List of works - Stefan Lienenklaus

Abortively Infected Astrocytes Appear To Represent the Main Source of Interferon Beta in the Virus-Infected Brain

scientific article published on 9 December 2015

Age-dependent enterocyte invasion and microcolony formation by Salmonella

scientific article (publication date: September 2014)

CD8(+) T cells armed with retrovirally transduced IFN-gamma.

scientific article

Concomitant TLR/RLH signaling of radioresistant and radiosensitive cells is essential for protection against vesicular stomatitis virus infection

scientific article published on 15 August 2014

Conditional IFNAR1 ablation reveals distinct requirements of Type I IFN signaling for NK cell maturation and tumor surveillance

scientific article published on October 2012

DNA damage primes the type I interferon system via the cytosolic DNA sensor STING to promote anti-microbial innate immunity

scientific article

Delayed apoptosis of tumor associated neutrophils in the absence of endogenous IFN-β.

scientific article published on 16 May 2014

Genetic models reveal origin, persistence and non-redundant functions of IL-17-producing γδ T cells

scientific article published on 19 November 2018

Glycine 184 in nonstructural protein NS1 determines the virulence of influenza A virus strain PR8 without affecting the host interferon response

scientific article

Hepatitis C virus replication in mouse cells is restricted by IFN-dependent and -independent mechanisms

scientific article published on 21 August 2013

Identification of tumor-specific Salmonella Typhimurium promoters and their regulatory logic ⬇️

scientific article published on December 2, 2011

Immunoglobulins drive terminal maturation of splenic dendritic cells.

scientific article published on 23 January 2013

In Vivo Visualizing the IFN-β Response Required for Tumor Growth Control in a Therapeutic Model of Polyadenylic-Polyuridylic Acid Administration.

scientific article

Induction of B-cell development in adult mice reveals the ability of bone marrow to produce B-1a cells.

scientific article

Induction of endogenous Type I interferon within the central nervous system plays a protective role in experimental autoimmune encephalomyelitis.

scientific article published on 14 April 2015

Influence of internalin A murinisation on host resistance to orally acquired listeriosis in mice.

scientific article

Innate imprinting of murine resident alveolar macrophages by allergic bronchial inflammation causes a switch from hypoinflammatory to hyperinflammatory reactivity

scientific article

Lack of interferon-beta leads to accelerated remyelination in a toxic model of central nervous system demyelination

scientific article published on 17 October 2007

M27 expressed by cytomegalovirus counteracts effective type I interferon induction of myeloid cells but not of plasmacytoid dendritic cells

scientific article published on 17 September 2014

Mouse SAMHD1 has antiretroviral activity and suppresses a spontaneous cell-intrinsic antiviral response

scientific article published on 22 August 2013

Murine toll-like receptor 2 activation induces type I interferon responses from endolysosomal compartments

scientific article

Neutrophils responsive to endogenous IFN-beta regulate tumor angiogenesis and growth in a mouse tumor model

scientific article

Norovirus triggered microbiota-driven mucosal inflammation in interleukin 10-deficient mice

scientific article published on March 2014

Novel reporter mouse reveals constitutive and inflammatory expression of IFN-beta in vivo

scientific article

PCR-based simultaneous analysis of the interferon-alpha family reveals distinct kinetics for early interferons.

scientific article

Priming of natural killer cells by nonmucosal mononuclear phagocytes requires instructive signals from commensal microbiota

scientific article published on 28 June 2012

Production of IFN-β during Listeria monocytogenes infection is restricted to monocyte/macrophage lineage

scientific article

RIG-I/MAVS and STING signaling promote gut integrity during irradiation- and immune-mediated tissue injury

scientific article published on April 2017

Reversible silencing of cytomegalovirus genomes by type I interferon governs virus latency.

scientific article

STING induces early IFN-β in the liver and constrains myeloid cell-mediated dissemination of murine cytomegalovirus

scientific article published on 27 June 2019

Signals triggered by a bacterial pore-forming toxin contribute to toll-like receptor redundancy in gram-positive bacterial recognition

scientific article published in January 2009

Strong interferon-inducing capacity of a highly virulent variant of influenza A virus strain PR8 with deletions in the NS1 gene

scientific article

TLR7 contributes to the rapid progression but not to the overall fatal outcome of secondary pneumococcal disease following influenza A virus infection.

scientific article published on 15 November 2012

Temporal and spatial resolution of type I and III interferon responses in vivo

scientific article

The lack of type I interferon induces neutrophil-mediated pre-metastatic niche formation in the mouse lung.

scientific article

The mucosal adjuvant cyclic di-AMP exerts immune stimulatory effects on dendritic cells and macrophages

scientific article

Transcriptional activation of prostate specific homeobox gene NKX3-1 in subsets of T-cell lymphoblastic leukemia (T-ALL).

scientific article

Transformation of mouse fibroblasts alters the induction pattern of type I IFNs after virus infection

scientific article

Tumor invasion of Salmonella enterica serovar Typhimurium is accompanied by strong hemorrhage promoted by TNF-alpha ⬇️

scientific article published on 20 August 2009

Type I Interferon Signaling Prevents IL-1β-Driven Lethal Systemic Hyperinflammation during Invasive Bacterial Infection of Soft Tissue.

scientific article

Type I interferon drives tumor necrosis factor-induced lethal shock

scientific article published on 17 August 2009

Type I interferon protects mice from fatal neurotropic infection with Langat virus by systemic and local antiviral responses.

