Search filters

List of works by Michelle Peckham

3D Palm Shows Distinct Distributions of Z-Disc Proteins with the Z-Discs in Cardiomyocytes

3Rs and biophysics

scientific article published on 24 August 2017

A Combination of Diffusion and Active Translocation Localizes Myosin 10 to the Filopodial Tip ⬇️

scientific article

A FERM domain autoregulates Drosophila myosin 7a activity

scientific article

A birefringence study of changes in myosin orientation during relaxation of skinned muscle fibers induced by photolytic ATP release

scientific article published in September 1994

A call to action from the lab bench

scientific article published in Nature

A targeted deletion of the C-terminal end of titin, including the titin kinase domain, impairs myofibrillogenesis

scientific article published in December 2003

A tubulin alpha 8 mouse knockout model indicates a likely role in spermatogenesis but not in brain development. ⬇️

scientific article

A1603P and K1617del, Mutations in β-Cardiac Myosin Heavy Chain that Cause Laing Early-Onset Distal Myopathy, Affect Secondary Structure and Filament Formation In Vitro and In Vivo ⬇️

scientific article published on 13 April 2018

ANGI-03. THE MIGRATORY SWITCH – INVESTIGATING MESENCHYMAL-AMOEBOID TRANSITION (MAT) IN HIGH GRADE GLIOMAS ⬇️

Actin Mutations and Their Role in Disease

scientific article published on 10 May 2020

Actin filament organization in aligned prefusion myoblasts

scientific article

Affimer proteins are versatile and renewable affinity reagents ⬇️

scientific article

Affimer proteins for F-actin: novel affinity reagents that label F-actin in live and fixed cells ⬇️

scientific article published on 26 April 2018

Alignment of myoblasts on ultrafine gratings inhibits fusion in vitro.

scientific article published on July 2002

Alteration in crossbridge kinetics caused by mutations in actin

scientific article published in November 1990

Alternative reagents to antibodies in imaging applications ⬇️

scientific article published on 27 July 2017

Apolipoprotein(a) acts as a chemorepellent to human vascular smooth muscle cells via integrin αVβ3 and RhoA/ROCK-mediated mechanisms

scientific article

Biological and Molecular Approaches to the Generation of Conditionally Immortal Neural Cells

Birefringence as a probe of crossbridge orientation in demembranated muscle fibres

Cardiomyopathy mutations in the tail of β-cardiac myosin modify the coiled-coil structure and affect integration into thick filaments in muscle sarcomeres in adult cardiomyocytes ⬇️

scientific article published on 18 September 2013

Cardiomyopathy mutations in the tail of β-cardiac myosin modify the coiled-coil structure and affect integration into thick filaments in muscle sarcomeres in adult cardiomyocytes

scientific article published in Journal of Biological Chemistry

Cell biochemistry studied by single-molecule imaging.

scientific article published on November 2006

Chapter 7 The cellular and molecular basis of skeletal and cardiac muscle contraction

Characterization of long and stable de novo single alpha-helix domains provides novel insight into their stability ⬇️

scientific article published on 13 March 2017

Coiled coils and SAH domains in cytoskeletal molecular motors ⬇️

scientific article published on October 1, 2011

Constitutive and variable regions of Z-disk titin/connectin in myofibril formation: a dominant-negative screen

scientific article published in February 1997

Construction of an instant structured illumination microscope ⬇️

scientific article published on 22 July 2015

Determining How Many Ionic Interactions are Needed for the High Stability of Single Alpha Helical (SAH) Domains

Determining Stable Single Alpha Helical (SAH) Domain Properties by Circular Dichroism and Atomic Force Microscopy

scientific article published on 01 January 2018

Different regional effects of voluntary exercise on the mechanical and electrical properties of rat ventricular myocytes

scientific article

Differential trafficking of Kif5c on tyrosinated and detyrosinated microtubules in live cells

scientific article

Dimerization of mammalian kinesin-3 motors results in superprocessive motion

scientific article published on 02 April 2014

Disease mutations in striated muscle myosins

scientific article published on 10 July 2020

Dynamic ion pair behavior stabilizes single alpha helices in proteins ⬇️

scientific article published in Journal of Biological Chemistry

Engineering a multi-nucleated myotube, the role of the actin cytoskeleton

scientific article published on September 2008

Evidence for differential post-translational modifications of slow myosin heavy chain during murine skeletal muscle development

scientific article published in February 2000

Exploiting nanobodies and Affimers for superresolution imaging in light microscopy

scientific article published on 01 October 2019

Functional integrity of the contractile actin cortex is safeguarded by multiple Diaphanous-related formins

scientific article published on 11 February 2019

Heterologous expression of wild-type and mutant beta-cardiac myosin changes the contractile kinetics of cultured mouse myotubes

scientific article published on 7 February 2003

Heterologous expression of wild-type and mutant beta-cardiac myosin changes the contractile kinetics of cultured mouse myotubes

Histone deacetylase 3 indirectly modulates tubulin acetylation ⬇️

scientific article published on 8 October 2015

How myosin organization of the actin cytoskeleton contributes to the cancer phenotype ⬇️

scientific article published on August 2016

Human congenital myopathy actin mutants cause myopathy and alter Z-disc structure in Drosophila flight muscle

scientific article published on 5 January 2013

Hypertrophic cardiomyopathy mutations in the calponin-homology domain of ACTN2 affect actin binding and cardiomyocyte Z-disc incorporation ⬇️

scientific article published on 10 June 2016

Imaging individual myosin molecules within living cells

scientific article published in January 2011

Intranuclear rod myopathy: molecular pathogenesis and mechanisms of weakness

scientific article published on December 2007

Journal club. A cell biologist ponders an outstanding mystery in muscle formation

scientific article published in April 2009

LOX-1 scavenger receptor mediates calcium-dependent recognition of phosphatidylserine and apoptotic cells

scientific article published on January 2006

Labile heat and changes in rate of relaxation of frog muscles.

scientific article published on May 1986

Local anesthetics inhibit kinesin motility and microtentacle protrusions in human epithelial and breast tumor cells

scientific article

Mechanical and Kinetic Properties of a Myosin 5-SAH Chimera

Microtubule assembly in cultured myoblasts and myotubes following nocodazole induced microtubule depolymerisation

scientific article published in January 2003

Microtubule proliferation in right ventricular myocytes of rats with monocrotaline-induced pulmonary hypertension

scientific article published on 21 December 2012

Modulation of cell spreading and cell-substrate adhesion dynamics by dystroglycan.

scientific article

Myogenic cells express multiple myosin isoforms

scientific article published on October 1, 1997

Myosin crossbridge orientation in demembranated muscle fibres studied by birefringence and X-ray diffraction measurements

scientific article published on 01 November 1989

Myosin tails and single α-helical domains ⬇️

scientific article published on February 2015

Myosin-6 Mobility at the Plasma Membrane of Cultured Mammalian Cells

article

N232S, G741R and D778G β-cardiac myosin mutants, implicated in familial hypertrophic cardiomyopathy, do not disrupt myofibrillar organisation in cultured myotubes

scientific article published on 01 December 2000

Nanoscale Pattern Extraction from Relative Positions of Sparse 3D Localizations

scientific article published on 30 November 2020

Non-muscle myosins 2A and 2B drive changes in cell morphology that occur as myoblasts align and fuse

scientific journal article

Novel murine clonal cell lines either express slow or mixed (fast and slow) muscle markers following differentiation in vitro

scientific article

Persistent Chikungunya Virus Replication in Human Cells is Associated with Presence of Stable Cytoplasmic Granules Containing Non-structural Protein 3

Persistent Replication of a Chikungunya Virus Replicon in Human Cells Is Associated with Presence of Stable Cytoplasmic Granules Containing Nonstructural Protein 3 ⬇️

scientific article published on 31 July 2018

Physiological properties of the dorsal longitudinal flight muscle and the tergal depressor of the trochanter muscle of Drosophila melanogaster

scientific article published on June 1990

Preferential Adhesion to and Survival on Patterned Laminin Organizes Myogenesisin Vitro

scientific article published on 01 February 1997

Promoting differentiation of cultured myoblasts using biomimetic surfaces that present alpha-laminin-2 peptides ⬇️

scientific article

Recent innovations in super-resolution microscopy

scientific article

Single Molecule Investigation of the Acto-Myosin-10 Complex Using Optical Tweezers

Site-Specific Labeling of Affimers for DNA-PAINT Microscopy ⬇️

scientific article published on 15 July 2018

Specific Myosins Control Actin Organization, Cell Morphology, and Migration in Prostate Cancer Cells ⬇️

scientific article published on 6 December 2015

Specific changes to the mechanism of cell locomotion induced by overexpression of beta-actin.

scientific article published in April 2001

Stable single α-helices are constant force springs in proteins ⬇️

scientific article

Structural Basis for The Regulation of Drosophila Myosin 7a

Structural Dynamics in the Myosin 7A Single α-Helix Domain

article

Structural implications of β-cardiac myosin heavy chain mutations in human disease

scientific article

Structure of the shutdown state of myosin-2

scientific article published on 02 December 2020

TMEM107 recruits ciliopathy proteins to subdomains of the ciliary transition zone and causes Joubert syndrome ⬇️

scientific journal article

Targeted homozygous deletion of M-band titin in cardiomyocytes prevents sarcomere formation

scientific article published on October 2006

The Function of Myosin-10 In Vitro and Inside Filopodia

The Inner Centromere Protein (INCENP) Coil Is a Single α-Helix (SAH) Domain That Binds Directly to Microtubules and Is Important for Chromosome Passenger Complex (CPC) Localization and Function in Mitosis. ⬇️

scientific article

The SAH domain extends the functional length of the myosin lever ⬇️

scientific article published on 15 December 2009

The predicted coiled-coil domain of myosin 10 forms a novel elongated domain that lengthens the head

scientific article published on 18 July 2005

The sarcomere length dependence of the rate of heat production during isometric tetanic contraction of frog muscles

article

The spatial and temporal dynamics of pleckstrin homology domain binding at the plasma membrane measured by imaging single molecules in live mouse myoblasts

scientific article published on 18 January 2004

Unravelling the Properties of Single α-Helical Domains in Myosin and other Proteins

Using molecular genetics as a tool in understanding crawling cell locomotion in myoblasts.

scientific article

Visualisation and analysis of hepatitis C virus non-structural proteins using super-resolution microscopy ⬇️

scientific article published in Scientific Reports

Visualizing single molecules inside living cells using total internal reflection fluorescence microscopy.

scientific article

When a predicted coiled coil is really a single α-helix, in myosins and other proteins

article

Paulina is supported by:

About Paulina

Help