List of works - James A. Bull

2-(Aryl-sulfonyl)oxetanes as designer 3-dimensional fragments for fragment screening: synthesis and strategies for functionalisation.

scientific article

A molecular rotor for measuring viscosity in plasma membranes of live cells.

scientific article

Acid-Mediated Ring Expansion of 2,2-Disubstituted Azetidine Carbamates to 6,6-Disubstituted 1,3-Oxazinan-2-ones

scientific article published on 04 March 2019

Catalytic Enantioselective Synthesis of Secondary Alkylboronate Building Blocks With and Without Metals ⬇️

scientific article published on July 23, 2012

Chemical and structural investigation of the paroxetine-human serotonin transporter complex

scientific article published on 03 July 2020

Copper catalysed oxidative α-sulfonylation of branched aldehydes using the acid enhanced reactivity of manganese(iv) oxide

scientific article published on 24 March 2020

Copper-catalyzed N-arylation of 2-imidazolines with aryl iodides

scientific article published on 15 March 2013

Copper-catalyzed direct alkenylation of N-iminopyridinium ylides

scientific article published in February 2010

Diazo-Transfer Reagent 2-Azido-4,6-dimethoxy-1,3,5-triazine Displays Highly Exothermic Decomposition Comparable to Tosyl Azide

scientific article published on 17 April 2019

Divergent Synthesis of Cyclopropane-Containing Lead-Like Compounds, Fragments and Building Blocks through a Cobalt Catalyzed Cyclopropanation of Phenyl Vinyl Sulfide

scientific article published on 11 September 2017

Highly Chemoselective NH- and O-Transfer to Thiols Using Hypervalent Iodine Reagents: Synthesis of Sulfonimidates and Sulfonamides

scientific article published on 13 April 2018

Highly cis-selective synthesis of iodo-aziridines using diiodomethyllithium and in situ generated N-Boc-imines

scientific article published on 01 December 2012

Imaging phase separation in model lipid membranes through the use of BODIPY based molecular rotors

scientific article published on 01 July 2015

Imaging tumor microscopic viscosity in vivo using molecular rotors

scientific article published on 30 January 2017

Intramolecular Simmons-Smith cyclopropanation. Studies into the reactivity of alkyl-substituted zinc carbenoids, effect of directing groups and synthesis of bicyclo[n.1.0]alkanes

scientific article published on 01 February 2010

Intramolecular palladium(ii)/(iv) catalysed C(sp3)-H arylation of tertiary aldehydes using a transient imine directing group

scientific article published on 01 July 2019

Lithium-Catalyzed Thiol Alkylation with Tertiary and Secondary Alcohols: Synthesis of 3-Sulfanyl-Oxetanes as Bioisosteres.

scientific article published on 27 November 2017

Methylene C(sp3)-H β,β'-Diarylation of Cyclohexanecarbaldehydes Promoted by a Transient Directing Group and Pyridone Ligand

scientific article published on 17 February 2020

N-4-Pyrimidinyl-1H-indazol-4-amine inhibitors of Lck: indazoles as phenol isosteres with improved pharmacokinetics

scientific article published on 13 April 2007

On the Use of Differential Scanning Calorimetry for Thermal Hazard Assessment of New Chemistry: Avoiding Explosive Mistakes

scientific article published on 17 August 2020

Oxetanes: Recent Advances in Synthesis, Reactivity, and Medicinal Chemistry.

scientific article published on 15 September 2016

Palladium-Catalyzed C(sp3 )-H Arylation of Primary Amines Using a Catalytic Alkyl Acetal to Form a Transient Directing Group

scientific article published on 08 November 2018

Palladium-catalyzed cross-coupling of aziridinylmetal species, generated by sulfinyl-magnesium exchange, with aryl bromides: reaction optimization, scope, and kinetic investigations

scientific article published on 23 January 2013

Probing supramolecular protein assembly using covalently attached fluorescent molecular rotors.

