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List of works by Bradley W. Doble

A CD133-AKT-Wnt signaling axis drives glioblastoma brain tumor-initiating cells

scientific article published on 06 November 2019

A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation

scientific article (publication date: 8 December 2005)

Abnormalities in brain structure and behavior in GSK-3alpha mutant mice

scientific article

BMI1 is a therapeutic target in recurrent medulloblastoma

scientific article published on 22 October 2018

Basic fibroblast growth factor stimulates connexin-43 expression and intercellular communication of cardiac fibroblasts

scientific article published on 01 February 1995

CUG-initiated FGF-2 induces chromatin compaction in cultured cardiac myocytes and in vitro

article

Calcium protects pituitary basic fibroblast growth factors from limited proteolysis by co-purifying proteases

scientific article published in December 1990

Cardiomyocyte gap junctions: a target of growth-promoting signaling

scientific article published on 01 May 1998

Deletion of GSK-3beta in mice leads to hypertrophic cardiomyopathy secondary to cardiomyoblast hyperproliferation

scientific article published on October 2008

Ectopic γ-catenin expression partially mimics the effects of stabilized β-catenin on embryonic stem cell differentiation

scientific article

Exploring pluripotency with chemical genetics

scientific article published on February 2009

FGF-2-induced Negative Inotropism and Cardioprotection are Inhibited by Chelerythrine: Involvement of Sarcolemmal Calcium-independent Protein Kinase C

scientific article published on 01 December 1998

Fine-Tuning of the RIG-I-Like Receptor/Interferon Regulatory Factor 3-Dependent Antiviral Innate Immune Response by the Glycogen Synthase Kinase 3/β-Catenin Pathway

scientific article

Functional redundancy of GSK-3alpha and GSK-3beta in Wnt/beta-catenin signaling shown by using an allelic series of embryonic stem cell lines

scientific article published on June 2007

GSK-3 is a master regulator of neural progenitor homeostasis

scientific article published on 04 October 2009

GSK-3: tricks of the trade for a multi-tasking kinase

scientific article

GSK-3alpha directly regulates beta-adrenergic signaling and the response of the heart to hemodynamic stress in mice

scientific journal article

GSK3 Deficiencies in Hematopoietic Stem Cells Initiate Pre-neoplastic State that Is Predictive of Clinical Outcomes of Human Acute Leukemia.

scientific article

Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistance

scientific article

Glycogen synthase kinase 3, circadian rhythms, and bipolar disorder: a molecular link in the therapeutic action of lithium

scientific article published on 12 February 2007

Glycogen synthase kinase 3alpha-specific regulation of murine hepatic glycogen metabolism

scientific article published in October 2007

Glycogen synthase kinase-3 (Gsk-3) plays a fundamental role in maintaining DNA methylation at imprinted loci in mouse embryonic stem cells

scientific article published on April 2015

IL-17 receptor signaling inhibits C/EBPbeta by sequential phosphorylation of the regulatory 2 domain

scientific article published on 24 February 2009

Inhibition of TGFbeta signaling potentiates the FGF-2-induced stimulation of cardiomyocyte DNA synthesis

scientific journal article

Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions.

scientific article published on 12 December 2007

Medulloblastoma stem cells: modeling tumor heterogeneity.

scientific article published on 14 July 2012

Medulloblastoma stem cells: where development and cancer cross pathways.

scientific article published on 08 February 2012

Over-expression of CUG- or AUG-initiated Forms of Basic Fibroblast Growth Factor in Cardiac Myocytes Results in Similar Effects on Mitosis and Protein Synthesis but Distinct Nuclear Morphologies

scientific article published on 01 August 1994

Phosphatidylinositol 3-kinase (PI3K) signaling via glycogen synthase kinase-3 (Gsk-3) regulates DNA methylation of imprinted loci

scientific journal article

Phosphorylation by p38 MAPK as an alternative pathway for GSK3beta inactivation.

scientific article published on May 2008

Phosphorylation of serine 262 in the gap junction protein connexin-43 regulates DNA synthesis in cell-cell contact forming cardiomyocytes

scientific journal article

Prevention of amino acid conversion in SILAC experiments with embryonic stem cells.

scientific article

Pyrvinium Targets CD133 in Human Glioblastoma Brain Tumor-Initiating Cells.

scientific article published on 7 July 2015

R-spondin1 is a high affinity ligand for LRP6 and induces LRP6 phosphorylation and beta-catenin signaling

scientific article published on 30 March 2007

Regulation of basic fibroblast growth factor (bFGF) and FGF receptors in the heart.

scientific article published on March 1995

Role of glycogen synthase kinase-3 in cell fate and epithelial-mesenchymal transitions

scientific article published on January 2007

Selective monoclonal antibody recognition and cellular localization of an unphosphorylated form of connexin43.

scientific article published on October 1997

The carboxy-tail of connexin-43 localizes to the nucleus and inhibits cell growth

scientific article published on 01 January 2003

The responses of neural stem cells to the level of GSK-3 depend on the tissue of origin

scientific article published on 20 June 2013

Tissue-specific role of glycogen synthase kinase 3beta in glucose homeostasis and insulin action

scientific article published on 11 August 2008

Wnt activation as a therapeutic strategy in medulloblastoma

scientific article published on 28 August 2020

β-Catenin Enhances Oct-4 Activity and Reinforces Pluripotency through a TCF-Independent Mechanism ⬇️

scientific article published on February 4, 2011

β-Catenin safeguards the ground state of mousepluripotency by strengthening the robustness of the transcriptional apparatus

scientific article published on 17 July 2020

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