List of works - Linos Vandekerckhove

Abacavir Hypersensitivity

scientific article published on 01 June 2008

Abacavir usage patterns and hypersensitivity reactions in the EuroSIDA cohort.

scientific article published on 22 December 2017

Accurate episomal HIV 2-LTR circles quantification using optimized DNA isolation and droplet digital PCR.

scientific article published on 2 November 2014

Accurate quantification of episomal HIV-1 two-long terminal repeat circles by use of optimized DNA isolation and droplet digital PCR.

scientific article published on 10 December 2014

Aggressive extensive cardiac mass in an HIV-1-infected patient: should we go for comfort therapy?

scientific article published on 14 June 2016

Antiretrovirals for HIV prevention: when should they be recommended?

scientific article published on April 2014

Aviremia 10 Years Postdiscontinuation of Antiretroviral Therapy Initiated During Primary Human Immunodeficiency Virus-1 Infection and Association With Gag-Specific T-Cell Responses

scientific article

Boosted protease inhibitor monotherapy in HIV-infected adults: outputs from a pan-European expert panel meeting

scientific article published on 24 January 2013

CXCR4-using HIV type 1 variants are more commonly found in peripheral blood mononuclear cell DNA than in plasma RNA.

scientific article

Calciphylaxis: a rare complication in alcoholic liver disease

scientific article published in March 2013

Cellular co-factors of HIV-1 integration

scientific article

Characterization of LEDGF/p75 genetic variants and association with HIV-1 disease progression

scientific article

Clinical use of HIV integrase inhibitors: a systematic review and meta-analysis

scientific article

Comparative performances of HIV-1 RNA load assays at low viral load levels: results of an international collaboration.

scientific article published on 04 December 2013

Comparison of droplet digital PCR and seminested real-time PCR for quantification of cell-associated HIV-1 RNA.

scientific article published on 21 January 2014

Comparison of methods for in-house screening of HLA-B*57:01 to prevent abacavir hypersensitivity in HIV-1 care

scientific article

Comparison of phenotypic and genotypic tropism determination in triple-class-experienced HIV patients eligible for maraviroc treatment

scientific article

Concordance between HIV-1 genotypic coreceptor tropism predictions based on plasma RNA and proviral DNA.

scientific article

Consensus statement of the European guidelines on clinical management of HIV-1 tropism testing.

scientific article published on 8 November 2010

Correction: Integrated and Total HIV-1 DNA Predict Ex Vivo Viral Outgrowth

scientific article published on 22 March 2016

Correlation of coreceptor usage and disease progression ⬇️

scientific article published on September 1, 2012

Corrigendum: Differential expression of lncRNAs during the HIV replication cycle: an underestimated layer in the HIV-host interplay

scientific article published on 24 January 2017

Cutaneous metastatic tuberculous abcess in a patient with cervico-mediastinal lymphatic tuberculosis

scientific article published in January 2013

Dependence on the CCR5 coreceptor for viral replication explains the lack of rebound of CXCR4-predicted HIV variants in the Berlin patient

scientific article published on 23 April 2014

Detection of drug resistance mutations as a predictor of subsequent virological failure in patients with HIV-1 viral rebounds of less than 1,000 RNA copies/ml

scientific article published in September 2007

Diagnostic utility of droplet digital PCR for HIV reservoir quantification

scientific article published on July 2016

Differential expression of lncRNAs during the HIV replication cycle: an underestimated layer in the HIV-host interplay

scientific article published on 26 October 2016

Digital PCR as a tool to measure HIV persistence

scientific article published on 30 January 2018

Disparities in HIV clinic care across Europe: findings from the EuroSIDA clinic survey

scientific article published on 20 July 2016

Disseminated infection with Mycobacterium tilburgii in a male immunocompromised patient

scientific article published on 12 February 2014

Drug resistance is rarely the cause or consequence of long-term persistent low-level viraemia in HIV-1-infected patients on ART.

