Search filters

List of works by John D Crispino

A CHAF1B-Dependent Molecular Switch in Hematopoiesis and Leukemia Pathogenesis

scientific article published on 01 November 2018

A model of early human embryonic stem cell differentiation reveals inter- and intracellular changes on transition to squamous epithelium.

scientific article

A novel role for survivin in erythroblast enucleation.

scientific article

AKT collaborates with ERG and Gata1s to dysregulate megakaryopoiesis and promote AMKL.

scientific article published on 5 February 2013

Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome

scientific article (publication date: September 2002)

Activating alleles of JAK3 in acute megakaryoblastic leukemia

scientific article published on July 2006

Activation of JAK/STAT Signaling in Megakaryocytes Sustains Myeloproliferation In Vivo

scientific article published on 19 June 2019

An international effort to cure a global health problem: A report on the 19th Hemoglobin Switching Conference

scientific article

Analysis of JAK3, JAK2, and C-MPL mutations in transient myeloproliferative disorder and myeloid leukemia of Down syndrome blasts in children with Down syndrome

scientific article published on 01 August 2007

Analysis of genomic aberrations and gene expression profiling identifies novel lesions and pathways in myeloproliferative neoplasms.

scientific article published on 11 November 2011

Aurora kinase A is required for hematopoiesis but is dispensable for murine megakaryocyte endomitosis and differentiation.

scientific article

BMP meets AML: induction of BMP signaling by a novel fusion gene promotes pediatric acute leukemia

scientific article

Biological Characterization of 8-Cyclopropyl-2-(pyridin-3-yl)thiazolo[5,4-f]quinazolin-9(8H)-one, a Promising Inhibitor of DYRK1A

scientific article published on 17 December 2019

Characterization of novel genomic alterations and therapeutic approaches using acute megakaryoblastic leukemia xenograft models

scientific article

Chromatin occupancy analysis reveals genome-wide GATA factor switching during hematopoiesis ⬇️

scientific article published on April 19, 2012

Chromatin occupancy and epigenetic analysis reveal new insights into the function of the GATA1 N terminus in erythropoiesis

scientific article published on 01 November 2019

Cofactor-mediated restriction of GATA-1 chromatin occupancy coordinates lineage-specific gene expression

scientific article published on 5 July 2012

Cohesin Mutations in Myeloid Malignancies

scientific article

Combinatorial regulation of tissue specification by GATA and FOG factors.

scientific article

Constitutive activation of RAS/MAPK pathway cooperates with trisomy 21 and is therapeutically exploitable in Down syndrome B-cell leukemia

scientific article published on 27 March 2020

Constitutively Photomorphogenic 1 Reduces the Sensitivity of Chronic Lymphocytic Leukemia Cells to Fludarabine Through Promotion of Ubiquitin-Mediated P53 Degradation

scientific article published on 13 November 2018

Control of megakaryocyte expansion and bone marrow fibrosis by lysyl oxidase

scientific article

DYRK1A controls the transition from proliferation to quiescence during lymphoid development by destabilizing Cyclin D3

scientific article published on 25 May 2015

Determinants and role of chromatin organization in acute leukemia

scientific article published on 20 July 2020

Differential requirements for the activation domain and FOG-interaction surface of GATA-1 in megakaryocyte gene expression and development

scientific article

Downregulation of GATA1 drives impaired hematopoiesis in primary myelofibrosis

scientific article published on 27 February 2017

ETO2-GLIS2 Hijacks Transcriptional Complexes to Drive Cellular Identity and Self-Renewal in Pediatric Acute Megakaryoblastic Leukemia.

scientific article published in March 2017

Erythro-megakaryocytic transcription factors associated with hereditary anemia

scientific article (publication date: 15 May 2014)

Erythroblast enucleation

scientific article published on 05 October 2011

FBXO11 is a candidate tumor suppressor in the leukemic transformation of myelodysplastic syndrome

scientific article published on 06 October 2020

FLIP: a novel regulator of macrophage differentiation and granulocyte homeostasis

scientific article

FOG-1-mediated recruitment of NuRD is required for cell lineage re-enforcement during haematopoiesis

scientific journal article

GATA-1: A potential novel biomarker for the differentiation of essential thrombocythemia and myelofibrosis

scientific article published on 25 April 2019

GATA-2 reinforces megakaryocyte development in the absence of GATA-1

scientific article published on 20 July 2009

GATA1 in normal and malignant hematopoiesis

scientific article

GATA1 mutations in red cell disorders

scientific article published on 25 October 2019

Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies

scientific article

Global transcriptome and chromatin occupancy analysis reveal the short isoform of GATA1 is deficient for erythroid specification and gene expression.

