List of works by Shahab Uddin

A very low incidence of BRAF mutations in Middle Eastern colorectal carcinoma.

scientific article

ALK gene amplification is associated with poor prognosis in colorectal carcinoma

scientific article published on 15 October 2013

Accelerated lipid catabolism and autophagy are cancer survival mechanisms under inhibited glutaminolysis

Activation of a CrkL-stat5 signaling complex by type I interferons.

scientific article

Activation of protein kinase C delta by IFN-gamma

scientific article

Activation of the Akt/FKHRL1 pathway mediates the antiapoptotic effects of erythropoietin in primary human erythroid progenitors

scientific article published on 01 August 2000

Activation of the Jak-Stat Pathway in Cells That Exhibit Selective Sensitivity to the Antiviral Effects of IFN-beta Compared with IFN-alpha

scientific article published on 01 July 1999

Activation of the p38 mitogen-activated protein kinase by type I interferons

scientific article

Activation of the p38 mitogen-activated protein kinase mediates the suppressive effects of type I interferons and transforming growth factor-beta on normal hematopoiesis

scientific article published on 31 December 2001

Activation of the p70 S6 kinase and phosphorylation of the 4E-BP1 repressor of mRNA translation by type I interferons

scientific article published on 20 May 2003

Activation of the phosphatidylinositol 3-kinase serine kinase by IFN-alpha

scientific article published on 01 March 1997

All-trans-retinoic acid induces tyrosine phosphorylation of the CrkL adapter in acute promyelocytic leukemia cells

scientific article (publication date: July 2000)

Anti-hypertrophic effect of Na+/H+ exchanger-1 inhibition is mediated by reduced cathepsin B

scientific article published on 08 August 2020

Anticancer Activity of Camel Milk via Induction of Autophagic Death in Human Colorectal and Breast Cancer Cells

scientific article published on 25 December 2018

Anticancer potential of sanguinarine for various human malignancies.

scientific article published on 21 June 2017

Antioxidants protection against cancer and other human diseases.

scientific article

Apigenin induces apoptosis via downregulation of S-phase kinase-associated protein 2-mediated induction of p27Kip1 in primary effusion lymphoma cells.

scientific article

Association of genes with phenotype in autism spectrum disorder

scientific article published on 19 November 2019

Association of the interferon-dependent tyrosine kinase Tyk-2 with the hematopoietic cell phosphatase

scientific article

Betulinic acid reduces ultraviolet-C-induced DNA breakage in congenital melanocytic naeval cells: evidence for a potential role as a chemopreventive agent.

scientific article

Bortezomib (Velcade) induces p27Kip1 expression through S-phase kinase protein 2 degradation in colorectal cancer.

scientific article

Bortezomib inhibits proteasomal degradation of IκBα and induces mitochondrial dependent apoptosis in activated B-cell diffuse large B-cell lymphoma.

scientific article published on 24 June 2013

Bortezomib-mediated downregulation of S-phase kinase protein-2 (SKP2) causes apoptotic cell death in chronic myelogenous leukemia cells

scientific article published on 09 March 2016

CAR-T Cell Therapies: An Overview of Clinical Studies Supporting Their Approved Use against Acute Lymphoblastic Leukemia and Large B-Cell Lymphomas

scientific article published on 30 May 2020

Cisplatin based therapy: the role of the mitogen activated protein kinase signaling pathway.

scientific article published on 11 April 2018

Claudin-1, A Double-Edged Sword in Cancer

scientific article published on 15 January 2020

Clinico-pathological significance of TNF alpha-induced protein3 (TNFAIP3) in Middle Eastern colorectal carcinoma

scientific article published on 14 July 2011

Co-targeting of Cyclooxygenase-2 and FoxM1 is a viable strategy in inducing anticancer effects in colorectal cancer cells

scientific article published on 10 July 2015

Coexpression of activated c-Met and death receptor 5 predicts better survival in colorectal carcinoma.

scientific article published on 5 October 2011

Colorectal cancer risk is not associated with increased levels of homozygosity in Saudi Arabia

scientific article published on 05 April 2012

Colorectal carcinoma from Saudi Arabia. Analysis of MLH-1, MSH-2 and p53 genes by immunohistochemistry and tissue microarray analysis

scientific article published on 01 March 2006

Colorectal carcinomas from Middle East. Molecular and tissue microarray analysis of genomic instability pathways

scientific article published on 01 January 2008

CrkL and CrkII participate in the generation of the growth inhibitory effects of interferons on primary hematopoietic progenitors

scientific journal article

Cross-talk between NFkB and the PI3-kinase/AKT pathway can be targeted in primary effusion lymphoma (PEL) cell lines for efficient apoptosis.

