List of works - Philip M Potter

ATP-dependent mitochondrial porphyrin importer ABCB6 protects against phenylhydrazine toxicity.

scientific article published on 31 January 2012

Activation and antitumor activity of CPT-11 in plasma esterase-deficient mice

scientific article published on 26 May 2005

An improved human carboxylesterase for enzyme/prodrug therapy with CPT-11.

scientific article

Analysis of mammalian carboxylesterase inhibition by trifluoromethylketone-containing compounds

scientific article published on 13 December 2006

Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils.

scientific article

Biochemical and molecular analysis of carboxylesterase-mediated hydrolysis of cocaine and heroin

scientific article published on August 2010

Bromodomain-selective BET inhibitors are potent antitumor agents against MYC-driven pediatric cancer

scientific article published on 10 July 2020

Carboxylesterase inhibitors.

scientific article published on 24 May 2011

Carboxylesterase-mediated sensitization of human tumor cells to CPT-11 cannot override ABCG2-mediated drug resistance

scientific article published in August 2003

Carboxylesterases: General detoxifying enzymes

scientific article published on 15 February 2016

Challenges and Opportunities with Non-CYP Enzymes Aldehyde Oxidase, Carboxylesterase, and UDP-Glucuronosyltransferase: Focus on Reaction Phenotyping and Prediction of Human Clearance.

scientific article published on 5 August 2016

Characterization of the promoter region of the human O6-methylguanine-DNA methyltransferase gene

scientific article published on November 1991

Comparison of Escherichia coli, Saccharomyces cerevisiae, Pichia pastoris, Spodoptera frugiperda, and COS7 cells for recombinant gene expression. Application to a rabbit liver carboxylesterase

scientific article published on November 2000

Comparison of benzil and trifluoromethyl ketone (TFK)-mediated carboxylesterase inhibition using classical and 3D-quantitative structure-activity relationship analysis

scientific article

Control of RhoA methylation by carboxylesterase I

scientific article published on 8 May 2013

Covalent inhibition of recombinant human carboxylesterase 1 and 2 and monoacylglycerol lipase by the carbamates JZL184 and URB597

scientific article published on 27 August 2012

Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine: from binding promiscuity to selective inhibition

scientific article (publication date: April 2003)

Development of a tumor-selective approach to treat metastatic cancer

scientific article

Development of an etoposide prodrug for dual prodrug-enzyme antitumor therapy.

scientific article

Development of prodrugs for enzyme-mediated, tumor-selective therapy.

scientific article

Discovery of novel selective inhibitors of human intestinal carboxylesterase for the amelioration of irinotecan-induced diarrhea: synthesis, quantitative structure-activity relationship analysis, and biological activity

scientific article

Evaluation of the 'side door' in carboxylesterase-mediated catalysis and inhibition

scientific article published in February 2008

Exploiting a water network to achieve enthalpy-driven, bromodomain-selective BET inhibitors.

scientific article published on 4 November 2017

Global and local molecular dynamics of a bacterial carboxylesterase provide insight into its catalytic mechanism.

scientific article published on 30 November 2011

High payload dual therapeutic-imaging nanocarriers for triggered tumor delivery

scientific article published on 06 July 2012

Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases

scientific article published in April 2005

Identification of human intestinal carboxylesterase as the primary enzyme for activation of a doxazolidine carbamate prodrug.

scientific article published on 4 January 2008

Immobilization of active human carboxylesterase 1 in biomimetic silica nanoparticles ⬇️

scientific article published on April 20, 2011

Immunohistological examination of the inter- and intracellular distribution of O6-alkylguanine DNA-alkyltransferase in human liver and melanoma

scientific article published on August 1992

Improved, selective, human intestinal carboxylesterase inhibitors designed to modulate 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (Irinotecan; CPT-11) toxicity

scientific article published on June 2009

In Silico Design and Evaluation of Carboxylesterase Inhibitors.

scientific article published on January 2010

Inactivation of lipid glyceryl ester metabolism in human THP1 monocytes/macrophages by activated organophosphorus insecticides: role of carboxylesterases 1 and 2

scientific article

Inhibition of SF3B1 by molecules targeting the spliceosome results in massive aberrant exon skipping

scientific article published on 29 May 2018

Inhibition of acetylcholinesterase by the anticancer prodrug CPT-11.

scientific article published on 28 October 2005

Inhibition of carboxylesterase 1 is associated with cholesteryl ester retention in human THP-1 monocyte/macrophages.

