List of works - Luc Brunsveld

A Binary Bivalent Supramolecular Assembly Platform Based on Cucurbit[8]uril and Dimeric Adapter Protein 14-3-3.

scientific article published on 16 May 2017

A Structural Study of the Cytoplasmic Chaperone Effect of 14-3-3 Proteins on Ataxin-1

scientific article published on 21 July 2021

A multi-gram-scale stereoselective synthesis of Z -endoxifen

scholarly article by Lech-Gustav Milroy published in May 2018

A natural-product switch for a dynamic protein interface

scientific article

A study on the effect of synthetic α-to-β3-amino acid mutations on the binding of phosphopeptides to 14-3-3 proteins

scientific article published on 01 December 2019

A supramolecular polymer as a self-assembling polyvalent scaffold

scientific article published in January 2009

A thermodynamic model for multivalency in 14-3-3 protein-protein interactions

article

Allosteric small molecule modulators of nuclear receptors

scientific article published on 28 January 2019

An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-κB-Utilizing a Reversible Covalent Tethering Approach

scientific article published on 02 June 2021

An on-bead assay for the identification of non-natural peptides targeting the androgen receptor-cofactor interaction.

scientific article

Application of protein semisynthesis for the construction of functionalized posttranslationally modified rab GTPases

scientific article published in January 2005

Batch and Flow Synthesis of Disulfides by Visible-Light-Induced TiO2 Photocatalysis

scientific article published on 22 June 2016

Bcrp1;Mdr1a/b;Mrp2 combination knockout mice: altered disposition of the dietary carcinogen PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) and its genotoxic metabolites.

scientific article

Bioactivity-guided mapping and navigation of chemical space.

scientific article

Biophysical Characterization of Nucleophosmin Interactions with Human Immunodeficiency Virus Rev and Herpes Simplex Virus US11.

scientific article published in December 2015

Bright Bioluminescent BRET Sensor Proteins for Measuring Intracellular Caspase Activity

scientific article published on 31 May 2017

Carborane–β-cyclodextrin complexes as a supramolecular connector for bioactive surfaces

scientific article published on 11 November 2014

Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR.

scientific article published on 17 February 2016

Chemical biology of protein lipidation: semi-synthesis and structure elucidation of prenylated RabGTPases

scientific article

Chemical-biological exploration of the limits of the Ras de- and repalmitoylating machinery

scientific article

Chiral Dihydrobenzofuran Acids Show Potent Retinoid X Receptor-Nuclear Receptor Related 1 Protein Dimer Activation

scientific article

Combining supramolecular chemistry with biology.

scientific article published on 12 May 2010

Comparison of design strategies for promotion of beta-peptide 14-helix stability in water.

scientific article

Competitive protein recruitment in artificial cells

scientific article published in 2024

Computational design, synthesis, and evaluation of miniproteins as androgen receptor coactivator mimics

scientific article published on 17 August 2009

Conformational ordering of apolar, chiral m-phenylene ethynylene oligomers

scientific article published in June 2000

Conjugated protein domains as engineered scaffold proteins

scientific article published on 06 May 2020

Cooperativity basis for small-molecule stabilization of protein-protein interactions

scientific article published on 25 January 2019

Cooperativity in the folding of helical m-phenylene ethynylene oligomers based upon the 'sergeants-and-soldiers' principle

scientific article published in October 2001

Cucurbit[8]uril induced heterodimerization of methylviologen and naphthalene functionalized proteins

scientific article published on 18 April 2011

Cucurbit[8]uril reactivation of an inactivated caspase-8 mutant reveals differentiated enzymatic substrate processing

scientific article published on 05 November 2018

Cucurbit[8]uril templated supramolecular ring structure formation and protein assembly modulation

scientific article published on 01 February 2015

Delineation of the molecular determinants of the unique allosteric binding site of the orphan nuclear receptor RORγt

scientific article published on 20 May 2020

Design and evaluation of fragment-like estrogen receptor tetrahydroisoquinoline ligands from a scaffold-detection approach

scientific article

Determination of dabigatran, rivaroxaban and apixaban by ultra-performance liquid chromatography - tandem mass spectrometry (UPLC-MS/MS) and coagulation assays for therapy monitoring of novel direct oral anticoagulants.