scientific article

Curcumin Induces Apoptotic Cell Death via Inhibition of PI3-Kinase/AKT Pathway in B-Precursor Acute Lymphoblastic Leukemia

scientific article published on 19 June 2019

Curcumin induces apoptosis via inhibition of PI3'-kinase/AKT pathway in acute T cell leukemias

scientific article published in February 2006

Curcumin suppresses constitutive activation of nuclear factor-kappa B and requires functional Bax to induce apoptosis in Burkitt's lymphoma cell lines.

scientific article published on October 2008

Curcumin suppresses growth and induces apoptosis in primary effusion lymphoma.

scientific article published on October 2005

Curcumin-Mediated Apoptotic Cell Death in Papillary Thyroid Cancer and Cancer Stem-Like Cells through Targeting of the JAK/STAT3 Signaling Pathway

scientific article published on 09 January 2020

Curcumin-Mediated Degradation of S-Phase Kinase Protein 2 Induces Cytotoxic Effects in Human Papillomavirus-Positive and Negative Squamous Carcinoma Cells

Cutting edge: activation of the p38 mitogen-activated protein kinase signaling pathway mediates cytokine-induced hemopoietic suppression in aplastic anemia

scientific article published on 01 June 2002

Cyclooxygenase-2 inhibition inhibits PI3K/AKT kinase activity in epithelial ovarian cancer.

scientific article

Cytokine-Mediated Dysregulation of Signaling Pathways in the Pathogenesis of Multiple Myeloma

scientific article published on 15 July 2020

Defective expression of the SHP-1 phosphatase in polycythemia vera

scientific article published on 01 July 1999

Demethylation of TMS1 Gene Sensitizes Thyroid Cancer Cells to TRAIL-Induced Apoptosis

scientific article published in November 2010

Demethylation ofTMS1Gene Sensitizes Thyroid Cancer Cells to TRAIL-Induced Apoptosis ⬇️

scientific article published on October 6, 2010

Developing curcumin into a viable therapeutic for lymphoma

scientific article published on 01 January 2009

Differences in interferon alpha and beta signaling. Interferon beta selectively induces the interaction of the alpha and betaL subunits of the type I interferon receptor

scientific article

Distinct functions of erythropoietin and stem cell factor are linked to activation of mTOR kinase signaling pathway in human erythroid progenitors

scientific article published on 11 November 2012

Distinct gene expression profiles: nodal versus extranodal diffuse large B-cell lymphoma

scientific article published on 12 September 2008

Dual Targeting of mTOR Activity with Torin2 Potentiates Anticancer Effects of Cisplatin in Epithelial Ovarian Cancer

scientific article

Dysregulated Phosphorylation of p53, Autophagy and Stemness Attributes the Mutant p53 Harboring Colon Cancer Cells Impaired Sensitivity to Oxaliplatin

scientific article published on 28 August 2020

Dysregulated expression of SKP2 and its role in hematological malignancies

scientific article published on 10 August 2017

Embelin: a benzoquinone possesses therapeutic potential for the treatment of human cancer.

scientific article published on 5 April 2018

Engagement of Gab1 and Gab2 in erythropoietin signaling

scientific article (publication date: 27 August 1999)

Engagement of the CrkL adaptor in interferon alpha signalling in BCR-ABL-expressing cells

scientific article (publication date: February 2001)

Epigenetic and Breast Cancer Therapy: Promising Diagnostic and Therapeutic Applications

scientific article published on 25 August 2020

Ethanol-induced alterations in the posttranslational processing, but not secretion of luteinizing hormone-releasing hormone in vitro.

scientific article published on May 1996

Evaluation of cationic channel TRPV2 as a novel biomarker and therapeutic target in Leukemia-Implications concerning the resolution of pulmonary inflammation

scientific article published in Scientific Reports

Exosomes: Emerging Diagnostic and Therapeutic Targets in Cutaneous Diseases

scientific article published on 04 December 2020

Extracellular vesicles-mediated intercellular communication: roles in the tumor microenvironment and anti-cancer drug resistance

scientific article published on 30 March 2019

Failure of ethanol metabolites to alter gonadotropin secretion or luteinizing hormone synthesis in vitro

scientific article published on August 1995

Fatty acid synthase and AKT pathway signaling in a subset of papillary thyroid cancers

scientific article published on 5 August 2008

FoxM1 and its association with matrix metalloproteinases (MMP) signaling pathway in papillary thyroid carcinoma.

scientific article

Frequent PIK3CA gene amplification and its clinical significance in colorectal cancer.

