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List of works by Javier Egea

1,8-Naphthyridine derivatives as Cholinesterases Inhibitors and Cell Ca2+ Regulators, a Multitarget Strategy for Alzheimer's Disease ⬇️

scientific article published on November 1, 2011

A review of metal-catalyzed molecular damage: protection by melatonin

scientific article published on 05 April 2014

Agmatine induces Nrf2 and protects against corticosterone effects in hippocampal neuronal cell line

scientific article

Agmatine, by Improving Neuroplasticity Markers and Inducing Nrf2, Prevents Corticosterone-Induced Depressive-Like Behavior in Mice

scientific article published on 13 May 2015

Alpha7 nicotinic receptor activation protects against oxidative stress via heme-oxygenase I induction

scientific article

Analysis of gene expression profiles of CR80, a neuroprotective 1,8-Naphthyridine

scientific article published on 21 March 2018

Anti-inflammatory role of microglial alpha7 nAChRs and its role in neuroprotection

scientific article published on 29 July 2015

Antioxidant, antiinflammatory and neuroprotective actions of chondroitin sulfate and proteoglycans

scientific article published on 24 April 2010

Benzothiazepine CGP37157 and its isosteric 2'-methyl analogue provide neuroprotection and block cell calcium entry

scientific article

Blockade of nicotinic receptors of bovine adrenal chromaffin cells by nanomolar concentrations of atropine

scientific article published on 10 March 2006

Both creatine and its product phosphocreatine reduce oxidative stress and afford neuroprotection in an in vitro Parkinson's model

scientific article published on 24 November 2014

CALHM1 and its polymorphism P86L differentially control Ca²⁺homeostasis, mitogen-activated protein kinase signaling, and cell vulnerability upon exposure to amyloid β.

scientific article published on 29 September 2015

Calcium signalling mediated through α7 and non-α7 nAChR stimulation is differentially regulated in bovine chromaffin cells to induce catecholamine release

scientific article published on January 2011

Chemical and pharmacological studies on enantiomerically pure p-methoxytacripyrines, promising multi-target-directed ligands for the treatment of Alzheimer's disease

scientific article published on 24 August 2011

Chondroitin sulfate reduces cell death of rat hippocampal slices subjected to oxygen and glucose deprivation by inhibiting p38, NFκB and iNOS.

scientific article published on 16 February 2011

ConBr, A Lectin Purified from the Seeds of Canavalia brasiliensis, Protects Against Ischemia in Organotypic Culture of Rat Hippocampus: Potential Implication of Voltage-Gated Calcium Channels.

scientific article published on 17 October 2016

Corrigendum to "European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)" [Redox Biol. 13 (2017) 94-162].

scientific article published on 26 October 2017

Curcumin reduces renal damage associated with rhabdomyolysis by decreasing ferroptosis-mediated cell death

scientific article published on 29 April 2019

Desensitized Nicotinic Receptors That, However, Afford Cytoprotection in Bovine Chromaffin Cells

scientific article published on 01 January 2006

Early toll-like receptor 4 blockade reduces ROS and inflammation triggered by microglial pro-inflammatory phenotype in rodent and human brain ischaemia models

scientific article published on 17 June 2019

Enantioselective neuroprotective effects of Tacripyrine ITH122 against oxygen and glucose deprivation in rat hippocampal slices

scientific article published on 26 February 2013

Enhancement of secretion by threshold nicotinic stimulation in bovine chromaffin cells

scientific article published in January 2006

Enzymatic and solid-phase synthesis of new donepezil-based L- and d-glutamic acid derivatives and their pharmacological evaluation in models related to Alzheimer's disease and cerebral ischemia

scientific article

European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS).

scientific article published on 18 May 2017

Folic Acid Protects Against Glutamate-Induced Excitotoxicity in Hippocampal Slices Through a Mechanism that Implicates Inhibition of GSK-3β and iNOS.

scientific article published on 10 February 2017

From single drug targets to synergistic network pharmacology in ischemic stroke

scientific article published on 20 March 2019

Functional interference between glycogen synthase kinase-3 beta and the transcription factor Nrf2 in protection against kainate-induced hippocampal cell death

scientific article published on 20 June 2008

Galantamine and memantine produce different degrees of neuroprotection in rat hippocampal slices subjected to oxygen-glucose deprivation

scientific article published in July 2004

Galantamine elicits neuroprotection by inhibiting iNOS, NADPH oxidase and ROS in hippocampal slices stressed with anoxia/reoxygenation.

scientific article

Guanosine controls inflammatory pathways to afford neuroprotection of hippocampal slices under oxygen and glucose deprivation conditions

scientific article published on 17 June 2013

Guanosine protects human neuroblastoma SH-SY5Y cells against mitochondrial oxidative stress by inducing heme oxigenase-1 via PI3K/Akt/GSK-3β pathway.