scientific article published on 05 August 2008

Inhibition of carboxylesterase activity of THP1 monocytes/macrophages and recombinant human carboxylesterase 1 by oxysterols and fatty acids

scientific article published on 15 September 2009

Inhibition of carboxylesterases by benzil (diphenylethane-1,2-dione) and heterocyclic analogues is dependent upon the aromaticity of the ring and the flexibility of the dione moiety

scientific article published in August 2005

Inhibition of human carboxylesterases hCE1 and hiCE by cholinesterase inhibitors

scientific article published on 2 November 2012

Inhibition of recombinant human carboxylesterase 1 and 2 and monoacylglycerol lipase by chlorpyrifos oxon, paraoxon and methyl paraoxon

scientific article

Isolation and characterization of a cDNA encoding a horse liver butyrylcholinesterase: evidence for CPT-11 drug activation

scientific article published on April 2000

Isolation and partial characterisation of a Chinese hamster O6-alkylguanine-DNA alkyltransferase cDNA ⬇️

scientific article published on April 25, 1992

Mapping of OGT in the E.coli chromosome.

scientific article published on December 1989

Metabolism of 2-naphthylamine and benzidine by rat and human bladder organ cultures.

scientific article

Modulation of esterified drug metabolism by tanshinones from Salvia miltiorrhiza ("Danshen")

scientific article published on 3 January 2013

Molecular modeling of CPT-11 metabolism by carboxylesterases (CEs): use of pnb CE as a model

scientific article published in February 2004

Mouse serum paraoxonase-1 lactonase activity is specific for medium-chain length fatty acid lactones

scientific article published on 29 October 2010

Multisite promiscuity in the processing of endogenous substrates by human carboxylesterase 1.

scientific article published on 15 August 2006

Nanoparticles containing anti-inflammatory agents as chemotherapy adjuvants II: role of plasma esterases in drug release

scientific article published on 19 February 2009

Nerve Agent Hydrolysis Activity Designed into a Human Drug Metabolism Enzyme ⬇️

scientific article published on March 18, 2011

Neural stem cell-mediated delivery of irinotecan-activating carboxylesterases to glioma: implications for clinical use.

scientific article published on 28 October 2013

Optimization of a Neural Stem-Cell-Mediated Carboxylesterase/Irinotecan Gene Therapy for Metastatic Neuroblastoma

scientific article published on 14 December 2016

Organ-specific carboxylesterase profiling identifies the small intestine and kidney as major contributors of activation of the anticancer prodrug CPT-11.

scientific article published on 15 September 2010

Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1.

scientific article published on 17 October 2007

Potent, Irreversible Inhibition of Human Carboxylesterases by Tanshinone Anhydrides Isolated from Salvia miltiorrhiza ("Danshen")

article

Requirements for mammalian carboxylesterase inhibition by substituted ethane-1,2-diones.

scientific article published on 4 July 2011

Selective Inhibitors of Human Liver Carboxylesterase Based on a β-Lapachone Scaffold: Novel Reagents for Reaction Profiling

scientific article published on 23 January 2017

Selective inhibition of carboxylesterases by isatins, indole-2,3-diones

scientific article published on 23 March 2007

Site directed mutagenesis of two cysteine residues in the E. coli ogt O6-alkylguanine DNA alkyltransferase protein.

scientific article

Species differences in the in vitro metabolism of deltamethrin and esfenvalerate: differential oxidative and hydrolytic metabolism by humans and rats

scientific article published on 19 July 2006

Structural basis of heroin and cocaine metabolism by a promiscuous human drug-processing enzyme

scientific article (publication date: May 2003)

Structural insights into drug processing by human carboxylesterase 1: tamoxifen, mevastatin, and inhibition by benzil

scientific article published in September 2005

Structure-activity relationships of substituted 1-pyridyl-2-phenyl-1,2-ethanediones: potent, selective carboxylesterase inhibitors.

scientific article

Sudemycin E influences alternative splicing and changes chromatin modifications

scientific article published on 11 March 2014

Sudemycins, novel small molecule analogues of FR901464, induce alternative gene splicing

scientific article published on 7 March 2011

Synthesis and evaluation of esters and carbamates to identify critical functional groups for esterase-specific metabolism

scientific article published in July 2003

Targeting ALK in pediatric RMS does not induce antitumor activity in vivo.

scientific article

Targeting oxidative stress in embryonal rhabdomyosarcoma.

scientific article published on December 2013

Targeting the DNA repair pathway in Ewing sarcoma

scientific article published on 23 October 2014

The 3D structure of the anticancer prodrug CPT-11 with Torpedo californica acetylcholinesterase rationalizes its inhibitory action on AChE and its hydrolysis by butyrylcholinesterase and carboxylesterase

scientific article

The crystal structure of the complex of the anticancer prodrug 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin (CPT-11) with Torpedo californica acetylcholinesterase provides a molecular explanation for its cholinergic action

scientific article

The development and application of small molecule modulators of SF3b as therapeutic agents for cancer.