scientific article

Genetic and Neuroimaging Approaches to Understanding Post-Traumatic Stress Disorder

scientific article published on 24 June 2020

Genetic polymorphisms of methylenetetrahydrofolate reductase and promoter methylation of MGMT and FHIT genes in diffuse large B cell lymphoma risk in Middle East

scientific article published on 22 August 2007

Genome-wide expression analysis of Middle Eastern papillary thyroid cancer reveals c-MET as a novel target for cancer therapy

scientific article published on 01 October 2007

Greensporone A, a Fungal Secondary Metabolite Suppressed Constitutively Activated AKT via ROS Generation and Induced Apoptosis in Leukemic Cell Lines

scientific article published on 29 March 2019

Greensporone C, a Freshwater Fungal Secondary Metabolite Induces Mitochondrial-Mediated Apoptotic Cell Death in Leukemic Cell Lines

scholarly article by Kirti S Prabhu et al published 2018 in Frontiers in Pharmacology

Growth inhibition of a human myeloma cell line by all-trans retinoic acid is not mediated through downregulation of interleukin-6 receptors but through upregulation of p21(WAF1).

scientific article published on July 1999

HGF/c-Met pathway has a prominent role in mediating antiapoptotic signals through AKT in epithelial ovarian carcinoma.

scientific article published on 26 July 2010

High prevalence of fatty acid synthase expression in colorectal cancers in Middle Eastern patients and its potential role as a therapeutic target.

scientific article

High prevalence of mTOR complex activity can be targeted using Torin2 in papillary thyroid carcinoma

scientific article published on 28 February 2014

IFN-gamma activates the C3G/Rap1 signaling pathway

scientific article published on 01 February 2000

Identification of a domain in the beta subunit of the type I interferon (IFN) receptor that exhibits a negative regulatory effect in the growth inhibitory action of type I IFNs.

scientific article

Illuminating the Molecular Intricacies of Exosomes and ncRNAs in Cardiovascular Diseases: Prospective Therapeutic and Biomarker Potential

scientific article published in 2022

Immunogenetics of Celiac Disease: A Focus on Arab Countries

scientific article published on 01 January 2020

Immunotherapeutic strategies in patients with advanced head and neck squamous cell carcinoma

scientific article published on 01 March 2019

Inducing Angiogenesis, a Key Step in Cancer Vascularization, and Treatment Approaches

scientific article published on 06 May 2020

Inhibition of c-MET is a potential therapeutic strategy for treatment of diffuse large B-cell lymphoma.

scientific article published on 7 June 2010

Inhibition of fatty acid synthase suppresses c-Met receptor kinase and induces apoptosis in diffuse large B-cell lymphoma.

scientific article

Inhibition of p90 ribosomal S6 kinase potentiates cisplatin activity in A549 human lung adenocarcinoma cells

scientific article published on 15 July 2020

Inhibition of phosphatidylinositol 3'-kinase induces preferentially killing of PTEN-null T leukemias through AKT pathway.

scientific article published on July 2004

Inhibition of phosphatidylinositol 3'-kinase/AKT signaling promotes apoptosis of primary effusion lymphoma cells.

scientific article

Insulin-dependent tyrosine phosphorylation of the vav protooncogene product in cells of hematopoietic origin.

scientific article

Insulin-like growth factor-1 induces rapid tyrosine phosphorylation of the vav proto-oncogene product.

scientific article

Interaction of p59fyn with interferon-activated Jak kinases

scientific article (publication date: 9 June 1997)

Interaction of the c-cbl proto-oncogene product with the Tyk-2 protein tyrosine kinase

scientific article

Interaction of the transcriptional activator Stat-2 with the type I interferon receptor

scientific article

Interferon alpha activates the tyrosine kinase Lyn in haemopoietic cells.

scientific article published on June 1998

Interferon-alpha resistance in a cutaneous T-cell lymphoma cell line is associated with lack of STAT1 expression.

scientific article published in January 1998

Interferon-α Engages the Insulin Receptor Substrate-1 to Associate with the Phosphatidylinositol 3′-Kinase ⬇️

scientific article published on July 7, 1995

Involvement of F-BOX proteins in progression and development of human malignancies

scientific article published on 24 September 2015

Jurkat cell proliferative activity is increased by luteinizing hormone-releasing hormone.

scientific article published on May 1997

Localization of death receptor 4 in lipid rafts sensitizes chronic lymphocytic leukemia to chemotherapeutic drug mediated apoptosis

scientific article published on 04 April 2011

Luteinizing hormone-releasing hormone (LHRH) in rat prostate: characterization of LHRH peptide, messenger ribonucleic acid expression, and molecular processing of LHRH in intact and castrated male rats

scientific article published on 01 September 1993

MMP7 Polymorphisms - A new tool in molecular pathology to understand esophageal cancer

scientific article published on September 2011

Mechanisms of type-I interferon signal transduction.