scientific article published in October 2014

Directed supramolecular surface assembly of SNAP-tag fusion proteins

scientific article published on 18 April 2012

Dual-Input Regulation and Positional Control in Hybrid Oligonucleotide/Discotic Supramolecular Wires

scientific article published on 19 February 2018

Dynamic modulation of proximity-induced enzyme activity using supramolecular polymers

scientific article published on 22 April 2020

Elucidation of an Allosteric Mode of Action for a Thienopyrazole RORγt Inverse Agonist

scientific article published on 12 March 2020

Estrogen Receptor Folding Modulates cSrc Kinase SH2 Interaction via a Helical Binding Mode

scientific article published on 9 September 2015

Estrogen Receptor α/β–cofactor motif interactions; interplay of tyrosine 537/488 phosphorylation and LXXLL motifs ⬇️

scientific article published on October 30, 2012

Evaluation of fluorophores to label SNAP-tag fused proteins for multicolor single-molecule tracking microscopy in live cells

scientific article

Exploration of a 14-3-3 PPI Pocket by Covalent Fragments as Stabilizers

scientific article published in 2021

Finite-size effects on bacterial population expansion under controlled flow conditions.

scientific article published on 6 March 2017

Fluorescence Anisotropy-Based Tethering for Discovery of Protein-Protein Interaction Stabilizers

scientific article published on 16 November 2020

Fragment-based Differential Targeting of PPI Stabilizer Interfaces

scientific article published on 05 June 2020

Fragment-based exploration of the 14-3-3/Amot-p130 interface

scientific article published on 29 December 2021

Glucocorticoid receptor Thr524 phosphorylation by MINK1 induces interactions with 14-3-3 protein regulators

scientific article published on 01 January 2021

Helical self-assembled polymers from cooperative stacking of hydrogen-bonded pairs

scientific article published in Nature

Hydrophobicity determines the fate of self-assembled fluorescent nanoparticles in cells

scientific article published on 18 January 2017

Identification of Two Secondary Ligand Binding Sites in 14-3-3 Proteins Using Fragment Screening

scientific article published on 6 July 2017

Identification of an allosteric binding site for RORγt inhibition

scientific article

Immobilization of Ferrocene-Modified SNAP-Fusion Proteins

scientific article published on 18 February 2013

Incorporation of native antibodies and Fc-fusion proteins on DNA nanostructures via a modular conjugation strategy.

scientific article

Influence of the lipidation motif on the partitioning and association of N-Ras in model membrane subdomains

scientific article published in February 2009

Inhibition of 14-3-3/Tau by Hybrid Small-Molecule Peptides Operating via Two Different Binding Modes

scientific article published on 17 May 2018

Integrin-Targeting Fluorescent Proteins: Exploration of RGD Insertion Sites.

scientific article

Investigational study of tamoxifen phase I metabolites using chromatographic and spectroscopic analytical techniques.

scientific article published on 18 February 2011

Ligand Dependent Switch from RXR Homo- to RXR-NURR1 Heterodimerization

scientific article published on 10 July 2017

Ligand-Based Design of Allosteric Retinoic Acid Receptor-Related Orphan Receptor γt (RORγt) Inverse Agonists

scientific article published on 24 December 2019

Lipidated Ras and Rab Peptides and Proteins — Synthesis, Structure, and Function

Lipidated ras and rab peptides and proteins--synthesis, structure, and function

scientific article published on October 2006

Lipidierte Ras- und Rab-Peptide und -Proteine: Synthese, Struktur und Funktion

Mapping the isoprenoid binding pocket of PDEdelta by a semisynthetic, photoactivatable N-Ras lipoprotein

scientific article

Membrane binding of lipidated Ras peptides and proteins--the structural point of view

scientific article published on 15 August 2008

Modular bioengineered kinase sensors via scaffold protein-mediated split-luciferase complementation

scientific article published on 12 May 2020

Modular columnar supramolecular polymers as scaffolds for biomedical applications.

