List of works by Honglin Chen

A model to control the epidemic of H5N1 influenza at the source.

scientific article

A multimechanistic antibody targeting the receptor binding site potently cross-protects against influenza B viruses.

scientific article

A positive autoregulatory loop of LMP1 expression and STAT activation in epithelial cells latently infected with Epstein-Barr virus.

scientific article

A triclade DNA vaccine designed on the basis of a comprehensive serologic study elicits neutralizing antibody responses against all clades and subclades of highly pathogenic avian influenza H5N1 viruses

scientific article

An NS-segment exonic splicing enhancer regulates influenza A virus replication in mammalian cells.

scientific article published on 21 March 2017

Analytical sensitivity of seven point-of-care influenza virus detection tests and two molecular tests for detection of avian origin H7N9 and swine origin H3N2 variant influenza A viruses

scientific article published on 19 June 2013

Antigenicity and transmissibility of a novel clade 2.3.2.1 avian influenza H5N1 virus

scientific article published on 28 September 2013

Assessing the risk of nasopharyngeal carcinoma on the basis of EBV antibody spectrum

scientific article published on 01 February 2002

Assessment of antigen and molecular tests with serial specimens from a patient with influenza A(H7N9) infection.

scientific article published on 26 March 2014

Attenuated SARS-CoV-2 variants with deletions at the S1/S2 junction

scientific article published on 17 April 2020

Avian flu: H5N1 virus outbreak in migratory waterfowl.

scientific article published in July 2005

Avian influenza A H5N1 virus: a continuous threat to humans

scientific article

Avian influenza A H7N9 virus induces severe pneumonia in mice without prior adaptation and responds to a combination of zanamivir and COX-2 inhibitor

scientific article

Avian influenza H5N1 in viverrids: implications for wildlife health and conservation.

scientific article published in July 2006

Avian metapneumovirus subtype A in China and subtypes A and B in Nigeria

scientific article published in September 2008

Avian-origin influenza A(H7N9) infection in influenza A(H7N9)-affected areas of China: a serological study

scientific article published on 9 August 2013

Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus

scientific article

CCAAT/enhancer binding protein alpha binds to the Epstein-Barr virus (EBV) ZTA protein through oligomeric interactions and contributes to cooperative transcriptional activation of the ZTA promoter through direct binding to the ZII and ZIIIB motifs d

scientific article published on May 2004

CCAAT/enhancer binding protein alpha interacts with ZTA and mediates ZTA-induced p21(CIP-1) accumulation and G(1) cell cycle arrest during the Epstein-Barr virus lytic cycle.

scientific article

CRISPR/Cas9-mediated genome editing of Epstein-Barr virus in human cells.

scientific article published on 12 December 2014

Cell cycle arrest by Kaposi's sarcoma-associated herpesvirus replication-associated protein is mediated at both the transcriptional and posttranslational levels by binding to CCAAT/enhancer-binding protein alpha and p21(CIP-1)

scientific article

Characterization of avian influenza viruses A (H5N1) from wild birds, Hong Kong, 2004-2008.

scientific article published on March 2009

Characterization of complementary determinant region 3δ in human MutS homologue 2-specific γδ T cells.

scientific article published on February 2015

Characterization of low-pathogenic H5 subtype influenza viruses from Eurasia: implications for the origin of highly pathogenic H5N1 viruses

scientific article published on 16 May 2007

Clinical and molecular epidemiological features of coronavirus HKU1-associated community-acquired pneumonia

scientific article published on 20 October 2005

Clinical and virological factors associated with viremia in pandemic influenza A/H1N1/2009 virus infection

scientific article (publication date: 2011)

Clinical, virological, and histopathological manifestations of fatal human infections by avian influenza A(H7N9) virus

scientific article

Complete Genome Sequence of Influenza Virus H9N2 Associated with a Fatal Outbreak among Chickens in Dubai

scientific article published on 18 August 2016

Contribution of C/EBP proteins to Epstein-Barr virus lytic gene expression and replication in epithelial cells

scientific article

Coronaviruses in bent-winged bats (Miniopterus spp.).

