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List of works by Marina A Lynch

A neural cell adhesion molecule-derived peptide, FGL, attenuates glial cell activation in the aged hippocampus

scientific article published on 24 September 2011

A novel anti-inflammatory role of NCAM-derived mimetic peptide, FGL.

scientific article published on 12 May 2008

A novel phospholipid-based drug formulation, VP025, modulates age- and LPS-induced microglial activity in the rat.

scientific article

A pivotal role for interleukin-4 in atorvastatin-associated neuroprotection in rat brain

scientific article published on 2 November 2007

A shift to glycolysis accompanies the inflammatory changes in PBMCs from individuals with an IQ-discrepant memory

scientific article published on 9 February 2018

A study of the synergism between metabotropic glutamate receptor activation and arachidonic acid in the rat hippocampus

scientific article published on 21 November 1994

A synthetic NCAM-derived mimetic peptide, FGL, exerts anti-inflammatory properties via IGF-1 and interferon-gamma modulation

scientific journal article

Activation of c-Jun-N-terminal kinase is critical in mediating lipopolysaccharide-induced changes in the rat hippocampus

scientific article published in April 2005

Activation of mixed glia by Abeta-specific Th1 and Th17 cells and its regulation by Th2 cells.

scientific article

Activation of p38 plays a pivotal role in the inhibitory effect of lipopolysaccharide and interleukin-1 beta on long term potentiation in rat dentate gyrus

scientific article published on 27 February 2003

Activation of p42 mitogen-activated protein kinase by arachidonic acid and trans-1-amino-cyclopentyl-1,3- dicarboxylate impacts on long-term potentiation in the dentate gyrus in the rat: analysis of age-related changes.

scientific article published in January 1999

Activation of the P2X7receptor induces migration of glial cells by inducing cathepsin B degradation of tissue inhibitor of metalloproteinase 1

scientific article published on 25 October 2012

Activation of the c-Jun N-terminal kinase signaling cascade mediates the effect of amyloid-beta on long term potentiation and cell death in hippocampus: a role for interleukin-1beta?

scientific article published on 7 May 2003

Activation of tyrosine receptor kinase plays a role in expression of long-term potentiation in the rat dentate gyrus

scientific article published in 1999

Adenosine A2A receptors control neuroinflammation and consequent hippocampal neuronal dysfunction.

scientific article

Age-associated dysregulation of microglial activation is coupled with enhanced blood-brain barrier permeability and pathology in APP/PS1 mice.

scientific article

Age-related changes in LTP and antioxidant defenses are reversed by an α-lipoic acid-enriched diet

scientific article published in November 1999

Age-related changes in synaptic function: analysis of the effect of dietary supplementation with ω-3 fatty acids

scientific article published in September 1999

Age-related impairment in LTP is accompanied by enhanced activity of stress-activated protein kinases: analysis of underlying mechanisms

scientific article published in January 2000

Age-related impairment in long-term potentiation in hippocampus: a role for the cytokine, interleukin-1 beta?

scientific article published in December 1998

Age-related neuroinflammatory changes negatively impact on neuronal function

scientific article published in 2010

Ageing is associated with changes in glutamate release, protein tyrosine kinase and Ca2+/calmodulin-dependent protein kinase II in rat hippocampus

scientific article published in August 1996

Alterations in Ca2+-dependent and Ca2+-independent release of catecholamines in preparations of rat brain produced by ethanol treatment in vivo

scientific article published in January 1985

Altered characteristics of [3H]dopamine release from superfused slices of corpus striatum obtained from rats receiving ethanol in vivo

scientific article published in June 1985

Amyloid-β-induced astrocytic phagocytosis is mediated by CD36, CD47 and RAGE

scientific journal article

An NCAM mimetic, FGL, alters hippocampal cellular morphometry in young adult (4 month-old) rats

scientific article published on 18 October 2012

Analysis of the Impact of CD200 on Phagocytosis.

scientific article published on 9 November 2016

Analysis of the effect of membrane arachidonic acid concentration on modulation of glutamate release by interleukin-1: an age-related study

scientific article published in June 1998

Analysis of the interaction between arachidonic acid and metabotropic glutamate receptor activation reveals that phospholipase C acts as a coincidence detector in the expression of long-term potentiation in the rat dentate gyrus

scientific article published in January 1998

Analysis of the mechanisms underlying the age-related impairment in long-term potentiation in the rat.

