List of works - Ugutz Unzueta

A Novel CXCR4-Targeted Diphtheria Toxin Nanoparticle Inhibits Invasion and Metastatic Dissemination in a Head and Neck Squamous Cell Carcinoma Mouse Model

scientific article published on 19 April 2022

A multivalent Ara-C-prodrug nanoconjugate achieves selective ablation of leukemic cells in an acute myeloid leukemia mouse model

A nanostructured bacterial bioscaffold for the sustained bottom-up delivery of protein drugs

scientific article published on 8 February 2013

A refined cocktailing of pro-apoptotic nanoparticles boosts anti-tumor activity

scientific article published on 27 June 2020

An Auristatin nanoconjugate targeting CXCR4+ leukemic cells blocks acute myeloid leukemia dissemination

scientific article published on 15 April 2020

Assembly of histidine-rich protein materials controlled through divalent cations

scientific article published on 24 October 2018

BBB-targeting, protein-based nanomedicines for drug and nucleic acid delivery to the CNS.

scientific article

Bacterial mimetics of endocrine secretory granules as immobilized in vivo depots for functional protein drugs.

scientific article published on 24 October 2016

Biofabrication of functional protein nanoparticles through simple His-tag engineering

scientific article published on 30 August 2021

Bottom-Up Instructive Quality Control in the Biofabrication of Smart Protein Materials

scientific article published on 28 October 2015

CXCR4(+)-targeted protein nanoparticles produced in the food-grade bacterium Lactococcus lactis.

scientific article

Cancer-specific uptake of a liganded protein nanocarrier targeting aggressive CXCR4 + colorectal cancer models

scientific article published on 13 April 2016

Collaborative membrane activity and receptor-dependent tumor cell targeting for precise nanoparticle delivery in CXCR4+ colorectal cancer

scientific article published on 05 September 2019

Conformational Conversion during Controlled Oligomerization into Nonamylogenic Protein Nanoparticles

scientific article published on 13 August 2018

Conformational and functional variants of CD44-targeted protein nanoparticles bio-produced in bacteria

scientific article published on 14 April 2016

Developing Protein-Antitumoral Drug Nanoconjugates as Bifunctional Antimicrobial Agents

scientific article published on 16 December 2020

Dialysis: a characterization method of aggregation tendency.

scientific article

Efficient bioactive oligonucleotide-protein conjugation for cell-targeted cancer therapy

scientific article published on 28 March 2019

Engineered biological entities for drug delivery and gene therapy protein nanoparticles.

scientific article published on January 2011

Engineering multifunctional protein nanoparticles by in vitro disassembling and reassembling of heterologous building blocks

scientific article published on 26 October 2017

Engineering tumor cell targeting in nanoscale amyloidal materials.

scientific article published on 28 November 2016

Fluorescent Dye Labeling Changes the Biodistribution of Tumor-Targeted Nanoparticles

scientific article published on 22 October 2020

Functional inclusion bodies produced in the yeast Pichia pastoris.

scientific article published on October 2016

Improved performance of protein-based recombinant gene therapy vehicles by tuning downstream procedures

scientific article published on 16 September 2013

In vivo architectonic stability of fully de novo designed protein-only nanoparticles

scientific article published on 14 April 2014

Internalization and kinetics of nuclear migration of protein-only, arginine-rich nanoparticles.

scientific article published on 24 September 2010

Intracellular CXCR4⁺ cell targeting with T22-empowered protein-only nanoparticles.

scientific article

Intracellular targeting of CD44+ cells with self-assembling, protein only nanoparticles

scientific article

Intracellular trafficking of a dynein-based nanoparticle designed for gene delivery.

scientific article published on 4 November 2017

Intrinsic functional and architectonic heterogeneity of tumor-targeted protein nanoparticles

scientific article published on 2 May 2017

Lymphocyte infiltration and antitumoral effect promoted by cytotoxic inflammatory proteins formulated as self-assembling, protein-only nanoparticles

Nanoparticulate architecture of protein-based artificial viruses is supported by protein-DNA interactions

scientific article published on 9 June 2011

Nanostructured toxins for the selective destruction of drug-resistant human CXCR4+ colorectal cancer stem cells

scientific article published on 10 January 2020

Non-amyloidogenic peptide tags for the regulatable self-assembling of protein-only nanoparticles

scientific article published on 03 September 2012

Novel Endometrial Cancer Models Using Sensitive Metastasis Tracing for CXCR4-Targeted Therapy in Advanced Disease