scientific article

During Stably Suppressive Antiretroviral Therapy Integrated HIV-1 DNA Load in Peripheral Blood is Associated with the Frequency of CD8 Cells Expressing HLA-DR/DP/DQ

scientific article

Early treated HIV-1 positive individuals demonstrate similar restriction factor expression profile as long-term non-progressors

article

Emerging PCR-Based Techniques to Study HIV-1 Reservoir Persistence

scientific article published on 28 January 2020

Epidemiological study of phylogenetic transmission clusters in a local HIV-1 epidemic reveals distinct differences between subtype B and non-B infections

scientific article

Erratum to: HIV integration sites in latently infected cell lines: evidence of ongoing replication

scientific article published on 27 March 2017

Evaluating predictive markers for viral rebound and safety assessment in blood and lumbar fluid during HIV-1 treatment interruption

scientific article published on 13 February 2020

Factors associated with the continuum of care of HIV-infected patients in Belgium

scientific article

Fight fire with fire: Gene therapy strategies to cure HIV.

scientific article

Fluconazole exposure and selection for Candida non-albicans

scientific article published in December 2008

Frequency and predictors of HIV-1 co-receptor switch in treatment naive patients

scientific article

GSK-1349572, a novel integrase inhibitor for the treatment of HIV infection.

scientific article published on February 2010

HIV Reservoir Characterization Symposium: 19 September 2016, Ghent, Belgium

scientific article published on January 2017

HIV-1 RNA and HIV-1 DNA persistence during suppressive ART with PI-based or nevirapine-based regimens

scientific article published on 31 August 2015

HIV-1 V3 envelope deep sequencing for clinical plasma specimens failing in phenotypic tropism assays

scientific article

HIV-1 Vpr N-terminal tagging affects alternative splicing of the viral genome

scientific article published on 10 October 2016

High prevalence of bevirimat resistance mutations in protease inhibitor-resistant HIV isolates

scientific article published on March 2010

Highlights from the 24th Conference on Retroviruses and Opportunistic Infections: 13-16 February 2017, Seattle, Washington, USA.

scientific article published on April 2017

Highlights from the Conference on Retroviruses and Opportunistic Infections 2016: 22-25 February 2016, Boston, Massachusetts, USA.

scientific article published on April 2016

IRF7 and RNH1 are modifying factors of HIV-1 reservoirs: a genome-wide association analysis

scientific article published in 2021

Impact of Delta 32-CCR5 heterozygosity on HIV-1 genetic evolution and variability--a study of 4 individuals infected with closely related HIV-1 strains

scientific article published on 9 August 2008

Impact of a decade of successful antiretroviral therapy initiated at HIV-1 seroconversion on blood and rectal reservoirs.

scientific article

Impact of the HIV-1 genetic background and HIV-1 population size on the evolution of raltegravir resistance

scientific article published on 5 January 2018

Impact of triplicate testing on HIV genotypic tropism prediction in routine clinical practice

scientific article

Impaired hemoglobin scavenging during an acute HIV-1 retroviral syndrome.

scientific article published on 13 January 2010

Implementation of a multidisciplinary infectious diseases team in a tertiary hospital within an Antimicrobial Stewardship Program

scientific article published on 16 July 2014

In-depth single-cell analysis of translation-competent HIV-1 reservoirs identifies cellular sources of plasma viremia

scientific article published on 17 June 2021

In-depth validation of total HIV-1 DNA assays for quantification of various HIV-1 subtypes

scientific article published in Scientific Reports

Integrase mutants defective for interaction with LEDGF/p75 are impaired in chromosome tethering and HIV-1 replication

scientific article published on 25 April 2005

Integrated and Total HIV-1 DNA Predict Ex Vivo Viral Outgrowth

scientific article

Left ventricular diastolic dysfunction and myocardial stiffness in diabetic mice is attenuated by inhibition of dipeptidyl peptidase 4.