scientific article published in July 1998

Analysis of the presynaptic signaling mechanisms underlying the inhibition of LTP in rat dentate gyrus by the tyrosine kinase inhibitor, genistein.

scientific article published in January 2002

Apoptotic changes in the aged brain are triggered by interleukin-1beta-induced activation of p38 and reversed by treatment with eicosapentaenoic acid

scientific article published on 28 June 2002

Arachidonic acid induces a long-term activity-dependent enhancement of synaptic transmission in the hippocampus

scientific article published in Nature

Atorvastatin prevents age-related and amyloid-β-induced microglial activation by blocking interferon-γ release from natural killer cells in the brain

scientific article published on 31 March 2011

Attenuation of LPS-induced changes in synaptic activity in rat hippocampus by Vasogen's Immune Modulation Therapy.

scientific article published in January 2002

BDNF-induced LTP in dentate gyrus is impaired with age: analysis of changes in cell signaling events

scientific article published in November 2004

Biphasic modulation of intracellular Ca2+ concentration by interleukin-1beta in cortical synaptosomes: involvement of a pertussis toxin-sensitive G-protein and mitogen-activated protein kinase

scientific article published in June 1998

Bone marrow-derived macrophages from AβPP/PS1 mice are sensitized to the effects of inflammatory stimuli

scientific article published in January 2015

Bone marrow-derived macrophages from aged rats are more responsive to inflammatory stimuli

scientific article

CD200 fusion protein decreases microglial activation in the hippocampus of aged rats

scientific article published on 24 October 2011

CD200 ligand receptor interaction modulates microglial activation in vivo and in vitro: a role for IL-4.

scientific article published in August 2007

Can the emerging field of immunometabolism provide insights into neuroinflammation?

scientific article published on 06 November 2019

Changes in brain gamma-aminobutyric acid concentrations following acute and chronic amphetamine administration and during post amphetamine depression

scientific article

Changes in protein synthesis and synthesis of the synaptic vesicle protein, synaptophysin, in entorhinal cortex following induction of long-term potentiation in dentate gyrus: an age-related study in the rat.

scientific article published in July 1997

Chronic brain inflammation results in cell loss in the entorhinal cortex and impaired LTP in perforant path-granule cell synapses

scientific article published in August 2002

Classical activation of microglia in CD200-deficient mice is a consequence of blood brain barrier permeability and infiltration of peripheral cells

scientific article published on 2 August 2013

Comparison of effects of ethanol on platelet function and synaptic transmission

scientific article published in January 1983

Correlation between long-term potentiation and release of endogenous amino acids from dentate gyrus of anaesthetized rats

scientific article published in August 1986

Decreased neuronal CD200 expression in IL-4-deficient mice results in increased neuroinflammation in response to lipopolysaccharide

scientific article published on 6 June 2009

Deficits in nerve growth factor release and tyrosine receptor kinase phosphorylation are associated with age-related impairment in long-term potentiation in the dentate gyrus

scientific article published on January 2000

Dietary antioxidant supplementation reverses age-related neuronal changes

scientific article

Dietary supplementation with vitamin E reverses the age-related deficit in long term potentiation in dentate gyrus

scientific article published in May 1998

Differential role of Dok1 and Dok2 in TLR2-induced inflammatory signaling in glia

scientific article published on 7 May 2013

Docosahexaenoic acid-induced changes in phospholipids in cortex of young and aged rats: a lipidomic analysis

scientific article published on 24 October 2007

Dok2 mediates the CD200Fc attenuation of Aβ-induced changes in glia ⬇️

scientific article published on May 29, 2012

Downregulation of IL-4-induced signalling in hippocampus contributes to deficits in LTP in the aged rat.

scientific article published in May 2005

Effect of D-amphetamine on the behaviour of rats in the open field apparatus: interaction with four neuroleptics and changes in biogenic amine metabolsm in discrete brain regions

scientific article

Effect of chronic amphetamine administration on the behaviour of rats in the open field apparatus: reversal of post-withdrawal depression by two antidepressants ⬇️

scientific article published on December 1, 1978

Eicosapentaenoic acid and gamma-linolenic acid increase hippocampal concentrations of IL-4 and IL-10 and abrogate lipopolysaccharide-induced inhibition of long-term potentiation.

