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List of works by David A. Horn

A developmentally regulated position effect at a telomeric locus in Trypanosoma brucei

scientific article published in November 1995

A distal region of the CALC-1 gene is necessary for regulated alternative splicing

article

A doubly inducible system for RNA interference and rapid RNAi plasmid construction in Trypanosoma brucei

scientific article published in January 2005

A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes

scholarly article

A post-transcriptional respiratome regulon in trypanosomes.

scientific article published on 26 July 2019

A sirtuin in the African trypanosome is involved in both DNA repair and telomeric gene silencing but is not required for antigenic variation.

scientific article published on 4 January 2007

Acetylation of histone H4K4 is cell cycle regulated and mediated by HAT3 in Trypanosoma brucei.

scientific article

Alternative splicing of the mRNA encoding the alpha subunits of the G(o) GTP-binding protein during brain development and in neuronal cell lines

scientific article published on May 1993

Analysis of Trypanosoma brucei vsg expression site switching in vitro

article

Analysis of small GTPase function in trypanosomes

scientific article published in January 2008

Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need

scientific article published on 27 February 2017

Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need

scientific article published on 05 June 2017

Antigenic variation in African trypanosomes

scientific article

Antigenic variation in African trypanosomes: the importance of chromosomal and nuclear context in VSG expression control

scientific article

Antigenic variation: extending the reach of telomeric silencing.

scientific article published on June 2009

Antitrypanosomal 8-Hydroxy-Naphthyridines Are Chelators of Divalent Transition Metals

scholarly article by Richard J Wall et al published August 2018 in Antimicrobial Agents and Chemotherapy

Aquaglyceroporin 2 controls susceptibility to melarsoprol and pentamidine in African trypanosomes

scientific article

Aquaglyceroporin-null trypanosomes display glycerol transport defects and respiratory-inhibitor sensitivity

scientific article

Aquaporin 2 mutations in Trypanosoma brucei gambiense field isolates correlate with decreased susceptibility to pentamidine and melarsoprol

scientific article (publication date: 2013)

Author Correction: Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need

scientific article published on 01 November 2018

Benzoxaborole treatment perturbs S-adenosyl-L-methionine metabolism in Trypanosoma brucei

scientific article published on 14 May 2018

Cathepsin-L can resist lysis by human serum in Trypanosoma brucei brucei

scientific article (publication date: May 2014)

Cell-cycle-regulated control of VSG expression site silencing by histones and histone chaperones ASF1A and CAF-1b in Trypanosoma brucei.

scientific article published on 31 August 2012

Chemogenomic Profiling of Antileishmanial Efficacy and Resistance in the Related Kinetoplastid Parasite Trypanosoma brucei

scientific article published on 25 July 2019

Chimerization at the AQP2-AQP3 locus is the genetic basis of melarsoprol-pentamidine cross-resistance in clinical Trypanosoma brucei gambiense isolates

scientific article published on 7 May 2015

Chromosome-wide analysis of gene function by RNA interference in the african trypanosome.

scientific article published on September 2006

Clinical and veterinary trypanocidal benzoxaboroles target CPSF3

article published in the Proceedings of the National Academy of Sciences of the United States of America

Co-dependence between trypanosome nuclear lamina components in nuclear stability and control of gene expression.

scientific article published on 12 September 2016

Codon usage bias controls mRNA and protein abundance in trypanosomatids.

scientific article

Codon usage suggests that translational selection has a major impact on protein expression in trypanosomatids

scientific article

Comparative genomics of drug resistance in Trypanosoma brucei rhodesiense

scientific article published on 14 March 2016

Control of Variant Surface Glycoprotein Expression by CFB2 in Trypanosoma brucei and Quantitative Proteomic Connections to Translation and Cytokinesis

scientific article published on 21 March 2022

Correction: Modulation of the Surface Proteome through Multiple Ubiquitylation Pathways in African Trypanosomes.

scientific article published on 23 November 2015

Cyclic AMP effectors in African trypanosomes revealed by genome-scale RNA interference library screening for resistance to the phosphodiesterase inhibitor CpdA

scientific article

DNA break site at fragile subtelomeres determines probability and mechanism of antigenic variation in African trypanosomes

scientific article

DNA breaks as triggers for antigenic variation in African trypanosomes

scientific article published on 08 June 2009

Deletion of a trypanosome telomere leads to loss of silencing and progressive loss of terminal DNA in the absence of cell cycle arrest

scientific article published on 23 January 2007

Deletion of the Trypanosoma brucei superoxide dismutase gene sodb1 increases sensitivity to nifurtimox and benznidazole.

scientific article

Distinct activation mechanisms trigger the trypanocidal activity of DNA damaging prodrugs

scientific article

Down-Regulating Gene Expression by RNA Interference in Trypanosoma brucei

article

Drug resistance in African trypanosomiasis: the melarsoprol and pentamidine story ⬇️

scientific article published on January 30, 2013

Epigenetic Regulation of Virulence Gene Expression in Parasitic Protozoa

scientific article

Epigenetic mechanisms, nuclear architecture and the control of gene expression in trypanosomes.

scientific article published on 29 May 2012

Exploiting the Achilles' heel of membrane trafficking in trypanosomes

scientific article

Expression of the SmN splicing protein is developmentally regulated in the rodent brain but not in the rodent heart

scientific journal article

Expression of the tissue specific splicing protein SmN in neuronal cell lines and in regions of the brain with different splicing capacities

scientific article published on November 1992

Faster growth with shorter antigens can explain a VSG hierarchy during African trypanosome infections: a feint attack by parasites

scientific article published in Scientific Reports

Functional characterisation of the iron superoxide dismutase gene repertoire in Trypanosoma brucei.

scientific article published on 18 August 2005

Genetic dissection of drug resistance in trypanosomes

scientific article

Genome-scale RNAi screens for high-throughput phenotyping in bloodstream-form African trypanosomes

scientific article published on 11 December 2014

Genome-wide RNAi screens in African trypanosomes identify the nifurtimox activator NTR and the eflornithine transporter AAT6 ⬇️

scientific article published on November 18, 2010

Genome-wide RNAi selection identifies a regulator of transmission stage-enriched gene families and cell-type differentiation in Trypanosoma brucei

scientific article

Genome-wide and protein kinase-focused RNAi screens reveal conserved and novel damage response pathways in Trypanosoma brucei

scientific article

Genome-wide dissection of the quorum sensing signalling pathway in Trypanosoma brucei.

scientific article

Gluconeogenesis using glycerol as a substrate in bloodstream-form Trypanosoma brucei ⬇️

scientific article published on 27 December 2018

High-resolution analysis of multi-copy variant surface glycoprotein gene expression sites in African trypanosomes

scientific article

High-throughput decoding of antitrypanosomal drug efficacy and resistance

scientific article published on 25 January 2012

High-throughput decoding of drug targets and drug resistance mechanisms in African trypanosomes ⬇️

scientific article published on April 8, 2013

High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome

scientific article

Histone Deacetylases

article

Histone deacetylases in Trypanosoma brucei: two are essential and another is required for normal cell cycle progression.

scientific article published on July 2002

Histone deacetylases play distinct roles in telomeric VSG expression site silencing in African trypanosomes.

scientific article

Host-parasite co-metabolic activation of antitrypanosomal aminomethyl-benzoxaboroles

scientific article published on 9 February 2018

How Antiparasitic Drugs Work-And Sometimes Stop Working!

scientific article

Identification of a Proteasome-Targeting Arylsulfonamide with Potential for the Treatment of Chagas' Disease

scientific article published on 04 October 2021

Inducible high-efficiency CRISPR-Cas9-targeted gene editing and precision base editing in African trypanosomes.

scientific article published on 21 May 2018

Inhibitors of human histone deacetylase with potent activity against the African trypanosome Trypanosoma brucei.

scientific article published on 28 January 2012

Insights into antitrypanosomal drug mode-of-action from cytology-based profiling

scientific article published on 26 November 2018

Intracellular redistribution of neuropeptides and secretory proteins during differentiation of neuronal cell lines

scientific article published on January 1992

Locus-specific control of DNA resection and suppression of subtelomeric VSG recombination by HAT3 in the African trypanosome

scientific article published on 9 October 2014

Melarsoprol Resistance in African Trypanosomiasis

scholarly article published by David A. Horn in 2018

Microhomology-mediated deletion and gene conversion in African trypanosomes

scientific article published on 21 October 2010

Modulation of the Surface Proteome through Multiple Ubiquitylation Pathways in African Trypanosomes

scientific article

Molecular mechanisms underlying the control of antigenic variation in African trypanosomes ⬇️

scientific article published on September 29, 2010

Monoallelic expression and epigenetic inheritance sustained by a Trypanosoma brucei variant surface glycoprotein exclusion complex

scientific article published on 09 July 2019

Multiplex analysis of RNA interference defects in Trypanosoma brucei

scientific article published on January 2005

NUP-1 Is a large coiled-coil nucleoskeletal protein in trypanosomes with lamin-like functions

scientific article (publication date: 2012)