scientific article published on 12 July 2013

Modulation of Protein Dimerization by a Supramolecular Host-Guest System

scientific article published on 01 September 2009

Modulators of 14-3-3 Protein-Protein Interactions ⬇️

scientific article

Modulators of protein-protein interactions

scientific article published on 15 April 2014

Molecular interference in antibody-antigen interaction studied with magnetic force immunoassay.

scientific article published on 9 February 2015

Multivalent Ultrasensitive Interfacing of Supramolecular 1D Nanoplatforms

scientific article published on 31 October 2019

Multivalent protein assembly using monovalent self-assembling building blocks

scientific article

Mutually Exclusive Cellular Uptake of Combinatorial Supramolecular Copolymers

scientific article published on 11 October 2018

Nuclear receptor crosstalk - defining the mechanisms for therapeutic innovation

scientific article published on 17 April 2020

Optimizing charge state distribution is a prerequisite for accurate protein biomarker quantification with LC-MS/MS, as illustrated by hepcidin measurement

scientific article published on 01 August 2018

PNA-induced assembly of fluorescent proteins using DNA as a framework.

scientific article published on 9 August 2013

Perturbation of Estrogen Receptor α Localization with Synthetic Nona-Arginine LXXLL-Peptide Coactivator Binding Inhibitors

scientific article published on 01 July 2009

Pharmaceutical implications of helix length control in helix-mediated protein-protein interactions.

scientific article published on December 2013

Positional screening and NMR structure determination of side-chain-to-side-chain cyclized β3-peptides

scientific article

Protease-Activatable Scaffold Proteins as Versatile Molecular Hubs in Synthetic Signaling Networks

scientific article published on 31 August 2018

Protein Dimerization Induced by Supramolecular Interactions with Cucurbit[8]uril

scientific article published in January 2010

Proteinassembly along a supramolecular wire

scientific article published on 23 August 2010

Proximity-induced caspase-9 activation on a DNA origami-based synthetic apoptosome ⬇️

scientific article published on 06 January 2020

Racemization-free synthesis of S-alkylated cysteines via thiol-ene reaction

scientific article published in April 2008

Rapid phenotype hemoglobin screening by high-resolution mass spectrometry on intact proteins

scientific article published on 11 July 2016

Rationally Designed Semisynthetic Natural Product Analogues for Stabilization of 14-3-3 Protein-Protein Interactions

scientific article published on 17 September 2018

Real life dabigatran and metabolite concentrations, focused on inter-patient variability and assay differences in patients with atrial fibrillation

scientific article published on 22 March 2017

Relationship between Side-Chain Polarity and the Self-Assembly Characteristics of Perylene Diimide Derivatives in Aqueous Solution

scientific article published on 20 January 2017

Reversible Polymers Formed from Self-Complementary Monomers Using Quadruple Hydrogen Bonding

scientific article published in Science

Reversible and Oriented Immobilization of Ferrocene-Modified Proteins

scientific article published on 08 November 2012

SH3-mediated targeting of Wrch1/RhoU by multiple adaptor proteins

scientific article published in March 2013

Selectivity via Cooperativity: Preferential Stabilization of the p65/14-3-3 interaction with Semi-Synthetic Natural Products

scientific article published on 05 June 2020

Self-Assembled Fluorescent Nanoparticles from π-Conjugated Small Molecules: En Route to Biological Applications.

scientific article published on 20 May 2015

Self-assembled fluorescent organic nanoparticles for live-cell imaging

scientific article published on 29 October 2013

Self-assembly of folded m-phenylene ethynylene oligomers into helical columns

scientific article

Semiconductive, One-Dimensional, Self-Assembled Nanostructures Based on Oligopeptides with π-Conjugated Segments

scientific article published on 14 March 2011

Single Particle Tracking Reveals that EGFR Signaling Activity Is Amplified in Clathrin-Coated Pits

scientific article (publication date: 2015)

