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List of works by George M. Burslem

A modular lead-oriented synthesis of diverse piperazine, 1,4-diazepane and 1,5-diazocane scaffolds ⬇️

scientific article published in April 2014

Aminomethylhydroxylation of alkenes: Exploitation in the synthesis of scaffolds for small molecule libraries.

scientific article published on 11 February 2015

An integrated approach to the discovery of inhibitors of protein-protein interactions ⬇️

doctoral thesis by George McEwan Burslem

Click-enabled heterotrifunctional template for sequential bioconjugations

article

Correction: Correction: Hypoxia inducible factor (HIF) as a model for studying inhibition of protein-protein interactions ⬇️

scientific article published on 02 February 2018

Development of solvent-free synthesis of hydrogen-bonded supramolecular polyurethanes ⬇️

scientific article

Double quick, double click reversible peptide "stapling". ⬇️

scientific article published on 31 May 2017

Efficient Synthesis of Immunomodulatory Drug Analogues Enables Exploration of Structure-Degradation Relationships

scientific article published on 04 July 2018

Enhancing Antiproliferative Activity and Selectivity of a FLT-3 Inhibitor by Proteolysis Targeting Chimera Conversion

scientific article published on 19 November 2018

Erratum: Further Correction: Hypoxia inducible factor (HIF) as a model for studying inhibition of protein-protein interactions ⬇️

scientific article published on 01 February 2018

Expeditious Synthesis of Isoquinolones and Isocoumarins with a Vinyl Borane as an Acetylene Equivalent

scientific article published on 26 July 2016

Exploration of the HIF-1α/p300 interface using peptide and Adhiron phage display technologies ⬇️

scientific article

Hypoxia inducible factor (HIF) as a model for studying inhibition of protein-protein interactions ⬇️

scientific article published on 26 April 2017

In-cell click labelling of small molecules to determine subcellular localisation

scientific article

Lessons in PROTAC Design from Selective Degradation with a Promiscuous Warhead.

scientific article published on 31 October 2017

Multivalent helix mimetics for PPI-inhibition ⬇️

scientific article published in January 2015

Orthogonal functionalisation of α-helix mimetics ⬇️

scientific article published on September 2014

Protein folding state-dependent sorting at the Golgi apparatus

scientific article published on 05 June 2019

Proteolysis-Targeting Chimeras as Therapeutics and Tools for Biological Discovery

scientific article published on 16 January 2020

Scaffold hopping enables direct access to more potent PROTACs with in vivo activity

scientific article published on 10 June 2020

Small-Molecule Modulation of Protein Homeostasis.

scientific article published on 4 August 2017

Small-molecule proteomimetic inhibitors of the HIF-1α-p300 protein-protein interaction ⬇️

scientific article

Synthesis of Oligobenzamide α-Helix Mimetics

Synthesis of highly functionalized oligobenzamide proteomimetic foldamers by late stage introduction of sensitive groups ⬇️

scientific article

Targeting BCR-ABL1 in Chronic Myeloid Leukemia by PROTAC-Mediated Targeted Protein Degradation

scientific article published on 16 July 2019

The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case Study

scientific article published on 25 October 2017

Towards "bionic" proteins: replacement of continuous sequences from HIF-1α with proteomimetics to create functional p300 binding HIF-1α mimics ⬇️

scientific article published on 24 March 2016

Trivalent Gd-DOTA reagents for modification of proteins ⬇️

scientific article

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