Nuclear gene transcription and chromatin in Trypanosoma brucei.

scientific article

Oligo targeting for profiling drug resistance mutations in the parasitic trypanosomatids

scientific article published in 2022

Ornithine uptake and the modulation of drug sensitivity in Trypanosoma brucei.

scientific article published on 5 July 2017

PPL2 translesion polymerase is essential for the completion of chromosomal DNA replication in the African trypanosome

scientific article published in November 2013

Pentamidine Is Not a Permeant but a Nanomolar Inhibitor of the Trypanosoma brucei Aquaglyceroporin-2

scientific article

Persistent DNA Damage Foci and DNA Replication with a Broken Chromosome in the African Trypanosome

scientific article published on 09 July 2019

Pharmacological Validation of N-Myristoyltransferase as a Drug Target in Leishmania donovani

scholarly article by Victoriano Corpas-Lopez et al published 12 November 2018 in ACS Infectious Diseases

Position-dependent and promoter-specific regulation of gene expression in Trypanosoma brucei.

scientific article published in December 1997

Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition

scientific article published on 08 April 2019

RNA interference identifies two hydroperoxide metabolizing enzymes that are essential to the bloodstream form of the african trypanosome.

scientific article published on 5 June 2003

RNA polymerase I transcription stimulates homologous recombination in Trypanosoma brucei.

scientific article published on 21 January 2007

Receptor-mediated endocytosis for drug delivery in African trypanosomes: fulfilling Paul Ehrlich's vision of chemotherapy.

scientific article published on 17 April 2013

Redistribution of secretory granule components precedes that of synaptic vesicle proteins during differentiation of a neuronal cell line in serum-free medium

scientific article published on December 1992

Repression of polymerase I-mediated gene expression at Trypanosoma brucei telomeres

scientific article published on January 2006

Sequence homology and microhomology dominate chromosomal double-strand break repair in African trypanosomes

scientific article published on 11 March 2008

Setting Our Sights on Infectious Diseases

scientific article published on 06 December 2019

Single-locus targeting constructs for reliable regulated RNAi and transgene expression in Trypanosoma brucei

scientific article published on 7 June 2008

Site-specific DNA double-strand breaks greatly increase stable transformation efficiency in Trypanosoma brucei

scientific article published on August 2009

Suramin exposure alters cellular metabolism and mitochondrial energy production in African trypanosomes

scientific article published on 30 April 2020

Tagging a T. brucei RRNA locus improves stable transfection efficiency and circumvents inducible expression position effects

scientific article published on 6 September 2005

Telomere maintenance and length regulation in Trypanosoma brucei.

scientific article published on May 2000

The Genome Sequence of Trypanosoma cruzi, Etiologic Agent of Chagas Disease

scientific article

The Role of Folate Transport in Antifolate Drug Action in Trypanosoma brucei

scientific article

The central roles of telomeres and subtelomeres in antigenic variation in African trypanosomes

scientific article published in January 2005

The genome of the kinetoplastid parasite, Leishmania major

scientific article

The tissue specific SmN protein does not influence the alternative splicing of endogenous N-Cam and C-SRC RNAs in transfected 3T3 cells

scientific article published on August 1993

Trypanosoma brucei J protein 2 is a stress inducible and essential Hsp40.

scientific article

Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs

scientific article

Trypanosomal histone γH2A and the DNA damage response ⬇️

scientific article published on February 14, 2012

Trypanosomatid histones.

scientific article published in July 2004

Two essential MYST-family proteins display distinct roles in histone H4K10 acetylation and telomeric silencing in trypanosomes.

scientific article published on 9 July 2008

VEX1 controls the allelic exclusion required for antigenic variation in trypanosomes

scientific article published on 25 May 2016

Vacuolar ATPase depletion affects mitochondrial ATPase function, kinetoplast dependency, and drug sensitivity in trypanosomes

scientific article published on 6 July 2015

Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs

scientific article published on 03 November 2020

Vitamin C biosynthesis in trypanosomes: a role for the glycosome

scientific article

What has DNA sequencing revealed about the VSG expression sites of African trypanosomes?

scientific article published on 23 July 2009

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