinical image-guided radiotherapy.

scientific article published on 24 August 2016

Multidisciplinary European Low Dose Initiative (MELODI): strategic research agenda for low dose radiation risk research

scientific article published on 15 December 2017

Nanodosimetric effects of gold nanoparticles in megavoltage radiation therapy

scientific article published on 15 September 2011

New advances in radiation biology.

scientific article

New insights into the cellular response to radiation using microbeams

Nitric oxide-mediated signaling in the bystander response of individually targeted glioma cells.

scientific article published on December 2003

Non-linear dose-effect curve for DNA double-strand breaks by low LET radiation: the effect of eluting buffer composition on the measurement of breaks by the filter elution technique

article

Non-targeted effects of ionising radiation--implications for low dose risk.

scientific article

Non-uniform radiation-induced biological responses at the tissue level involved in the health risk of environmental radiation: a radiobiological hypothesis

article

Nothing endures but change

scientific article published in January 2017

Opportunities for research in molecular radiotherapy.

scientific article published on 5 January 2017

Optimising element choice for nanoparticle radiosensitisers

scientific article published on 01 January 2016

Out-of-field cell survival following exposure to intensity-modulated radiation fields.

scientific article published on 27 January 2011

PTEN deficiency promotes macrophage infiltration and hypersensitivity of prostate cancer to IAP antagonist/radiation combination therapy.

scientific article published on 20 January 2016

Physical basis and biological mechanisms of gold nanoparticle radiosensitization.

scientific article published on 06 July 2012

Preclinical evaluation of gold-DTDTPA nanoparticles as theranostic agents in prostate cancer radiotherapy

scientific article

Preclinical models of radiation-induced lung damage: challenges and opportunities for small animal radiotherapy

scientific article published on 13 February 2019

Pro-inflammatory Signaling in a 3D Organotypic Skin Model after Low LET Irradiation-NF-κB, COX-2 Activation, and Impact on Cell Differentiation.

scientific article published on 10 February 2017

Prostate cancer treated with brachytherapy; an exploratory study of dose-dependent biomarkers and quality of life.

scientific article published on 14 March 2017

Protein disulphide isomerase as a target for nanoparticle-mediated sensitisation of cancer cells to radiation

scientific article published on 15 April 2016

Quantification of radiation induced DNA double-strand breaks in human fibroblasts by PFGE: testing the applicability of random breakage models

scientific article published on 01 May 2002

Radiation effects on the cytoskeleton of endothelial cells and endothelial monolayer permeability

scientific article published on 24 October 2007

Radiation induced bystander signals are independent of DNA damage and DNA repair capacity of the irradiated cells.

scientific article published on 28 February 2007

Radiation microbeams as spatial and temporal probes of subcellular and tissue response

scientific article

Radiation responses of stem cells: targeted and non-targeted effects

scientific article

Radiation-induced bystander and adaptive responses in cell and tissue models.

scientific article published on 23 September 2006

Radiation-induced bystander effects. Mechanisms, biological implications, and current investigations at the Leipzig LIPSION facility.

scientific article

Radiation-induced bystander signalling in cancer therapy

scientific article

Radiation-induced intercellular signaling mediated by cytochrome-c via a p53-dependent pathway in hepatoma cells ⬇️

scientific article published on December 6, 2010

Radiobiological Implications of Fukushima Nuclear Accident for Personalized Medical Approach

scientific article published in January 2017

Radioprotection of targeted and bystander cells by methylproamine

scientific article published on 23 September 2014

Rates for repair of pBR 322 DNA radicals by thiols as measured by the gas explosion technique: evidence that counter-ion condensation and co-ion depletion are significant at physiological ionic strength

scientific article published on 01 April 1991

Real-time imaging of novel spatial and temporal responses to photodynamic stress.

scientific article published on 3 May 2009

Relative Biological Effect/Linear Energy Transfer in Proton Beam Therapy: A Primer

scientific article published on 10 July 2019

Relative biological effectiveness (RBE) and out-of-field cell survival responses to passive scattering and pencil beam scanning proton beam deliveries.

scientific article

Relative biological effectiveness variation along monoenergetic and modulated Bragg peaks of a 62-MeV therapeutic proton beam: a preclinical assessment.

scientific article published on 28 June 2014

Reply to 'State of the art in research into the risk of low dose radiation exposure'

scientific article published in March 2014

Robustness of differential gene expression analysis of RNA-seq

scientific article published on 26 May 2021

Role of TGF-beta1 and nitric oxide in the bystander response of irradiated glioma cells.

