Search filters

List of works by Mark A. Dawson

5-Formylcytosine organizes nucleosomes and forms Schiff base interactions with histones in mouse embryonic stem cells

scientific article published on 22 October 2018

An Erg-driven transcriptional program controls B cell lymphopoiesis

scientific article published on 15 June 2020

BET inhibitor resistance emerges from leukaemia stem cells

scientific article published on 14 September 2015

BRD4 bimodal binding at promoters and drug-induced displacement at Pol II pause sites associates with I-BET sensitivity

scientific article published on 02 July 2019

Blood transfusion requirements for patients undergoing chemotherapy for acute myeloid leukemia how much is enough?

scientific article

Burkitt lymphoma in the setting of common variable immunodeficiency

scientific article published on 28 February 2009

CDK9 inhibition by dinaciclib potently suppresses Mcl-1 to induce durable apoptotic responses in aggressive MYC-driven B-cell lymphoma in vivo.

scientific article published on 12 January 2014

Cancer epigenetics: from mechanism to therapy

scientific article (publication date: 6 July 2012)

Circulating tumour DNA in metastatic breast cancer to guide clinical trial enrolment and precision oncology: A cohort study

scientific article published on 01 October 2020

Click chemistry enables preclinical evaluation of targeted epigenetic therapies.

scientific article published on 15 June 2017

Clinical and immunohistochemical features associated with a response to bortezomib in patients with multiple myeloma

scientific article

Combined targeting of JAK2 and Bcl-2/Bcl-xL to cure mutant JAK2-driven malignancies and overcome acquired resistance to JAK2 inhibitors

scientific article

Demethylases go mental

scientific article published in April 2010

Design, Synthesis, and Biological Activity of 1,2,3-Triazolobenzodiazepine BET Bromodomain Inhibitors

scientific article published on 14 November 2017

Dual Targeting of Bromodomain and Extraterminal Domain Proteins, and WNT or MAPK Signaling, Inhibits c-MYC Expression and Proliferation of Colorectal Cancer Cells.

scientific article published on 16 March 2016

Dynamic molecular monitoring reveals that SWI-SNF mutations mediate resistance to ibrutinib plus venetoclax in mantle cell lymphoma

scientific article published on 19 November 2018

Endogenous retroviruses are a source of enhancers with oncogenic potential in acute myeloid leukaemia ⬇️

scientific article published on 14 July 2020

Epigenetics in the hematologic malignancies.

scientific article

Extramedullary relapse of multiple myeloma associated with a shift in secretion from intact immunoglobulin to light chains

scientific article published on 01 January 2007

Functional interdependence of BRD4 and DOT1L in MLL leukemia

scientific article published on 13 June 2016

GENE SILENCING. Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells.

scientific article published on 28 May 2015

ID1 promotes expansion and survival of primary erythroid cells and is a target of JAK2V617F-STAT5 signaling

scientific article published on July 2009

Ibrutinib plus Venetoclax for the Treatment of Mantle-Cell Lymphoma

scientific article published in March 2018

Id2 and E Proteins Orchestrate the Initiation and Maintenance of MLL-Rearranged Acute Myeloid Leukemia

scientific article published on 30 June 2016

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

scientific article

Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population

scientific article

Interconversion between Tumorigenic and Differentiated States in Acute Myeloid Leukemia

scientific article published on 01 August 2019

JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin

scientific article

Jarid2 regulates hematopoietic stem cell function by acting with polycomb repressive complex 2.

scientific article published on 2 February 2015

LIF-independent JAK signalling to chromatin in embryonic stem cells uncovered from an adult stem cell disease

scientific article

Molecular disease monitoring using circulating tumor DNA in myelodysplastic syndromes

scientific article published on 26 January 2017

Multiplexed Proteome Dynamics Profiling Reveals Mechanisms Controlling Protein Homeostasis.

scientific article published on 3 March 2018

Non-genetic mechanisms of therapeutic resistance in cancer

scientific article published on 08 October 2020

Nuclear JAK2.

scientific article published in December 2011

Pharmacologic Reduction of Mitochondrial Iron Triggers a Noncanonical BAX/BAK-Dependent Cell Death

scientific article published in 2022

Phosphorylation of histone H3 Thr-45 is linked to apoptosis

scientific article

Primary cardiac lymphoma

scientific article published on 01 March 2010

Recurrent mutations, including NPM1c, activate a BRD4-dependent core transcriptional program in acute myeloid leukemia

scientific article published on 13 November 2013

Regulating BETs at central station

scientific article published in October 2015

Regulation of perforin activation and pre-synaptic toxicity through C-terminal glycosylation

scientific article published on 14 August 2017

SPOP tips the balance of BETs in cancer

scientific article

Selective targeting of BD1 and BD2 of the BET proteins in cancer and immuno-inflammation

scientific article

Successful mobilization of peripheral blood stem cells using recombinant human stem cell factor in heavily pretreated patients who have failed a previous attempt with a granulocyte colony-stimulating factor-based regimen

scientific article published in September 2005

Survival of the Fittest: Darwinian Selection Underpins Chemotherapy Resistance in AML.

scientific article published in September 2017

TFIID and MYB Share a Therapeutic Handshake in AML.

scientific article

Targeting enhancer switching overcomes non-genetic drug resistance in acute myeloid leukaemia.

scientific article published on 20 June 2019

Targeting epigenetic readers in cancer.

scientific article published on August 2012

Targeting the epigenetic regulation of antitumour immunity

scientific article published on 14 September 2020

The PRKAR1A gene is fused to RARA in a new variant acute promyelocytic leukemia

scientific article published on 21 August 2007

The cancer epigenome: Concepts, challenges, and therapeutic opportunities

scientific article

The roles of DNA, RNA and histone methylation in ageing and cancer

scientific article published on 03 July 2019

The transcriptional coactivator Cbp regulates self-renewal and differentiation in adult hematopoietic stem cells.

scientific article

The transcriptional program controlled by the stem cell leukemia gene Scl/Tal1 during early embryonic hematopoietic development.

scientific article published on 3 April 2009

Three distinct patterns of histone H3Y41 phosphorylation mark active genes.

scientific article

Three-dimensional CRISPR screening reveals epigenetic interaction with anti-angiogenic therapy

scientific article published on 15 July 2021

Two routes to leukemic transformation after a JAK2 mutation-positive myeloproliferative neoplasm.

scientific article published on 11 December 2009

Understanding resistance mechanisms to BTK and BCL2 inhibitors in mantle cell lymphoma: implications for design of clinical trials

scientific article published on 18 June 2018

Paulina is supported by:

About Paulina

Help