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List of works by Alfonso Gutiérrez-Adán

A novel antioxidant formulation designed to treat male infertility associated with oxidative stress: promising preclinical evidence from animal models.

scientific article published on 4 January 2016

Acute fasting before conception affects metabolic and endocrine status without impacting follicle and oocyte development and embryo gene expression in the rabbit

scientific article published in January 2011

Additions and Corrections

scientific article published on 16 December 2015

Altered gene transcription and telomere length in trout embryo and larvae obtained with DNA cryodamaged sperm ⬇️

scientific article published on 08 July 2011

Amino acid metabolism of bovine blastocysts: a biomarker of sex and viability.

scientific article published in March 2010

An approach to study the local embryo effect on gene expression in the bovine oviduct epithelium in vivo

scientific article published on 20 September 2019

An efficient system to establish biopsy-derived trophoblastic cell lines from bovine embryos.

scientific article

Analysis of gene transcription alterations at the blastocyst stage related to the long-term consequences of in vitro culture in mice

scientific article published on 18 November 2008

Antioxidant Nobiletin Enhances Oocyte Maturation and Subsequent Embryo Development and Quality

scientific article published on 27 July 2020

Ascorbic acid-cyclodextrin complex alters the expression of genes associated with lipid metabolism in bovine in vitro produced embryos

scientific article published on 01 January 2019

Behavioral, neurochemical and morphological changes induced by the overexpression of munc18-1a in brain of mice: relevance to schizophrenia.

scientific article

Biased Agonism of Three Different Cannabinoid Receptor Agonists in Mouse Brain Cortex.

scientific article published on 4 November 2016

Biological differences between in vitro produced bovine embryos and parthenotes.

scientific article published on 26 November 2008

Bottlenose Dolphin (Tursiops truncatus) Spermatozoa: Collection, Cryopreservation, and Heterologous In Vitro Fertilization

scientific article

Bovine embryo culture in the presence or absence of serum: implications for blastocyst development, cryotolerance, and messenger RNA expression.

scientific article published on January 2003

Bovine embryo-oviduct interaction in vitro reveals an early cross talk mediated by BMP signaling

scientific article published in March 2017

Bovine oviductal and uterine fluid support in vitro embryo development.

scientific article

CB1 cannabinoid receptor drives oocyte maturation and embryo development via PI3K/Akt and MAPK pathways

scientific article published on 20 April 2017

CMV-driven expression of green fluorescent protein (GFP) in male germ cells of transgenic mice and its effect on fertility

scientific article published on 01 October 2001

Can bovine in vitro-matured oocytes selectively process X- or Y-sorted sperm differentially?

scientific article published on 25 June 2008

Cancer development induced by graded expression of Snail in mice.

scientific article published on 5 October 2005

Changes in testosterone or temperature during the in vitro oocyte culture do not alter the sex ratio of bovine embryos.

scientific article published in July 2009

Characterisation of the deleted in azoospermia like (Dazl)-green fluorescent protein mouse model generated by a two-step embryonic stem cell-based strategy to identify pluripotent and germ cells.

scientific article

Comparison of four methods to evaluate sperm DNA integrity between mouse caput and cauda epididymidis.

scientific article published on 17 October 2011

Consequences of in vitro culture conditions on embryo development and quality.

scientific article published on October 2008

Crucial role of CB(2) cannabinoid receptor in the regulation of central immune responses during neuropathic pain

scientific article

Cultured bovine embryo biopsy conserves methylation marks from original embryo.

scientific article published in August 2017

D-Chiro-Inositol Treatment Affects Oocyte and Embryo Quality and Improves Glucose Intolerance in Both Aged Mice and Mouse Models of Polycystic Ovarian Syndrome

scientific article published on 22 August 2020

D-Pinitol from Ceratonia siliqua Is an Orally Active Natural Inositol That Reduces Pancreas Insulin Secretion and Increases Circulating Ghrelin Levels in Wistar Rats

scientific article published on 08 July 2020

Daily supplementation with ghrelin improves in vitro bovine blastocysts formation rate and alters gene expression related to embryo quality

scientific article published on 20 November 2013

Depression-resistant endophenotype in mice overexpressing cannabinoid CB(2) receptors

scientific article

Development and pattern of mRNA relative abundance of bovine embryos cultured in the isolated mouse oviduct in organ culture

scientific article

Development, molecular composition and freeze tolerance of bovine embryos cultured in TCM-199 supplemented with hyaluronan

scientific article published in February 2008

Developmental kinetics and gene expression in male and female bovine embryos produced in vitro with sex-sorted spermatozoa.

