List of works - Jeffrey D. Rudolf

A Mutasynthetic Library of Platensimycin and Platencin Analogues

scientific article

A genetically amenable platensimycin- and platencin-overproducer as a platform for biosynthetic explorations: a showcase of PtmO4, a long-chain acyl-CoA dehydrogenase.

scientific article published on 09 June 2015

Angucyclines and Angucyclinones from Streptomyces sp. CB01913 Featuring C-Ring Cleavage and Expansion ⬇️

scientific article published on 3 September 2015

Antibacterial sulfur-containing platensimycin and platencin congeners from Streptomyces platensis SB12029. ⬇️

scientific article

Bacterial terpenome

scientific article published on 10 November 2020

Biochemical and Structural Characterization of TtnD, a Prenylated FMN-Dependent Decarboxylase from the Tautomycetin Biosynthetic Pathway

scientific article published on 10 September 2018

Biosynthesis of thiocarboxylic acid-containing natural products. ⬇️

scientific article published on 18 June 2018

Biosynthetic Origin of the Ether Ring in Platensimycin.

scientific article

Biosynthetic potential-based strain prioritization for natural product discovery: a showcase for diterpenoid-producing actinomycetes

scientific article published on 31 January 2014

BlmB and TlmB provide resistance to the bleomycin family of antitumor antibiotics by N-acetylating metal-free bleomycin, tallysomycin, phleomycin, and zorbamycin

scientific article

Characterization and Crystal Structure of a Nonheme Diiron Monooxygenase Involved in Platensimycin and Platencin Biosynthesis

scientific article published on 23 July 2019

Correction to multisite prenylation of 4-substituted tryptophans by dimethylallyltryptophan synthase

scientific article published on 12 July 2013

Cryptic and Stereospecific Hydroxylation, Oxidation, and Reduction in Platensimycin and Platencin Biosynthesis.

scientific article published on 19 February 2019

Crystal Structure of Thioesterase SgcE10 Supporting Common Polyene Intermediates in 9- and 10-Membered Enediyne Core Biosynthesis

scientific article published on 30 August 2017

Crystal Structure of the Zorbamycin-Binding Protein ZbmA, the Primary Self-Resistance Element in Streptomyces flavoviridis ATCC21892

scientific article

Crystal Structures of SgcE6 and SgcC, the Two-Component Monooxygenase That Catalyzes Hydroxylation of a Carrier Protein-Tethered Substrate during the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027 in Streptomyces globisporus.

scientific article

Crystal structure of SgcJ, an NTF2-like superfamily protein involved in biosynthesis of the nine-membered enediyne antitumor antibiotic C-1027

scientific article

Cytochrome P450-Catalyzed Hydroxylation Initiating Ether Formation in Platensimycin Biosynthesis

scientific article published on 18 September 2018

Cytochromes P450 for natural product biosynthesis in Streptomyces: sequence, structure, and function.

scientific article published on 31 July 2017

Discovery and Biosynthesis of a Structurally Dynamic Antibacterial Diterpenoid ⬇️

Discovery of the Tiancilactone Antibiotics by Genome Mining of Atypical Bacterial Type II Diterpene Synthases ⬇️

scientific article published on 27 May 2018

Discovery, Structure, and Mechanism of a Class II Sesquiterpene Cyclase

scientific article published in 2022

Divergent synthesis of complex diterpenes through a hybrid oxidative approach

scientific article published on 01 August 2020

Enediyne polyketide synthases stereoselectively reduce the β-ketoacyl intermediates to β-D-hydroxyacyl intermediates in enediyne core biosynthesis

scientific article

Enediynes: Exploration of microbial genomics to discover new anticancer drug leads.

scientific article

Evaluation of Platensimycin and Platensimycin-Inspired Thioether Analogues against Methicillin-Resistant Staphylococcus aureus in Topical and Systemic Infection Mouse Models

scientific article published on 19 June 2019

Genome neighborhood network reveals insights into enediyne biosynthesis and facilitates prediction and prioritization for discovery

scientific article published on 29 August 2015

Germicidins H-J from Streptomyces sp. CB00361. ⬇️

scientific article

In vivo instability of platensimycin and platencin: Synthesis and biological evaluation of urea- and carbamate-platensimycin

scientific article

Mechanisms of self-resistance in the platensimycin- and platencin-producing Streptomyces platensis MA7327 and MA7339 strains.

scientific article

Natural separation of the acyl-CoA ligase reaction results in a non-adenylating enzyme

scientific article published on 04 June 2018

Nutritional control of antibiotic production by Streptomyces platensis MA7327: importance of l-aspartic acid. ⬇️

scientific article published on 03 May 2017

P450-Catalyzed Tailoring Steps in Leinamycin Biosynthesis Featuring Regio- and Stereoselective Hydroxylations and Substrate Promiscuities

scientific article

Platensimycin and platencin: Inspirations for chemistry, biology, enzymology, and medicine

scientific article

Resistance to Enediyne Antitumor Antibiotics by Sequestration

scientific article published on 21 June 2018

Strain Prioritization and Genome Mining for Enediyne Natural Products

scientific article (publication date: 20 December 2016)

Strain prioritization for natural product discovery by a high-throughput real-time PCR method.

scientific article

Structural Insights into the Free-Standing Condensation Enzyme SgcC5 Catalyzing Ester-Bond Formation in the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027.