scientific article published on 03 August 2012

Tissue-specific expression and induction of human O6-alkylguanine-DNA alkyltransferase in transgenic mice

scientific article published on 01 January 1992

Toxicology and Biodistribution Studies for MGH2.1, an Oncolytic Virus that Expresses Two Prodrug-activating Genes, in Combination with Prodrugs

scientific article published on 06 August 2013

Tumour-selective targeting of drug metabolizing enzymes to treat metastatic cancer

scientific article

Upregulation of O6-alkylguanine-DNA-alkyltransferase expression and the presence of double minute chromosomes in alkylating agent selected Chinese hamster cells

scientific article published on March 1992

Use of the ornithine decarboxylase promoter to achieve N-MYC-mediated overexpression of a rabbit carboxylesterase to sensitize neuroblastoma cells to CPT-11

scientific article published on 01 May 2000

p53-mediated regulation of expression of a rabbit liver carboxylesterase confers sensitivity to 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11).

scientific article published in February 2003

List of works by Philip M Potter

ATP-dependent mitochondrial porphyrin importer ABCB6 protects against phenylhydrazine toxicity.

Activation and antitumor activity of CPT-11 in plasma esterase-deficient mice

An improved human carboxylesterase for enzyme/prodrug therapy with CPT-11.

Analysis of mammalian carboxylesterase inhibition by trifluoromethylketone-containing compounds

Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils.

Biochemical and molecular analysis of carboxylesterase-mediated hydrolysis of cocaine and heroin

Bromodomain-selective BET inhibitors are potent antitumor agents against MYC-driven pediatric cancer

Carboxylesterase inhibitors.

Carboxylesterase-mediated sensitization of human tumor cells to CPT-11 cannot override ABCG2-mediated drug resistance

Carboxylesterases: General detoxifying enzymes

Challenges and Opportunities with Non-CYP Enzymes Aldehyde Oxidase, Carboxylesterase, and UDP-Glucuronosyltransferase: Focus on Reaction Phenotyping and Prediction of Human Clearance.

Characterization of the promoter region of the human O6-methylguanine-DNA methyltransferase gene

Comparison of Escherichia coli, Saccharomyces cerevisiae, Pichia pastoris, Spodoptera frugiperda, and COS7 cells for recombinant gene expression. Application to a rabbit liver carboxylesterase

Comparison of benzil and trifluoromethyl ketone (TFK)-mediated carboxylesterase inhibition using classical and 3D-quantitative structure-activity relationship analysis

Control of RhoA methylation by carboxylesterase I

Covalent inhibition of recombinant human carboxylesterase 1 and 2 and monoacylglycerol lipase by the carbamates JZL184 and URB597

Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine: from binding promiscuity to selective inhibition

Development of a tumor-selective approach to treat metastatic cancer

Development of an etoposide prodrug for dual prodrug-enzyme antitumor therapy.

Development of prodrugs for enzyme-mediated, tumor-selective therapy.

Discovery of novel selective inhibitors of human intestinal carboxylesterase for the amelioration of irinotecan-induced diarrhea: synthesis, quantitative structure-activity relationship analysis, and biological activity

Evaluation of the 'side door' in carboxylesterase-mediated catalysis and inhibition

Exploiting a water network to achieve enthalpy-driven, bromodomain-selective BET inhibitors.

Global and local molecular dynamics of a bacterial carboxylesterase provide insight into its catalytic mechanism.

High payload dual therapeutic-imaging nanocarriers for triggered tumor delivery

Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases

Identification of human intestinal carboxylesterase as the primary enzyme for activation of a doxazolidine carbamate prodrug.

Immobilization of active human carboxylesterase 1 in biomimetic silica nanoparticles ⬇️

Immunohistological examination of the inter- and intracellular distribution of O6-alkylguanine DNA-alkyltransferase in human liver and melanoma

Improved, selective, human intestinal carboxylesterase inhibitors designed to modulate 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (Irinotecan; CPT-11) toxicity

In Silico Design and Evaluation of Carboxylesterase Inhibitors.

Inactivation of lipid glyceryl ester metabolism in human THP1 monocytes/macrophages by activated organophosphorus insecticides: role of carboxylesterases 1 and 2

Inhibition of SF3B1 by molecules targeting the spliceosome results in massive aberrant exon skipping

Inhibition of acetylcholinesterase by the anticancer prodrug CPT-11.

Inhibition of carboxylesterase 1 is associated with cholesteryl ester retention in human THP-1 monocyte/macrophages.