scientific article published in January 2010

Different behavior toward bovine spongiform encephalopathy infection of bovine prion protein transgenic mice with one extra repeat octapeptide insert mutation.

scientific article published in March 2004

Differential effects of culture and nuclear transfer on relative transcript levels of genes with key roles during preimplantation.

scientific article published in February 2006

Differential effects of high and low glucose concentrations during lipolysis-like conditions on bovine in vitro oocyte quality, metabolism and subsequent embryo development

scientific article

Differential expression of two genes located on the X chromosome between male and female in vitro-produced bovine embryos at the blastocyst stage

scientific article published in February 2000

Differential isoform expression and alternative splicing in sex determination in mice

scientific article published on 12 March 2019

Differential sensitivity of male and female mouse embryos to oxidative induced heat-stress is mediated by glucose-6-phosphate dehydrogenase gene expression.

scientific article

Downstream regulatory element antagonist modulator regulates Ca2+ homeostasis and viability in cerebellar neurons.

scientific article published on November 2005

Early detection of PrPres in BSE-infected bovine PrP transgenic mice

scientific article published in April 2003

Early sex-dependent differences in response to environmental stress

scientific article

Early transcription of the SRY gene by bovine preimplantation embryos ⬇️

scientific article published on October 1, 1997

Effect of bovine oviductal extracellular vesicles on embryo development and quality in vitro.

scientific article published on 19 January 2017

Effect of bovine oviductal fluid on development and quality of bovine embryos produced in vitro

scientific article

Effect of chronic THC administration in the reproductive organs of male mice, spermatozoa and in vitro fertilization

scientific article published on 03 August 2018

Effect of duration of oocyte maturation on the kinetics of cleavage, embryo yield and sex ratio in cattle.

scientific article

Effect of exogenous DNA on bovine sperm functionality using the sperm mediated gene transfer (SMGT) technique.

scientific article published in August 2010

Effect of flanking matrix attachment regions on the expression of microinjected transgenes during preimplantation development of mouse embryos.

scientific article published on April 2000

Effect of genistein supplementation of thawing medium on characteristics of frozen human spermatozoa

scientific article published on 22 February 2010

Effect of leptin during in vitro maturation of prepubertal calf oocytes: embryonic development and relative mRNA abundances of genes involved in apoptosis and oocyte competence.

scientific article published in December 2011

Effect of leptin supplementation during in vitro oocyte maturation and embryo culture on bovine embryo development and gene expression patterns.

scientific article published on 31 December 2010

Effect of liver growth factor on both testicular regeneration and recovery of spermatogenesis in busulfan-treated mice

scientific article published on 4 February 2011

Effect of long-term culture of mouse embryonic stem cells under low oxygen concentration as well as on glycosaminoglycan hyaluronan on cell proliferation and differentiation

scientific article published in February 2011

Effect of nutritionally induced hyperlipidaemia on in vitro bovine embryo quality depends on the type of major fatty acid in the diet

scientific article published on 01 September 2017

Effect of speed of development on mRNA expression pattern in early bovine embryos cultured in vivo or in vitro.

scientific article

Effect of sperm treatment on efficiency of EGFP-expressing porcine embryos produced by ICSI-SMGT.

scientific article published on 5 June 2009

Effect of stem cell activation, culture media of manipulated embryos, and site of embryo transfer in the production of F0 embryonic stem cell mice.

scientific article

Effect of the bovine oviductal fluid on in vitro fertilization, development and gene expression of in vitro-produced bovine blastocysts.

scientific article published on 22 August 2012

Effect of the in vitro culture system on the kinetics of blastocyst development and sex ratio of bovine embryos

scientific article published on 01 March 2001

Effect of transgene concentration, flanking matrix attachment regions, and RecA-coating on the efficiency of mouse transgenesis mediated by intracytoplasmic sperm injection.