scientific article

Cross-reactive antibodies in convalescent SARS patients' sera against the emerging novel human coronavirus EMC (2012) by both immunofluorescent and neutralizing antibody tests

scientific article published on 10 April 2013

Cross-species transmission and emergence of novel viruses from birds

scientific article published on 31 January 2015

D225G mutation in hemagglutinin of pandemic influenza H1N1 (2009) virus enhances virulence in mice

scientific article

Dating the emergence of pandemic influenza viruses

scientific article

Delayed clearance of viral load and marked cytokine activation in severe cases of pandemic H1N1 2009 influenza virus infection.

scientific article

Delayed induction of proinflammatory cytokines and suppression of innate antiviral response by the novel Middle East respiratory syndrome coronavirus: implications for pathogenesis and treatment.

scientific article

Detection of a novel and highly divergent coronavirus from asian leopard cats and Chinese ferret badgers in Southern China.

scientific article published on 25 April 2007

Detection of diverse astroviruses from bats in China

scientific article

Differences in antibody responses of individuals with natural infection and those vaccinated against pandemic H1N1 2009 influenza

scientific article

Differential cell line susceptibility to the emerging novel human betacoronavirus 2c EMC/2012: implications for disease pathogenesis and clinical manifestation

scientific article published on 26 March 2013

Differential susceptibility of different cell lines to swine-origin influenza A H1N1, seasonal human influenza A H1N1, and avian influenza A H5N1 viruses.

scientific article

Differentiated human airway organoids to assess infectivity of emerging influenza virus

article published in the Proceedings of the National Academy of Sciences of the United States of America

Distribution of amantadine-resistant H5N1 avian influenza variants in Asia.

scientific article

Draft genome sequence of the novel agarolytic bacterium Aquimarina agarilytica ZC1.

scientific article

EBV-miR-BART8-3p induces epithelial-mesenchymal transition and promotes metastasis of nasopharyngeal carcinoma cells through activating NF-κB and Erk1/2 pathways

scientific article published on 26 November 2018

Early activation of the Kaposi's sarcoma-associated herpesvirus RTA, RAP, and MTA promoters by the tetradecanoyl phorbol acetate-induced AP1 pathway.

scientific article published on April 2004

Early gene expression events in ferrets in response to SARS coronavirus infection versus direct interferon-alpha2b stimulation.

scientific article published on 28 October 2010

Effect of clinical and virological parameters on the level of neutralizing antibody against pandemic influenza A virus H1N1 2009.

scientific article

Efficacy of Clarithromycin-Naproxen-Oseltamivir Combination in the Treatment of Patients Hospitalized for Influenza A(H3N2) Infection: An Open-label Randomized, Controlled, Phase IIb/III Trial.

scientific article

Emergence and predominance of an H5N1 influenza variant in China.

scientific article

Emergence in China of human disease due to avian influenza A(H10N8)--cause for concern?

scientific article published on 06 January 2014

Epstein-Barr virus infection in immortalized nasopharyngeal epithelial cells: regulation of infection and phenotypic characterization.

scientific article

Establishment and characterization of new tumor xenografts and cancer cell lines from EBV-positive nasopharyngeal carcinoma

scientific article published in Nature Communications

Establishment of an H6N2 influenza virus lineage in domestic ducks in southern China

scientific article

Establishment of influenza A virus (H6N1) in minor poultry species in southern China.

scientific article

Evolution and adaptation of H5N1 influenza virus in avian and human hosts in Indonesia and Vietnam.

scientific article

Evolution and molecular epidemiology of H9N2 influenza A viruses from quail in southern China, 2000 to 2005.

scientific article

Evolutionary dynamics and emergence of panzootic H5N1 influenza viruses.

scientific article

Evolutionary insights into the ecology of coronaviruses.

scientific article

GC/MS-based metabolomics reveals fatty acid biosynthesis and cholesterol metabolism in cell lines infected with influenza A virus

scientific article

Generation of DelNS1 Influenza Viruses: a Strategy for Optimizing Live Attenuated Influenza Vaccines

scientific article published on 17 September 2019

Generation of recombinant influenza A virus without M2 ion-channel protein by introduction of a point mutation at the 5' end of the viral intron.

scientific article

Genesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern Asia.

scientific article

Genomic characterizations of bat coronaviruses (1A, 1B and HKU8) and evidence for co-infections in Miniopterus bats.