scientific article

Graded repression of PU.1/Sfpi1 gene transcription by GATA factors regulates hematopoietic cell fate

scientific article published on 02 June 2009

Haploinsufficiency of EGR1, a candidate gene in the del(5q), leads to the development of myeloid disorders

scientific article

Highly penetrant myeloproliferative disease in the Ts65Dn mouse model of Down syndrome

scientific article

Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL

scientific article

Identification of submicroscopic genetic changes and precise breakpoint mapping in myelofibrosis using high resolution mate‐pair sequencing ⬇️

scientific article published on August 1, 2013

Ikaros inhibits megakaryopoiesis through functional interaction with GATA-1 and NOTCH signaling

scientific article published on 18 January 2013

JAKing up AML1-ETO ⬇️

scientific article published on July 26, 2012

Kinase signaling and targeted therapy for primary myelofibrosis

scientific article published on 30 December 2016

Loss of pleckstrin-2 reverts lethality and vascular occlusions in JAK2V617F-positive myeloproliferative neoplasms

scientific article published on 20 November 2017

MicroRNA-486-5p is an erythroid oncomiR of the myeloid leukemias of Down syndrome

scientific article

Molecular insights into Down syndrome-associated leukemia

scientific article published on February 2007

Molecular pathways: induction of polyploidy as a novel differentiation therapy for leukemia.

scientific article published on 20 August 2013

Mutational analysis of candidate tumor-associated genes in acute megakaryoblastic leukemia

scientific article published on 06 August 2009

Not All H3K4 Methylations Are Created Equal: Mll2/COMPASS Dependency in Primordial Germ Cell Specification.

scientific article published in February 2017

Notch: of mice and men? ⬇️

scientific article published on December 16, 2010

Onset of rosette formation during spontaneous neural differentiation of hESC and hiPSC colonies ⬇️

scientific article published on August 15, 2013

Overexpression of survivin initiates hematologic malignancies in vivo

scientific article published on 30 September 2010

PSTPIP2 dysregulation contributes to aberrant terminal differentiation in GATA-1-deficient megakaryocytes by activating LYN

scientific article

Perturbation of fetal hematopoiesis in a mouse model of Down syndrome's transient myeloproliferative disorder

scientific article published on 29 May 2013

Preface to IUBMB life special issue on GATA transcription factors in development, differentiation, and disease

scientific article published on 28 November 2019

Prenatal origin of GATA1 mutations may be an initiating step in the development of megakaryocytic leukemia in Down syndrome

scientific article published on 01 September 2004

Recent insights into the mechanisms of myeloid leukemogenesis in Down syndrome

scientific article (publication date: 15 January 2004)

Response: JAK mutations in Down syndrome-associated transient myeloproliferative disorder and acute megakaryocytic leukemia

scholarly article by Paresh Vyas & John D Crispino published 8 February 2008 in Blood

Rho Kinase Regulates the Survival and Transformation of Cells Bearing Oncogenic Forms of KIT, FLT3, and BCR-ABL ⬇️

scientific article published on September 13, 2011

STAT1 promotes megakaryopoiesis downstream of GATA-1 in mice

scientific article

Survivin overexpression alone does not alter megakaryocyte ploidy nor interfere with erythroid/megakaryocytic lineage development in transgenic mice

scientific article published on February 2008

Targeting megakaryocytic-induced fibrosis in myeloproliferative neoplasms by AURKA inhibition.

scientific article

The Hippo-p53 pathway in megakaryopoiesis.

scientific article published on December 2016

The aurora kinases in cell cycle and leukemia

scientific article

The biology, pathogenesis and clinical aspects of acute lymphoblastic leukemia in children with Down syndrome

scientific article

The cohesin subunit Rad21 is a negative regulator of hematopoietic self-renewal through epigenetic repression of Hoxa7 and Hoxa9.

scientific article published on 24 August 2016

The role of the chromatin assembly complex (CAF-1) and its p60 subunit (CHAF1b) in homeostasis and disease

scientific article published on 9 June 2015

Therapeutic Targeting of MLL Degradation Pathways in MLL-Rearranged Leukemia

scientific article published on 2 January 2017

Transcription factor GATA-1 and Down syndrome leukemogenesis

scientific article

Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation

scientific article

Tyrosine 625 plays a key role and cooperates with tyrosine 630 in MPL W515L-induced signaling and myeloproliferative neoplasms.

scientific article published on 23 May 2016

[Novel ETO2-GLIS2 fusion and therapeutic strategy in acute megakaryoblastic leukemia]

scientific article published on 12 November 2012

iPSCs Offer a New Look at GATA1-Trisomy 21 Cooperation

scientific article published in May 2016

Paulina is supported by:

About Paulina

Help