Potent Anticancer Activity of CXCR4-Targeted Nanostructured Toxins in Aggressive Endometrial Cancer Models

Protein aggregation and soluble aggregate formation screened by a fast microdialysis assay

scientific article published on 16 March 2010

Protein nanodisk assembling and intracellular trafficking powered by an arginine-rich (R9) peptide

scientific article published in February 2010

Protein nanoparticles are nontoxic, tuneable cell stressors

scientific article published on 17 January 2018

Protein-Based Therapeutic Killing for Cancer Therapies.

scientific article

Protein-driven nanomedicines in oncotherapy.

scientific article published on 24 January 2019

Protein-only, antimicrobial peptide-containing recombinant nanoparticles with inherent built-in antibacterial activity.

scientific article published on 19 July 2017

RGD-based cell ligands for cell-targeted drug delivery act as potent trophic factors

scientific article published on 25 July 2012

Rational engineering of single-chain polypeptides into protein-only, BBB-targeted nanoparticles.

scientific article published on 3 March 2016

Recruiting potent membrane penetrability in tumor cell-targeted protein-only nanoparticles

scientific article published on 18 December 2018

Rehosting of bacterial chaperones for high-quality protein production.

scientific article published on 9 October 2009

Release of targeted protein nanoparticles from functional bacterial amyloids: A death star-like approach.

scientific article published on 8 April 2018

Selective CXCR4+ Cancer Cell Targeting and Potent Antineoplastic Effect by a Nanostructured Version of Recombinant Ricin

scientific article published on 29 May 2018

Selective delivery of T22-PE24-H6 to CXCR4+ diffuse large B-cell lymphoma cells leads to wide therapeutic index in a disseminated mouse model

scientific article published on 06 April 2020

Selective depletion of metastatic stem cells as therapy for human colorectal cancer

scientific article published on 01 October 2018

Self-assembling as regular nanoparticles dramatically minimizes photobleaching of tumour-targeted GFP

scientific article published on 06 December 2019

Self-assembling toxin-based nanoparticles as self-delivered antitumoral drugs.

scientific article published on 30 January 2018

Sheltering DNA in self-organizing, protein-only nano-shells as artificial viruses for gene delivery.

scientific article published on 21 November 2013

Strategies for the production of difficult-to-express full-length eukaryotic proteins using microbial cell factories: production of human alpha-galactosidase A.

scientific article published on 24 January 2015

Structural and functional features of self-assembling protein nanoparticles produced in endotoxin-free Escherichia coli.

scientific article published on 08 April 2016

Switching cell penetrating and CXCR4-binding activities of nanoscale-organized arginine-rich peptides.

scientific article

The fusogenic peptide HA2 impairs selectivity of CXCR4-targeted protein nanoparticles.

scientific article

Topographically targeted osteogenesis of mesenchymal stem cells stimulated by inclusion bodies attached to polycaprolactone surfaces

scientific article published on 30 April 2013

Towards protein-based viral mimetics for cancer therapies.

scientific article

List of works by Ugutz Unzueta

A Novel CXCR4-Targeted Diphtheria Toxin Nanoparticle Inhibits Invasion and Metastatic Dissemination in a Head and Neck Squamous Cell Carcinoma Mouse Model

A multivalent Ara-C-prodrug nanoconjugate achieves selective ablation of leukemic cells in an acute myeloid leukemia mouse model

A nanostructured bacterial bioscaffold for the sustained bottom-up delivery of protein drugs

A refined cocktailing of pro-apoptotic nanoparticles boosts anti-tumor activity

An Auristatin nanoconjugate targeting CXCR4+ leukemic cells blocks acute myeloid leukemia dissemination

Assembly of histidine-rich protein materials controlled through divalent cations

BBB-targeting, protein-based nanomedicines for drug and nucleic acid delivery to the CNS.

Bacterial mimetics of endocrine secretory granules as immobilized in vivo depots for functional protein drugs.

Biofabrication of functional protein nanoparticles through simple His-tag engineering

Bottom-Up Instructive Quality Control in the Biofabrication of Smart Protein Materials

CXCR4(+)-targeted protein nanoparticles produced in the food-grade bacterium Lactococcus lactis.

