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List of works by Tomohiro Aoki

A sphingosine-1-phosphate receptor type 1 agonist, ASP4058, suppresses intracranial aneurysm through promoting endothelial integrity and blocking macrophage transmigration

scientific article

CCAAT/enhancer-binding protein delta/miR135a/thrombospondin 1 axis mediates PGE2-induced angiogenesis in Alzheimer's disease

scientific article published on 4 December 2014

Cathepsin B, K, and S are expressed in cerebral aneurysms and promote the progression of cerebral aneurysms

scientific article published on 17 July 2008

Complementary inhibition of cerebral aneurysm formation by eNOS and nNOS

scientific article published on 14 February 2011

Contribution of mast cells to cerebral aneurysm formation

scientific article published in May 2010

Critical role of TNF-alpha-TNFR1 signaling in intracranial aneurysm formation

scientific article published on 31 March 2014

Dedifferentiation of smooth muscle cells in intracranial aneurysms and its potential contribution to the pathogenesis

scientific article published on 20 May 2020

Definition of Prostaglandin E2-EP2 Signals in the Colon Tumor Microenvironment That Amplify Inflammation and Tumor Growth.

scientific article

Dipeptidyl Peptidase-4 Inhibitor Anagliptin Prevents Intracranial Aneurysm Growth by Suppressing Macrophage Infiltration and Activation

scientific article published on 19 June 2017

Ets-1 promotes the progression of cerebral aneurysm by inducing the expression of MCP-1 in vascular smooth muscle cells

scientific article published on 29 April 2010

Exacerbation of intracranial aneurysm and aortic dissection in hypertensive rat treated with the prostaglandin F-receptor antagonist AS604872.

scientific article published on 23 October 2014

Future prospects for the development of a novel medical therapy for intracranial aneurysm.

scientific article published on August 2016

Gene expression during the development of experimentally induced cerebral aneurysms.

scientific article

Imidapril inhibits cerebral aneurysm formation in an angiotensin-converting enzyme-independent and matrix metalloproteinase-9-dependent manner

scientific article published on 01 March 2012

Macrophage Imaging of Cerebral Aneurysms with Ferumoxytol: an Exploratory Study in an Animal Model and in Patients.

scientific article published on 31 July 2017

Macrophage-derived matrix metalloproteinase-2 and -9 promote the progression of cerebral aneurysms in rats.

scientific article

Molecular basis for intracranial aneurysm formation.

scientific article

NF-kappaB is a key mediator of cerebral aneurysm formation

scientific article published on 19 November 2007

Nifedipine inhibits the progression of an experimentally induced cerebral aneurysm in rats with associated down-regulation of NF-kappa B transcriptional activity.

scientific article

PGE(2) -EP(2) signalling in endothelium is activated by haemodynamic stress and induces cerebral aneurysm through an amplifying loop via NF-κB.

scientific article

Pitavastatin suppresses formation and progression of cerebral aneurysms through inhibition of the nuclear factor kappaB pathway.

scientific article published in February 2009

Preemptive Medicine for Cerebral Aneurysms

scientific article published on 06 April 2016

Prostaglandin E2 stimulates adaptive IL-22 production and promotes allergic contact dermatitis

scientific article published on 2 June 2017

Prostaglandin E2-EP2-NF-κB signaling in macrophages as a potential therapeutic target for intracranial aneurysms.

scientific article published on 7 February 2017

Prostaglandin E2-EP4 signaling persistently amplifies CD40-mediated induction of IL-23 p19 expression through canonical and non-canonical NF-κB pathways.

scientific article published on 20 July 2015

RNA sequencing analysis revealed the induction of CCL3 expression in human intracranial aneurysms

scientific article published on 17 July 2019

Reactive oxygen species modulate growth of cerebral aneurysms: a study using the free radical scavenger edaravone and p47phox(-/-) mice.

scientific article published on 20 April 2009

Reduced collagen biosynthesis is the hallmark of cerebral aneurysm: contribution of interleukin-1beta and nuclear factor-kappaB.

scientific article

Regression of intracranial aneurysms by simultaneous inhibition of nuclear factor-κB and Ets with chimeric decoy oligodeoxynucleotide treatment.

scientific article published in June 2012

Role of TIMP-1 and TIMP-2 in the progression of cerebral aneurysms

scientific article published on 14 June 2007

Role of angiotensin II type 1 receptor in cerebral aneurysm formation in rats.

scientific article published in September 2009

Simvastatin suppresses the progression of experimentally induced cerebral aneurysms in rats

scientific article

Sustained expression of MCP-1 by low wall shear stress loading concomitant with turbulent flow on endothelial cells of intracranial aneurysm

scientific article published on 9 May 2016

T cell function is dispensable for intracranial aneurysm formation and progression

scientific article

Targeting chronic inflammation in cerebral aneurysms: focusing on NF-kappaB as a putative target of medical therapy.

scientific article published on March 2010

The development and the use of experimental animal models to study the underlying mechanisms of CA formation.

scientific article

The efficacy of apolipoprotein E deficiency in cerebral aneurysm formation.

scientific article

Toll-like receptor 4 expression during cerebral aneurysm formation. Laboratory investigation

scientific article published on 01 October 2010

Two Diverse Hemodynamic Forces, a Mechanical Stretch and a High Wall Shear Stress, Determine Intracranial Aneurysm Formation

scientific article published on 08 February 2019

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