scientific article published on 23 October 2014

Lentiviral nuclear import: a complex interplay between virus and host

scientific article

Maraviroc: integration of a new antiretroviral drug class into clinical practice

scientific article published on 9 April 2008

Maraviroc: perspectives for use in antiretroviral-naive HIV-1-infected patients

scientific article

Markers associated with persisting low-level viraemia under antiretroviral therapy in HIV-1 infection

scientific article published on 12 December 2013

Minimal Requirements for Primary HIV Latency Models Based on a Systematic Review

scientific article

Morbidity and mortality of bloodstream infections in patients with severe burn injury

scientific article published in November 2010

Overexpression of the lens epithelium-derived growth factor/p75 integrase binding domain inhibits human immunodeficiency virus replication

scientific article

Polyfunctional CD4(+) T cell responses in HIV-1-infected viral controllers compared with those in healthy recipients of an adjuvanted polyprotein HIV-1 vaccine.

scientific article published on 21 May 2013

Presence of CXCR4-using HIV-1 in patients with recently diagnosed infection: correlates and evidence for transmission

scientific article published on 5 December 2011

Proceedings of the Frontiers of Retrovirology Conference 2016.

scientific article published on 26 September 2016

Processing of blood samples influences PBMC viability and outcome of cell-mediated immune responses in antiretroviral therapy-naïve HIV-1-infected patients

scientific article published on 16 September 2014

Protein expression from unintegrated HIV-1 DNA introduces bias in primary in vitro post-integration latency models

scientific article

Quantification of integrated HIV DNA by repetitive-sampling Alu-HIV PCR on the basis of poisson statistics

scientific article published on 24 March 2014

Raltegravir 1200 mg once daily versus raltegravir 400 mg twice daily, with tenofovir disoproxil fumarate and emtricitabine, for previously untreated HIV-1 infection: a randomised, double-blind, parallel-group, phase 3, non-inferiority trial

scientific article published on 11 September 2017

Reference gene validation for RT-qPCR, a note on different available software packages

scientific article published on 31 March 2015

Replication competent virus as an important source of bias in HIV latency models utilizing single round viral constructs

scientific article

Robust regression methods for real-time polymerase chain reaction

scientific article published on 8 April 2015

Severe drug-induced liver injury associated with prolonged use of linezolid

scientific article published on September 2010

Th1/17 Polarization of CD4 T Cells Supports HIV-1 Persistence during Antiretroviral Therapy

scientific article

The Architecture of Circulating Immune Cells Is Dysregulated in People Living With HIV on Long Term Antiretroviral Treatment and Relates With Markers of the HIV-1 Reservoir, Cytomegalovirus, and Microbial Translocation

scientific article published in 2021

The Future of Digital Polymerase Chain Reaction in Virology

scientific article published on 28 June 2016

The impact of nevirapine- versus protease inhibitor-based regimens on virological markers of HIV-1 persistence during seemingly suppressive ART.

scientific article published on 2 November 2014

The use of HIV-1 integration site analysis information in clinical studies aiming at HIV cure

scientific article published on July 2016

Touchdown digital polymerase chain reaction for quantification of highly conserved sequences in the HIV-1 genome

scientific article

Transient and stable knockdown of the integrase cofactor LEDGF/p75 reveals its role in the replication cycle of human immunodeficiency virus

scientific article

Ultra-Deep Sequencing of HIV-1 Reverse Transcriptase Before Start of an NNRTI-based Regimen in Treatment-naive Patients ⬇️

scientific article published on February 4, 2012

Virus evolution reveals an exclusive role for LEDGF/p75 in chromosomal tethering of HIV.

scientific article

ddpcRquant: threshold determination for single channel droplet digital PCR experiments

scientific article published on 29 May 2015

List of works by Linos Vandekerckhove

Abacavir Hypersensitivity

Abacavir usage patterns and hypersensitivity reactions in the EuroSIDA cohort.

