List of works - Dominique Bonnet

A Time-Resolved FRET Cell-Based Binding Assay for the Apelin Receptor

scientific article published on 4 April 2017

A near-infrared fluorogenic dimer enables background-free imaging of endogenous GPCRs in living mice

scientific article published on 17 June 2020

A step-economical multicomponent synthesis of 3D-shaped aza-diketopiperazines and their drug-like chemical space analysis

scientific article published in September 2016

Biased agonist pharmacochaperones of the AVP V2 receptor may treat congenital nephrogenic diabetes insipidus

scientific article published on 3 September 2009

Chemoselective acylation of fully deprotected hydrazino acetyl peptides. Application to the synthesis of lipopetides

scientific article

Combinatorial aid for underprivileged scaffolds: solution and solid-phase strategies for a rapid and efficient access to novel aza-diketopiperazines (Aza-DKP).

scientific article

Comparative Study of the Synthesis and Structural and Physicochemical Properties of Diketopiperazines vs Aza-diketopiperazines.

scientific article

Convenient Access to Fluorescent Probes by Chemoselective Acylation of Hydrazinopeptides: Application to the Synthesis of the First Far-Red Ligand for Apelin Receptor Imaging.

scientific article published on 18 December 2015

Convenient method to access new 4,4-dialkoxy- and 4,4-diaryloxy-diaza-s-indacene dyes: Synthesis and spectroscopic evaluation

scientific article published on 01 January 2007

Diastereoselective synthesis of novel aza-diketopiperazines via a domino cyclohydrocarbonylation/addition process

scientific article published in September 2014

Discovery of a Locally and Orally Active CXCL12 Neutraligand (LIT-927) with Anti-inflammatory Effect in a Murine Model of Allergic Airway Hypereosinophilia

scientific article published on 28 August 2018

Fluorescent derivatives of AC-42 to probe bitopic orthosteric/allosteric binding mechanisms on muscarinic M1 receptors

scientific article published on 27 February 2012

Fluorogenic squaraine dimers with polarity-sensitive folding as bright far-red probes for background-free bioimaging.

scientific article published on 29 December 2014

From the Promiscuous Asenapine to Potent Fluorescent Ligands Acting at a Series of Aminergic G-Protein-Coupled Receptors

scientific article published on 8 December 2017

Hetero-Diels–Alder click reaction of dithioesters for a catalyst-free indirect <sup>18</sup>F-radiolabelling of peptides

scientific article published in 2022

Homodimerization of the death-associated protein kinase catalytic domain: development of a new small molecule fluorescent reporter

scientific article

Identification and pharmacological properties of E339-3D6, the first nonpeptidic apelin receptor agonist

scientific article

Increasing cellular immunogenicity to peptide-based vaccine candidates using a fluorocarbon antigen delivery system

scientific article published on 6 January 2015

Involvement of the TGFβ pathway in the regulation of α5 β1 integrins by caveolin-1 in human glioblastoma

scientific article

Neutralizing endogenous chemokines with small molecules. Principles and potential therapeutic applications.

scientific article published on February 2010

New fluorescein precursors for live bacteria detection

scientific article

Pharmacological tools to mobilise mesenchymal stromal cells into the blood promote bone formation after surgery

scientific article published on 21 February 2020

Prodrugs of a CXC Chemokine-12 (CXCL12) Neutraligand Prevent Inflammatory Reactions in an Asthma Model in Vivo

scientific article

Proper desensitization of CXCR4 is required for lymphocyte development and peripheral compartmentalization in mice

article

Reactivity of Lys(NH2)-containing peptides toward endopeptidases.

scientific article

Red fluorescent turn-on ligands for imaging and quantifying G protein-coupled receptors in living cells

scientific article published on 21 January 2014

Selective nonpeptidic fluorescent ligands for oxytocin receptor: design, synthesis, and application to time-resolved FRET binding assay

scientific article published on 12 February 2015

Simultaneous lipidation of a characterized peptide mixture by chemoselective ligation

scientific article published in March 2003

Small neutralizing molecules to inhibit actions of the chemokine CXCL12.

scientific article

Solid-Phase Synthesis of Tetrahydro-β-carbolinehydantoins via theN-Acyliminium Pictet−Spengler Reaction and Cyclative Cleavage

scientific article published on 01 November 2002

Solid-phase functionalization of peptides by an alpha-hydrazinoacetyl group

scientific article published in September 2003

Solid-phase organic tagging resins for labeling biomolecules by 1,3-dipolar cycloaddition: application to the synthesis of a fluorescent non-peptidic vasopressin receptor ligand

scientific article

Solid-phase preparation of a pilot library derived from the 2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-amine scaffold

scientific article

Squaraine as a bright, stable and environment-sensitive far-red label for receptor-specific cellular imaging

scientific article published in February 2015

Structure-activity relationship studies toward the discovery of selective apelin receptor agonists

scientific article published on 27 March 2014

Synthesis by chemoselective ligation and biological evaluation of novel cell-permeable PKC-zeta pseudosubstrate lipopeptides

scientific article

Synthesis of hydrazinopeptides using solid-phase N-electrophilic amination: extension to the Fmoc/tert-butyl strategy and chemistry of the N-N bond in strong acid media

scientific article published on 01 October 1999

Time-resolved FRET binding assay to investigate hetero-oligomer binding properties: proof of concept with dopamine D1/D3 heterodimer.