scientific article published on 11 October 2006

Effect of urokinase type plasminogen activator on in vitro bovine oocyte maturation.

scientific article

Effects of guaiazulene on in vitro bovine embryo production and on mRNA transcripts related to embryo quality

scientific article published on 15 February 2011

Effects of hyaluronan, BSA, and serum on bovine embryo in vitro development, ultrastructure, and gene expression patterns

scientific article published in December 2006

Effects of oviductal fluid on the development, quality, and gene expression of porcine blastocysts produced in vitro

scientific article

Effects of recombinant OVGP1 protein on in vitro bovine embryo development

scientific article published on 06 August 2018

Effects of synchronous and asynchronous embryo transfer on postnatal development, adult health, and behavior in mice

scientific article

Effects of the HDAC inhibitor scriptaid on the in vitro development of bovine embryos and on imprinting gene expression levels.

scientific article published on 11 January 2018

Effects of vitrification on the expression of pluripotency, apoptotic and stress genes in in vitro-produced porcine blastocysts

scientific article published on 3 April 2014

Efficient generation of transgenic mice with intact yeast artificial chromosomes by intracytoplasmic sperm injection.

scientific article published on 30 July 2004

Elevated non-esterified fatty acid concentrations during bovine oocyte maturation compromise early embryo physiology.

scientific article

Elevated non-esterified fatty acid concentrations during in vitro murine follicle growth alter follicular physiology and reduce oocyte developmental competence.

scientific article

Elimination of methylation marks at lysines 4 and 9 of histone 3 (H3K4 and H3K9) of spermatozoa alters offspring phenotype

scientific article published on 01 April 2017

Embryo culture in presence of oviductal fluid induces DNA methylation changes in bovine blastocysts.

scientific article published on 13 April 2017

Embryo gene expression in response to maternal supplementation with glycogenic precursors in the rabbit

scientific article published in November 2013

Embryo responses to stress induced by assisted reproductive technologies

scientific article published on 04 February 2019

Epigenetic differences between male and female bovine blastocysts produced in vitro.

scientific article

Exocannabinoids effect on in vitro bovine oocyte maturation via activation of AKT and ERK1/2.

scientific article published on December 2016

Expanded equine cumulus?oocyte complexes exhibit higher meiotic competence and lower glucose consumption than compact cumulus?oocyte complexes

scientific article

Experimental demonstration that pre- and post-conceptional mechanisms influence sex ratio in mouse embryos.

scientific article published in October 2003

Expression and localization of ARTEMIN in the bovine uterus and embryos

scientific article published on 6 December 2016

Expression of the FUS domain restores liposarcoma development in CHOP transgenic mice

scientific article published on 01 March 2002

Extracellular Vesicles from BOEC in In Vitro Embryo Development and Quality

scientific article published on 4 February 2016

Extracellular vesicles derived from endometrial human mesenchymal stem cells enhance embryo yield and quality in an aged murine model†

scientific article published on 01 May 2019

Extracellular vesicles derived from endometrial human mesenchymal stem cells improve IVF outcome in an aged murine model

scientific article published on 01 September 2018

Factors affecting porcine sperm mediated gene transfer

scientific article published on 25 October 2010

Factors from damaged sperm affect its DNA integrity and its ability to promote embryo implantation in mice

scientific article published in August 2007

Gene expression and metabolic response of bovine oviduct epithelial cells to the early embryo

scientific article published on 01 July 2019

Gene expression in early expanded parthenogenetic and in vitro fertilized bovine blastocysts.

scientific article published on 24 August 2009

Gene expression profiles of bovine genital ridges during sex determination and early differentiation of the gonads†

scientific article published on 01 February 2020

Germ-cell culture conditions facilitate the production of mouse embryonic stem cells.

scientific article published on 16 June 2014

Ghrelin accelerates in vitro maturation of bovine oocytes

scientific article published on 2 June 2014

Global transcriptomic response of bovine endometrium to blastocyst-stage embryos

scientific article published on 01 September 2019

Hematopoietic stem cell transplantation in utero produces sheep-goat chimeras

scientific article published in January 2001

Hepatoma-derived growth factor: Protein quantification in uterine fluid, gene expression in endometrial-cell culture and effects on in vitro embryo development, pregnancy and birth

scientific article

Heterologous murine and bovine IVF using bottlenose dolphin (Tursiops truncatus) spermatozoa.

