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List of works by Dirk J Snyders

A K+ channel splice variant common in human heart lacks a C-terminal domain required for expression of rapidly activating delayed rectifier current

scientific article published in October 1998

A Kv channel with an altered activation gate sequence displays both "fast" and "slow" activation kinetics.

scientific article

A polyether biotoxin binding site on the lipid-exposed face of the pore domain of Kv channels revealed by the marine toxin gambierol

scientific article

A rapidly activating and slowly inactivating potassium channel cloned from human heart. Functional analysis after stable mammalian cell culture expression

scientific article

ATP-inhibitable Cl- channel in apical membranes of cultured rabbit cortical collecting duct cells

scientific article published on 01 October 1993

Alinidine modifies the pacemaker current in sheep Purkinje fibers

scientific article published on 01 September 1987

Being flexible: the voltage-controllable activation gate of kv channels.

scientific article published on 13 September 2012

Benzocaine enhances and inhibits the K+ current through a human cardiac cloned channel (Kv1.5).

scientific article published in May 1999

Block of human cardiac Kv1.5 channels by loratadine: voltage-, time- and use-dependent block at concentrations above therapeutic levels

scientific article published on August 1997

Class III antiarrhythmic agents have a lot of potential but a long way to go. Reduced effectiveness and dangers of reverse use dependence

scientific article published on 01 February 1990

Class III antiarrhythmic effects of zatebradine. Time-, state-, use-, and voltage-dependent block of hKv1.5 channels

scientific article published in August 1996

Conserved negative charges in the N-terminal tetramerization domain mediate efficient assembly of Kv2.1 and Kv2.1/Kv6.4 channels.

scientific article

Deletion of highly conserved C-terminal sequences in the Kv1 K+ channel sub-family does not prevent expression of currents with wild-type characteristics

scientific article published in February 1994

Determinants of antiarrhythmic drug action. Electrostatic and hydrophobic components of block of the human cardiac hKv1.5 channel

scientific article

Differential modulation of Kv4 kinetics by KCHIP1 splice variants.

scientific article

Distinct domains of the voltage-gated K+ channel Kv beta 1.3 beta-subunit affect voltage-dependent gating.

scientific article

Domain analysis of Kv6.3, an electrically silent channel

scientific article

Drug associated sodium channels inactivate and reactivate at more negative potentials than drug-free channels.

scientific article published in January 1987

Drug block of I(kr): model systems and relevance to human arrhythmias

scientific article

Dual effect of phosphatidylinositol (4,5)-bisphosphate PIP(2) on Shaker K(+) [corrected] channels

scientific article published on 29 August 2012

Dual effect of phosphatidylinositol (4,5)-bisphosphate PIP2 on Shaker K+ channels.

scientific article published in April 2013

Effects of 4-aminopyridine on inward rectifying and pacemaker currents of cardiac Purkinje fibres

scientific article published on 01 September 1982

Effects of a quaternary bupivacaine derivative on delayed rectifier K(+) currents

scientific article published in May 2000

Effects of antiarrhythmic drugs on cloned cardiac voltage-gated potassium channels expressed in Xenopus oocytes

scientific article published in July 2000

Effects of quinidine on the sodium current of guinea pig ventricular myocytes. Evidence for a drug-associated rested state with altered kinetics

scientific article published on February 1990

Effects of ropivacaine on a potassium channel (hKv1.5) cloned from human ventricle

scientific article published in March 1997

Electrophysiological and pharmacological correspondence between Kv4.2 current and rat cardiac transient outward current

scientific journal article

Evidence for multiple open and inactivated states of the hKv1.5 delayed rectifier

scientific article

Functional antagonism of voltage-gated K+ channel α-subunits in the developing brain ventricular system.

scientific article published on 11 October 2016

Functional effects of a KCNQ1 mutation associated with the long QT syndrome

scientific article published on 28 February 2006

Functional expression of an inactivating potassium channel (Kv4.3) in a mammalian cell line

scientific article published on January 1999

Functional expression of an inactivating potassium channel cloned from human heart

scientific article published on September 1992

Functional interactions between residues in the S1, S4, and S5 domains of Kv2.1.

scientific article published on 01 April 2011

Gambierol, a toxin produced by the dinoflagellate Gambierdiscus toxicus, is a potent blocker of voltage-gated potassium channels.

scientific article published on 12 January 2008

Gating of shaker-type channels requires the flexibility of S6 caused by prolines

scientific article published on 17 September 2003

HERG mutation predicts short QT based on channel kinetics but causes long QT by heterotetrameric trafficking deficiency.

scientific article published on August 2005

Heteromultimeric assembly of human potassium channels. Molecular basis of a transient outward current?

scientific article

High affinity open channel block by dofetilide of HERG expressed in a human cell line.

scientific article published on June 1996

Ibutilide, a methanesulfonanilide antiarrhythmic, is a potent blocker of the rapidly activating delayed rectifier K+ current (IKr) in AT-1 cells. Concentration-, time-, voltage-, and use-dependent effects.

scientific article published on March 1995

K+ currents and K+ channel mRNA in cultured atrial cardiac myocytes (AT-1 cells).

scientific article published on November 1994

KCNQ1 channels voltage dependence through a voltage-dependent binding of the S4-S5 linker to the pore domain.

scientific article

Kv channel gating requires a compatible S4-S5 linker and bottom part of S6, constrained by non-interacting residues

scientific article published in December 2008

Kv2.1 and silent Kv subunits underlie the delayed rectifier K+ current in cultured small mouse DRG neurons

scientific article published on 8 April 2009

Kv3 channels contribute to the delayed rectifier current in small cultured mouse dorsal root ganglion neurons

scientific article published on 06 June 2012

Kv3.3b expression defines the shape of the complex spike in the Purkinje cell

scientific article published on 13 November 2013

Mechanism of block of a human cardiac potassium channel by terfenadine racemate and enantiomers

scientific article published on May 1995

Modulation of HERG gating by a charge cluster in the N-terminal proximal domain.

scientific article published on 22 September 2006

Modulation of an inactivating human cardiac K+ channel by protein kinase C.

scientific article published on December 1994

Molecular analysis of a binding site for quinidine in a human cardiac delayed rectifier K+ channel. Role of S6 in antiarrhythmic drug binding

scientific article published on June 1996

Molecular and functional diversity of cloned cardiac potassium channels

scientific article published in August 1993

Molecular determinants of stereoselective bupivacaine block of hKv1.5 channels

scientific article published on December 1997

Mutations in the S6 gate isolate a late step in the activation pathway and reduce 4-AP sensitivity in shaker K(v) channel

scientific article published on January 2014

Mutations throughout the S6 region of the hKv1.5 channel alter the stability of the activation gate.

scientific article

Obligatory heterotetramerization of three previously uncharacterized Kv channel alpha-subunits identified in the human genome.

scientific article

Purification, molecular cloning and functional characterization of HelaTx1 (Heterometrus laoticus): the first member of a new κ-KTX subfamily

scientific article published on 24 January 2012

Quantitative single-cell ion-channel gene expression profiling through an improved qRT-PCR technique combined with whole cell patch clamp ⬇️

scientific article published on June 20, 2012

Quinidine delays IK activation in guinea pig ventricular myocytes

scientific article

Rapid inactivation determines the rectification and [K+]o dependence of the rapid component of the delayed rectifier K+ current in cardiac cells.

scientific article published on June 1997

Role of the S6 C-terminus in KCNQ1 channel gating

scientific article published on 11 October 2007

Stereoselective block of a human cardiac potassium channel (Kv1.5) by bupivacaine enantiomers

scientific article

Stereoselective block of cardiac sodium channels by bupivacaine in guinea pig ventricular myocytes

scientific article published on November 1995

Structure and function of cardiac potassium channels

scientific article

Temperature and voltage dependence of sodium channel blocking and unblocking by O-demethyl encainide in isolated guinea pig myocytes

scientific article published in June 1989

The S4-S5 linker of KCNQ1 channels forms a structural scaffold with the S6 segment controlling gate closure

scientific article published on 8 November 2010

The aromatic cluster in KCHIP1b affects Kv4 inactivation gating

scientific article published on 19 July 2007

The electrically silent Kv6.4 subunit confers hyperpolarized gating charge movement in Kv2.1/Kv6.4 heterotetrameric channels.

scientific article

The interactions of apamin and tetraethylammonium are differentially affected by single mutations in the pore mouth of small conductance calcium-activated potassium (SK) channels

scientific article published on 24 December 2012

The ladder-shaped polyether toxin gambierol anchors the gating machinery of Kv3.1 channels in the resting state ⬇️

scientific article published on February 11, 2013

The rate-dependent biophysical properties of the LQT1 H258R mutant are counteracted by a dominant negative effect on channel trafficking.

scientific article

The subfamily-specific interaction between Kv2.1 and Kv6.4 subunits is determined by interactions between the N- and C-termini.

scientific article

Voltage-gated delayed rectifier K v 1-subunits may serve as distinctive markers for enteroglial cells with different phenotypes in the murine ileum

scientific article published on 21 June 2009

Voltage-sensor conformation shapes the intra-membrane drug binding site that determines gambierol affinity in Kv channels.

scientific article published on 05 March 2016

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