List of works - Carol MacKintosh

14-3-3 Binding to Pim-phosphorylated Ser166 and Ser186 of human Mdm2--Potential interplay with the PKB/Akt pathway and p14(ARF)

scientific article

14-3-3-Pred: improved methods to predict 14-3-3-binding phosphopeptides

scientific article

14-3-3-affinity purification of over 200 human phosphoproteins reveals new links to regulation of cellular metabolism, proliferation and trafficking

scientific article published on April 2004

14-3-3s regulate fructose-2,6-bisphosphate levels by binding to PKB-phosphorylated cardiac fructose-2,6-bisphosphate kinase/phosphatase

scientific article

A PKB-SPEG signaling nexus links insulin resistance with diabetic cardiomyopathy by regulating calcium homeostasis

scientific article published on 04 May 2020

A Tbc1d1 Ser231Ala-knockin mutation partially impairs AICAR- but not exercise-induced muscle glucose uptake in mice.

scientific article published on 8 November 2016

A myofibrillar protein phosphatase from rabbit skeletal muscle contains the beta isoform of protein phosphatase-1 complexed to a regulatory subunit which greatly enhances the dephosphorylation of myosin

scientific article published on 01 December 1992

AMP-activated protein kinase: a cellular energy sensor that comes in 12 flavours

scientific article

ANIA: ANnotation and Integrated Analysis of the 14-3-3 interactome

scientific article published on 5 February 2014

AS160 deficiency causes whole-body insulin resistance via composite effects in multiple tissues

scientific article published on January 2013

Bioinformatic and experimental survey of 14-3-3-binding sites.

scientific article

Characterization of the major phosphofructokinase-dephosphorylating protein phosphatases from Ascaris suum muscle

scientific article published on July 13, 1992

Cytosolic glutamine synthetase and not nitrate reductase from the green alga Chlamydomonas reinhardtii is phosphorylated and binds 14-3-3 proteins.

scientific article

Differential 14-3-3 affinity capture reveals new downstream targets of phosphatidylinositol 3-kinase signaling

scientific article

Differential regulation of NHE1 phosphorylation and glucose uptake by inhibitors of the ERK pathway and p90RSK in 3T3-L1 adipocytes

scientific article published on 15 September 2009

Disruption of the AMPK-TBC1D1 nexus increases lipogenic gene expression and causes obesity in mice via promoting IGF1 secretion.

scientific article published on 15 June 2016

Dynamic interactions between 14-3-3 proteins and phosphoproteins regulate diverse cellular processes.

scientific article published on July 2004

ERK/p90(RSK)/14-3-3 signalling has an impact on expression of PEA3 Ets transcription factors via the transcriptional repressor capicúa

scientific article published on February 2011

Effect of IRS4 levels on PI 3-kinase signalling

scientific article

Evolution of signal multiplexing by 14-3-3-binding 2R-ohnologue protein families in the vertebrates.

scientific article published on July 2012

Fasting and Systemic Insulin Signaling Regulate Phosphorylation of Brain Proteins That Modulate Cell Morphology and Link to Neurological Disorders

scientific article

First identification of microcystins in Irish lakes aided by a new derivatisation procedure for electrospray mass spectrometric analysis

scientific article published in January 1997

Further evidence that inhibitor-2 acts like a chaperone to fold PP1 into its native conformation.

scientific article

GARNL1, a major RalGAP α subunit in skeletal muscle, regulates insulin-stimulated RalA activation and GLUT4 trafficking via interaction with 14-3-3 proteins.

scientific article published on 24 April 2014

Genetic disruption of AMPK signaling abolishes both contraction- and insulin-stimulated TBC1D1 phosphorylation and 14-3-3 binding in mouse skeletal muscle

scientific journal article

Glucocorticoid receptor Thr524 phosphorylation by MINK1 induces interactions with 14-3-3 protein regulators

scientific article published on 01 January 2021

Identification of 2R-ohnologue gene families displaying the same mutation-load skew in multiple cancers

scientific article

Identification of a Protein That Inhibits the Phosphorylated Form of Nitrate Reductase from Spinach (Spinacia oleracea) Leaves

scientific article published on 01 February 1995

Identification of the amino acids 300-600 of IRS-2 as 14-3-3 binding region with the importance of IGF-1/insulin-regulated phosphorylation of Ser-573

scientific journal article

Illumination increases the phosphorylation state of maize leaf phospho enolpyruvate car☐ylase by causing an increase in the activity of a protein kinase ⬇️

scientific article published on July 10, 1991

Inhibition of T cell signaling by immunophilin-ligand complexes correlates with loss of calcineurin phosphatase activity

scientific article published on 01 April 1992

Mechanism of activation of PKB/Akt by the protein phosphatase inhibitor Calyculin A.

scientific article published on December 2010

Mice with AS160/TBC1D4-Thr649Ala knockin mutation are glucose intolerant with reduced insulin sensitivity and altered GLUT4 trafficking.

scientific article

Modulators of 14-3-3 Protein-Protein Interactions ⬇️

scientific article

PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex

scientific article

Phosphodiesterase 3A binds to 14-3-3 proteins in response to PMA-induced phosphorylation of Ser428.