Site-Directed Fragment-Based Screening for the Discovery of Protein-Protein Interaction Stabilizers

scientific article published on 19 February 2019

Site-specific protection and dual labeling of human epidermal growth factor (hEGF) for targeting, imaging, and cargo delivery

scientific article published on 3 April 2014

Small-Molecule-Induced and Cooperative Enzyme Assembly on a 14-3-3 Scaffold

scientific article

Small-molecule inhibition of APT1 affects Ras localization and signaling

scientific article

Small-molecule stabilization of the p53 - 14-3-3 protein-protein interaction.

scientific article published on 22 June 2017

Solid-Phase Synthesis of Lipidated Ras Peptides Employing the Ellman Sulfonamide Linker

Solution structure of a cucurbit[8]uril induced compact supramolecular protein dimer.

scientific article

Stabilization of protein-protein interactions in drug discovery

scientific article published on 11 July 2017

Stabilizer-Guided Inhibition of Protein-Protein Interactions

scientific article

Stable helical beta 3-peptides in water via covalent bridging of side chains

scientific article

Stable helical peptoids via covalent side chain to side chain cyclization

scientific article published on 26 June 2008

Strong and reversible monovalent supramolecular protein immobilization

scientific article published in January 2010

Structural interface between LRRK2 and 14-3-3 protein.

scientific article published on 15 February 2017

Structure of Rab GDP-dissociation inhibitor in complex with prenylated YPT1 GTPase

scientific article

Structure of doubly prenylated Ypt1:GDI complex and the mechanism of GDI-mediated Rab recycling

scientific article

Structure-based evolution of a promiscuous inhibitor to a selective stabilizer of protein-protein interactions

scientific article published on 07 August 2020

Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation

scientific article

Subcellular fractionation and localization studies reveal a direct interaction of the fragile X mental retardation protein (FMRP) with nucleolin

scientific journal article

Subtype-specific modulation of estrogen receptor-coactivator interaction by phosphorylation.

scientific article

Supramolecular Chemistry Targeting Proteins.

scientific article published on 19 September 2017

Supramolecular Control over Split-Luciferase Complementation

scientific article published on 29 June 2016

Supramolecular Nanoscaffolds within Cytomimetic Protocells as Signal Localization Hubs

scientific article published on 01 May 2020

Supramolecular Polymers as Dynamic Multicomponent Cellular Uptake Carriers

scientific article published on 07 May 2012

Supramolecular Protein Immobilization on Lipid Bilayers

scientific article published on 3 November 2015

Supramolecular chemical biology; bioactive synthetic self-assemblies.

scientific article

Supramolecular control of cell adhesion via ferrocene–cucurbit[7]uril host–guest binding on gold surfaces

scientific article published on 01 May 2013

Supramolecular control over donor-acceptor photoinduced charge separation

scientific article

Supramolecularly Oriented Immobilization of Proteins Using Cucurbit[8]uril

scientific article published on 12 November 2012

Switching from infliximab innovator to biosimilar in patients with inflammatory bowel disease: a 12-month multicentre observational prospective cohort study.

scientific article published on 5 December 2017

Synthesis and Self-Assembly of Bay-Substituted Perylene Diimide Gemini-Type Surfactants as Off-On Fluorescent Probes for Lipid Bilayers.

scientific article

Synthesis and crystal structure of a phosphorylated estrogen receptor ligand binding domain

scientific article

Synthesis of Functionalized Rab GTPases by a Combination of Solution- or Solid-Phase Lipopeptide Synthesis with Expressed Protein Ligation

scientific article published on 01 April 2005

Synthesis of a fluorescent analogue of geranylgeranyl pyrophosphate and its use in a high-throughput fluorometric assay for Rab geranylgeranyltransferase

scientific article published in January 2007

Synthesis of the Rheb and K-Ras4B GTPases

Tetrazine- trans-Cyclooctene Chemistry Applied to Fabricate Self-Assembled Fluorescent and Radioactive Nanoparticles for in Vivo Dual Mode Imaging

scientific article published on 12 February 2019

The Molecular Tweezer CLR01 Stabilizes a Disordered Protein-Protein Interface.

