List of works - Izidor Sosič

4,6-Substituted-1,3,5-triazin-2(1H)-ones as monocyclic catalytic inhibitors of human DNA topoisomerase IIα targeting the ATP binding site

scientific article published on 2 July 2015

A MedChem toolbox for cereblon-directed PROTACs

scientific article published on 28 May 2019

A focused structure-activity relationship study of psoralen-based immunoproteasome inhibitors

scientific article published on 13 September 2019

A microwave-assisted nucleophilic substitution reaction on a quinoline system: the synthesis of amino analogues of nitroxoline

A new 'golden age' for the antitubercular target InhA.

scientific article published on 20 September 2016

A patent review of immunoproteasome inhibitors

article

Addition of 2-(ethylamino)acetonitrile group to nitroxoline results in significantly improved anti-tumor activity in vitro and in vivo

scientific article published on 17 July 2017

Andrographolide Derivatives Target the KEAP1/NRF2 Axis and Possess Potent Anti-SARS-CoV-2 Activity

scientific article published on 31 January 2022

Antibacterial and β-Lactamase Inhibitory Activity of Monocyclic β-Lactams

scientific article published on 16 August 2017

Biological Evaluation of 8-Hydroxyquinolines as Multi-Target Directed Ligands for Treating Alzheimer's Disease

scientific article published on 01 January 2019

Cathepsin B inhibitors: Further exploration of the nitroxoline core.

scientific article published on 23 February 2018

Chlorocarbonylsulfenyl Chloride Cyclizations Towards Piperidin-3-yl-oxathiazol-2-ones as Potential Covalent Inhibitors of Threonine Proteases

scientific article published in December 2017

Clioquinol-ruthenium complex impairs tumour cell invasion by inhibiting cathepsin B activity

scientific article published on 30 September 2016

Combined liquid chromatography-tandem mass spectrometry analysis of progesterone metabolites

scientific article

Design, synthesis, and evaluation of new thiadiazole-based direct inhibitors of enoyl acyl carrier protein reductase (InhA) for the treatment of tuberculosis

scientific article published on 29 December 2014

Development of new cathepsin B inhibitors: combining bioisosteric replacements and structure-based design to explore the structure-activity relationships of nitroxoline derivatives

scientific article

Discovery and kinetic evaluation of 6-substituted 4-benzylthio-1,3,5-triazin-2(1H)-ones as inhibitors of cathepsin B.

scientific article

Discovery of Immunoproteasome Inhibitors Using Large-Scale Covalent Virtual Screening

scientific article published on 16 July 2019

Discovery of novel small-molecule compounds with selective cytotoxicity for Burkitt's lymphoma cells using 3D ligand-based virtual screening

scientific article published on 19 November 2014

Expression of human aldo-keto reductase 1C2 in cell lines of peritoneal endometriosis: potential implications in metabolism of progesterone and dydrogesterone and inhibition by progestins

scientific article published on 8 January 2012

In Silico Design and Enantioselective Synthesis of Functionalized Monocyclic 3-Amino-1-carboxymethyl-β-lactams as Inhibitors of Penicillin-Binding Proteins of Resistant Bacteria

scientific article published on 13 September 2018

Inhibition of endopeptidase and exopeptidase activity of cathepsin B impairs extracellular matrix degradation and tumour invasion

scientific article published on 13 November 2015

Inhibitors of the peptidoglycan biosynthesis enzymes MurA-F.

scientific article published on 02 April 2014

Molecular dynamics to enhance structure-based virtual screening on cathepsin B.

scientific article published on 7 May 2015

MurD enzymes from different bacteria: Evaluation of inhibitors

scientific article published on 15 June 2012

N-Benzoyl anthranilic acid derivatives as selective inhibitors of aldo-keto reductase AKR1C3.

scientific article published on 22 July 2012

New direct inhibitors of InhA with antimycobacterial activity based on a tetrahydropyran scaffold

scientific article published on 8 February 2016

New noncovalent inhibitors of penicillin-binding proteins from penicillin-resistant bacteria

scientific article

Nonpeptidic Selective Inhibitors of the Chymotrypsin-Like (β5 i) Subunit of the Immunoproteasome

scientific article published on April 2016

Novel mechanism of cathepsin B inhibition by antibiotic nitroxoline and related compounds

scientific article

Organoruthenated Nitroxoline Derivatives Impair Tumor Cell Invasion through Inhibition of Cathepsin B Activity

scientific article published on 29 August 2019

Psoralen Derivatives as Inhibitors of Mycobacterium tuberculosis Proteasome

scientific article published on 12 March 2020

Redox-based inactivation of cysteine cathepsins by compounds containing the 4-aminophenol moiety

scientific article

Second-generation sulfonamide inhibitors of D-glutamic acid-adding enzyme: activity optimisation with conformationally rigid analogues of D-glutamic acid

scientific article

Structural characterization and biological evaluation of a clioquinol-ruthenium complex with copper-independent antileukaemic activity

scientific article published on June 2014

Structure-Activity Relationships of Novel Tryptamine-Based Inhibitors of Bacterial Transglycosylase

scientific article published on 20 November 2015

Structure-activity relationships of new cyanothiophene inhibitors of the essential peptidoglycan biosynthesis enzyme MurF

scientific article published in August 2013

Structure-based development of nitroxoline derivatives as potential multifunctional anti-Alzheimer agents

scientific article

Structure-guided optimization of 4,6-substituted-1,3,5-triazin-2(1H)-ones as catalytic inhibitors of human DNA topoisomerase IIα

scientific article published on 25 April 2019

Synthesis and Penicillin-binding Protein Inhibitory Assessment of Dipeptidic 4-Phenyl-β-lactams from α-Amino Acid-derived Imines

scientific article published on 28 November 2019

The Synthesis of Novel 2,4,6-Trisubstituted 1,3,5-Triazines: A Search for Potential MurF Enzyme Inhibitors