scientific article published on 7 June 2012

Haeme oxygenase-1 overexpression via nAChRs and the transcription factor Nrf2 has antinociceptive effects in the formalin test

scientific article published on 5 August 2009

ITH12410/SC058: a new neuroprotective compound with potential in the treatment of Alzheimer's disease

scientific article published on 15 July 2014

Identification of 4,6-diaryl-1,4-dihydropyridines as a new class of neuroprotective agents

Ischemic brain injury: New insights on the protective role of melatonin

scientific article published on 5 January 2017

Lectin from Canavalia brasiliensis (ConBr) protects hippocampal slices against glutamate neurotoxicity in a manner dependent of PI3K/Akt pathway

scientific article

Melatonin Reduces NLRP3 Inflammasome Activation by Increasing α7 nAChR-Mediated Autophagic Flux

scientific article published on 18 December 2020

Melatonin as a versatile molecule to design novel multitarget hybrids against neurodegeneration

scientific article published on 12 May 2017

Melatonin protects against oxygen and glucose deprivation by decreasing extracellular glutamate and Nox-derived ROS in rat hippocampal slices

scientific article published on 9 September 2016

Melatonin-sulforaphane hybrid ITH12674 induces neuroprotection in oxidative stress conditions by a 'drug-prodrug' mechanism of action

scientific article

Microglial HO-1 induction by curcumin provides antioxidant, antineuroinflammatory, and glioprotective effects

scientific article published on 5 June 2015

Mitochondrial Na+/Ca2+ exchanger, a new target for neuroprotection in rat hippocampal slices

scientific article published on 14 August 2010

Mitochondrial Na+/Ca2+-exchanger blocker CGP37157 protects against chromaffin cell death elicited by veratridine.

scientific article

Modulation of serine/threonine phosphatases by melatonin: therapeutic approaches in neurodegenerative diseases

scientific article published on 19 June 2018

Multipotente Liganden mit kombinierter Cholinesterase- und Monoaminooxidase-Inhibition sowie Histamin-H3 R-Antagonismus bei neurodegenerativen Erkrankungen

Multitarget-Directed Ligands Combining Cholinesterase and Monoamine Oxidase Inhibition with Histamine H3 R Antagonism for Neurodegenerative Diseases.

scientific article published in September 2017

N-acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease

scientific article

NOX4-dependent neuronal autotoxicity and BBB breakdown explain the superior sensitivity of the brain to ischemic damage.

scientific article

NP04634 prevents cell damage caused by calcium overload and mitochondrial disruption in bovine chromaffin cells

scientific article published on 21 February 2009

Na+ controls hypoxic signalling by the mitochondrial respiratory chain

scientific article published on 29 July 2020

Neuroprotectant minocycline depresses glutamatergic neurotransmission and Ca(2+) signalling in hippocampal neurons.

scientific article published in November 2007

Neuroprotection afforded by nicotine against oxygen and glucose deprivation in hippocampal slices is lost in alpha7 nicotinic receptor knockout mice

scientific journal article

Neuroprotection by nicotine in hippocampal slices subjected to oxygen-glucose deprivation: involvement of the alpha7 nAChR subtype

scientific article

Neuroprotective effect of dimebon against ischemic neuronal damage

scientific article published on 4 March 2014

Neuroprotective effect of guanosine against glutamate-induced cell death in rat hippocampal slices is mediated by the phosphatidylinositol-3 kinase/Akt/ glycogen synthase kinase 3β pathway activation and inducible nitric oxide synthase inhibition.

scientific article

Neuroprotective effect of melatonin against ischemia is partially mediated by alpha-7 nicotinic receptor modulation and HO-1 overexpression

scientific article published on 16 January 2014

Neuroprotective effect of the new thiadiazolidinone NP00111 against oxygen-glucose deprivation in rat hippocampal slices: implication of ERK1/2 and PPARgamma receptors

scientific article published on 25 March 2008

Neuroprotective effects of E-PodoFavalin-15999 (Atremorine®).

scientific article published on 30 March 2017

Neuroprotective mechanism of the novel melatonin derivative Neu-P11 in brain ischemia related models

scientific article published on 15 July 2015

Neurotoxicity induced by dexamethasone in the human neuroblastoma SH-SY5Y cell line can be prevented by folic acid.

scientific article published on 31 May 2011

Neurotoxicity induced by okadaic acid in the human neuroblastoma SH-SY5Y line can be differentially prevented by α7 and β2* nicotinic stimulation

scientific article published on 29 June 2011

Neurotransmitters, calcium signalling and neuronal communication

scientific article

New 5-unsubstituted dihydropyridines with improved CaV1.3 selectivity as potential neuroprotective agents against ischemic injury

scientific article published on 7 May 2014

New melatonin-cinnamate hybrids as multi-target drugs for neurodegenerative diseases: Nrf2-induction, antioxidant effect and neuroprotection.

