List of works - Helen R. Mott

(1)H, (13)C and (15)N resonance assignments of the Cdc42-binding domain of TOCA1

scientific article published on 18 March 2016

1H, 13C and 15N resonance assignments for Binder of Arl2, BART.

scientific article published on 16 December 2008

1H, 13C and 15N resonance assignments for the active conformation of the small G protein RalB in complex with its effector RLIP76.

scientific article published on 19 October 2008

1H, 13C and 15N resonance assignments for the small G protein RalB in its active conformation.

scientific article

1H, 13C and 15N resonance assignments of the GTPase-activating (GAP) and Ral binding domains (GBD) of RLIP76 (RalBP1).

scientific article published on 14 September 2011

1H, 15N and 13C resonance assignments of the HR1c domain of PRK1, a protein kinase C-related kinase

scientific article published on 04 June 2020

A Complete Survey of RhoGDI Targets Reveals Novel Interactions with Atypical Small GTPases

scientific article published on 29 April 2021

A dock and coalesce mechanism driven by hydrophobic interactions governs Cdc42 binding with its effector protein ACK

scientific article

Affinity maturation of the RLIP76 Ral binding domain to inform the design of stapled peptides targeting the Ral GTPases

scientific article published on 19 November 2020

Atomic structure and hierarchical assembly of a cross- amyloid fibril

scientific article

Bioblockades join the assault on small G protein signalling.

scientific article published on 4 January 2018

Cdc42 in actin dynamics: An ordered pathway governed by complex equilibria and directional effector handover

scientific article

Differential binding of RhoA, RhoB, and RhoC to protein kinase C-related kinase (PRK) isoforms PRK1, PRK2, and PRK3: PRKs have the highest affinity for RhoB.

scientific article published on 31 October 2013

Double mutant cycle thermodynamic analysis of the hydrophobic Cdc42-ACK protein-protein interaction

scientific article

Erratum to: (1)H, (13)C and (15)N resonance assignments of the Cdc42-binding domain of TOCA1.

scientific article

Fluorescence properties of green fluorescent protein FRET pairs concatenated with the small G protein, Rac, and its interacting domain of the kinase, p21-activated kinase

scientific article

Genomic Subtypes of Non-invasive Bladder Cancer with Distinct Metabolic Profile and Female Gender Bias in KDM6A Mutation Frequency ⬇️

scientific article published in November 2017

Human interleukin-1 receptor antagonist. High yield expression in E. coli and examination of cysteine residues

scientific article published on September 21, 1992

Hydrodynamic gene delivery of baboon trypanosome lytic factor eliminates both animal and human-infective African trypanosomes

scientific article

In support of the BMRB.

scientific article published in September 2012

Inhibition of Ral GTPases Using a Stapled Peptide Approach.

scientific article published on 22 June 2016

Integral membrane protein structure determination using pseudocontact shifts.

scientific article

Investigation of the Interaction between Cdc42 and Its Effector TOCA1: HANDOVER OF Cdc42 TO THE ACTIN REGULATOR N-WASP IS FACILITATED BY DIFFERENTIAL BINDING AFFINITIES.

scientific article published on 22 April 2016

Molecular dissection of the interaction between the small G proteins Rac1 and RhoA and protein kinase C-related kinase 1 (PRK1)

scientific article

Mutational analysis reveals a single binding interface between RhoA and its effector, PRK1.

scientific article published on 16 March 2011

NMR Analysis of Interacting Soluble Forms of the Cell−Cell Recognition Molecules CD2 and CD48†

article

NMR resonance assignments for the active and inactive conformations of the small G protein RalA

scientific article published on 08 January 2020

RLIP76 (RalBP1): The first piece of the structural puzzle

scientific article

Resonance assignments for the RLIP76 Ral binding domain in its free form and in complex with the small G protein RalB.

scientific article published on 7 October 2008

Role of intermolecular forces in defining material properties of protein nanofibrils

scientific article

Secondary structure of human interleukin 2 from 3D heteronuclear NMR experiments

scientific article published on August 25, 1992

Solution structure and dynamics of the small GTPase RalB in its active conformation: significance for effector protein binding

scientific article

Specificity determinants on Cdc42 for binding its effector protein ACK.

