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List of works by David A. Horn

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The Genome Sequence of Trypanosoma cruzi, Etiologic Agent of Chagas Disease

scientific article
The genome of the kinetoplastid parasite, Leishmania major

scientific article
High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome

scientific article
Gluconeogenesis using glycerol as a substrate in bloodstream-form Trypanosoma brucei

scientific article published on 27 December 2018
High-throughput decoding of antitrypanosomal drug efficacy and resistance

scientific article published on 25 January 2012
A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes

scholarly article
Genome-wide dissection of the quorum sensing signalling pathway in Trypanosoma brucei.

scientific article
Antigenic variation in African trypanosomes

scientific article
A developmentally regulated position effect at a telomeric locus in Trypanosoma brucei

scientific article published in November 1995
A doubly inducible system for RNA interference and rapid RNAi plasmid construction in Trypanosoma brucei

scientific article published in January 2005
Molecular mechanisms underlying the control of antigenic variation in African trypanosomes

scientific article published on September 29, 2010
Tagging a T. brucei RRNA locus improves stable transfection efficiency and circumvents inducible expression position effects

scientific article published on 6 September 2005
Single-locus targeting constructs for reliable regulated RNAi and transgene expression in Trypanosoma brucei

scientific article published on 7 June 2008
Drug resistance in African trypanosomiasis: the melarsoprol and pentamidine story

scientific article published on January 30, 2013
Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need

scientific article published on 27 February 2017
A sirtuin in the African trypanosome is involved in both DNA repair and telomeric gene silencing but is not required for antigenic variation.

scientific article published on 4 January 2007
Aquaglyceroporin 2 controls susceptibility to melarsoprol and pentamidine in African trypanosomes

scientific article
RNA interference identifies two hydroperoxide metabolizing enzymes that are essential to the bloodstream form of the african trypanosome.

scientific article published on 5 June 2003
Sequence homology and microhomology dominate chromosomal double-strand break repair in African trypanosomes

scientific article published on 11 March 2008
Chromosome-wide analysis of gene function by RNA interference in the african trypanosome.

scientific article published on September 2006
Genome-wide RNAi screens in African trypanosomes identify the nifurtimox activator NTR and the eflornithine transporter AAT6

scientific article published on November 18, 2010
Position-dependent and promoter-specific regulation of gene expression in Trypanosoma brucei.

scientific article published in December 1997
NUP-1 Is a large coiled-coil nucleoskeletal protein in trypanosomes with lamin-like functions

scientific article (publication date: 2012)
Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs

scientific article
Two essential MYST-family proteins display distinct roles in histone H4K10 acetylation and telomeric silencing in trypanosomes.

scientific article published on 9 July 2008
Cyclic AMP effectors in African trypanosomes revealed by genome-scale RNA interference library screening for resistance to the phosphodiesterase inhibitor CpdA

scientific article
The central roles of telomeres and subtelomeres in antigenic variation in African trypanosomes

scientific article published in January 2005
Analysis of Trypanosoma brucei vsg expression site switching in vitro

article
Trypanosomal histone γH2A and the DNA damage response

scientific article published on February 14, 2012
PPL2 translesion polymerase is essential for the completion of chromosomal DNA replication in the African trypanosome

scientific article published in November 2013
Codon usage suggests that translational selection has a major impact on protein expression in trypanosomatids

scientific article
Histone deacetylases play distinct roles in telomeric VSG expression site silencing in African trypanosomes.

scientific article
Functional characterisation of the iron superoxide dismutase gene repertoire in Trypanosoma brucei.

scientific article published on 18 August 2005
DNA break site at fragile subtelomeres determines probability and mechanism of antigenic variation in African trypanosomes

scientific article
Acetylation of histone H4K4 is cell cycle regulated and mediated by HAT3 in Trypanosoma brucei.

scientific article
Trypanosomatid histones.

scientific article published in July 2004
VEX1 controls the allelic exclusion required for antigenic variation in trypanosomes

scientific article published on 25 May 2016
Intracellular redistribution of neuropeptides and secretory proteins during differentiation of neuronal cell lines

scientific article published on January 1992
Aquaporin 2 mutations in Trypanosoma brucei gambiense field isolates correlate with decreased susceptibility to pentamidine and melarsoprol

scientific article (publication date: 2013)
Histone deacetylases in Trypanosoma brucei: two are essential and another is required for normal cell cycle progression.

scientific article published on July 2002
Repression of polymerase I-mediated gene expression at Trypanosoma brucei telomeres

scientific article published on January 2006
Antigenic variation in African trypanosomes: the importance of chromosomal and nuclear context in VSG expression control

scientific article
Microhomology-mediated deletion and gene conversion in African trypanosomes

scientific article published on 21 October 2010
Vitamin C biosynthesis in trypanosomes: a role for the glycosome

scientific article
Telomere maintenance and length regulation in Trypanosoma brucei.

scientific article published on May 2000
Cell-cycle-regulated control of VSG expression site silencing by histones and histone chaperones ASF1A and CAF-1b in Trypanosoma brucei.

scientific article published on 31 August 2012
Deletion of a trypanosome telomere leads to loss of silencing and progressive loss of terminal DNA in the absence of cell cycle arrest

scientific article published on 23 January 2007
Receptor-mediated endocytosis for drug delivery in African trypanosomes: fulfilling Paul Ehrlich's vision of chemotherapy.

scientific article published on 17 April 2013
Vacuolar ATPase depletion affects mitochondrial ATPase function, kinetoplast dependency, and drug sensitivity in trypanosomes

scientific article published on 6 July 2015
Site-specific DNA double-strand breaks greatly increase stable transformation efficiency in Trypanosoma brucei

scientific article published on August 2009

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