scientific article published on 9 July 2007

Role of charge in the radioprotection of E. coli by thiols

scientific article published in April 1995

Signaling factors for irradiated glioma cells induced bystander responses in fibroblasts.

scientific article published on 26 September 2007

Small animal image-guided radiotherapy

scientific article published in January 2017

Small animal image-guided radiotherapy: status, considerations and potential for translational impact

scientific article

Small field dosimetry for the small animal radiotherapy research platform (SARRP).

scientific article published on 28 December 2017

Spatiotemporal investigations of DNA damage repair using microbeams

scientific article published on 12 December 2010

State of the art in research into the risk of low dose radiation exposure--findings of the fourth MELODI workshop

scientific article

Substrate evaluation for a microbeam endstation using unstained cell imaging.

scientific article published on 22 June 2008

Targeted cytoplasmic irradiation induces bystander responses.

scholarly article

Temporal characterization and in vitro comparison of cell survival following the delivery of 3D-conformal, intensity-modulated radiation therapy (IMRT) and volumetric modulated arc therapy (VMAT).

scientific article published on 22 March 2011

The Impact of Hypoxia on Out-of-Field Cell Survival after Exposure to Modulated Radiation Fields

scientific article published on 11 October 2017

The Irradiation of V79 Mammalian Cells by Protons with Energies below 2 MeV

scientific article published on 01 September 1989

The Radiobiology of Proton Therapy: Challenges and Opportunities Around Relative Biological Effectiveness

scientific article published on 15 February 2018

The Tissue-Sparing Effect of Spatially Fractionated X-rays for Maintaining Spermatogenesis: A Radiobiological Approach for the Preservation of Male Fertility after Radiotherapy

scientific article published on 11 April 2020

The application of charged-particle microbeams in radiobiology

The irradiation of V79 mammalian cells by protons with energies below 2 MeV. Part II. Measurement of oxygen enhancement ratios and DNA damage

scientific article published on 01 August 1990

The relationship between radiation-induced DNA double-strand breaks and cell kill in hamster V79 fibroblasts irradiated with 250 kVp X-rays, 2.3 MeV neutrons or 238Pu alpha-particles

scientific article published on 01 December 1987

The relationship between the RBE of alpha particles and the radiosensitivity of different mutations of Chinese hamster cells ⬇️

scientific article published on September 1, 2001

The role of PTEN as a cancer biomarker

scientific article published on 3 March 2016

The role of mitochondrial function in gold nanoparticle mediated radiosensitisation.

scientific article published on 16 September 2014

The role of non-protein sulphydryls in determining the chemical repair rates of free radical precursors of DNA damage and cell killing in Chinese hamster V79 cells

scientific article published on September 1, 1992

The use of microbeams to investigate radiation damage in living cells

scientific article

The use of theranostic gadolinium-based nanoprobes to improve radiotherapy efficacy.

scientific article published on 3 July 2014

Time and Cell Type Dependency of Survival Responses in Co-cultured Tumor and Fibroblast Cells after Exposure to Modulated Radiation Fields

scientific article published on 14 May 2015

Time-resolved dosimetric verification of respiratory-gated radiotherapy exposures using a high-resolution 2D ionisation chamber array.

scientific article published on 6 July 2016

Use of the γ-H2AX assay to investigate DNA repair dynamics following multiple radiation exposures

scientific article

Using the Proton Energy Spectrum and Microdosimetry to Model Proton Relative Biological Effectiveness

scientific article published on 05 February 2019

Validation of a Metastatic Assay using biopsies to improve risk stratification in patients with prostate cancer treated with radical radiation therapy.

scientific article

Variations in the Processing of DNA Double-Strand Breaks Along 60-MeV Therapeutic Proton Beams

scientific article published on 29 July 2015

What is the Role of the Bystander Response in Radionuclide Therapies?

scientific article published on 19 August 2013

What role for DNA damage and repair in the bystander response?

scientific article

Workshop Report for Cancer Research: Defining the Shades of Gy: Utilizing the Biological Consequences of Radiotherapy in the Development of New Treatment Approaches-Meeting Viewpoint.

scientific article published on 23 April 2018

hSSB1 rapidly binds at the sites of DNA double-strand breaks and is required for the efficient recruitment of the MRN complex

scientific article

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