scientific article published on September 2005

Structural analysis of the SH3 domain of beta-PIX and its interaction with alpha-p21 activated kinase (PAK)

scientific article

Structural and Functional Analysis of a Mutant Ras Protein That Is Insensitive to Nitric Oxide Activation†

article

Structural basis for the shielding function of the dynamic trypanosome variant surface glycoprotein coat

scientific article

Structural basis of HP1/PXVXL motif peptide interactions and HP1 localisation to heterochromatin

scientific article

Structure and function of RLIP76 (RalBP1): an intersection point between Ras and Rho signalling

scientific article

Structure determination of the seven-helix transmembrane receptor sensory rhodopsin II by solution NMR spectroscopy

scientific article

Structure of a glycosylphosphatidylinositol-anchored domain from a trypanosome variant surface glycoprotein

scientific article

Structure of the C-terminal domain from Trypanosoma brucei variant surface glycoprotein MITat1.2.

scientific article published on 22 November 2004

Structure of the GTPase-binding domain of Sec5 and elucidation of its Ral binding site

scientific article (publication date: 9 May 2003)

Structure of the HP1 chromodomain bound to histone H3 methylated at lysine 9

scientific article

Structure of the small G protein Cdc42 bound to the GTPase-binding domain of ACK

scientific article

Structure of the sterile alpha motif (SAM) domain of the Saccharomyces cerevisiae mitogen-activated protein kinase pathway-modulating protein STE50 and analysis of its interaction with the STE11 SAM

scientific article

Structures of Ras superfamily effector complexes: What have we learnt in two decades?

scientific article published on March 2015

The IQGAP1-Rac1 and IQGAP1-Cdc42 interactions: interfaces differ between the complexes

scientific article published on 5 November 2007

The Rac1 polybasic region is required for interaction with its effector PRK1

scientific article

The RalB-RLIP76 Complex Reveals a Novel Mode of Ral-Effector Interaction

scientific article

The Structure of the RLIP76 RhoGAP-Ral Binding Domain Dyad: Fixed Position of the Domains Leads to Dual Engagement of Small G Proteins at the Membrane

scientific article

The discovery and maturation of peptide biologics targeting the small G-protein Cdc42: A bioblockade for Ras-driven signaling

scientific article published on 20 January 2020

The solution structure of the Raf-1 cysteine-rich domain: a novel ras and phospholipid binding site

scientific article

The structure of binder of Arl2 (BART) reveals a novel G protein binding domain: implications for function

scientific article

Thermodynamic mapping of effector protein interfaces with RalA and RalB.

scientific article published on 5 February 2015

Variant Surface Glycoprotein gene repertoires in Trypanosoma brucei have diverged to become strain-specific

scientific article

List of works by Helen R. Mott

(1)H, (13)C and (15)N resonance assignments of the Cdc42-binding domain of TOCA1

1H, 13C and 15N resonance assignments for Binder of Arl2, BART.

1H, 13C and 15N resonance assignments for the active conformation of the small G protein RalB in complex with its effector RLIP76.

1H, 13C and 15N resonance assignments for the small G protein RalB in its active conformation.

1H, 13C and 15N resonance assignments of the GTPase-activating (GAP) and Ral binding domains (GBD) of RLIP76 (RalBP1).

1H, 15N and 13C resonance assignments of the HR1c domain of PRK1, a protein kinase C-related kinase

A Complete Survey of RhoGDI Targets Reveals Novel Interactions with Atypical Small GTPases

A dock and coalesce mechanism driven by hydrophobic interactions governs Cdc42 binding with its effector protein ACK

Affinity maturation of the RLIP76 Ral binding domain to inform the design of stapled peptides targeting the Ral GTPases

Atomic structure and hierarchical assembly of a cross- amyloid fibril

Bioblockades join the assault on small G protein signalling.

Cdc42 in actin dynamics: An ordered pathway governed by complex equilibria and directional effector handover

Differential binding of RhoA, RhoB, and RhoC to protein kinase C-related kinase (PRK) isoforms PRK1, PRK2, and PRK3: PRKs have the highest affinity for RhoB.