The binding mode of second-generation sulfonamide inhibitors of MurD: clues for rational design of potent MurD inhibitors

scientific article

α-Unsaturated 3-Amino-1-carboxymethyl-β-lactams as Bacterial PBP Inhibitors: Synthesis and Biochemical Assessment

scientific article published on 09 October 2019

List of works by Izidor Sosič

4,6-Substituted-1,3,5-triazin-2(1H)-ones as monocyclic catalytic inhibitors of human DNA topoisomerase IIα targeting the ATP binding site

A MedChem toolbox for cereblon-directed PROTACs

A focused structure-activity relationship study of psoralen-based immunoproteasome inhibitors

A microwave-assisted nucleophilic substitution reaction on a quinoline system: the synthesis of amino analogues of nitroxoline

A new 'golden age' for the antitubercular target InhA.

A patent review of immunoproteasome inhibitors

Addition of 2-(ethylamino)acetonitrile group to nitroxoline results in significantly improved anti-tumor activity in vitro and in vivo

Andrographolide Derivatives Target the KEAP1/NRF2 Axis and Possess Potent Anti-SARS-CoV-2 Activity

Antibacterial and β-Lactamase Inhibitory Activity of Monocyclic β-Lactams

Biological Evaluation of 8-Hydroxyquinolines as Multi-Target Directed Ligands for Treating Alzheimer's Disease

Cathepsin B inhibitors: Further exploration of the nitroxoline core.

Chlorocarbonylsulfenyl Chloride Cyclizations Towards Piperidin-3-yl-oxathiazol-2-ones as Potential Covalent Inhibitors of Threonine Proteases

Clioquinol-ruthenium complex impairs tumour cell invasion by inhibiting cathepsin B activity

Combined liquid chromatography-tandem mass spectrometry analysis of progesterone metabolites

Design, synthesis, and evaluation of new thiadiazole-based direct inhibitors of enoyl acyl carrier protein reductase (InhA) for the treatment of tuberculosis

Development of new cathepsin B inhibitors: combining bioisosteric replacements and structure-based design to explore the structure-activity relationships of nitroxoline derivatives

Discovery and kinetic evaluation of 6-substituted 4-benzylthio-1,3,5-triazin-2(1H)-ones as inhibitors of cathepsin B.

Discovery of Immunoproteasome Inhibitors Using Large-Scale Covalent Virtual Screening

Discovery of novel small-molecule compounds with selective cytotoxicity for Burkitt's lymphoma cells using 3D ligand-based virtual screening

Expression of human aldo-keto reductase 1C2 in cell lines of peritoneal endometriosis: potential implications in metabolism of progesterone and dydrogesterone and inhibition by progestins

In Silico Design and Enantioselective Synthesis of Functionalized Monocyclic 3-Amino-1-carboxymethyl-β-lactams as Inhibitors of Penicillin-Binding Proteins of Resistant Bacteria

Inhibition of endopeptidase and exopeptidase activity of cathepsin B impairs extracellular matrix degradation and tumour invasion

Inhibitors of the peptidoglycan biosynthesis enzymes MurA-F.

Molecular dynamics to enhance structure-based virtual screening on cathepsin B.

MurD enzymes from different bacteria: Evaluation of inhibitors

N-Benzoyl anthranilic acid derivatives as selective inhibitors of aldo-keto reductase AKR1C3.

New direct inhibitors of InhA with antimycobacterial activity based on a tetrahydropyran scaffold

New noncovalent inhibitors of penicillin-binding proteins from penicillin-resistant bacteria

Nonpeptidic Selective Inhibitors of the Chymotrypsin-Like (β5 i) Subunit of the Immunoproteasome

Novel mechanism of cathepsin B inhibition by antibiotic nitroxoline and related compounds

Organoruthenated Nitroxoline Derivatives Impair Tumor Cell Invasion through Inhibition of Cathepsin B Activity

Psoralen Derivatives as Inhibitors of Mycobacterium tuberculosis Proteasome

Redox-based inactivation of cysteine cathepsins by compounds containing the 4-aminophenol moiety

Second-generation sulfonamide inhibitors of D-glutamic acid-adding enzyme: activity optimisation with conformationally rigid analogues of D-glutamic acid

Structural characterization and biological evaluation of a clioquinol-ruthenium complex with copper-independent antileukaemic activity

Structure-Activity Relationships of Novel Tryptamine-Based Inhibitors of Bacterial Transglycosylase

Structure-activity relationships of new cyanothiophene inhibitors of the essential peptidoglycan biosynthesis enzyme MurF

Structure-based development of nitroxoline derivatives as potential multifunctional anti-Alzheimer agents

Structure-guided optimization of 4,6-substituted-1,3,5-triazin-2(1H)-ones as catalytic inhibitors of human DNA topoisomerase IIα

Synthesis and Penicillin-binding Protein Inhibitory Assessment of Dipeptidic 4-Phenyl-β-lactams from α-Amino Acid-derived Imines

The Synthesis of Novel 2,4,6-Trisubstituted 1,3,5-Triazines: A Search for Potential MurF Enzyme Inhibitors

The binding mode of second-generation sulfonamide inhibitors of MurD: clues for rational design of potent MurD inhibitors

α-Unsaturated 3-Amino-1-carboxymethyl-β-lactams as Bacterial PBP Inhibitors: Synthesis and Biochemical Assessment