scientific article published in May 2008

Hemagglutinin amino acids related to receptor specificity could affect the protection efficacy of H5N1 and H7N9 avian influenza virus vaccines in mice.

scientific article

Hemagglutinin of influenza A virus binds specifically to cell surface nucleolin and plays a role in virus internalization

scientific article published on 13 April 2016

High incidence of severe influenza among individuals over 50 years of age.

scientific article

Human H7N9 virus induces a more pronounced pro-inflammatory cytokine but an attenuated interferon response in human bronchial epithelial cells when compared with an epidemiologically-linked chicken H7N9 virus.

scientific article

Human infection with an avian H9N2 influenza A virus in Hong Kong in 2003.

scientific article

Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome

scientific article

Identification of amino acid substitutions in avian influenza virus (H5N1) matrix protein 1 by using nanoelectrospray MS and MS/MS.

scientific article published on 18 October 2008

Identification of amino acid substitutions in mutated peptides of nucleoprotein from avian influenza virus.

scientific article published on 10 February 2009

Identification of influenza A nucleoprotein as an antiviral target

scientific article

Identification of the progenitors of Indonesian and Vietnamese avian influenza A (H5N1) viruses from southern China

scientific article

Identification of unusual truncated forms of nucleocapsid protein in MDCK cells infected by Avian influenza virus (H9N2).

scientific article

Immunogenicity of a Heterologous Prime-Boost COVID-19 Vaccination with mRNA and Inactivated Virus Vaccines Compared with Homologous Vaccination Strategy against SARS-CoV-2 Variants

scientific article published in 2022

Infection of bat and human intestinal organoids by SARS-CoV-2

scientific article published on 13 May 2020

Infection of immunocompromised patients by avian H9N2 influenza A virus.

scientific article published on 26 February 2011

Is the discovery of the novel human betacoronavirus 2c EMC/2012 (HCoV-EMC) the beginning of another SARS-like pandemic?

scientific article

Large-scale sequence analysis reveals novel human-adaptive markers in PB2 segment of seasonal influenza A viruses.

scientific article

Long-term evolution and transmission dynamics of swine influenza A virus

scientific article

Low population serum microneutralization antibody titer against the predominating influenza A(H3N2) N121K virus during the severe influenza summer peak of Hong Kong in 2017.

scientific article published on 6 March 2018

MERS coronavirus induces apoptosis in kidney and lung by upregulating Smad7 and FGF2.

scientific article published on 22 February 2016

Molecular analysis of avian H7 influenza viruses circulating in Eurasia in 1999-2005: detection of multiple reassortant virus genotypes

scientific article published in January 2008

Molecular characterization of in vivo adjuvant activity in ferrets vaccinated against influenza virus

scientific article

Molecular epidemiology of chicken anemia virus (CAV) in southeastern Chinese live birds markets

scientific article published in March 2008

Mutations in influenza virus replication and transcription: detection of amino acid substitutions in hemagglutinin of an avian influenza virus (H1N1).

scientific article published on 24 June 2009

Mycophenolic acid, an immunomodulator, has potent and broad-spectrum in vitro antiviral activity against pandemic, seasonal and avian influenza viruses affecting humans

scientific article

NF-κB Signaling Regulates Epstein-Barr Virus BamHI-Q-Driven EBNA1 Expression.

scientific article published on 16 April 2018

Neuraminidase antibodies and H5N1: geographic-dependent influenza epidemiology could determine cross-protection against emerging strains

scientific article published on June 2007

Novel avian-origin human influenza A(H7N9) can be transmitted between ferrets via respiratory droplets.

scientific article

Novel reassortment of Eurasian avian-like and pandemic/2009 influenza viruses in swine: infectious potential for humans

scientific article

Nuclear factor 90 negatively regulates influenza virus replication by interacting with viral nucleoprotein

scientific article

Oseltamivir-resistant influenza A pandemic (H1N1) 2009 virus, Hong Kong, China.