scientific article published on 13 March 2018

Structure of the ent-Copalyl Diphosphate Synthase PtmT2 from Streptomyces platensis CB00739, a Bacterial Type II Diterpene Synthase.

scientific article

Terpene synthases in disguise: enzymology, structure, and opportunities of non-canonical terpene synthases

scientific article published on 01 March 2020

The Natural Products Atlas 2.0: a database of microbially-derived natural products

scientific article published on 04 October 2021

Tyrosine O-prenyltransferase SirD catalyzes S-, C-, and N-prenylations on tyrosine and tryptophan derivatives

scientific article published on 14 October 2013

List of works by Jeffrey D. Rudolf

A Mutasynthetic Library of Platensimycin and Platencin Analogues

A genetically amenable platensimycin- and platencin-overproducer as a platform for biosynthetic explorations: a showcase of PtmO4, a long-chain acyl-CoA dehydrogenase.

Angucyclines and Angucyclinones from Streptomyces sp. CB01913 Featuring C-Ring Cleavage and Expansion ⬇️

Antibacterial sulfur-containing platensimycin and platencin congeners from Streptomyces platensis SB12029. ⬇️

Bacterial terpenome

Biochemical and Structural Characterization of TtnD, a Prenylated FMN-Dependent Decarboxylase from the Tautomycetin Biosynthetic Pathway

Biosynthesis of thiocarboxylic acid-containing natural products. ⬇️

Biosynthetic Origin of the Ether Ring in Platensimycin.

Biosynthetic potential-based strain prioritization for natural product discovery: a showcase for diterpenoid-producing actinomycetes

BlmB and TlmB provide resistance to the bleomycin family of antitumor antibiotics by N-acetylating metal-free bleomycin, tallysomycin, phleomycin, and zorbamycin

Characterization and Crystal Structure of a Nonheme Diiron Monooxygenase Involved in Platensimycin and Platencin Biosynthesis

Correction to multisite prenylation of 4-substituted tryptophans by dimethylallyltryptophan synthase

Cryptic and Stereospecific Hydroxylation, Oxidation, and Reduction in Platensimycin and Platencin Biosynthesis.

Crystal Structure of Thioesterase SgcE10 Supporting Common Polyene Intermediates in 9- and 10-Membered Enediyne Core Biosynthesis

Crystal Structure of the Zorbamycin-Binding Protein ZbmA, the Primary Self-Resistance Element in Streptomyces flavoviridis ATCC21892

Crystal Structures of SgcE6 and SgcC, the Two-Component Monooxygenase That Catalyzes Hydroxylation of a Carrier Protein-Tethered Substrate during the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027 in Streptomyces globisporus.

Crystal structure of SgcJ, an NTF2-like superfamily protein involved in biosynthesis of the nine-membered enediyne antitumor antibiotic C-1027

Cytochrome P450-Catalyzed Hydroxylation Initiating Ether Formation in Platensimycin Biosynthesis

Cytochromes P450 for natural product biosynthesis in Streptomyces: sequence, structure, and function.

Discovery and Biosynthesis of a Structurally Dynamic Antibacterial Diterpenoid ⬇️

Discovery of the Tiancilactone Antibiotics by Genome Mining of Atypical Bacterial Type II Diterpene Synthases ⬇️

Discovery, Structure, and Mechanism of a Class II Sesquiterpene Cyclase

Divergent synthesis of complex diterpenes through a hybrid oxidative approach

Enediyne polyketide synthases stereoselectively reduce the β-ketoacyl intermediates to β-D-hydroxyacyl intermediates in enediyne core biosynthesis

Enediynes: Exploration of microbial genomics to discover new anticancer drug leads.

Evaluation of Platensimycin and Platensimycin-Inspired Thioether Analogues against Methicillin-Resistant Staphylococcus aureus in Topical and Systemic Infection Mouse Models

Genome neighborhood network reveals insights into enediyne biosynthesis and facilitates prediction and prioritization for discovery

Germicidins H-J from Streptomyces sp. CB00361. ⬇️

In vivo instability of platensimycin and platencin: Synthesis and biological evaluation of urea- and carbamate-platensimycin

Mechanisms of self-resistance in the platensimycin- and platencin-producing Streptomyces platensis MA7327 and MA7339 strains.

Natural separation of the acyl-CoA ligase reaction results in a non-adenylating enzyme

Nutritional control of antibiotic production by Streptomyces platensis MA7327: importance of l-aspartic acid. ⬇️

P450-Catalyzed Tailoring Steps in Leinamycin Biosynthesis Featuring Regio- and Stereoselective Hydroxylations and Substrate Promiscuities

Platensimycin and platencin: Inspirations for chemistry, biology, enzymology, and medicine

Resistance to Enediyne Antitumor Antibiotics by Sequestration

Strain Prioritization and Genome Mining for Enediyne Natural Products

Strain prioritization for natural product discovery by a high-throughput real-time PCR method.

Structural Insights into the Free-Standing Condensation Enzyme SgcC5 Catalyzing Ester-Bond Formation in the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027.

Structure of the ent-Copalyl Diphosphate Synthase PtmT2 from Streptomyces platensis CB00739, a Bacterial Type II Diterpene Synthase.

Terpene synthases in disguise: enzymology, structure, and opportunities of non-canonical terpene synthases

The Natural Products Atlas 2.0: a database of microbially-derived natural products

Tyrosine O-prenyltransferase SirD catalyzes S-, C-, and N-prenylations on tyrosine and tryptophan derivatives