scientific article published in April 2004

Enhanced [3H]-noradrenaline release in synaptosomes from ethanol-tolerant animals: the role of nerve terminal calcium ion concentrations

scientific article published in January 1985

Evidence for a role for synaptophysin in expression of long-term potentiation in rat dentate gyrus

scientific article published in August 1998

Evidence of a protective effect of phosphatidylserine-containing liposomes on lipopolysaccharide-induced impairment of long-term potentiation in the rat hippocampus

scientific article

Evidence of an anti-inflammatory role for Vasogen's immune modulation therapy.

scientific article published in January 2005

Evidence that increased hippocampal expression of the cytokine interleukin-1 beta is a common trigger for age- and stress-induced impairments in long-term potentiation.

scientific article published in April 1998

Evidence that nerve growth factor plays a role in long-term potentiation in the rat dentate gyrus

scientific article

Evidence that vitamin D3 reverses age-related inflammatory changes in the rat hippocampus

scientific article published in August 2005

Expression of long-term potentiation in aged rats involves perforated synapses but dendritic spine branching results from high-frequency stimulation alone

scientific article published on January 2004

FTY720 Attenuates Infection-Induced Enhancement of Aβ Accumulation in APP/PS1 Mice by Modulating Astrocytic Activation.

scientific article published on 15 June 2017

Glial Activation in AβPP/PS1 Mice is Associated with Infiltration of IFNγ-Producing Cells

scientific article published on 18 June 2013

Glial uptake of amyloid beta induces NLRP3 inflammasome formation via cathepsin-dependent degradation of NLRP10.

scientific article published on 7 November 2013

Glycerol-induced seizure: involvement of IL-1beta and glutamate

scientific article

How dependent is synaptic plasticity on microglial phenotype?

scientific article

IFN-γ Production by amyloid β-specific Th1 cells promotes microglial activation and increases plaque burden in a mouse model of Alzheimer's disease

scientific article published on 30 January 2013

IL-1F5 mediates anti-inflammatory activity in the brain through induction of IL-4 following interaction with SIGIRR/TIR8

scientific article published on 18 February 2008

IL-1beta-dependent neurological effects of the whole cell pertussis vaccine: a role for IL-1-associated signalling components in vaccine reactogenicity

scientific article published in March 2003

Identifying Early Inflammatory Changes in Monocyte-Derived Macrophages from a Population with IQ-Discrepant Episodic Memory ⬇️

scientific article published on May 6, 2013

Immunology meets neuroscience--opportunities for immune intervention in neurodegenerative diseases

scientific article published on 31 May 2011

Impaired performance of female APP/PS1 mice in the Morris water maze is coupled with increased Aβ accumulation and microglial activation

scientific article published on 24 May 2012

Impaired spatial memory in aged rats is associated with alterations in inositol phospholipid metabolism

scientific article published in July 1994

In-vitro release of [14C]glutamate from dentate gyrus is modulated by GABA.

scientific article published in May 1986

Increase in K+-stimulated, Ca2+-dependent release of [3H]glutamate from rat dentate gyrus three days after induction of long-term potentiation

scientific article

Increase in arachidonic acid concentration in a postsynaptic membrane fraction following the induction of long-term potentiation in the dentate gyrus ⬇️

scientific article published on January 1, 1991

Increase in synaptic vesicle proteins accompanies long-term potentiation in the dentate gyrus

scientific article published in May 1994

Increased IL-1beta in cortex of aged rats is accompanied by downregulation of ERK and PI-3 kinase

scientific article

Increased hydrolysis of phosphatidylinositol-4,5-bisphosphate in long-term potentiation

scientific article

Increased sensitivity of transmitter release to calcium in ethanol tolerance

scientific article published in April 1986

Infiltration of Th1 and Th17 cells and activation of microglia in the CNS during the course of experimental autoimmune encephalomyelitis

scientific article published on 6 February 2010

Inflammatory microglia are glycolytic and iron retentive and typify the microglia in APP/PS1 mice

scientific article

Inhibiting TLR2 activation attenuates amyloid accumulation and glial activation in a mouse model of Alzheimer's disease

scientific article published on 12 July 2016

Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice.