scientific article

Molecular markers and pathway analysis of colorectal carcinoma in the Middle East.

scientific article published on 28 July 2015

Non-Coding RNAs as Regulators and Markers for Targeting of Breast Cancer and Cancer Stem Cells

scientific article published on 04 February 2020

Overexpression of fatty acid synthase in Middle Eastern epithelial ovarian carcinoma activates AKT and Its inhibition potentiates cisplatin-induced apoptosis.

scientific article

Overexpression of leptin receptor predicts an unfavorable outcome in Middle Eastern ovarian cancer.

scientific article published on 18 September 2009

PIK3CA mutations are mutually exclusive with PTEN loss in diffuse large B-cell lymphoma

scientific article published on 26 July 2007

Phosphorylated IκBα predicts poor prognosis in activated B-cell lymphoma and its inhibition with thymoquinone induces apoptosis via ROS release

scientific article

Phosphorylation of forkhead transcription factors by erythropoietin and stem cell factor prevents acetylation and their interaction with coactivator p300 in erythroid progenitor cells

scientific article (publication date: 28 February 2002)

Polymorphisms of drug-metabolizing enzymes CYP1A1, GSTT and GSTP contribute to the development of diffuse large B-cell lymphoma risk in the Saudi Arabian population.

scientific article

Polymorphisms of selected xenobiotic genes contribute to the development of papillary thyroid cancer susceptibility in Middle Eastern population

scientific article

Potential therapeutic targets of Guggulsterone in cancer

scientific article published on 28 February 2017

Poxvirus infection rapidly activates tyrosine kinase signal transduction

scientific article published on 8 October 2001

Prevalence of Lynch syndrome in a Middle Eastern population with colorectal cancer.

scientific article published on 24 February 2015

Prevalence of fragile histidine triad expression in tumors from saudi arabia: a tissue microarray analysis

scientific article published on 01 September 2006

Prognostic significance of TRAIL death receptors in Middle Eastern colorectal carcinomas and their correlation to oncogenic KRAS alterations ⬇️

scientific article published on July 30, 2010

Prognostic significance of XIAP expression in DLBCL and effect of its inhibition on AKT signalling.

scientific article published on October 2010

Prognostic significance of alterations in KRAS isoforms KRAS-4A/4B and KRAS mutations in colorectal carcinoma.

scientific article published in December 2009

Proteasome inhibitor MG-132 mediated expression of p27Kip1 via S-phase kinase protein 2 degradation induces cell cycle coupled apoptosis in primary effusion lymphoma cells.

scientific article

Protein Expression Profiling Identifies Key Proteins and Pathways Involved in Growth Inhibitory Effects Exerted by Guggulsterone in Human Colorectal Cancer Cells

scientific article published on 01 October 2019

Protein kinase B/Akt mediates effects of insulin on hepatic insulin-like growth factor-binding protein-1 gene expression through a conserved insulin response sequence

scientific article published on 01 March 1998

Protein kinase C-delta regulates thrombin-induced ICAM-1 gene expression in endothelial cells via activation of p38 mitogen-activated protein kinase.

scientific article

RAD52 polymorphisms contribute to the development of papillary thyroid cancer susceptibility in Middle Eastern population

scientific article published on 01 October 2008

RAS-mediated oncogenic signaling pathways in human malignancies.

scientific article published on 7 March 2018

Reactions of furfural and methylfurfural with DNA

scientific article published on 01 January 1995

Reduced or absent cyclin H expression is an independent prognostic marker for poor outcome in diffuse large B-cell lymphoma.

scientific article

Regulation of leukemic cell differentiation and retinoid-induced gene expression by statins

scientific article published on 24 February 2009

Role of Epstein-Barr Virus in the Pathogenesis of Head and Neck Cancers and Its Potential as an Immunotherapeutic Target

Role of Non Receptor Tyrosine Kinases in Hematological Malignances and its Targeting by Natural Products.

scientific article

Role of RAS signaling in ovarian cancer

scientific article published in 2022

Role of Stat5 in type I interferon-signaling and transcriptional regulation

scientific article published in August 2003

Role of X-Linked Inhibitor of Apoptosis as a Prognostic Marker and Therapeutic Target in Papillary Thyroid Carcinoma.

scientific article published on 14 May 2015

Role of dysregulated expression of leptin and leptin receptors in colorectal carcinogenesis.