Accurate episomal HIV 2-LTR circles quantification using optimized DNA isolation and droplet digital PCR.

Accurate quantification of episomal HIV-1 two-long terminal repeat circles by use of optimized DNA isolation and droplet digital PCR.

Aggressive extensive cardiac mass in an HIV-1-infected patient: should we go for comfort therapy?

Antiretrovirals for HIV prevention: when should they be recommended?

Aviremia 10 Years Postdiscontinuation of Antiretroviral Therapy Initiated During Primary Human Immunodeficiency Virus-1 Infection and Association With Gag-Specific T-Cell Responses

Boosted protease inhibitor monotherapy in HIV-infected adults: outputs from a pan-European expert panel meeting

CXCR4-using HIV type 1 variants are more commonly found in peripheral blood mononuclear cell DNA than in plasma RNA.

Calciphylaxis: a rare complication in alcoholic liver disease

Cellular co-factors of HIV-1 integration

Characterization of LEDGF/p75 genetic variants and association with HIV-1 disease progression

Clinical use of HIV integrase inhibitors: a systematic review and meta-analysis

Comparative performances of HIV-1 RNA load assays at low viral load levels: results of an international collaboration.

Comparison of droplet digital PCR and seminested real-time PCR for quantification of cell-associated HIV-1 RNA.

Comparison of methods for in-house screening of HLA-B*57:01 to prevent abacavir hypersensitivity in HIV-1 care

Comparison of phenotypic and genotypic tropism determination in triple-class-experienced HIV patients eligible for maraviroc treatment

Concordance between HIV-1 genotypic coreceptor tropism predictions based on plasma RNA and proviral DNA.

Consensus statement of the European guidelines on clinical management of HIV-1 tropism testing.

Correction: Integrated and Total HIV-1 DNA Predict Ex Vivo Viral Outgrowth

Correlation of coreceptor usage and disease progression ⬇️

Corrigendum: Differential expression of lncRNAs during the HIV replication cycle: an underestimated layer in the HIV-host interplay

Cutaneous metastatic tuberculous abcess in a patient with cervico-mediastinal lymphatic tuberculosis

Dependence on the CCR5 coreceptor for viral replication explains the lack of rebound of CXCR4-predicted HIV variants in the Berlin patient

Detection of drug resistance mutations as a predictor of subsequent virological failure in patients with HIV-1 viral rebounds of less than 1,000 RNA copies/ml

Diagnostic utility of droplet digital PCR for HIV reservoir quantification

Differential expression of lncRNAs during the HIV replication cycle: an underestimated layer in the HIV-host interplay

Digital PCR as a tool to measure HIV persistence

Disparities in HIV clinic care across Europe: findings from the EuroSIDA clinic survey

Disseminated infection with Mycobacterium tilburgii in a male immunocompromised patient

Drug resistance is rarely the cause or consequence of long-term persistent low-level viraemia in HIV-1-infected patients on ART.

During Stably Suppressive Antiretroviral Therapy Integrated HIV-1 DNA Load in Peripheral Blood is Associated with the Frequency of CD8 Cells Expressing HLA-DR/DP/DQ

Early treated HIV-1 positive individuals demonstrate similar restriction factor expression profile as long-term non-progressors

Emerging PCR-Based Techniques to Study HIV-1 Reservoir Persistence

Epidemiological study of phylogenetic transmission clusters in a local HIV-1 epidemic reveals distinct differences between subtype B and non-B infections

Erratum to: HIV integration sites in latently infected cell lines: evidence of ongoing replication

Evaluating predictive markers for viral rebound and safety assessment in blood and lumbar fluid during HIV-1 treatment interruption

Factors associated with the continuum of care of HIV-infected patients in Belgium

Fight fire with fire: Gene therapy strategies to cure HIV.

Fluconazole exposure and selection for Candida non-albicans

Frequency and predictors of HIV-1 co-receptor switch in treatment naive patients

GSK-1349572, a novel integrase inhibitor for the treatment of HIV infection.

