List of works - Laura Ferraiuolo

<i>C9ORF72</i>-derived poly-GA DPRs undergo endocytic uptake in iAstrocytes and spread to motor neurons

scientific article published on 13 May 2022

Additive amelioration of ALS by co-targeting independent pathogenic mechanisms

scientific article published on 11 January 2017

Applications of machine learning to diagnosis and treatment of neurodegenerative diseases

scientific article published on 15 July 2020

Astrocyte adenosine deaminase loss increases motor neuron toxicity in amyotrophic lateral sclerosis

article

Can Astrocytes Be a Target for Precision Medicine?

scientific article

Delayed disease onset and extended survival in the SOD1G93A rat model of amyotrophic lateral sclerosis after suppression of mutant SOD1 in the motor cortex

scientific article

Differences in protein quality control correlate with phenotype variability in 2 mouse models of familial amyotrophic lateral sclerosis.

scientific article published on 2 July 2014

Direct conversion of patient fibroblasts demonstrates non-cell autonomous toxicity of astrocytes to motor neurons in familial and sporadic ALS

scientific article published on 30 December 2013

Directly converted astrocytes retain the ageing features of the donor fibroblasts and elucidate the astrocytic contribution to human CNS health and disease

scientific article published on 13 December 2020

Dysregulation of astrocyte-motoneuron cross-talk in mutant superoxide dismutase 1-related amyotrophic lateral sclerosis

scientific article

Gene delivery improvement for treating the lysosomal storage disorder metachromatic leukodystrophy

scientific article

Gene expression profiling in human neurodegenerative disease

scientific article published on 14 August 2012

High content analysis in amyotrophic lateral sclerosis

scientific article published on 10 December 2016

Improving single injection CSF delivery of AAV9-mediated gene therapy for SMA: a dose-response study in mice and nonhuman primates

scientific article

Loss of nuclear TDP-43 in amyotrophic lateral sclerosis (ALS) causes altered expression of splicing machinery and widespread dysregulation of RNA splicing in motor neurones.

scientific article

Lysosomal and phagocytic activity is increased in astrocytes during disease progression in the SOD1 (G93A) mouse model of amyotrophic lateral sclerosis

scientific article published on 15 October 2015

Major histocompatibility complex class I molecules protect motor neurons from astrocyte-induced toxicity in amyotrophic lateral sclerosis

scientific article

Micro-RNAs secreted through astrocyte-derived extracellular vesicles cause neuronal network degeneration in C9orf72 ALS

scientific article published on 31 January 2019

MicroNeurotrophins Improve Survival in Motor Neuron-Astrocyte Co-Cultures but Do Not Improve Disease Phenotypes in a Mutant SOD1 Mouse Model of Amyotrophic Lateral Sclerosis

scientific article

Microarray analysis of the cellular pathways involved in the adaptation to and progression of motor neuron injury in the SOD1 G93A mouse model of familial ALS.

scientific article

Microglia induce motor neuron death via the classical NF-κB pathway in amyotrophic lateral sclerosis

scientific article

Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis

scientific article

Mutations in CHMP2B in lower motor neuron predominant amyotrophic lateral sclerosis (ALS).

scientific article

Neural stem cells as a therapeutic approach for amyotrophic lateral sclerosis

scientific article published on March 2013

New In Vitro Models to Study Amyotrophic Lateral Sclerosis

scientific article

OUP accepted manuscript

article by Laura Ferraiuolo & Pamela J. Shaw published 2018 in Brain

Oligodendrocytes contribute to motor neuron death in ALS via SOD1-dependent mechanism

scientific article published on 29 September 2016

Phosphatase and tensin homologue/protein kinase B pathway linked to motor neuron survival in human superoxide dismutase 1-related amyotrophic lateral sclerosis

scientific article

SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits

scientific article

The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy

scientific article published on 22 June 2016

The non-cell-autonomous component of ALS: new in vitro models and future challenges.

scientific article published on October 2014

Therapeutic AAV9-mediated suppression of mutant SOD1 slows disease progression and extends survival in models of inherited ALS

scientific article published on 06 September 2013

Transcriptional response of the neuromuscular system to exercise training and potential implications for ALS

scientific article published on 01 April 2009

Transcriptomic indices of fast and slow disease progression in two mouse models of amyotrophic lateral sclerosis.

scientific article

Translating SOD1 Gene Silencing toward the Clinic: A Highly Efficacious, Off-Target-free, and Biomarker-Supported Strategy for fALS.

scientific article

Translational profiling identifies a cascade of damage initiated in motor neurons and spreading to glia in mutant SOD1-mediated ALS.

scientific article published on 30 November 2015

Ursodeoxycholic Acid Improves Mitochondrial Function and Redistributes Drp1 in Fibroblasts from Patients with Either Sporadic or Familial Alzheimer's Disease

scientific article published on 29 August 2018

List of works by Laura Ferraiuolo

<i>C9ORF72</i>-derived poly-GA DPRs undergo endocytic uptake in iAstrocytes and spread to motor neurons

Additive amelioration of ALS by co-targeting independent pathogenic mechanisms

Applications of machine learning to diagnosis and treatment of neurodegenerative diseases

Astrocyte adenosine deaminase loss increases motor neuron toxicity in amyotrophic lateral sclerosis

Can Astrocytes Be a Target for Precision Medicine?

Delayed disease onset and extended survival in the SOD1G93A rat model of amyotrophic lateral sclerosis after suppression of mutant SOD1 in the motor cortex

Differences in protein quality control correlate with phenotype variability in 2 mouse models of familial amyotrophic lateral sclerosis.

Direct conversion of patient fibroblasts demonstrates non-cell autonomous toxicity of astrocytes to motor neurons in familial and sporadic ALS

Directly converted astrocytes retain the ageing features of the donor fibroblasts and elucidate the astrocytic contribution to human CNS health and disease

Dysregulation of astrocyte-motoneuron cross-talk in mutant superoxide dismutase 1-related amyotrophic lateral sclerosis

Gene delivery improvement for treating the lysosomal storage disorder metachromatic leukodystrophy

Gene expression profiling in human neurodegenerative disease

High content analysis in amyotrophic lateral sclerosis

Improving single injection CSF delivery of AAV9-mediated gene therapy for SMA: a dose-response study in mice and nonhuman primates

Loss of nuclear TDP-43 in amyotrophic lateral sclerosis (ALS) causes altered expression of splicing machinery and widespread dysregulation of RNA splicing in motor neurones.

Lysosomal and phagocytic activity is increased in astrocytes during disease progression in the SOD1 (G93A) mouse model of amyotrophic lateral sclerosis

Major histocompatibility complex class I molecules protect motor neurons from astrocyte-induced toxicity in amyotrophic lateral sclerosis

Micro-RNAs secreted through astrocyte-derived extracellular vesicles cause neuronal network degeneration in C9orf72 ALS

MicroNeurotrophins Improve Survival in Motor Neuron-Astrocyte Co-Cultures but Do Not Improve Disease Phenotypes in a Mutant SOD1 Mouse Model of Amyotrophic Lateral Sclerosis

Microarray analysis of the cellular pathways involved in the adaptation to and progression of motor neuron injury in the SOD1 G93A mouse model of familial ALS.

Microglia induce motor neuron death via the classical NF-κB pathway in amyotrophic lateral sclerosis

Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis

Mutations in CHMP2B in lower motor neuron predominant amyotrophic lateral sclerosis (ALS).

Neural stem cells as a therapeutic approach for amyotrophic lateral sclerosis

New In Vitro Models to Study Amyotrophic Lateral Sclerosis

OUP accepted manuscript

Oligodendrocytes contribute to motor neuron death in ALS via SOD1-dependent mechanism

Phosphatase and tensin homologue/protein kinase B pathway linked to motor neuron survival in human superoxide dismutase 1-related amyotrophic lateral sclerosis

SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits

The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy

The non-cell-autonomous component of ALS: new in vitro models and future challenges.

Therapeutic AAV9-mediated suppression of mutant SOD1 slows disease progression and extends survival in models of inherited ALS

Transcriptional response of the neuromuscular system to exercise training and potential implications for ALS

Transcriptomic indices of fast and slow disease progression in two mouse models of amyotrophic lateral sclerosis.

Translating SOD1 Gene Silencing toward the Clinic: A Highly Efficacious, Off-Target-free, and Biomarker-Supported Strategy for fALS.

Translational profiling identifies a cascade of damage initiated in motor neurons and spreading to glia in mutant SOD1-mediated ALS.

Ursodeoxycholic Acid Improves Mitochondrial Function and Redistributes Drp1 in Fibroblasts from Patients with Either Sporadic or Familial Alzheimer's Disease