List of works - Georg Meisl

Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation

scientific article

Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptides

scientific article

Molecular mechanisms of protein aggregation from global fitting of kinetic models.

scientific article published on 7 January 2016

Mutations associated with familial Parkinson's disease alter the initiation and amplification steps of α-synuclein aggregation

scientific article

A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity

scientific article

The Aβ40 and Aβ42 peptides self-assemble into separate homomolecular fibrils in binary mixtures but cross-react during primary nucleation.

scientific article published on 8 May 2015

Ostwald's rule of stages governs structural transitions and morphology of dipeptide supramolecular polymers

scientific article

Quantitative analysis of intrinsic and extrinsic factors in the aggregation mechanism of Alzheimer-associated Aβ-peptide

scientific article

Electrostatically-guided inhibition of Curli amyloid nucleation by the CsgC-like family of chaperones

scientific article published on 21 April 2016

Secondary nucleation in amyloid formation

scientific article published on 01 August 2018

N-Terminal Extensions Retard Aβ42 Fibril Formation but Allow Cross-Seeding and Coaggregation with Aβ42

scientific article

Solvent and conformation dependence of amide I vibrations in peptides and proteins containing proline

scientific article published in December 2011

Self-assembly of MPG1, a hydrophobin protein from the rice blast fungus that forms functional amyloid coatings, occurs by a surface-driven mechanism

scientific article published on 4 May 2016

Physical determinants of the self-replication of protein fibrils

scientific article published on 18 July 2016

Scaling behaviour and rate-determining steps in filamentous self-assembly

scientific article

Modulation of electrostatic interactions to reveal a reaction network unifying the aggregation behaviour of the Aβ42 peptide and its variants

scientific article published on 26 April 2017

Phage display and kinetic selection of antibodies that specifically inhibit amyloid self-replication

scientific article

Dynamics of oligomer populations formed during the aggregation of Alzheimer's Aβ42 peptide

scientific article published on 13 April 2020

α-Synuclein strains target distinct brain regions and cell types

scientific article published on 02 December 2019

Trodusquemine enhances Aβ aggregation but suppresses its toxicity by displacing oligomers from cell membranes

scientific article published in Nature Communications

Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine

article

Oligomer Diversity during the Aggregation of the Repeat Region of Tau

scientific article published on 17 July 2018

Origin of metastable oligomers and their effects on amyloid fibril self-assembly

scientific article published on 13 June 2018

Measurement of Tau Filament Fragmentation Provides Insights into Prion-like Spreading

scientific article published on 8 April 2018

Kinetic barriers to α-synuclein protofilament formation and conversion into mature fibrils

scientific article published on 01 July 2018

On the role of sidechain size and charge in the aggregation of A42 with familial mutations

article published in the Proceedings of the National Academy of Sciences of the United States of America

Preventing peptide and protein misbehavior.

scientific article published on 20 April 2015

Diffuse transition state structure for the unfolding of a leucine-rich repeat protein.

scientific article published on 18 February 2014

A microfluidic diffusion platform for characterizing the size of lipid vesicles and the thermodynamics of protein-lipid interactions.

scientific article published on 9 January 2018

Extrinsic Amyloid-Binding Dyes for Detection of Individual Protein Aggregates in Solution

scholarly article by Christopher G Taylor et al published 4 September 2018 in Analytical Chemistry

Mechanism of Fibril and Soluble Oligomer Formation in Amyloid Beta and Hen Egg White Lysozyme Proteins

scientific article published on 27 June 2019

Direct observation of murine prion protein replication in vitro

scientific article published on 23 October 2018

Transthyretin Inhibits Primary and Secondary Nucleations of Amyloid-β Peptide Aggregation and Reduces the Toxicity of Its Oligomers

scientific article published on 17 February 2020

Direct observation of prion protein oligomer formation reveals an aggregation mechanism with multiple conformationally distinct species

scientific article published on 25 March 2019

Kinetic diversity of amyloid oligomers

scientific article published on 15 May 2020

Author Correction: Dynamics of oligomer populations formed during the aggregation of Alzheimer's Aβ42 peptide

scientific article published on 17 April 2020

Plant Polyphenols Inhibit Functional Amyloid and Biofilm Formation in Pseudomonas Strains by Directing Monomers to Off-Pathway Oligomers

scientific article published on 26 October 2019

The molecular processes underpinning prion-like spreading and seed amplification in protein aggregation

scientific article published on 21 February 2020

An Environmentally Sensitive Fluorescent Dye as a Multidimensional Probe of Amyloid Formation

scientific article published on 11 February 2016

On-chip measurements of protein unfolding from direct observations of micron-scale diffusion.

scientific article

Ultrastructural evidence for self-replication of Alzheimer-associated Aβ42 amyloid along the sides of fibrils

scientific article published on 21 May 2020

Absolute Quantification of Amyloid Propagons by Digital Microfluidics

scientific article published on 3 October 2017

Autocatalytic amplification of Alzheimer-associated Aβ42 peptide aggregation in human cerebrospinal fluid

scientific article published on 08 October 2019

Rare bioactive tau oligomers from Alzheimer brain support both templated misfolding and fibril formation