scientific article published on 17 October 2017

The palmitoylation machinery is a spatially organizing system for peripheral membrane proteins

scientific article

Therapeutic drug monitoring of infliximab: performance evaluation of three commercial ELISA kits

scientific article published on 20 November 2015

Therapeutic intervention based on protein prenylation and associated modifications

scientific article

Twist Sense Bias Induced by Chiral Side Chains in Helically Folded Oligomers

scientific article published on 01 January 2000

Using the IPTG-Inducible Pgrac212 Promoter for Overexpression of Human Rhinovirus 3C Protease Fusions in the Cytoplasm of Bacillus subtilis Cells

scientific article published on 14 October 2019

List of works by Luc Brunsveld

A Binary Bivalent Supramolecular Assembly Platform Based on Cucurbit[8]uril and Dimeric Adapter Protein 14-3-3.

A Structural Study of the Cytoplasmic Chaperone Effect of 14-3-3 Proteins on Ataxin-1

A multi-gram-scale stereoselective synthesis of Z -endoxifen

A natural-product switch for a dynamic protein interface

A study on the effect of synthetic α-to-β3-amino acid mutations on the binding of phosphopeptides to 14-3-3 proteins

A supramolecular polymer as a self-assembling polyvalent scaffold

A thermodynamic model for multivalency in 14-3-3 protein-protein interactions

Allosteric small molecule modulators of nuclear receptors

An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-κB-Utilizing a Reversible Covalent Tethering Approach

An on-bead assay for the identification of non-natural peptides targeting the androgen receptor-cofactor interaction.

Application of protein semisynthesis for the construction of functionalized posttranslationally modified rab GTPases

Batch and Flow Synthesis of Disulfides by Visible-Light-Induced TiO2 Photocatalysis

Bcrp1;Mdr1a/b;Mrp2 combination knockout mice: altered disposition of the dietary carcinogen PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) and its genotoxic metabolites.

Bioactivity-guided mapping and navigation of chemical space.

Biophysical Characterization of Nucleophosmin Interactions with Human Immunodeficiency Virus Rev and Herpes Simplex Virus US11.

Bright Bioluminescent BRET Sensor Proteins for Measuring Intracellular Caspase Activity

Carborane–β-cyclodextrin complexes as a supramolecular connector for bioactive surfaces

Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR.

Chemical biology of protein lipidation: semi-synthesis and structure elucidation of prenylated RabGTPases

Chemical-biological exploration of the limits of the Ras de- and repalmitoylating machinery

Chiral Dihydrobenzofuran Acids Show Potent Retinoid X Receptor-Nuclear Receptor Related 1 Protein Dimer Activation

Combining supramolecular chemistry with biology.

Comparison of design strategies for promotion of beta-peptide 14-helix stability in water.

Competitive protein recruitment in artificial cells

Computational design, synthesis, and evaluation of miniproteins as androgen receptor coactivator mimics

Conformational ordering of apolar, chiral m-phenylene ethynylene oligomers

Conjugated protein domains as engineered scaffold proteins

Cooperativity basis for small-molecule stabilization of protein-protein interactions

Cooperativity in the folding of helical m-phenylene ethynylene oligomers based upon the 'sergeants-and-soldiers' principle

Cucurbit[8]uril induced heterodimerization of methylviologen and naphthalene functionalized proteins

Cucurbit[8]uril reactivation of an inactivated caspase-8 mutant reveals differentiated enzymatic substrate processing

Cucurbit[8]uril templated supramolecular ring structure formation and protein assembly modulation

Delineation of the molecular determinants of the unique allosteric binding site of the orphan nuclear receptor RORγt

Design and evaluation of fragment-like estrogen receptor tetrahydroisoquinoline ligands from a scaffold-detection approach

Determination of dabigatran, rivaroxaban and apixaban by ultra-performance liquid chromatography - tandem mass spectrometry (UPLC-MS/MS) and coagulation assays for therapy monitoring of novel direct oral anticoagulants.