scientific article published on 18 December 2016

Inhibition of JAK2 attenuates the increase in inflammatory markers in microglia from APP/PS1 mice

scientific article published on 11 July 2015

Innate IFN-γ promotes development of experimental autoimmune encephalomyelitis: a role for NK cells and M1 macrophages.

scientific article

Interaction between interferon gamma and insulin-like growth factor-1 in hippocampus impacts on the ability of rats to sustain long-term potentiation

scientific article published on 8 February 2006

Interactions of ethanol with ionophore A23187 in human platelets and erythrocytes and in rat brain slices

scientific article

Interleukin-1 beta exerts a myriad of effects in the brain and in particular in the hippocampus: analysis of some of these actions.

scientific article

Interleukin-1 beta inhibits glutamate release in hippocampus of young, but not aged, rats

scientific article published in May 1997

Interleukin-1 induces lipid peroxidation and membrane changes in rat hippocampus: An age-related study

scientific article published in May 1999

Interleukin-1 receptor antagonist exerts agonist activity in the hippocampus independent of the interleukin-1 type I receptor

scientific journal article

Interleukin-1alpha and HMGB1 mediate hippocampal dysfunction in SIGIRR-deficient mice

scientific article published in March 2011

Interleukin-1β (IL-1β) and tumour necrosis factor (TNF) inhibit long-term potentiation in the rat dentate gyrus in vitro

scientific article published in January 1996

Interleukin-1β-dependent changes in the hippocampus following parenteral immunization with a whole cell pertussis vaccine

scientific article published on 01 November 2000

Involvement of IGF-1 and Akt in M1/M2 activation state in bone marrow-derived macrophages.

scientific article

Iron accumulation in microglia triggers a cascade of events that leads to altered metabolism and compromised function in APP/PS1 mice

scientific article published on 17 February 2019

LPS-induced release of IL-6 from glia modulates production of IL-1β in a JAK2-dependent manner

scientific article published on 14 June 2012

LTP occludes the interaction between arachidonic acid and ACPD and NGF and ACPD.

scientific article

Linking T cells to Alzheimer's disease: from neurodegeneration to neurorepair

scientific article

Lipoic acid confers protection against oxidative injury in non-neuronal and neuronal tissue.

scientific article

Lipopolysaccharide Inhibits Long Term Potentiation in the Rat Dentate Gyrus by Activating Caspase-1

scientific article published in Journal of Biological Chemistry

Lipopolysaccharide-induced increase in signalling in hippocampus is abrogated by IL-10--a role for IL-1 beta?

scientific article published in February 2004

Long term potentiation is impaired in membrane glycoprotein CD200-deficient mice: a role for Toll-like receptor activation.

scientific article

Long-Term Potentiation and Memory

scientific article

Long-term Activation of Phosphoinositide Turnover Associated with Increased Release of Amino Acids in the Dentate Gyrus and Hippocampus Following Classical Conditioning in the Rat.

scientific article published in January 1990

Long-term potentiation and spatial learning are associated with increased phosphorylation of TrkB and extracellular signal-regulated kinase (ERK) in the dentate gyrus: evidence for a role for brain-derived neurotrophic factor

scientific article published on June 2002

Long-term potentiation in aged rats is restored when the age-related decrease in polyunsaturated fatty acid concentration is reversed

scientific article published in August 2002

Long-term potentiation in dentate gyrus of the rat is inhibited by the phosphoinositide 3–kinase inhibitor, wortmannin

scientific article published in March 2000

Long-term potentiation in the dentate gyrus of the rat hippocampus is accompanied by brain-derived neurotrophic factor-induced activation of TrkB.

scientific article

Long-term potentiation in the dentate gyrus: induction and increased glutamate release are blocked by D(-)aminophosphonovalerate

scientific article

Long-term potentiation is associated with an increase in calcium-dependent, potassium-stimulated release of [14C]glutamate from hippocampal slices: an ex vivo study in the rat.