scientific article published on 13 August 2014

Upon intranasal vesicular stomatitis virus infection, astrocytes in the olfactory bulb are important interferon Beta producers that protect from lethal encephalitis

scientific article published on 24 December 2014

Visualizing production of beta interferon by astrocytes and microglia in brain of La Crosse virus-infected mice

scientific article published on 8 August 2012

Visualizing the beta interferon response in mice during infection with influenza A viruses expressing or lacking nonstructural protein 1. ⬇️

scientific article published on 10 April 2013

List of works by Stefan Lienenklaus

Abortively Infected Astrocytes Appear To Represent the Main Source of Interferon Beta in the Virus-Infected Brain

Age-dependent enterocyte invasion and microcolony formation by Salmonella

CD8(+) T cells armed with retrovirally transduced IFN-gamma.

Concomitant TLR/RLH signaling of radioresistant and radiosensitive cells is essential for protection against vesicular stomatitis virus infection

Conditional IFNAR1 ablation reveals distinct requirements of Type I IFN signaling for NK cell maturation and tumor surveillance

DNA damage primes the type I interferon system via the cytosolic DNA sensor STING to promote anti-microbial innate immunity

Delayed apoptosis of tumor associated neutrophils in the absence of endogenous IFN-β.

Genetic models reveal origin, persistence and non-redundant functions of IL-17-producing γδ T cells

Glycine 184 in nonstructural protein NS1 determines the virulence of influenza A virus strain PR8 without affecting the host interferon response

Hepatitis C virus replication in mouse cells is restricted by IFN-dependent and -independent mechanisms

Identification of tumor-specific Salmonella Typhimurium promoters and their regulatory logic ⬇️

Immunoglobulins drive terminal maturation of splenic dendritic cells.

In Vivo Visualizing the IFN-β Response Required for Tumor Growth Control in a Therapeutic Model of Polyadenylic-Polyuridylic Acid Administration.

Induction of B-cell development in adult mice reveals the ability of bone marrow to produce B-1a cells.

Induction of endogenous Type I interferon within the central nervous system plays a protective role in experimental autoimmune encephalomyelitis.

Influence of internalin A murinisation on host resistance to orally acquired listeriosis in mice.

Innate imprinting of murine resident alveolar macrophages by allergic bronchial inflammation causes a switch from hypoinflammatory to hyperinflammatory reactivity

Lack of interferon-beta leads to accelerated remyelination in a toxic model of central nervous system demyelination

M27 expressed by cytomegalovirus counteracts effective type I interferon induction of myeloid cells but not of plasmacytoid dendritic cells

Mouse SAMHD1 has antiretroviral activity and suppresses a spontaneous cell-intrinsic antiviral response

Murine toll-like receptor 2 activation induces type I interferon responses from endolysosomal compartments

Neutrophils responsive to endogenous IFN-beta regulate tumor angiogenesis and growth in a mouse tumor model

Norovirus triggered microbiota-driven mucosal inflammation in interleukin 10-deficient mice

Novel reporter mouse reveals constitutive and inflammatory expression of IFN-beta in vivo

PCR-based simultaneous analysis of the interferon-alpha family reveals distinct kinetics for early interferons.

Priming of natural killer cells by nonmucosal mononuclear phagocytes requires instructive signals from commensal microbiota

Production of IFN-β during Listeria monocytogenes infection is restricted to monocyte/macrophage lineage

RIG-I/MAVS and STING signaling promote gut integrity during irradiation- and immune-mediated tissue injury

Reversible silencing of cytomegalovirus genomes by type I interferon governs virus latency.

STING induces early IFN-β in the liver and constrains myeloid cell-mediated dissemination of murine cytomegalovirus

Signals triggered by a bacterial pore-forming toxin contribute to toll-like receptor redundancy in gram-positive bacterial recognition

Strong interferon-inducing capacity of a highly virulent variant of influenza A virus strain PR8 with deletions in the NS1 gene

TLR7 contributes to the rapid progression but not to the overall fatal outcome of secondary pneumococcal disease following influenza A virus infection.

Temporal and spatial resolution of type I and III interferon responses in vivo

The lack of type I interferon induces neutrophil-mediated pre-metastatic niche formation in the mouse lung.

The mucosal adjuvant cyclic di-AMP exerts immune stimulatory effects on dendritic cells and macrophages

Transcriptional activation of prostate specific homeobox gene NKX3-1 in subsets of T-cell lymphoblastic leukemia (T-ALL).

Transformation of mouse fibroblasts alters the induction pattern of type I IFNs after virus infection

Tumor invasion of Salmonella enterica serovar Typhimurium is accompanied by strong hemorrhage promoted by TNF-alpha ⬇️

Type I Interferon Signaling Prevents IL-1β-Driven Lethal Systemic Hyperinflammation during Invasive Bacterial Infection of Soft Tissue.

Type I interferon drives tumor necrosis factor-induced lethal shock

Type I interferon protects mice from fatal neurotropic infection with Langat virus by systemic and local antiviral responses.

Upon intranasal vesicular stomatitis virus infection, astrocytes in the olfactory bulb are important interferon Beta producers that protect from lethal encephalitis

Visualizing production of beta interferon by astrocytes and microglia in brain of La Crosse virus-infected mice

Visualizing the beta interferon response in mice during infection with influenza A viruses expressing or lacking nonstructural protein 1. ⬇️