scientific article

Histone modifications at the blastocyst Axin1(Fu) locus mark the heritability of in vitro culture-induced epigenetic alterations in mice.

scientific article

Hyperglycemia-induced apoptosis affects sex ratio of bovine and murine preimplantation embryos.

scientific article published in June 2003

Hyperplastic obesity and liver steatosis as long-term consequences of suboptimal in vitro culture of mouse embryos

scientific article published on 11 June 2014

Impaired Spermatogenesis, Muscle, and Erythrocyte Function in U12 Intron Splicing-Defective Zrsr1 Mutant Mice.

scientific article

In vivo and in vitro maturation of rabbit oocytes differently affects the gene expression profile, mitochondrial distribution, apoptosis and early embryo development.

scientific article published on 28 September 2016

Inadvertent presence of pluripotent cells in monolayers derived from differentiated embryoid bodies

scientific article published in January 2007

Inadvertent transgenesis by conventional ICSI in mice.

scientific article published on 5 August 2005

Interaction between differential gene expression profile and phenotype in bovine blastocysts originating from oocytes exposed to elevated non-esterified fatty acid concentrations

scientific article published in January 2015

Intracytoplasmic sperm injection using DNA-fragmented sperm in mice negatively affects embryo-derived embryonic stem cells, reduces the fertility of male offspring and induces heritable changes in epialleles

scientific article

Intrafollicular conditions as a major link between maternal metabolism and oocyte quality: a focus on dairy cow fertility ⬇️

scientific article published on January 1, 2011

In vitro cultured bovine endometrial cells recognize embryonic sex.

scientific article published on 5 December 2017

Isolation of pluripotent stem cells from cultured porcine primordial germ cells

scientific article

Local activation of uterine Toll-like receptor 2 and 2/6 decreases embryo implantation and affects uterine receptivity in mice

scientific article published on 25 April 2014

Long-term and transgenerational effects of in vitro culture on mouse embryos.

scientific article published on March 2012

Long-term effect of in vitro culture of mouse embryos with serum on mRNA expression of imprinting genes, development, and behavior.

scholarly article

Long-term effects of mouse intracytoplasmic sperm injection with DNA-fragmented sperm on health and behavior of adult offspring.

scientific article published on 16 January 2008

Longitudinal analysis of somatic and germ-cell telomere dynamics in outbred mice

scientific article published on 17 June 2019

Low oxygen tension during IVM improves bovine oocyte competence and enhances anaerobic glycolysis.

scientific article published on 16 December 2009

Male fertility is reduced by chronic intermittent hypoxia mimicking sleep apnea in mice

scientific article

Male mice produced by in vitro culture have reduced fertility and transmit organomegaly and glucose intolerance to their male offspring

scientific article published on 9 August 2012

Maternal metabolic stress may affect oviduct gatekeeper function.

scientific article

Maternal-embryo interaction in the bovine oviduct: Evidence from in vivo and in vitro studies.

scientific article published on 21 April 2016

Minor Splicing Factors Zrsr1 and Zrsr2 Are Essential for Early Embryo Development and 2-Cell-Like Conversion

scientific article published on 09 June 2020

Most regions of mouse epididymis are able to phagocytose immature germ cells

scientific article published on 3 October 2013

Mouse ICSI with frozen-thawed sperm: the impact of sperm freezing procedure and sperm donor strain

scientific article published in September 2003

New challenges in the analysis of gene transcription in bovine blastocysts.

scientific article published on September 2011

Oocyte and embryo quality: effect of origin, culture conditions and gene expression patterns.

scientific article

Oocyte developmental failure in response to elevated nonesterified fatty acid concentrations: mechanistic insights.

scientific article published on 8 January 2013

Ovarian response and embryo gene expression patterns after nonsuperovulatory gonadotropin stimulation in primiparous rabbits does.

scientific article published on 13 November 2012

Oviduct-Embryo Interactions in Cattle: Two-Way Traffic or a One-Way Street?

scientific article published on 29 April 2015

Oviductal response to gametes and early embryos in mammals

scientific article

Oviductal secretions: will they be key factors for the future ARTs?