scientific article

Phosphoproteomics combined with quantitative 14-3-3-affinity capture identifies SIRT1 and RAI as novel regulators of cytosolic double-stranded RNA recognition pathway.

scientific article

Phosphorylated nitrate reductase from spinach leaves is inhibited by 14-3-3 proteins and activated by fusicoccin.

scientific article

Phosphorylation and 14-3-3 binding of Arabidopsis trehalose-phosphate synthase 5 in response to 2-deoxyglucose

scientific article published on 08 June 2006

Phosphorylation of the glycogen-binding subunit of protein phosphatase-1G in response to adrenalin

scientific article published on 01 July 1988

Phosphorylation-dependent interactions between enzymes of plant metabolism and 14-3-3 proteins

scientific article published on 01 April 1999

Potential role of TBC1D4 in enhanced post-exercise insulin action in human skeletal muscle.

scientific article published on 28 February 2009

Protein histidine phosphatase activity in rat liver and spinach leaves

scientific article published on 01 May 1995

Protein kinase C-mediated phosphorylation and activation of PDE3A regulate cAMP levels in human platelets.

scientific article published on 4 March 2009

Proteomic screen in the simple metazoan Hydra identifies 14-3-3 binding proteins implicated in cellular metabolism, cytoskeletal organisation and Ca2+ signalling

scientific article

Purification of a nitrate reductase kinase from Spinacea oleracea leaves, and its identification as a calmodulin-domain protein kinase

scientific article published on 01 October 1998

Purification of a plant nucleotide pyrophosphatase as a protein that interferes with nitrate reductase and glutamine synthetase assays

scientific article published in March 2003

Purification of the hepatic glycogen-associated form of protein phosphatase-1 by microcystin-Sepharose affinity chromatography

scientific journal article

Recent advances in understanding the roles of whole genome duplications in evolution.

scientific article published on 31 August 2017

Regulation of multisite phosphorylation and 14-3-3 binding of AS160 in response to IGF-1, EGF, PMA and AICAR.

scientific article

Regulation of spinach-leaf nitrate reductase by reversible phosphorylation

scientific article published on 01 October 1992

SPEG Controls Calcium Reuptake Into the Sarcoplasmic Reticulum Through Regulating SERCA2a by Its Second Kinase-Domain

scientific article published on 01 March 2019

Sucrose-phosphate synthase is dephosphorylated by protein phosphatase 2A in spinach leaves

scientific article published on 01 September 1990

Synthesis and Use of the Protein Phosphatase Affinity Matrices Microcystin-Sepharose and Microcystin-Biotin-Sepharose

scientific article published on 01 January 2007

Tautomycin from the bacterium Streptomyces verticillatus

scientific article published on 01 December 1990

The E3 ubiquitin ligase ZNRF2 is a substrate of mTORC1 and regulates its activation by amino acids

scientific article

The capture of phosphoproteins by 14-3-3 proteins mediates actions of insulin.

scientific article published on 24 August 2011

Thr649Ala-AS160 knock-in mutation does not impair contraction/AICAR-induced glucose transport in mouse muscle

scientific article published on 7 February 2012

Visualization and biochemical analyses of the emerging mammalian 14-3-3-phosphoproteome

scientific article

ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase

scientific article

List of works by Carol MacKintosh

14-3-3 Binding to Pim-phosphorylated Ser166 and Ser186 of human Mdm2--Potential interplay with the PKB/Akt pathway and p14(ARF)

14-3-3-Pred: improved methods to predict 14-3-3-binding phosphopeptides

14-3-3-affinity purification of over 200 human phosphoproteins reveals new links to regulation of cellular metabolism, proliferation and trafficking

14-3-3s regulate fructose-2,6-bisphosphate levels by binding to PKB-phosphorylated cardiac fructose-2,6-bisphosphate kinase/phosphatase

A PKB-SPEG signaling nexus links insulin resistance with diabetic cardiomyopathy by regulating calcium homeostasis

A Tbc1d1 Ser231Ala-knockin mutation partially impairs AICAR- but not exercise-induced muscle glucose uptake in mice.

A myofibrillar protein phosphatase from rabbit skeletal muscle contains the beta isoform of protein phosphatase-1 complexed to a regulatory subunit which greatly enhances the dephosphorylation of myosin

AMP-activated protein kinase: a cellular energy sensor that comes in 12 flavours

ANIA: ANnotation and Integrated Analysis of the 14-3-3 interactome

AS160 deficiency causes whole-body insulin resistance via composite effects in multiple tissues

Bioinformatic and experimental survey of 14-3-3-binding sites.

Characterization of the major phosphofructokinase-dephosphorylating protein phosphatases from Ascaris suum muscle

Cytosolic glutamine synthetase and not nitrate reductase from the green alga Chlamydomonas reinhardtii is phosphorylated and binds 14-3-3 proteins.