scientific article published on 7 June 2017

Rapid Assembly of Saturated Nitrogen Heterocycles in One-Pot: Diazo-Heterocycle "Stitching" by N-H Insertion and Cyclization

scientific article published on 28 December 2018

Regio- and Stereoselective Palladium-Catalyzed C(sp3)-H Arylation of Pyrrolidines and Piperidines with C(3) Directing Groups

scientific article published on 13 June 2018

Regio- and stereospecific synthesis of C-3 functionalized proline derivatives by palladium catalyzed directed C(sp3)-H arylation

scientific article published on 05 September 2014

Single operation palladium catalysed C(sp3)-H functionalisation of tertiary aldehydes: investigations into transient imine directing groups

scientific article published on 4 May 2017

Stereocontrolled total synthesis of bengazole a: a marine bisoxazole natural product displaying potent antifungal properties

scientific article published in October 2006

Stereospecific functionalization of iodoaziridines via unstabilized aziridinyllithiums generated by iodine-lithium exchange

scientific article published on 01 May 2014

Structurally Divergent Lithium Catalyzed Friedel-Crafts Reactions on Oxetan-3-ols: Synthesis of 3,3-Diaryloxetanes and 2,3-Dihydrobenzofurans

scientific article published on 10 October 2016

Studies on the synthesis, stability and conformation of 2-sulfonyl-oxetane fragments.

scientific article published on May 2015

Surface functionalisation with viscosity-sensitive BODIPY molecular rotor.

scientific article published on 3 April 2018

Synthesis and purification of iodoaziridines involving quantitative selection of the optimal stationary phase for chromatography

scientific article published on 16 May 2014

Synthesis of 2- and 2,3-substituted pyrazolo[1,5-a]pyridines: scope and mechanistic considerations of a domino direct alkynylation and cyclization of N-iminopyridinium ylides using alkenyl bromides, alkenyl iodides, and alkynes

scientific article published on 30 September 2011

Synthesis of 3,3-Diarylazetidines by Calcium(II)-Catalyzed Friedel-Crafts Reaction of Azetidinols with Unexpected Cbz Enhanced Reactivity

scientific article published on 24 December 2018

Synthesis of 3-Aryl-3-Sulfanyl Azetidines by Iron-Catalyzed Thiol Alkylation with N-Cbz Azetidinols

scientific article published on 19 April 2019

Synthesis of NH-sulfoximines from sulfides by chemoselective one-pot N- and O-transfers.

scientific article

Synthesis of Selenoaziridines: A Study on Stereochemical Outcomes of the Reaction of Aziridine Radicals and Anions Generated from Iodoaziridines

scientific article published on 10 January 2019

Synthesis of Substituted 1,4-Dioxenes through O-H Insertion and Cyclization Using Keto-Diazo Compounds

scientific article published on 17 October 2016

Synthesis of Sulfonimidamides from Sulfenamides via an Alkoxy-amino-λ6 -sulfanenitrile Intermediate

scientific article published on 28 August 2019

Synthesis of Sulfoximine Carbamates by Rhodium-Catalyzed Nitrene Transfer of Carbamates to Sulfoxides

scientific article published on 02 June 2015

Synthesis of cis-C-iodo-N-tosyl-aziridines using diiodomethyllithium: reaction optimization, product scope and stability, and a protocol for selection of stationary phase for chromatography

scientific article published on 18 June 2013

Synthesis of di-, tri-, and tetrasubstituted oxetanes by rhodium-catalyzed O-H insertion and C-C bond-forming cyclization

scientific article published on 14 October 2014

Synthesis of diversely functionalised 2,2-disubstituted oxetanes: fragment motifs in new chemical space

scientific article published on 01 October 2015

Synthesis of glycosyl sulfoximines by a highly chemo- and stereoselective NH- and O-transfer to thioglycosides

scientific article published on 11 May 2020

Thermal Stability and Explosive Hazard Assessment of Diazo Compounds and Diazo Transfer Reagents

scientific article published on 28 November 2019

Total Synthesis of Potent Antifungal Marine Bisoxazole Natural Products Bengazoles A and B

scientific article published on 01 January 2007

Transfer of Electrophilic NH Using Convenient Sources of Ammonia: Direct Synthesis of NH Sulfoximines from Sulfoxides

scientific article published on 29 April 2016

Transient imine directing groups for the C-H functionalisation of aldehydes, ketones and amines: an update 2018-2020

scientific article published on 14 September 2020

Transient imines as 'next generation' directing groups for the catalytic functionalisation of C-H bonds in a single operation

scientific article published on 25 May 2018

Visualising the membrane viscosity of porcine eye lens cells using molecular rotors

scientific article published on 14 February 2017

List of works by James A. Bull

2-(Aryl-sulfonyl)oxetanes as designer 3-dimensional fragments for fragment screening: synthesis and strategies for functionalisation.

A molecular rotor for measuring viscosity in plasma membranes of live cells.

Acid-Mediated Ring Expansion of 2,2-Disubstituted Azetidine Carbamates to 6,6-Disubstituted 1,3-Oxazinan-2-ones

Catalytic Enantioselective Synthesis of Secondary Alkylboronate Building Blocks With and Without Metals ⬇️

Chemical and structural investigation of the paroxetine-human serotonin transporter complex

Copper catalysed oxidative α-sulfonylation of branched aldehydes using the acid enhanced reactivity of manganese(iv) oxide

Copper-catalyzed N-arylation of 2-imidazolines with aryl iodides

Copper-catalyzed direct alkenylation of N-iminopyridinium ylides

Diazo-Transfer Reagent 2-Azido-4,6-dimethoxy-1,3,5-triazine Displays Highly Exothermic Decomposition Comparable to Tosyl Azide

Divergent Synthesis of Cyclopropane-Containing Lead-Like Compounds, Fragments and Building Blocks through a Cobalt Catalyzed Cyclopropanation of Phenyl Vinyl Sulfide

Highly Chemoselective NH- and O-Transfer to Thiols Using Hypervalent Iodine Reagents: Synthesis of Sulfonimidates and Sulfonamides

Highly cis-selective synthesis of iodo-aziridines using diiodomethyllithium and in situ generated N-Boc-imines

Imaging phase separation in model lipid membranes through the use of BODIPY based molecular rotors

Imaging tumor microscopic viscosity in vivo using molecular rotors

Intramolecular Simmons-Smith cyclopropanation. Studies into the reactivity of alkyl-substituted zinc carbenoids, effect of directing groups and synthesis of bicyclo[n.1.0]alkanes

Intramolecular palladium(ii)/(iv) catalysed C(sp3)-H arylation of tertiary aldehydes using a transient imine directing group

Lithium-Catalyzed Thiol Alkylation with Tertiary and Secondary Alcohols: Synthesis of 3-Sulfanyl-Oxetanes as Bioisosteres.

Methylene C(sp3)-H β,β'-Diarylation of Cyclohexanecarbaldehydes Promoted by a Transient Directing Group and Pyridone Ligand

N-4-Pyrimidinyl-1H-indazol-4-amine inhibitors of Lck: indazoles as phenol isosteres with improved pharmacokinetics

On the Use of Differential Scanning Calorimetry for Thermal Hazard Assessment of New Chemistry: Avoiding Explosive Mistakes

Oxetanes: Recent Advances in Synthesis, Reactivity, and Medicinal Chemistry.

Palladium-Catalyzed C(sp3 )-H Arylation of Primary Amines Using a Catalytic Alkyl Acetal to Form a Transient Directing Group

Palladium-catalyzed cross-coupling of aziridinylmetal species, generated by sulfinyl-magnesium exchange, with aryl bromides: reaction optimization, scope, and kinetic investigations

Probing supramolecular protein assembly using covalently attached fluorescent molecular rotors.

Rapid Assembly of Saturated Nitrogen Heterocycles in One-Pot: Diazo-Heterocycle "Stitching" by N-H Insertion and Cyclization

Regio- and Stereoselective Palladium-Catalyzed C(sp3)-H Arylation of Pyrrolidines and Piperidines with C(3) Directing Groups

Regio- and stereospecific synthesis of C-3 functionalized proline derivatives by palladium catalyzed directed C(sp3)-H arylation

Single operation palladium catalysed C(sp3)-H functionalisation of tertiary aldehydes: investigations into transient imine directing groups

Stereocontrolled total synthesis of bengazole a: a marine bisoxazole natural product displaying potent antifungal properties

Stereospecific functionalization of iodoaziridines via unstabilized aziridinyllithiums generated by iodine-lithium exchange

Structurally Divergent Lithium Catalyzed Friedel-Crafts Reactions on Oxetan-3-ols: Synthesis of 3,3-Diaryloxetanes and 2,3-Dihydrobenzofurans

Studies on the synthesis, stability and conformation of 2-sulfonyl-oxetane fragments.

Surface functionalisation with viscosity-sensitive BODIPY molecular rotor.

Synthesis and purification of iodoaziridines involving quantitative selection of the optimal stationary phase for chromatography

Synthesis of 2- and 2,3-substituted pyrazolo[1,5-a]pyridines: scope and mechanistic considerations of a domino direct alkynylation and cyclization of N-iminopyridinium ylides using alkenyl bromides, alkenyl iodides, and alkynes

Synthesis of 3,3-Diarylazetidines by Calcium(II)-Catalyzed Friedel-Crafts Reaction of Azetidinols with Unexpected Cbz Enhanced Reactivity

Synthesis of 3-Aryl-3-Sulfanyl Azetidines by Iron-Catalyzed Thiol Alkylation with N-Cbz Azetidinols

Synthesis of NH-sulfoximines from sulfides by chemoselective one-pot N- and O-transfers.

Synthesis of Selenoaziridines: A Study on Stereochemical Outcomes of the Reaction of Aziridine Radicals and Anions Generated from Iodoaziridines

Synthesis of Substituted 1,4-Dioxenes through O-H Insertion and Cyclization Using Keto-Diazo Compounds

Synthesis of Sulfonimidamides from Sulfenamides via an Alkoxy-amino-λ6 -sulfanenitrile Intermediate

Synthesis of Sulfoximine Carbamates by Rhodium-Catalyzed Nitrene Transfer of Carbamates to Sulfoxides

Synthesis of cis-C-iodo-N-tosyl-aziridines using diiodomethyllithium: reaction optimization, product scope and stability, and a protocol for selection of stationary phase for chromatography

Synthesis of di-, tri-, and tetrasubstituted oxetanes by rhodium-catalyzed O-H insertion and C-C bond-forming cyclization

Synthesis of diversely functionalised 2,2-disubstituted oxetanes: fragment motifs in new chemical space

Synthesis of glycosyl sulfoximines by a highly chemo- and stereoselective NH- and O-transfer to thioglycosides

Thermal Stability and Explosive Hazard Assessment of Diazo Compounds and Diazo Transfer Reagents

Total Synthesis of Potent Antifungal Marine Bisoxazole Natural Products Bengazoles A and B

Transfer of Electrophilic NH Using Convenient Sources of Ammonia: Direct Synthesis of NH Sulfoximines from Sulfoxides

Transient imine directing groups for the C-H functionalisation of aldehydes, ketones and amines: an update 2018-2020

Transient imines as 'next generation' directing groups for the catalytic functionalisation of C-H bonds in a single operation

Visualising the membrane viscosity of porcine eye lens cells using molecular rotors