scientific article published on 28 June 2010

Oxygen tension during in vitro oocyte maturation and fertilization affects embryo quality in sheep and deer

scientific article published on 10 January 2020

Potential Health Risks Associated to ICSI: Insights from Animal Models and Strategies for a Safe Procedure

scientific article

Prion protein expression regulates embryonic stem cell pluripotency and differentiation

scientific article

Prion protein in ESC regulation ⬇️

scientific article published on July 1, 2011

Production of transgenic piglets using ICSI-sperm-mediated gene transfer in combination with recombinase RecA.

scientific article published on 25 May 2010

Progesterone and conceptus elongation in cattle: a direct effect on the embryo or an indirect effect via the endometrium?

scientific article published on 25 June 2009

Progesterone effects on mouse sperm kinetics in conditions of viscosity.

scientific article published on 23 February 2016

Reduced Mid1 Expression and Delayed Neuromotor Development in daDREAM Transgenic Mice

scientific article published on 3 May 2012

Reduced susceptibility to bovine spongiform encephalopathy prions in transgenic mice expressing a bovine PrP with five octapeptide repeats.

scientific article

Relationship between non-return rate and chromatin condensation of deep frozen bull spermatozoa.

scientific article published on 29 December 2004

Relationship between stage of development and sex of bovine IVM-IVF embryos cultured in vitro versus in the sheep oviduct.

scientific article published in August 1996

Relative messenger RNA abundance in bovine oocytes collected in vitro or in vivo before and 20 hr after the preovulatory luteinizing hormone surge

scientific article published in November 2003

Resveratrol-cyclodextrin complex affects the expression of genes associated with lipid metabolism in bovine in vitro produced embryos.

scientific article published on 26 March 2018

Retinoid-dependent mRNA expression and poly-(A) contents in bovine oocytes meiotically arrested and/or matured in vitro

scientific article

Role of the goat K222-PrP(C) polymorphic variant in prion infection resistance

scientific article published on 18 December 2013

SLUG (SNAI2) overexpression in embryonic development

scientific article

SLUG in cancer development.

scientific article published on April 2005

Scrotal heat stress effects on sperm viability, sperm DNA integrity, and the offspring sex ratio in mice

scientific article published on 01 January 2008

Search for the bovine homolog of the murine ped gene and characterization of its messenger RNA expression during bovine preimplantation development.

scientific article published on 20 October 2003

Selection against spermatozoa with fragmented DNA after postovulatory mating depends on the type of damage

scientific article

Seminal plasma amino acid profile in different breeds of chicken: Role of seminal plasma on sperm cryoresistance

scientific article published in PLoS ONE

Sex determination of porcine embryos using a new developed duplex polymerase chain reaction procedure based on the amplification of repetitive sequences

scientific article published in January 2013

Sex-Dimorphic Behavioral Alterations and Altered Neurogenesis in U12 Intron Splicing-Defective Zrsr1 Mutant Mice

scientific article published on 19 July 2019

Sex-specific embryonic origin of postnatal phenotypic variability.

scientific article published on January 2012

Sexually Dimorphic Gene Expression in Bovine Conceptuses at the Initiation of Implantation ⬇️

scientific article published on 3 August 2016

Short- and long-term outcomes of the absence of protein during bovine blastocyst formation in vitro

scientific article published on 6 April 2016

Single in vitro bovine embryo production: coculture with autologous cumulus cells, developmental competence, embryo quality and gene expression profiles.

scientific article published on 12 July 2011

Solving the "X" in embryos and stem cells

scientific article

Spatial differences in gene expression in the bovine oviduct

scientific article published on 11 April 2016

Species-related differences in blastocyst quality are associated with differences in relative mRNA transcription.

scientific article published on December 2004

Sperm selection by thermotaxis improves ICSI outcome in mice

scientific article published on 13 February 2018

Spermatozoa telomeres determine telomere length in early embryos and offspring.

scientific article

Spontaneous generation of infectious prion disease in transgenic mice

scientific article published on December 2013

Stage-specific metabolomic changes in equine oviductal fluid: New insights into the equine fertilization environment

scientific article published on 30 November 2019

Subclinical bovine spongiform encephalopathy infection in transgenic mice expressing porcine prion protein.