Directed supramolecular surface assembly of SNAP-tag fusion proteins

Dual-Input Regulation and Positional Control in Hybrid Oligonucleotide/Discotic Supramolecular Wires

Dynamic modulation of proximity-induced enzyme activity using supramolecular polymers

Elucidation of an Allosteric Mode of Action for a Thienopyrazole RORγt Inverse Agonist

Estrogen Receptor Folding Modulates cSrc Kinase SH2 Interaction via a Helical Binding Mode

Estrogen Receptor α/β–cofactor motif interactions; interplay of tyrosine 537/488 phosphorylation and LXXLL motifs ⬇️

Evaluation of fluorophores to label SNAP-tag fused proteins for multicolor single-molecule tracking microscopy in live cells

Exploration of a 14-3-3 PPI Pocket by Covalent Fragments as Stabilizers

Finite-size effects on bacterial population expansion under controlled flow conditions.

Fluorescence Anisotropy-Based Tethering for Discovery of Protein-Protein Interaction Stabilizers

Fragment-based Differential Targeting of PPI Stabilizer Interfaces

Fragment-based exploration of the 14-3-3/Amot-p130 interface

Glucocorticoid receptor Thr524 phosphorylation by MINK1 induces interactions with 14-3-3 protein regulators

Helical self-assembled polymers from cooperative stacking of hydrogen-bonded pairs

Hydrophobicity determines the fate of self-assembled fluorescent nanoparticles in cells

Identification of Two Secondary Ligand Binding Sites in 14-3-3 Proteins Using Fragment Screening

Identification of an allosteric binding site for RORγt inhibition

Immobilization of Ferrocene-Modified SNAP-Fusion Proteins

Incorporation of native antibodies and Fc-fusion proteins on DNA nanostructures via a modular conjugation strategy.

Influence of the lipidation motif on the partitioning and association of N-Ras in model membrane subdomains

Inhibition of 14-3-3/Tau by Hybrid Small-Molecule Peptides Operating via Two Different Binding Modes

Integrin-Targeting Fluorescent Proteins: Exploration of RGD Insertion Sites.

Investigational study of tamoxifen phase I metabolites using chromatographic and spectroscopic analytical techniques.

Ligand Dependent Switch from RXR Homo- to RXR-NURR1 Heterodimerization

Ligand-Based Design of Allosteric Retinoic Acid Receptor-Related Orphan Receptor γt (RORγt) Inverse Agonists

Lipidated Ras and Rab Peptides and Proteins — Synthesis, Structure, and Function

Lipidated ras and rab peptides and proteins--synthesis, structure, and function

Lipidierte Ras- und Rab-Peptide und -Proteine: Synthese, Struktur und Funktion

Mapping the isoprenoid binding pocket of PDEdelta by a semisynthetic, photoactivatable N-Ras lipoprotein

Membrane binding of lipidated Ras peptides and proteins--the structural point of view

Modular bioengineered kinase sensors via scaffold protein-mediated split-luciferase complementation

Modular columnar supramolecular polymers as scaffolds for biomedical applications.

Modulation of Protein Dimerization by a Supramolecular Host-Guest System

Modulators of 14-3-3 Protein-Protein Interactions ⬇️

Modulators of protein-protein interactions

Molecular interference in antibody-antigen interaction studied with magnetic force immunoassay.

Multivalent Ultrasensitive Interfacing of Supramolecular 1D Nanoplatforms

Multivalent protein assembly using monovalent self-assembling building blocks

Mutually Exclusive Cellular Uptake of Combinatorial Supramolecular Copolymers

Nuclear receptor crosstalk - defining the mechanisms for therapeutic innovation

Optimizing charge state distribution is a prerequisite for accurate protein biomarker quantification with LC-MS/MS, as illustrated by hepcidin measurement

PNA-induced assembly of fluorescent proteins using DNA as a framework.

Perturbation of Estrogen Receptor α Localization with Synthetic Nona-Arginine LXXLL-Peptide Coactivator Binding Inhibitors

Pharmaceutical implications of helix length control in helix-mediated protein-protein interactions.