scientific article

Outbreaks of highly pathogenic avian influenza H5N1 clade 2.3.2.1c in hunting falcons and kept wild birds in Dubai implicate intercontinental virus spread

scientific article published on 7 September 2015

Peptide mimics of a conserved H5N1 avian influenza virus neutralization site

scientific article

Perturbation of biogenesis and targeting of Epstein-Barr virus-encoded miR-BART3 microRNA by adenosine-to-inosine editing

scientific article published on 17 September 2013

Preclinical evaluation of the safety and pathogenicity of a live attenuated recombinant influenza A/H7N9 seed strain and corresponding MF59-adjuvanted split vaccine.

scientific article published on 19 October 2016

Prevalence and genetic diversity of coronaviruses in bats from China

scientific article

Proteomics analysis of differential expression of cellular proteins in response to avian H9N2 virus infection in human cells.

scientific article

Proteomics study of N-acetylcysteine response in H1N1-infected cells by using mass spectrometry

scientific article

Quasispecies of the D225G substitution in the hemagglutinin of pandemic influenza A(H1N1) 2009 virus from patients with severe disease in Hong Kong, China

scientific article

Rapid detection of MERS coronavirus-like viruses in bats: pote1ntial for tracking MERS coronavirus transmission and animal origin.

scientific article published on 7 March 2018

Recombinant influenza A virus hemagglutinin HA2 subunit protects mice against influenza A(H7N9) virus infection.

scientific article published on 24 January 2015

Reliable universal RT-PCR assays for studying influenza polymerase subunit gene sequences from all 16 haemagglutinin subtypes

article

Resistance to anti-influenza agents

scientific article

Serologic survey of pandemic (H1N1) 2009 virus, Guangxi Province, China

scientific article

Severe Acute Respiratory Syndrome (SARS) Coronavirus ORF8 Protein Is Acquired from SARS-Related Coronavirus from Greater Horseshoe Bats through Recombination

scientific article

Structural Basis for the Broad, Antibody-Mediated Neutralization of H5N1 Influenza Virus

scientific article published on 16 August 2018

Suboptimal Humoral Immune Response against Influenza A(H7N9) Virus Is Related to Its Internal Genes.

scientific article

Systemic infection of avian influenza A virus H5N1 subtype in humans.

scientific article published on 3 January 2009

Targeted activation of human Vγ9Vδ2-T cells controls epstein-barr virus-induced B cell lymphoproliferative disease

scientific article published on 11 September 2014

Targeting of DICE1 tumor suppressor by Epstein-Barr virus-encoded miR-BART3* microRNA in nasopharyngeal carcinoma

scientific article published on 12 February 2013

The PB2 Polymerase Host Adaptation Substitutions Prime Avian Indonesia Sub Clade 2.1 H5N1 Viruses for Infecting Humans

scientific article published on 22 March 2019

The Therapeutic Effect of Pamidronate on Lethal Avian Influenza A H7N9 Virus Infected Humanized Mice

scientific article (publication date: 2015)

The development and genetic diversity of H5N1 influenza virus in China, 1996-2006.

scientific article published on 06 September 2008

The emergence of influenza A H7N9 in human beings 16 years after influenza A H5N1: a tale of two cities

scientific article published on September 2013

The genesis and evolution of H9N2 influenza viruses in poultry from southern China, 2000 to 2005

scientific article

Topical imiquimod before intradermal trivalent influenza vaccine for protection against heterologous non-vaccine and antigenically drifted viruses: a single-centre, double-blind, randomised, controlled phase 2b/3 trial

scientific article

Transcription of BamHI-A region of the EBV genome in NPC tissues and B cells.

scientific article published in November 1992

Treatment With Lopinavir/Ritonavir or Interferon-β1b Improves Outcome of MERS-CoV Infection in a Nonhuman Primate Model of Common Marmoset

scientific article published on 21 July 2015

Unique reassortant of influenza A(H7N9) virus associated with severe disease emerging in Hong Kong.

scientific article published on 24 February 2014

Viral genome and antiviral drug sensitivity analysis of two patients from a family cluster caused by the influenza A(H7N9) virus in Zhejiang, China, 2013.

scientific article published on 13 November 2014

Viruses harness YxxØ motif to interact with host AP2M1 for replication: A vulnerable broad-spectrum antiviral target

scientific article published on 28 August 2020

Wild type and mutant 2009 pandemic influenza A (H1N1) viruses cause more severe disease and higher mortality in pregnant BALB/c mice

scientific article

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