Kinetic analysis reveals that independent nucleation events determine the progression of polyglutamine aggregation in C. elegans

scientific article published on 8 March 2021

Uncovering the universality of self-replication in protein aggregation and its link to disease

scientific article published on 12 August 2022

The catalytic nature of protein aggregation

scientific article published on 01 January 2020

The role of fibril structure and surface hydrophobicity in secondary nucleation of amyloid fibrils

scientific article published on 01 October 2020

Pulsed Hydrogen-Deuterium Exchange Reveals Altered Structures and Mechanisms in the Aggregation of Familial Alzheimer's Disease Mutants

scientific article published on 14 May 2021

The C-terminal tail of α-synuclein protects against aggregate replication but is critical for oligomerization

scientific article published on 10 February 2022

List of works by Georg Meisl

Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation

Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptides

Molecular mechanisms of protein aggregation from global fitting of kinetic models.

Mutations associated with familial Parkinson's disease alter the initiation and amplification steps of α-synuclein aggregation

A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity

The Aβ40 and Aβ42 peptides self-assemble into separate homomolecular fibrils in binary mixtures but cross-react during primary nucleation.

Ostwald's rule of stages governs structural transitions and morphology of dipeptide supramolecular polymers

Quantitative analysis of intrinsic and extrinsic factors in the aggregation mechanism of Alzheimer-associated Aβ-peptide

Electrostatically-guided inhibition of Curli amyloid nucleation by the CsgC-like family of chaperones

Secondary nucleation in amyloid formation

N-Terminal Extensions Retard Aβ42 Fibril Formation but Allow Cross-Seeding and Coaggregation with Aβ42

Solvent and conformation dependence of amide I vibrations in peptides and proteins containing proline

Self-assembly of MPG1, a hydrophobin protein from the rice blast fungus that forms functional amyloid coatings, occurs by a surface-driven mechanism

Physical determinants of the self-replication of protein fibrils

Scaling behaviour and rate-determining steps in filamentous self-assembly

Modulation of electrostatic interactions to reveal a reaction network unifying the aggregation behaviour of the Aβ42 peptide and its variants

Phage display and kinetic selection of antibodies that specifically inhibit amyloid self-replication

Dynamics of oligomer populations formed during the aggregation of Alzheimer's Aβ42 peptide

α-Synuclein strains target distinct brain regions and cell types

Trodusquemine enhances Aβ aggregation but suppresses its toxicity by displacing oligomers from cell membranes

Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine

Oligomer Diversity during the Aggregation of the Repeat Region of Tau

Origin of metastable oligomers and their effects on amyloid fibril self-assembly

Measurement of Tau Filament Fragmentation Provides Insights into Prion-like Spreading

Kinetic barriers to α-synuclein protofilament formation and conversion into mature fibrils

On the role of sidechain size and charge in the aggregation of A42 with familial mutations

Preventing peptide and protein misbehavior.

Diffuse transition state structure for the unfolding of a leucine-rich repeat protein.

A microfluidic diffusion platform for characterizing the size of lipid vesicles and the thermodynamics of protein-lipid interactions.

Extrinsic Amyloid-Binding Dyes for Detection of Individual Protein Aggregates in Solution

Mechanism of Fibril and Soluble Oligomer Formation in Amyloid Beta and Hen Egg White Lysozyme Proteins

Direct observation of murine prion protein replication in vitro

Transthyretin Inhibits Primary and Secondary Nucleations of Amyloid-β Peptide Aggregation and Reduces the Toxicity of Its Oligomers

Direct observation of prion protein oligomer formation reveals an aggregation mechanism with multiple conformationally distinct species

Kinetic diversity of amyloid oligomers

Author Correction: Dynamics of oligomer populations formed during the aggregation of Alzheimer's Aβ42 peptide

Plant Polyphenols Inhibit Functional Amyloid and Biofilm Formation in Pseudomonas Strains by Directing Monomers to Off-Pathway Oligomers

The molecular processes underpinning prion-like spreading and seed amplification in protein aggregation

An Environmentally Sensitive Fluorescent Dye as a Multidimensional Probe of Amyloid Formation

On-chip measurements of protein unfolding from direct observations of micron-scale diffusion.

Ultrastructural evidence for self-replication of Alzheimer-associated Aβ42 amyloid along the sides of fibrils

Absolute Quantification of Amyloid Propagons by Digital Microfluidics

Autocatalytic amplification of Alzheimer-associated Aβ42 peptide aggregation in human cerebrospinal fluid

Rare bioactive tau oligomers from Alzheimer brain support both templated misfolding and fibril formation

Kinetic analysis reveals that independent nucleation events determine the progression of polyglutamine aggregation in C. elegans

Uncovering the universality of self-replication in protein aggregation and its link to disease

The catalytic nature of protein aggregation

The role of fibril structure and surface hydrophobicity in secondary nucleation of amyloid fibrils

Pulsed Hydrogen-Deuterium Exchange Reveals Altered Structures and Mechanisms in the Aggregation of Familial Alzheimer's Disease Mutants

The C-terminal tail of α-synuclein protects against aggregate replication but is critical for oligomerization