Inhibition of carboxylesterase activity of THP1 monocytes/macrophages and recombinant human carboxylesterase 1 by oxysterols and fatty acids

Inhibition of carboxylesterases by benzil (diphenylethane-1,2-dione) and heterocyclic analogues is dependent upon the aromaticity of the ring and the flexibility of the dione moiety

Inhibition of human carboxylesterases hCE1 and hiCE by cholinesterase inhibitors

Inhibition of recombinant human carboxylesterase 1 and 2 and monoacylglycerol lipase by chlorpyrifos oxon, paraoxon and methyl paraoxon

Isolation and characterization of a cDNA encoding a horse liver butyrylcholinesterase: evidence for CPT-11 drug activation

Isolation and partial characterisation of a Chinese hamster O6-alkylguanine-DNA alkyltransferase cDNA ⬇️

Mapping of OGT in the E.coli chromosome.

Metabolism of 2-naphthylamine and benzidine by rat and human bladder organ cultures.

Modulation of esterified drug metabolism by tanshinones from Salvia miltiorrhiza ("Danshen")

Molecular modeling of CPT-11 metabolism by carboxylesterases (CEs): use of pnb CE as a model

Mouse serum paraoxonase-1 lactonase activity is specific for medium-chain length fatty acid lactones

Multisite promiscuity in the processing of endogenous substrates by human carboxylesterase 1.

Nanoparticles containing anti-inflammatory agents as chemotherapy adjuvants II: role of plasma esterases in drug release

Nerve Agent Hydrolysis Activity Designed into a Human Drug Metabolism Enzyme ⬇️

Neural stem cell-mediated delivery of irinotecan-activating carboxylesterases to glioma: implications for clinical use.

Optimization of a Neural Stem-Cell-Mediated Carboxylesterase/Irinotecan Gene Therapy for Metastatic Neuroblastoma

Organ-specific carboxylesterase profiling identifies the small intestine and kidney as major contributors of activation of the anticancer prodrug CPT-11.

Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1.

Potent, Irreversible Inhibition of Human Carboxylesterases by Tanshinone Anhydrides Isolated from Salvia miltiorrhiza ("Danshen")

Requirements for mammalian carboxylesterase inhibition by substituted ethane-1,2-diones.

Selective Inhibitors of Human Liver Carboxylesterase Based on a β-Lapachone Scaffold: Novel Reagents for Reaction Profiling

Selective inhibition of carboxylesterases by isatins, indole-2,3-diones

Site directed mutagenesis of two cysteine residues in the E. coli ogt O6-alkylguanine DNA alkyltransferase protein.

Species differences in the in vitro metabolism of deltamethrin and esfenvalerate: differential oxidative and hydrolytic metabolism by humans and rats

Structural basis of heroin and cocaine metabolism by a promiscuous human drug-processing enzyme

Structural insights into drug processing by human carboxylesterase 1: tamoxifen, mevastatin, and inhibition by benzil

Structure-activity relationships of substituted 1-pyridyl-2-phenyl-1,2-ethanediones: potent, selective carboxylesterase inhibitors.

Sudemycin E influences alternative splicing and changes chromatin modifications

Sudemycins, novel small molecule analogues of FR901464, induce alternative gene splicing

Synthesis and evaluation of esters and carbamates to identify critical functional groups for esterase-specific metabolism

Targeting ALK in pediatric RMS does not induce antitumor activity in vivo.

Targeting oxidative stress in embryonal rhabdomyosarcoma.

Targeting the DNA repair pathway in Ewing sarcoma

The 3D structure of the anticancer prodrug CPT-11 with Torpedo californica acetylcholinesterase rationalizes its inhibitory action on AChE and its hydrolysis by butyrylcholinesterase and carboxylesterase

The crystal structure of the complex of the anticancer prodrug 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin (CPT-11) with Torpedo californica acetylcholinesterase provides a molecular explanation for its cholinergic action

The development and application of small molecule modulators of SF3b as therapeutic agents for cancer.

Tissue-specific expression and induction of human O6-alkylguanine-DNA alkyltransferase in transgenic mice

Toxicology and Biodistribution Studies for MGH2.1, an Oncolytic Virus that Expresses Two Prodrug-activating Genes, in Combination with Prodrugs

Tumour-selective targeting of drug metabolizing enzymes to treat metastatic cancer

Upregulation of O6-alkylguanine-DNA-alkyltransferase expression and the presence of double minute chromosomes in alkylating agent selected Chinese hamster cells

Use of the ornithine decarboxylase promoter to achieve N-MYC-mediated overexpression of a rabbit carboxylesterase to sensitize neuroblastoma cells to CPT-11

p53-mediated regulation of expression of a rabbit liver carboxylesterase confers sensitivity to 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11).