Double mutant cycle thermodynamic analysis of the hydrophobic Cdc42-ACK protein-protein interaction

Erratum to: (1)H, (13)C and (15)N resonance assignments of the Cdc42-binding domain of TOCA1.

Fluorescence properties of green fluorescent protein FRET pairs concatenated with the small G protein, Rac, and its interacting domain of the kinase, p21-activated kinase

Genomic Subtypes of Non-invasive Bladder Cancer with Distinct Metabolic Profile and Female Gender Bias in KDM6A Mutation Frequency ⬇️

Human interleukin-1 receptor antagonist. High yield expression in E. coli and examination of cysteine residues

Hydrodynamic gene delivery of baboon trypanosome lytic factor eliminates both animal and human-infective African trypanosomes

In support of the BMRB.

Inhibition of Ral GTPases Using a Stapled Peptide Approach.

Integral membrane protein structure determination using pseudocontact shifts.

Investigation of the Interaction between Cdc42 and Its Effector TOCA1: HANDOVER OF Cdc42 TO THE ACTIN REGULATOR N-WASP IS FACILITATED BY DIFFERENTIAL BINDING AFFINITIES.

Molecular dissection of the interaction between the small G proteins Rac1 and RhoA and protein kinase C-related kinase 1 (PRK1)

Mutational analysis reveals a single binding interface between RhoA and its effector, PRK1.

NMR Analysis of Interacting Soluble Forms of the Cell−Cell Recognition Molecules CD2 and CD48†

NMR resonance assignments for the active and inactive conformations of the small G protein RalA

RLIP76 (RalBP1): The first piece of the structural puzzle

Resonance assignments for the RLIP76 Ral binding domain in its free form and in complex with the small G protein RalB.

Role of intermolecular forces in defining material properties of protein nanofibrils

Secondary structure of human interleukin 2 from 3D heteronuclear NMR experiments

Solution structure and dynamics of the small GTPase RalB in its active conformation: significance for effector protein binding

Specificity determinants on Cdc42 for binding its effector protein ACK.

Structural analysis of the SH3 domain of beta-PIX and its interaction with alpha-p21 activated kinase (PAK)

Structural and Functional Analysis of a Mutant Ras Protein That Is Insensitive to Nitric Oxide Activation†

Structural basis for the shielding function of the dynamic trypanosome variant surface glycoprotein coat

Structural basis of HP1/PXVXL motif peptide interactions and HP1 localisation to heterochromatin

Structure and function of RLIP76 (RalBP1): an intersection point between Ras and Rho signalling

Structure determination of the seven-helix transmembrane receptor sensory rhodopsin II by solution NMR spectroscopy

Structure of a glycosylphosphatidylinositol-anchored domain from a trypanosome variant surface glycoprotein

Structure of the C-terminal domain from Trypanosoma brucei variant surface glycoprotein MITat1.2.

Structure of the GTPase-binding domain of Sec5 and elucidation of its Ral binding site

Structure of the HP1 chromodomain bound to histone H3 methylated at lysine 9

Structure of the small G protein Cdc42 bound to the GTPase-binding domain of ACK

Structure of the sterile alpha motif (SAM) domain of the Saccharomyces cerevisiae mitogen-activated protein kinase pathway-modulating protein STE50 and analysis of its interaction with the STE11 SAM

Structures of Ras superfamily effector complexes: What have we learnt in two decades?

The IQGAP1-Rac1 and IQGAP1-Cdc42 interactions: interfaces differ between the complexes

The Rac1 polybasic region is required for interaction with its effector PRK1

The RalB-RLIP76 Complex Reveals a Novel Mode of Ral-Effector Interaction

The Structure of the RLIP76 RhoGAP-Ral Binding Domain Dyad: Fixed Position of the Domains Leads to Dual Engagement of Small G Proteins at the Membrane

The discovery and maturation of peptide biologics targeting the small G-protein Cdc42: A bioblockade for Ras-driven signaling

The solution structure of the Raf-1 cysteine-rich domain: a novel ras and phospholipid binding site

The structure of binder of Arl2 (BART) reveals a novel G protein binding domain: implications for function

Thermodynamic mapping of effector protein interfaces with RalA and RalB.

Variant Surface Glycoprotein gene repertoires in Trypanosoma brucei have diverged to become strain-specific