scientific article published on 07 September 2013

Role of leptin and leptin receptors in hematological malignancies.

scientific article published on 16 June 2015

Role of miRNA-Regulated Cancer Stem Cells in the Pathogenesis of Human Malignancies

scientific article published on 05 August 2019

Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance

scientific article published on 12 March 2020

Role of nuclear factor-κB regulators TNFAIP3 and CARD11 in Middle Eastern diffuse large B-cell lymphoma

scientific article published on 18 April 2012

Role of phosphatidylinositol 3'-kinase/AKT pathway in diffuse large B-cell lymphoma survival

scientific article published on 31 August 2006

S-phase kinase protein 2 is an attractive therapeutic target in a subset of diffuse large B-cell lymphoma.

scientific article published on December 2008

Sanguinarine Induces Apoptosis Pathway in Multiple Myeloma Cell Lines via Inhibition of the JaK2/STAT3 Signaling

scientific article published on 17 April 2019

Sanguinarine Induces Apoptosis in Papillary Thyroid Cancer Cells via Generation of Reactive Oxygen Species

scientific article published on 09 March 2020

Sanguinarine suppresses growth and induces apoptosis in childhood acute lymphoblastic leukemia

scientific article published on 06 September 2018

Sanguinarine-dependent induction of apoptosis in primary effusion lymphoma cells.

scientific article published on April 2007

Sphingosine kinase is an attractive target for novel pharmacological interventions in non-Hodgkin lymphomas.

scientific article published on May 2008

Squamous Cell Carcinomas of the Head and Neck Cancer Response to Programmed Cell Death Protein-1 Targeting and Differential Expression of Immunological Markers: A Case Report

scientific article published on 30 July 2018

Targeting acute myeloid leukemia stem cell signaling by natural products.

scientific article published on 30 January 2017

Targeting of X-linked inhibitor of apoptosis protein and PI3-kinase/AKT signaling by embelin suppresses growth of leukemic cells

scientific article published on 13 July 2017

The CrkL adapter protein is required for type I interferon-dependent gene transcription and activation of the small G-protein Rap1.

scientific article

The IRS-pathway operates distinctively from the Stat-pathway in hematopoietic cells and transduces common and distinct signals during engagement of the insulin or interferon-alpha receptors

scientific article published on 01 October 1997

The PI3' kinase pathway in interferon signaling.

scientific article

The Rac1/p38 mitogen-activated protein kinase pathway is required for interferon alpha-dependent transcriptional activation but not serine phosphorylation of Stat proteins

scientific article published on 01 September 2000

The Role of Extracellular Vesicles as Modulators of the Tumor Microenvironment, Metastasis and Drug Resistance in Colorectal Cancer

scientific article published on 29 May 2019

The biological and clinical impact of inhibition of NF-κB-initiated apoptosis in diffuse large B cell lymphoma (DLBCL)

scientific article published on 19 April 2011

The effect of in vitro ethanol exposure on luteinizing hormone and follicle stimulating hormone mRNA levels, content, and secretion

scientific article published in May 1994

The effects of ethanol on pituitary function.

scientific article published on January 1994

The proximal tyrosines of the cytoplasmic domain of the beta chain of the type I interferon receptor are essential for signal transducer and activator of transcription (Stat) 2 activation. Evidence that two Stat2 sites are required to reach a thresh

scientific article published on February 1999

The role of gonadectomy and testosterone replacement on thymic luteinizing hormone-releasing hormone production

scientific journal article

The type I interferon receptor mediates tyrosine phosphorylation of insulin receptor substrate 2

scientific article

The vav proto-oncogene product (p95vav) interacts with the Tyk-2 protein tyrosine kinase

scientific article published on 01 February 1997

Therapeutic Effects of Curcumol in Several Diseases; An Overview

scientific article published on 14 April 2020

Therapeutic Potential of Resveratrol in Lymphoid Malignancies.

scientific article published on 30 March 2016

Tight Junction Proteins and Signaling Pathways in Cancer and Inflammation: A Functional Crosstalk

scientific article published on 01 January 2018

Tyrosine phosphorylation of the alpha and beta subunits of the type I interferon receptor. Interferon-beta selectively induces tyrosine phosphorylation of an alpha subunit-associated protein

scientific article published on 01 July 1994

Urine as a Main Effector in Urological Tissue Engineering-A Double-Edged Sword

scientific article published on 26 February 2020

Vascular Endothelial Growth Factor (VEGF) Signaling in Tumour Vascularization: Potential and Challenges

scientific article

p38 MAPK activation coupled to endocytosis is a determinant of endothelial monolayer integrity

scientific article published on 04 August 2006

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