HIV Reservoir Characterization Symposium: 19 September 2016, Ghent, Belgium

HIV-1 RNA and HIV-1 DNA persistence during suppressive ART with PI-based or nevirapine-based regimens

HIV-1 V3 envelope deep sequencing for clinical plasma specimens failing in phenotypic tropism assays

HIV-1 Vpr N-terminal tagging affects alternative splicing of the viral genome

High prevalence of bevirimat resistance mutations in protease inhibitor-resistant HIV isolates

Highlights from the 24th Conference on Retroviruses and Opportunistic Infections: 13-16 February 2017, Seattle, Washington, USA.

Highlights from the Conference on Retroviruses and Opportunistic Infections 2016: 22-25 February 2016, Boston, Massachusetts, USA.

IRF7 and RNH1 are modifying factors of HIV-1 reservoirs: a genome-wide association analysis

Impact of Delta 32-CCR5 heterozygosity on HIV-1 genetic evolution and variability--a study of 4 individuals infected with closely related HIV-1 strains

Impact of a decade of successful antiretroviral therapy initiated at HIV-1 seroconversion on blood and rectal reservoirs.

Impact of the HIV-1 genetic background and HIV-1 population size on the evolution of raltegravir resistance

Impact of triplicate testing on HIV genotypic tropism prediction in routine clinical practice

Impaired hemoglobin scavenging during an acute HIV-1 retroviral syndrome.

Implementation of a multidisciplinary infectious diseases team in a tertiary hospital within an Antimicrobial Stewardship Program

In-depth single-cell analysis of translation-competent HIV-1 reservoirs identifies cellular sources of plasma viremia

In-depth validation of total HIV-1 DNA assays for quantification of various HIV-1 subtypes

Integrase mutants defective for interaction with LEDGF/p75 are impaired in chromosome tethering and HIV-1 replication

Integrated and Total HIV-1 DNA Predict Ex Vivo Viral Outgrowth

Left ventricular diastolic dysfunction and myocardial stiffness in diabetic mice is attenuated by inhibition of dipeptidyl peptidase 4.

Lentiviral nuclear import: a complex interplay between virus and host

Maraviroc: integration of a new antiretroviral drug class into clinical practice

Maraviroc: perspectives for use in antiretroviral-naive HIV-1-infected patients

Markers associated with persisting low-level viraemia under antiretroviral therapy in HIV-1 infection

Minimal Requirements for Primary HIV Latency Models Based on a Systematic Review

Morbidity and mortality of bloodstream infections in patients with severe burn injury

Overexpression of the lens epithelium-derived growth factor/p75 integrase binding domain inhibits human immunodeficiency virus replication

Polyfunctional CD4(+) T cell responses in HIV-1-infected viral controllers compared with those in healthy recipients of an adjuvanted polyprotein HIV-1 vaccine.

Presence of CXCR4-using HIV-1 in patients with recently diagnosed infection: correlates and evidence for transmission

Proceedings of the Frontiers of Retrovirology Conference 2016.

Processing of blood samples influences PBMC viability and outcome of cell-mediated immune responses in antiretroviral therapy-naïve HIV-1-infected patients

Protein expression from unintegrated HIV-1 DNA introduces bias in primary in vitro post-integration latency models

Quantification of integrated HIV DNA by repetitive-sampling Alu-HIV PCR on the basis of poisson statistics

Raltegravir 1200 mg once daily versus raltegravir 400 mg twice daily, with tenofovir disoproxil fumarate and emtricitabine, for previously untreated HIV-1 infection: a randomised, double-blind, parallel-group, phase 3, non-inferiority trial

Reference gene validation for RT-qPCR, a note on different available software packages

Replication competent virus as an important source of bias in HIV latency models utilizing single round viral constructs

Robust regression methods for real-time polymerase chain reaction

Severe drug-induced liver injury associated with prolonged use of linezolid