scientific article published in January 1986

Long-term potentiation of synaptic transmission in the dentate gyrus: increased release of [14C]glutamate without increase in receptor binding

scientific article published in November 1985

Long-term potentiation of synaptic transmission in the hippocampus of the rat; effect of calmodulin and oleoyl-acetyl-glycerol on release of [3H]glutamate

scientific article published in April 1986

Low doses of T3 induce a rapid metabolic response in young lambs

scientific article published in February 1985

Lung CD4 Tissue-Resident Memory T Cells Mediate Adaptive Immunity Induced by Previous Infection of Mice with Bordetella pertussis.

scientific article published on 22 May 2017

Mechanisms underlying induction and maintenance of long-term potentiation in the hippocampus.

scientific article published on February 1989

Membrane arachidonic acid concentration correlates with age and induction of long-term potentiation in the dentate gyrus in the rat.

scientific article

Modest amyloid deposition is associated with iron dysregulation, microglial activation, and oxidative stress

scientific article

Modulation of intestinal microbiota by the probiotic VSL#3 resets brain gene expression and ameliorates the age-related deficit in LTP

scientific article

Neuroinflammatory changes increase the impact of stressors on neuronal function

scientific article published in February 2009

Neuroinflammatory changes negatively impact on LTP: A focus on IL-1β.

scientific article published on 02 September 2014

Neuropeptide Y inhibits glutamate release and long-term potentiation in rat dentate gyrus

scientific article

Neuroprotective actions of eicosapentaenoic acid on lipopolysaccharide-induced dysfunction in rat hippocampus

scientific article published in October 2004

Neuroprotective effect of eicosapentaenoic acid in hippocampus of rats exposed to gamma-irradiation

scientific article published on 23 March 2002

Noradrenaline modulates the release of [14C]glutamate from dentate but not from CA1/CA3 slices of rat hippocampus

scientific article published in May 1986

Nordihydroguaiaretic acid blocks the synaptic component of long-term potentiation and the associated increases in release of glutamate and arachidonate: An in vivo study in the dentate gyrus of the rat

scientific article published in January 1989

Picrotoxin inhibits the effect of ethanol on the spontaneous efflux of [3H]-dopamine from superfused slices of rat corpus striatum

scientific article published in December 1983

Possible association of alcohol tolerance with increased synaptic Ca2+ sensitivity

scientific article published in May 1983

Presynaptic Changes in Long-Term Potentiation: Elevated Synaptosomal Calcium Concentration and Basal Phosphoinositide Turnover in Dentate Gyrus ⬇️

scientific article published on January 1, 1991

Proinflammatory cytokines in the adverse systemic and neurologic effects associated with parenteral injection of a whole cell pertussis vaccine

scientific article

Proinflammatory responses in the murine brain after intranasal delivery of cholera toxin: implications for the use of AB toxins as adjuvants in intranasal vaccines

scientific article

Regulation of intracellular Ca2+ concentration by interleukin-1beta in rat cortical synaptosomes: an age-related study

scientific article published in November 1998

Respiratory infection promotes T cell infiltration and amyloid-β deposition in APP/PS1 mice

scientific article published on 29 August 2013

Role of Interleukin-4 in Regulation of Age-related Inflammatory Changes in the Hippocampus

scientific article published in Journal of Biological Chemistry

Rosiglitazone attenuates the age-related changes in astrocytosis and the deficit in LTP.

scientific article published on 10 April 2010

SIGIRR modulates the inflammatory response in the brain

scientific article published on 13 April 2010

Synaptophysin immunogold labelling of synapses decreases in dentate gyrus of the hippocampus of aged rats.

scientific article published in October 2003

Systemic inflammatory markers and sources of social support among older adults in the Memory Research Unit cohort.

scientific article published on 3 November 2016

T Cells-Protective or Pathogenic in Alzheimer's Disease?