scientific article published on 11 November 2014

Use of a fluorescent polarization based high throughput assay to identify new calmodulin ligands

scientific article

Versatile Synthetic Approach for Selective Diversification of Bicyclic Aza-Diketopiperazines

scientific article published on 09 November 2018

alpha5beta1 integrin antagonists reduce chemotherapy-induced premature senescence and facilitate apoptosis in human glioblastoma cells

scientific article published in September 2010

List of works by Dominique Bonnet

A Time-Resolved FRET Cell-Based Binding Assay for the Apelin Receptor

A near-infrared fluorogenic dimer enables background-free imaging of endogenous GPCRs in living mice

A step-economical multicomponent synthesis of 3D-shaped aza-diketopiperazines and their drug-like chemical space analysis

Biased agonist pharmacochaperones of the AVP V2 receptor may treat congenital nephrogenic diabetes insipidus

Chemoselective acylation of fully deprotected hydrazino acetyl peptides. Application to the synthesis of lipopetides

Combinatorial aid for underprivileged scaffolds: solution and solid-phase strategies for a rapid and efficient access to novel aza-diketopiperazines (Aza-DKP).

Comparative Study of the Synthesis and Structural and Physicochemical Properties of Diketopiperazines vs Aza-diketopiperazines.

Convenient Access to Fluorescent Probes by Chemoselective Acylation of Hydrazinopeptides: Application to the Synthesis of the First Far-Red Ligand for Apelin Receptor Imaging.

Convenient method to access new 4,4-dialkoxy- and 4,4-diaryloxy-diaza-s-indacene dyes: Synthesis and spectroscopic evaluation

Diastereoselective synthesis of novel aza-diketopiperazines via a domino cyclohydrocarbonylation/addition process

Discovery of a Locally and Orally Active CXCL12 Neutraligand (LIT-927) with Anti-inflammatory Effect in a Murine Model of Allergic Airway Hypereosinophilia

Fluorescent derivatives of AC-42 to probe bitopic orthosteric/allosteric binding mechanisms on muscarinic M1 receptors

Fluorogenic squaraine dimers with polarity-sensitive folding as bright far-red probes for background-free bioimaging.

From the Promiscuous Asenapine to Potent Fluorescent Ligands Acting at a Series of Aminergic G-Protein-Coupled Receptors

Hetero-Diels–Alder click reaction of dithioesters for a catalyst-free indirect <sup>18</sup>F-radiolabelling of peptides

Homodimerization of the death-associated protein kinase catalytic domain: development of a new small molecule fluorescent reporter

Identification and pharmacological properties of E339-3D6, the first nonpeptidic apelin receptor agonist

Increasing cellular immunogenicity to peptide-based vaccine candidates using a fluorocarbon antigen delivery system

Involvement of the TGFβ pathway in the regulation of α5 β1 integrins by caveolin-1 in human glioblastoma

Neutralizing endogenous chemokines with small molecules. Principles and potential therapeutic applications.

New fluorescein precursors for live bacteria detection

Pharmacological tools to mobilise mesenchymal stromal cells into the blood promote bone formation after surgery

Prodrugs of a CXC Chemokine-12 (CXCL12) Neutraligand Prevent Inflammatory Reactions in an Asthma Model in Vivo

Proper desensitization of CXCR4 is required for lymphocyte development and peripheral compartmentalization in mice

Reactivity of Lys(NH2)-containing peptides toward endopeptidases.

Red fluorescent turn-on ligands for imaging and quantifying G protein-coupled receptors in living cells

Selective nonpeptidic fluorescent ligands for oxytocin receptor: design, synthesis, and application to time-resolved FRET binding assay

Simultaneous lipidation of a characterized peptide mixture by chemoselective ligation

Small neutralizing molecules to inhibit actions of the chemokine CXCL12.

Solid-Phase Synthesis of Tetrahydro-β-carbolinehydantoins via theN-Acyliminium Pictet−Spengler Reaction and Cyclative Cleavage

Solid-phase functionalization of peptides by an alpha-hydrazinoacetyl group

Solid-phase organic tagging resins for labeling biomolecules by 1,3-dipolar cycloaddition: application to the synthesis of a fluorescent non-peptidic vasopressin receptor ligand

Solid-phase preparation of a pilot library derived from the 2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-amine scaffold

Squaraine as a bright, stable and environment-sensitive far-red label for receptor-specific cellular imaging

Structure-activity relationship studies toward the discovery of selective apelin receptor agonists

Synthesis by chemoselective ligation and biological evaluation of novel cell-permeable PKC-zeta pseudosubstrate lipopeptides

Synthesis of hydrazinopeptides using solid-phase N-electrophilic amination: extension to the Fmoc/tert-butyl strategy and chemistry of the N-N bond in strong acid media

Time-resolved FRET binding assay to investigate hetero-oligomer binding properties: proof of concept with dopamine D1/D3 heterodimer.

Use of a fluorescent polarization based high throughput assay to identify new calmodulin ligands

Versatile Synthetic Approach for Selective Diversification of Bicyclic Aza-Diketopiperazines

alpha5beta1 integrin antagonists reduce chemotherapy-induced premature senescence and facilitate apoptosis in human glioblastoma cells