scientific article published in May 2004

Subfertility in bulls carrying a nonsense mutation in transmembrane protein 95 is due to failure to interact with the oocyte vestments.

scientific article published in July 2017

Suboptimal culture conditions induce more deviations in gene expression in male than female bovine blastocysts

scientific article published on 22 January 2016

Suboptimal in vitro culture conditions: an epigenetic origin of long-term health effects.

scientific article published on September 2007

Successful ICSI in Mice Using Caput Epididymal Spermatozoa

scientific article published on 17 December 2019

Superovulatory response of Murciana goats to treatments based on PMSG/Anti-PMSG or combined FSH/PMSG administration.

scientific article published in August 1998

Sustained leukaemic phenotype after inactivation of BCR-ABLp190 in mice.

scientific article published on 18 September 2006

Targeting host metabolism by inhibition of acetyl-Coenzyme A carboxylase reduces flavivirus infection in mouse models

scientific article published on 01 January 2019

Temporal divergence in the pattern of messenger RNA expression in bovine embryos cultured from the zygote to blastocyst stage in vitro or in vivo.

scientific article

Tet-mediated imprinting erasure in H19 locus following reprogramming of spermatogonial stem cells to induced pluripotent stem cells.

scientific article

The Presence of D-Penicillamine during the In Vitro Capacitation of Stallion Spermatozoa Prolongs Hyperactive-Like Motility and Allows for Sperm Selection by Thermotaxis

scientific article published on 21 August 2020

The effect of different zwitterionic buffers and PBS used for out-of-incubator procedures during standard in vitro embryo production on development, morphology and gene expression of bovine embryos

scientific article published in December 2008

The effect of human follicular fluid on bovine oocyte developmental competence and embryo quality

scientific article published on 22 October 2014

The effect of nutritionally induced hyperlipidaemia on in vitro bovine embryo quality

scientific article published on 10 December 2009

The epigenetic environment: secondary sex ratio depends on differential survival in embryogenesis: comment 1

scientific article published on 01 September 2005

The oviduct: from sperm selection to the epigenetic landscape of the embryo.

scientific article published on 8 December 2017

Tissue plasminogen activator (tPA) of paternal origin is necessary for the success of invitro but not of invivo fertilisation in the mouse

article

Transcriptional and post-transcriptional regulation of retrotransposons IAP and MuERV-L affect pluripotency of mice ES cells.

scientific article

Transcriptional repressor DREAM regulates T-lymphocyte proliferation and cytokine gene expression.

scientific article

Transcriptional sexual dimorphism during preimplantation embryo development and its consequences for developmental competence and adult health and disease.

scientific article published on 21 February 2011

Transcriptional sexual dimorphism in elongating bovine embryos: implications for XCI and sex determination genes.

scientific article published on 16 March 2011

Transcriptome changes at the initiation of elongation in the bovine conceptus

scientific article published on 20 April 2011

Transcriptome profiling of liver of non-genetic low birth weight and long term health consequences.

scientific article

Transgenic mice expressing bovine PrP with a four extra repeat octapeptide insert mutation show a spontaneous, non-transmissible, neurodegenerative disease and an expedited course of BSE infection.

scientific article published on 19 October 2005

Transgenic mouse offspring generated by ROSI.

scientific article published on 24 October 2015

Treatment with cholesterol-loaded methyl-β-cyclodextrin increased the cholesterol in rabbit oocytes, but did not improve developmental competence of cryopreserved oocytes.

scientific article published on 29 May 2013

Vertical transmission of bovine spongiform encephalopathy prions evaluated in a transgenic mouse model.

scientific article

Why we should not select the faster embryo: lessons from mice and cattle

scientific article published on 11 September 2014

ZP4 Is Present in Murine Zona Pellucida and Is Not Responsible for the Specific Gamete Interaction

scientific article published on 01 January 2020

Zrsr2 and functional U12-dependent spliceosome are necessary for follicular development

scientific article published on 02 February 2022

α-Tocopherol modifies the expression of genes related to oxidative stress and apoptosis during in vitro maturation and enhances the developmental competence of rabbit oocytes

scientific article published on 01 November 2018

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