List of works - Kamyar Hadian

A 3D-microtissue-based phenotypic screening of radiation resistant tumor cells with synchronized chemotherapeutic treatment

scientific article

A drug screen with approved compounds identifies amlexanox as a novel Wnt/β-catenin activator inducing lung epithelial organoid formation

scientific article published on 31 July 2021

A high-content screen for small-molecule regulators of epithelial cell-adhesion molecule (EpCAM) cleavage yields a robust inhibitor.

scientific article published on 26 April 2018

Acriflavine, a clinically approved drug, inhibits SARS-CoV-2 and other betacoronaviruses

scientific article published on 11 January 2022

An in vivo high-throughput screening for riboswitch ligands using a reverse reporter gene system.

scientific article published on 10 August 2017

Analysis of the influence of subcellular localization of the HIV Rev protein on Rev-dependent gene expression by multi-fluorescence live-cell imaging

scientific article published on February 2006

CellDeathPred: a deep learning framework for ferroptosis and apoptosis prediction based on cell painting

scientific article published in 2023

Combination therapies induce cancer cell death through the integrated stress response and disturbed pyrimidine metabolism

scientific article published on 05 March 2021

Control of HIV replication in astrocytes by a family of highly conserved host proteins with a common Rev-interacting domain (Risp).

scientific article

Dephosphorylation of Carma1 by PP2A negatively regulates T-cell activation

scientific article

Development of A Cell-Based Assay to Identify Small Molecule Inhibitors of FGF23 Signaling

scientific article published on October 2015

Ferroptosis Suppressor Protein 1 (FSP1) and Coenzyme Q10 Cooperatively Suppress Ferroptosis

scientific article published on 31 January 2020

Heterogenous nuclear ribonucleoprotein Q increases protein expression from HIV-1 Rev-dependent transcripts

scientific article published on 16 May 2013

Identification of Small-Molecule Frequent Hitters from AlphaScreen High-Throughput Screens

scientific article

Identification of Small-Molecule Frequent Hitters of Glutathione S-Transferase-Glutathione Interaction

scientific article

Identification of a heterogeneous nuclear ribonucleoprotein-recognition region in the HIV Rev protein

scientific article published on 5 October 2009

Identification of phenothiazine derivatives as UHM-binding inhibitors of early spliceosome assembly

scientific article published on 06 November 2020

In vitro detection of NEMO-ubiquitin binding using DELFIA and microscale thermophoresis assays.

scientific article

Inhibition of Canonical NF-κB Signaling by a Small Molecule Targeting NEMO-Ubiquitin Interaction

scientific article published on 7 January 2016

Inhibitors of PEX14 disrupt protein import into glycosomes and kill Trypanosoma parasites.

scientific article published on March 2017

Live-cell assay for simultaneous monitoring of expression and interaction of proteins

scientific article published in December 2006

Modulation of human endogenous retrovirus (HERV) transcription during persistent and de novo HIV-1 infection

scientific article

NF-κB essential modulator (NEMO) interaction with linear and lys-63 ubiquitin chains contributes to NF-κB activation

scientific article

New small molecules targeting apoptosis and cell viability in osteosarcoma

scientific article

Novel small molecules targeting ciliary transport of Smoothened and oncogenic Hedgehog pathway activation

scientific article

Nuisance compounds in cellular assays

scientific article published in 2021

Pharmacologic inhibition of MALT1 protease by phenothiazines as a therapeutic approach for the treatment of aggressive ABC-DLBCL.

scientific article published on December 2012

Phenotypic drug screening in a human fibrosis model identified a novel class of antifibrotic therapeutics

scientific article published on 22 December 2021

Post-surgical adhesions are triggered by calcium-dependent membrane bridges between mesothelial surfaces

scientific article published on 17 June 2020

Protein-protein interaction modulator drug discovery: past efforts and future opportunities using a rich source of low- and high-throughput screening assays

scientific article

Retinoic acid signaling is critical during the totipotency window in early mammalian development

scientific article published on 27 May 2021

Signals from the Nucleus: Activation of NF- B by Cytosolic ATM in the DNA Damage Response

scientific article published on 18 January 2011

Small molecule screening at Helmholtz Zentrum München - from biology to molecules

scientific article

Sox2 controls Schwann cell self-organization through fibronectin fibrillogenesis

scientific article published on 06 February 2020

Structure-Activity Relationship in Pyrazolo[4,3-c]pyridines, First Inhibitors of PEX14-PEX5 Protein-Protein Interaction with Trypanocidal Activity

scientific article published on 06 January 2020

Targeting TRAF6 E3 ligase activity with a small-molecule inhibitor combats autoimmunity

scientific article published on 27 June 2018

The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO

scientific article

The let-7 target gene mouse lin-41 is a stem cell specific E3 ubiquitin ligase for the miRNA pathway protein Ago2

scientific article

The periplasmic E. coli chaperone Skp is a trimer in solution: biophysical and preliminary crystallographic characterization

scientific article published in February 2004

Ubiquitin Conjugation and Deconjugation in NF-κB Signaling

scientific article published on January 2010

List of works by Kamyar Hadian

A 3D-microtissue-based phenotypic screening of radiation resistant tumor cells with synchronized chemotherapeutic treatment