scientific article published on 23 October 2015

Nicotinic receptor activation by epibatidine induces heme oxygenase-1 and protects chromaffin cells against oxidative stress

Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography

scientific article published on 3 December 2015

Novel multitarget ligand ITH33/IQM9.21 provides neuroprotection in in vitro and in vivo models related to brain ischemia

scientific article

Novel tacrine-grafted Ugi adducts as multipotent anti-Alzheimer drugs: a synthetic renewal in tacrine-ferulic acid hybrids

scientific article published on 23 December 2014

Nrf2-ARE pathway: An emerging target against oxidative stress and neuroinflammation in neurodegenerative diseases.

scientific article

Nrf2-mediated haeme oxygenase-1 up-regulation induced by cobalt protoporphyrin has antinociceptive effects against inflammatory pain in the formalin test in mice

scientific article published on 26 October 2007

Participation of calbindin-D28K in nociception: results from calbindin-D28K knockout mice

scientific article published on 03 December 2011

Podocytes are new cellular targets of haemoglobin-mediated renal damage.

scientific article published on 4 December 2017

Positive allosteric modulation of alpha-7 nicotinic receptors promotes cell death by inducing Ca(2+) release from the endoplasmic reticulum

scientific article

Poststress treatment with PNU282987 can rescue SH-SY5Y cells undergoing apoptosis via α7 nicotinic receptors linked to a Jak2/Akt/HO-1 signaling pathway

scientific article published on 26 September 2010

Protective Role of Nrf2 in Renal Disease

scientific article published on 31 December 2020

Protective effect of creatine against 6-hydroxydopamine-induced cell death in human neuroblastoma SH-SY5Y cells: Involvement of intracellular signaling pathways.

scientific article published on 26 February 2013

QuinoxalineTacrine QT78, a Cholinesterase Inhibitor as a Potential Ligand for Alzheimer's Disease Therapy

scientific article published on 17 April 2019

Redox control of microglial function: molecular mechanisms and functional significance

scientific article

Regulation by L channels of Ca(2+)-evoked secretory responses in ouabain-treated chromaffin cells

scientific article published on 24 August 2016

Sensory Input-Dependent Changes in Glutamatergic Neurotransmission- Related Genes and Proteins in the Adult Rat Trigeminal Ganglion

scientific article published on 28 November 2016

Serum Amyloid A1 as a Potential Intracranial and Extracranial Clinical Severity Biomarker in Traumatic Brain Injury

scientific article published on 08 April 2019

Small synthetic hyaluronan disaccharides afford neuroprotection in brain ischemia-related models

scientific article published on 28 January 2014

Subthreshold Concentrations of Melatonin and Galantamine Improves Pathological AD-Hallmarks in Hippocampal Organotypic Cultures

scientific article published on 17 June 2015

Synergistic neuroprotective effect of combined low concentrations of galantamine and melatonin against oxidative stress in SH-SY5Y neuroblastoma cells

scientific article published on June 2010

Synthesis and biological assessment of diversely substituted furo[2,3-b]quinolin-4-amine and pyrrolo[2,3-b]quinolin-4-amine derivatives, as novel tacrine analogues

Synthesis, inhibitory activity of cholinesterases, and neuroprotective profile of novel 1,8-naphthyridine derivatives

scientific article published on July 2010

Targeting Nrf2 in the Protection against Renal Disease.

scientific article

The Antioxidant Additive Approach for Alzheimer's Disease Therapy: New Ferulic (Lipoic) Acid Plus Melatonin Modified Tacrines as Cholinesterases Inhibitors, Direct Antioxidants, and Nuclear Factor (Erythroid-Derived 2)-Like 2 Activators

scientific article published on 13 October 2016

The N-terminal tripeptide of insulin-like growth factor-I protects against beta-amyloid-induced somatostatin depletion by calcium and glycogen synthase kinase 3 beta modulation.

scientific article published on 11 February 2009

The antinociceptive effects of AR-A014418, a selective inhibitor of glycogen synthase kinase-3 beta, in mice.

scientific article

The melatonin-N,N-dibenzyl(N-methyl)amine hybrid ITH91/IQM157 affords neuroprotection in an in vitro Alzheimer's model via hemo-oxygenase-1 induction

scientific article

The microglial α7-acetylcholine nicotinic receptor is a key element in promoting neuroprotection by inducing heme oxygenase-1 via nuclear factor erythroid-2-related factor 2.

scientific article published on 25 February 2013

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