Cancer-specific uptake of a liganded protein nanocarrier targeting aggressive CXCR4 + colorectal cancer models

Collaborative membrane activity and receptor-dependent tumor cell targeting for precise nanoparticle delivery in CXCR4+ colorectal cancer

Conformational Conversion during Controlled Oligomerization into Nonamylogenic Protein Nanoparticles

Conformational and functional variants of CD44-targeted protein nanoparticles bio-produced in bacteria

Developing Protein-Antitumoral Drug Nanoconjugates as Bifunctional Antimicrobial Agents

Dialysis: a characterization method of aggregation tendency.

Efficient bioactive oligonucleotide-protein conjugation for cell-targeted cancer therapy

Engineered biological entities for drug delivery and gene therapy protein nanoparticles.

Engineering multifunctional protein nanoparticles by in vitro disassembling and reassembling of heterologous building blocks

Engineering tumor cell targeting in nanoscale amyloidal materials.

Fluorescent Dye Labeling Changes the Biodistribution of Tumor-Targeted Nanoparticles

Functional inclusion bodies produced in the yeast Pichia pastoris.

Improved performance of protein-based recombinant gene therapy vehicles by tuning downstream procedures

In vivo architectonic stability of fully de novo designed protein-only nanoparticles

Internalization and kinetics of nuclear migration of protein-only, arginine-rich nanoparticles.

Intracellular CXCR4⁺ cell targeting with T22-empowered protein-only nanoparticles.

Intracellular targeting of CD44+ cells with self-assembling, protein only nanoparticles

Intracellular trafficking of a dynein-based nanoparticle designed for gene delivery.

Intrinsic functional and architectonic heterogeneity of tumor-targeted protein nanoparticles

Lymphocyte infiltration and antitumoral effect promoted by cytotoxic inflammatory proteins formulated as self-assembling, protein-only nanoparticles

Nanoparticulate architecture of protein-based artificial viruses is supported by protein-DNA interactions

Nanostructured toxins for the selective destruction of drug-resistant human CXCR4+ colorectal cancer stem cells

Non-amyloidogenic peptide tags for the regulatable self-assembling of protein-only nanoparticles

Novel Endometrial Cancer Models Using Sensitive Metastasis Tracing for CXCR4-Targeted Therapy in Advanced Disease

Potent Anticancer Activity of CXCR4-Targeted Nanostructured Toxins in Aggressive Endometrial Cancer Models

Protein aggregation and soluble aggregate formation screened by a fast microdialysis assay

Protein nanodisk assembling and intracellular trafficking powered by an arginine-rich (R9) peptide

Protein nanoparticles are nontoxic, tuneable cell stressors

Protein-Based Therapeutic Killing for Cancer Therapies.

Protein-driven nanomedicines in oncotherapy.

Protein-only, antimicrobial peptide-containing recombinant nanoparticles with inherent built-in antibacterial activity.

RGD-based cell ligands for cell-targeted drug delivery act as potent trophic factors

Rational engineering of single-chain polypeptides into protein-only, BBB-targeted nanoparticles.

Recruiting potent membrane penetrability in tumor cell-targeted protein-only nanoparticles

Rehosting of bacterial chaperones for high-quality protein production.

Release of targeted protein nanoparticles from functional bacterial amyloids: A death star-like approach.

Selective CXCR4+ Cancer Cell Targeting and Potent Antineoplastic Effect by a Nanostructured Version of Recombinant Ricin

Selective delivery of T22-PE24-H6 to CXCR4+ diffuse large B-cell lymphoma cells leads to wide therapeutic index in a disseminated mouse model

Selective depletion of metastatic stem cells as therapy for human colorectal cancer

Self-assembling as regular nanoparticles dramatically minimizes photobleaching of tumour-targeted GFP

Self-assembling toxin-based nanoparticles as self-delivered antitumoral drugs.

Sheltering DNA in self-organizing, protein-only nano-shells as artificial viruses for gene delivery.

Strategies for the production of difficult-to-express full-length eukaryotic proteins using microbial cell factories: production of human alpha-galactosidase A.

Structural and functional features of self-assembling protein nanoparticles produced in endotoxin-free Escherichia coli.

Switching cell penetrating and CXCR4-binding activities of nanoscale-organized arginine-rich peptides.

The fusogenic peptide HA2 impairs selectivity of CXCR4-targeted protein nanoparticles.

Topographically targeted osteogenesis of mesenchymal stem cells stimulated by inclusion bodies attached to polycaprolactone surfaces

Towards protein-based viral mimetics for cancer therapies.