A drug screen with approved compounds identifies amlexanox as a novel Wnt/β-catenin activator inducing lung epithelial organoid formation

A high-content screen for small-molecule regulators of epithelial cell-adhesion molecule (EpCAM) cleavage yields a robust inhibitor.

Acriflavine, a clinically approved drug, inhibits SARS-CoV-2 and other betacoronaviruses

An in vivo high-throughput screening for riboswitch ligands using a reverse reporter gene system.

Analysis of the influence of subcellular localization of the HIV Rev protein on Rev-dependent gene expression by multi-fluorescence live-cell imaging

CellDeathPred: a deep learning framework for ferroptosis and apoptosis prediction based on cell painting

Combination therapies induce cancer cell death through the integrated stress response and disturbed pyrimidine metabolism

Control of HIV replication in astrocytes by a family of highly conserved host proteins with a common Rev-interacting domain (Risp).

Dephosphorylation of Carma1 by PP2A negatively regulates T-cell activation

Development of A Cell-Based Assay to Identify Small Molecule Inhibitors of FGF23 Signaling

Ferroptosis Suppressor Protein 1 (FSP1) and Coenzyme Q10 Cooperatively Suppress Ferroptosis

Heterogenous nuclear ribonucleoprotein Q increases protein expression from HIV-1 Rev-dependent transcripts

Identification of Small-Molecule Frequent Hitters from AlphaScreen High-Throughput Screens

Identification of Small-Molecule Frequent Hitters of Glutathione S-Transferase-Glutathione Interaction

Identification of a heterogeneous nuclear ribonucleoprotein-recognition region in the HIV Rev protein

Identification of phenothiazine derivatives as UHM-binding inhibitors of early spliceosome assembly

In vitro detection of NEMO-ubiquitin binding using DELFIA and microscale thermophoresis assays.

Inhibition of Canonical NF-κB Signaling by a Small Molecule Targeting NEMO-Ubiquitin Interaction

Inhibitors of PEX14 disrupt protein import into glycosomes and kill Trypanosoma parasites.

Live-cell assay for simultaneous monitoring of expression and interaction of proteins

Modulation of human endogenous retrovirus (HERV) transcription during persistent and de novo HIV-1 infection

NF-κB essential modulator (NEMO) interaction with linear and lys-63 ubiquitin chains contributes to NF-κB activation

New small molecules targeting apoptosis and cell viability in osteosarcoma

Novel small molecules targeting ciliary transport of Smoothened and oncogenic Hedgehog pathway activation

Nuisance compounds in cellular assays

Pharmacologic inhibition of MALT1 protease by phenothiazines as a therapeutic approach for the treatment of aggressive ABC-DLBCL.

Phenotypic drug screening in a human fibrosis model identified a novel class of antifibrotic therapeutics

Post-surgical adhesions are triggered by calcium-dependent membrane bridges between mesothelial surfaces

Protein-protein interaction modulator drug discovery: past efforts and future opportunities using a rich source of low- and high-throughput screening assays

Retinoic acid signaling is critical during the totipotency window in early mammalian development

Signals from the Nucleus: Activation of NF- B by Cytosolic ATM in the DNA Damage Response

Small molecule screening at Helmholtz Zentrum München - from biology to molecules

Sox2 controls Schwann cell self-organization through fibronectin fibrillogenesis

Structure-Activity Relationship in Pyrazolo[4,3-c]pyridines, First Inhibitors of PEX14-PEX5 Protein-Protein Interaction with Trypanocidal Activity

Targeting TRAF6 E3 ligase activity with a small-molecule inhibitor combats autoimmunity

The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO

The let-7 target gene mouse lin-41 is a stem cell specific E3 ubiquitin ligase for the miRNA pathway protein Ago2

The periplasmic E. coli chaperone Skp is a trimer in solution: biophysical and preliminary crystallographic characterization

Ubiquitin Conjugation and Deconjugation in NF-κB Signaling