scientific article published on 10 May 2015

THE ROLE OF CERAMIDE IN THE MODULATION OF INTRACELLULAR Ca2+LEVELS BY INTERLEUKIN 1β IN RAT CORTICAL SYNAPTOSOMES

scientific article published in May 2000

Targeting innate immunity for neurodegenerative disorders of the central nervous system

scientific article

The HMG-CoA reductase inhibitor, atorvastatin, attenuates the effects of acute administration of amyloid-beta1-42 in the rat hippocampus in vivo

scientific article published on 21 August 2006

The NLRP3 inflammasome modulates glycolysis by increasing PFKFB3 in an IL-1β-dependent manner in macrophages

scientific article published on 11 March 2019

The ability of aged rats to sustain long-term potentiation is restored when the age-related decrease in membrane arachidonic acid concentration is reversed

scientific article published in November 1997

The age- and amyloid-β-related increases in Nogo B contribute to microglial activation

scientific article published on 24 November 2010

The age-related attenuation in long-term potentiation is associated with microglial activation.

scientific article published on 18 September 2006

The age-related deficit in LTP is associated with changes in perfusion and blood-brain barrier permeability.

scientific article published on 8 November 2011

The age-related gliosis and accompanying deficit in spatial learning are unaffected by dimebon.

scientific article published on 26 September 2012

The age-related neuroinflammatory environment promotes macrophage activation, which negatively impacts synaptic function

scientific article published on 13 April 2016

The deficit in long-term potentiation induced by chronic administration of amyloid-β is attenuated by treatment of rats with a novel phospholipid-based drug formulation, VP025

scientific article published in April 2009

The effects of IL-1 receptor antagonist on beta amyloid mediated depression of LTP in the rat CA1 in vivo

scientific article published in July 2009

The fatty acid amide hydrolase inhibitor URB597 exerts anti-inflammatory effects in hippocampus of aged rats and restores an age-related deficit in long-term potentiation

scientific article

The impact of aging on the brain--risk, resilience and repair

scientific article published on 25 February 2012

The impact of neuroimmune changes on development of amyloid pathology; relevance to Alzheimer's disease.

scientific article published on March 2014

The increase in [3H]glutamate release associated with long-term potentiation in the dentate gyrus is blocked by commissural stimulation

scientific article published in August 1989

The inhibitory effect of interleukin-1beta on long-term potentiation is coupled with increased activity of stress-activated protein kinases

scientific article published on 15 September 2000

The multifaceted profile of activated microglia.

scientific article published on 23 July 2009

The neural cell adhesion molecule-derived peptide, FGL, attenuates lipopolysaccharide-induced changes in glia in a CD200-dependent manner

scientific article published on 18 January 2013

The neuroprotective effect of a specific P2X₇ receptor antagonist derives from its ability to inhibit assembly of the NLRP3 inflammasome in glial cells

scientific article published on 27 October 2011

The polyunsaturated fatty acids, EPA and DPA exert a protective effect in the hippocampus of the aged rat.

scientific article

The risky business of ageing

scientific article published in March 2008

The role of the immune system in driving neuroinflammation

scientific article published on 29 January 2020

The synergism between ACPD and arachidonic acid on glutamate release in hippocampus is age-dependent

scientific article published in August 1996

The synergism between metabotropic glutamate receptor activation and arachidonic acid on glutamate release is occluded by induction of long-term potentiation in the dentate gyrus

scientific article published in June 1996

Time-related Changes in Basal Phosphoinositide Turnover after Induction of Long-term Potentiation in the Dentate Gyrus are Blocked by Commissural Stimulation

scientific article

Toll-like receptor 3 activation modulates hippocampal network excitability, via glial production of interferon-β.

scientific article

Training in the Morris water maze occludes the synergism between ACPD and arachidonic acid on glutamate release in synaptosomes prepared from rat hippocampus

scientific article

Treatment with dexamethasone and vitamin D3 attenuates neuroinflammatory age-related changes in rat hippocampus

scientific journal article

What is the biological significance of an age-related increase in IL-1beta in hippocampus?

scientific article

Whole-cell but not acellular pertussis vaccines induce convulsive activity in mice: evidence of a role for toxin-induced interleukin-1beta in a new murine model for analysis of neuronal side effects of vaccination

scientific article

With mouse age comes wisdom: A review and suggestions of relevant mouse models for age-related conditions

scientific article

α-TLR2 antibody attenuates the Aβ-mediated inflammatory response in microglia through enhanced expression of SIGIRR.

scientific article published on 22 January 2015

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