Differential 14-3-3 affinity capture reveals new downstream targets of phosphatidylinositol 3-kinase signaling

Differential regulation of NHE1 phosphorylation and glucose uptake by inhibitors of the ERK pathway and p90RSK in 3T3-L1 adipocytes

Disruption of the AMPK-TBC1D1 nexus increases lipogenic gene expression and causes obesity in mice via promoting IGF1 secretion.

Dynamic interactions between 14-3-3 proteins and phosphoproteins regulate diverse cellular processes.

ERK/p90(RSK)/14-3-3 signalling has an impact on expression of PEA3 Ets transcription factors via the transcriptional repressor capicúa

Effect of IRS4 levels on PI 3-kinase signalling

Evolution of signal multiplexing by 14-3-3-binding 2R-ohnologue protein families in the vertebrates.

Fasting and Systemic Insulin Signaling Regulate Phosphorylation of Brain Proteins That Modulate Cell Morphology and Link to Neurological Disorders

First identification of microcystins in Irish lakes aided by a new derivatisation procedure for electrospray mass spectrometric analysis

Further evidence that inhibitor-2 acts like a chaperone to fold PP1 into its native conformation.

GARNL1, a major RalGAP α subunit in skeletal muscle, regulates insulin-stimulated RalA activation and GLUT4 trafficking via interaction with 14-3-3 proteins.

Genetic disruption of AMPK signaling abolishes both contraction- and insulin-stimulated TBC1D1 phosphorylation and 14-3-3 binding in mouse skeletal muscle

Glucocorticoid receptor Thr524 phosphorylation by MINK1 induces interactions with 14-3-3 protein regulators

Identification of 2R-ohnologue gene families displaying the same mutation-load skew in multiple cancers

Identification of a Protein That Inhibits the Phosphorylated Form of Nitrate Reductase from Spinach (Spinacia oleracea) Leaves

Identification of the amino acids 300-600 of IRS-2 as 14-3-3 binding region with the importance of IGF-1/insulin-regulated phosphorylation of Ser-573

Illumination increases the phosphorylation state of maize leaf phospho enolpyruvate car☐ylase by causing an increase in the activity of a protein kinase ⬇️

Inhibition of T cell signaling by immunophilin-ligand complexes correlates with loss of calcineurin phosphatase activity

Mechanism of activation of PKB/Akt by the protein phosphatase inhibitor Calyculin A.

Mice with AS160/TBC1D4-Thr649Ala knockin mutation are glucose intolerant with reduced insulin sensitivity and altered GLUT4 trafficking.

Modulators of 14-3-3 Protein-Protein Interactions ⬇️

PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex

Phosphodiesterase 3A binds to 14-3-3 proteins in response to PMA-induced phosphorylation of Ser428.

Phosphoproteomics combined with quantitative 14-3-3-affinity capture identifies SIRT1 and RAI as novel regulators of cytosolic double-stranded RNA recognition pathway.

Phosphorylated nitrate reductase from spinach leaves is inhibited by 14-3-3 proteins and activated by fusicoccin.

Phosphorylation and 14-3-3 binding of Arabidopsis trehalose-phosphate synthase 5 in response to 2-deoxyglucose

Phosphorylation of the glycogen-binding subunit of protein phosphatase-1G in response to adrenalin

Phosphorylation-dependent interactions between enzymes of plant metabolism and 14-3-3 proteins

Potential role of TBC1D4 in enhanced post-exercise insulin action in human skeletal muscle.

Protein histidine phosphatase activity in rat liver and spinach leaves

Protein kinase C-mediated phosphorylation and activation of PDE3A regulate cAMP levels in human platelets.

Proteomic screen in the simple metazoan Hydra identifies 14-3-3 binding proteins implicated in cellular metabolism, cytoskeletal organisation and Ca2+ signalling

Purification of a nitrate reductase kinase from Spinacea oleracea leaves, and its identification as a calmodulin-domain protein kinase

Purification of a plant nucleotide pyrophosphatase as a protein that interferes with nitrate reductase and glutamine synthetase assays

Purification of the hepatic glycogen-associated form of protein phosphatase-1 by microcystin-Sepharose affinity chromatography

Recent advances in understanding the roles of whole genome duplications in evolution.

Regulation of multisite phosphorylation and 14-3-3 binding of AS160 in response to IGF-1, EGF, PMA and AICAR.

Regulation of spinach-leaf nitrate reductase by reversible phosphorylation

SPEG Controls Calcium Reuptake Into the Sarcoplasmic Reticulum Through Regulating SERCA2a by Its Second Kinase-Domain

Sucrose-phosphate synthase is dephosphorylated by protein phosphatase 2A in spinach leaves

Synthesis and Use of the Protein Phosphatase Affinity Matrices Microcystin-Sepharose and Microcystin-Biotin-Sepharose

Tautomycin from the bacterium Streptomyces verticillatus

The E3 ubiquitin ligase ZNRF2 is a substrate of mTORC1 and regulates its activation by amino acids

The capture of phosphoproteins by 14-3-3 proteins mediates actions of insulin.

Thr649Ala-AS160 knock-in mutation does not impair contraction/AICAR-induced glucose transport in mouse muscle

Visualization and biochemical analyses of the emerging mammalian 14-3-3-phosphoproteome

ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase