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List of works by Pavel Souček

5' Untranslated Region Elements Show High Abundance and Great Variability in Homologous ABCA Subfamily Genes

scientific article published on 23 November 2020

A dual function of the furanocoumarin chalepensin in inhibiting Cyp2a and inducing Cyp2b in mice: the protein stabilization and receptor-mediated activation

scientific article

ABC Transporters and Their Role in the Neoadjuvant Treatment of Esophageal Cancer.

scientific article published on 15 March 2018

ABO blood groups and pancreatic cancer risk and survival: results from the PANcreatic Disease ReseArch (PANDoRA) consortium.

scientific article published on 12 February 2013

An evaluation of styrene genotoxicity using several biomarkers in a 3-year follow-up study of hand-lamination workers

scientific article published on 01 September 1999

Analysis of CHEK2 FHA domain in Czech patients with sporadic breast cancer revealed distinct rare genetic alterations

scientific article published on 04 December 2007

Ancient phylogenetic beginnings of immunoglobulin hypermutation.

scientific article published on 6 October 2006

Association of DNA repair polymorphisms with DNA repair functional outcomes in healthy human subjects

scientific article published on 06 October 2006

Association of Germline CHEK2 Gene Variants with Risk and Prognosis of Non-Hodgkin Lymphoma

scientific article published on 27 October 2015

Association of NQO1 polymorphism with spontaneous breast cancer in two independent populations.

scientific article published on May 2004

Association of superoxide dismutases and NAD(P)H quinone oxidoreductases with prognosis of patients with breast carcinomas

scientific article published on 20 April 2011

Biomonitoring of occupational exposure to styrene in a plastics lamination plant

scientific article published on 01 July 1999

Breast cancer: role of polymorphisms in biotransformation enzymes.

scientific article

CHEK2 gene alterations in the forkhead-associated domain, 1100delC and del5395 do not modify the risk of sporadic pancreatic cancer.

scientific article

CYP1B1 gene polymorphism modifies pancreatic cancer risk but not survival

article

CYP2A13, ADH1B, and ADH1C gene polymorphisms and pancreatic cancer risk

scientific article

Catechins Variously Affect Activities of Conjugation Enzymes in Proliferating and Differentiated Caco-2 Cells.

scientific article published on 7 September 2016

Chromosomal aberrations in tire plant workers and interaction with polymorphisms of biotransformation and DNA repair genes

scientific article published on 4 March 2008

Comparison of in vitro activities of biotransformation enzymes in pig, cattle, goat and sheep.

scientific article

Cytochrome P450 catalyzed oxidation of monochlorobenzene, 1,2- and 1,4-dichlorobenzene in rat, mouse, and human liver microsomes

scientific article published on August 1998

Cytochrome P450 destruction and radical scavenging by benzene and its metabolites. Evidence for the key role of quinones

scientific article published on 01 June 1994

Cytochrome P450 destruction by benzene metabolites 1,4-benzoquinone and 1,4-hydroquinone and the formation of hydroxyl radicals in minipig liver microsomes

scientific article published on 16 November 2006

Cytochrome P450 destruction by quinones: comparison of effects in rat and human liver microsomes

scientific article

Cytotoxicity of cyclophosphamide, paclitaxel, and docetaxel for tumor cell lines in vitro: effects of concentration, time and cytochrome P450-catalyzed metabolism

scientific article published on 01 October 2000

DNA damage, DNA repair rates and mRNA expression levels of cell cycle genes (TP53, p21(CDKN1A), BCL2 and BAX) with respect to occupational exposure to styrene

scientific article published on 21 October 2010

Detection of frequent ABCB1 polymorphisms by high-resolution melting curve analysis and their effect on breast carcinoma prognosis

scientific article published in November 2012

Detection of photosynthetic herbicides: algal growth inhibition test vs. electrochemical photosystem II biosensor

scientific article published on 09 September 2010

Differences in transcript levels of ABC transporters between pancreatic adenocarcinoma and nonneoplastic tissues.

scientific article published in May 2013

Different in vitro metabolism of paclitaxel and docetaxel in humans, rats, pigs, and minipigs

scientific article

Differential inductive profiles of hepatic cytochrome P450s by the extracts of Sophora flavescens in male and female C57BL/6JNarl mice

scientific article published on 20 September 2009

Do GST polymorphisms modulate the frequency of chromosomal aberrations in healthy subjects?

scientific article published on September 2009

Effect of ivermectin on activities of cytochrome P450 isoenzymes in mouflon (Ovis musimon) and fallow deer (Dama dama).

scientific article

Effect of the microsomal system on interconversions between hydroquinone, benzoquinone, oxygen activation, and lipid peroxidation

scientific article published on 01 April 2000

Effects of paclitaxel, docetaxel and their combinations on subcutaneous lymphomas in inbred Sprague-Dawley/Cub rats.

scientific article published on 23 August 2006

Evaluation of reference genes and normalization strategy for quantitative real-time PCR in human pancreatic carcinoma.

scientific article published on January 2012

Exposure to polycyclic aromatic hydrocarbons in women from Poland, Serbia and Italy--relation between PAH metabolite excretion, DNA damage, diet and genotype (the EU DIEPHY project)

scientific article published on 05 February 2013

Exposure to various benzene derivatives differently induces cytochromes P450 2B1 and P450 2E1 in rat liver

scientific article published on January 1993

Expression of Selenoprotein Genes and Association with Selenium Status in Colorectal Adenoma and Colorectal Cancer

article

Expression of cytochrome P450 2A6 in Escherichia coli: purification, spectral and catalytic characterization, and preparation of polyclonal antibodies

scientific article published on 01 October 1999

Expression of cytochrome P450 genes in CD34+ hematopoietic stem and progenitor cells.

scientific article

Expression of oxysterol pathway genes in oestrogen-positive breast carcinomas

scientific article published on 25 March 2017

Flexibility and stability of the structure of cytochromes P450 3A4 and BM-3

scientific article published on 01 May 2000

Formation of indigo by recombinant mammalian cytochrome P450.

scientific article published in November 1999

Functional, genetic, and epigenetic aspects of base and nucleotide excision repair in colorectal carcinomas

scientific article

Fusobacterium nucleatum associates with stages of colorectal neoplasia development, colorectal cancer and disease outcome.

scientific article

Genetic determinants of telomere length and risk of pancreatic cancer: a PANDoRA study

scientific article published on 12 November 2018

Genetic polymorphisms and possible gene–gene interactions in metabolic and DNA repair genes: Effects on DNA damage

article

Genetic polymorphisms in DNA repair genes and possible links with DNA repair rates, chromosomal aberrations and single-strand breaks in DNA

article

Genetic polymorphisms of biotransformation enzymes: allele frequencies in the population of the Czech Republic

scientific article published on 01 December 2000

Genetic susceptibility to pancreatic cancer and its functional characterisation: the PANcreatic Disease ReseArch (PANDoRA) consortium

scientific article published in December 2012

Genetic variants in selenoprotein genes increase risk of colorectal cancer

scientific article published on 8 April 2010

Genome-wide association study identifies an early onset pancreatic cancer risk locus

scientific article published on 09 April 2020

Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer

scientific article

Genotype and Haplotype Analyses of TP53 Gene in Breast Cancer Patients: Association with Risk and Clinical Outcomes

scientific article published on 30 July 2015

Genotype and haplotype analysis of TP53 gene and the risk of pancreatic cancer: an association study in the Czech Republic.

scientific article

Hedgehog pathway overexpression in pancreatic cancer is abrogated by new-generation taxoid SB-T-1216.

scientific article published on 30 August 2016

Identification of a common cytochrome P450 epitope near the conserved heme-binding petide with antibodies raised against recombinant cytochrome P450 family 2 proteins

scientific article published on 01 December 1995

Importance of ABCC1 for cancer therapy and prognosis.

scientific article published on 26 March 2014

Importance of Transcript Levels of Caspase-2 Isoforms S and L for Breast Carcinoma Progression ⬇️

scientific article published on March 1, 2013

Importance of genetic background of oxysterol signaling in cancer

scientific article published on 07 May 2018

Inter-species comparisons of hepatic cytochrome P450 enzyme levels in male ruminants.

scientific article published on 28 May 2003

Lack of Replication of Seven Pancreatic Cancer Susceptibility Loci Identified in Two Asian Populations

article

Markers of individual susceptibility and DNA repair rate in workers exposed to xenobiotics in a tire plant

scientific article published in January 2004

Mechanism‐based inhibition of cytochrome P450 (CYP)2A6 by chalepensin in recombinant systems, in human liver microsomes and in mice in vivo ⬇️

scientific article published on July 1, 2011

Metabolic gene variants associated with chromosomal aberrations in healthy humans

scientific article published on 27 January 2015

Metabolism of new-generation taxanes in human, pig, minipig and rat liver microsomes

scientific article published on 01 September 2006

Microsomal epoxide hydrolase 1 (EPHX1): Gene, structure, function, and role in human disease

scientific article

Minipig cytochrome P450 2E1: comparison with human enzyme

scientific article

Minipig cytochrome P450 3A, 2A and 2C enzymes have similar properties to human analogs ⬇️

scientific article published on December 5, 2001

Model systems based on experimental animals for studies on drug metabolism in man: (mini)pig cytochromes P450 3A29 and 2E1.

scientific article published in March 2005

Modulation of DNA repair capacity and mRNA expression levels of XRCC1, hOGG1 and XPC genes in styrene-exposed workers

scientific article published on 6 August 2010

Multiplex single-tube screening for mutations in the Nijmegen Breakage Syndrome (NBS1) gene in Hodgkin's and non-Hodgkin's lymphoma patients of Slavic origin.

scientific article

NAD(P)H:quinone oxidoreductase 1 Pro187Ser polymorphism and expression do not cosegregate with clinico-pathological characteristics of human mammary tumors.

scientific article published in July 2009

NBN 657del5 heterozygous mutations and colorectal cancer risk in the Czech Republic.

scientific article published on 22 April 2009

New model system for testing effects of flavonoids on doxorubicin-related formation of hydroxyl radicals

scientific article published on 01 February 2011

No association between the TP53 codon 72 polymorphism and risk or prognosis of Hodgkin and non-Hodgkin lymphoma

scientific article published on 05 May 2011

Non-coding polymorphisms in nucleotide binding domain 1 in ABCC1 gene associate with transcript level and survival of patients with breast cancer.

scientific article

Ornithine decarboxylase G316A genotype and colorectal cancer risk

scientific article published on 29 April 2010

Pharmacogenomics to Predict Tumor Therapy Response: A Focus on ATP-Binding Cassette Transporters and Cytochromes P450

scientific article published on 28 August 2020

Pig and minipig cytochromes P450

scientific article published on 01 January 2002

Plasma oxysterol levels in luminal subtype breast cancer patients are associated with clinical data

scientific article published on 23 December 2019

Polymorphisms in metabolizing enzymes and the risk of head and neck squamous cell carcinoma in the Slavic population of the central Europe.

scientific article published on January 2010

Population-based study of BRCA1/2 mutations: family history based criteria identify minority of mutation carriers

scientific article published in January 2010

Protein expression of ABCC2 and SLC22A3 associates with prognosis of pancreatic adenocarcinoma

scientific article published on 24 December 2019

Relationship between the capacity to repair 8-oxoguanine, biomarkers of genotoxicity and individual susceptibility in styrene-exposed workers

scientific article published on 09 August 2007

Role of Genetic Variation in ABC Transporters in Breast Cancer Prognosis and Therapy Response

scientific article published on 15 December 2020

Role of family D ATP-binding cassette transporters (ABCD) in cancer

scientific article

Sequence similarities of protein kinase substrates and inhibitors with immunoglobulins and model immunoglobulin homologue: cell adhesion molecule from the living fossil sponge Geodia cydonium. Mapping of coherent database similarities and implicatio

scientific article published in January 2004

Single nucleotide polymorphism in 5'-flanking region of BCL6 is not associated with increased risk of non-Hodgkin's lymphoma

scientific article published on 25 August 2005

Single nucleotide polymorphisms in the multidrug resistance gene 1 (ABCB1): effects on its expression and clinicopathological characteristics in breast cancer patients.

scientific article

Spectrum of mutations in BRCA1, BRCA2, CHEK2, and TP53 in families at high risk of breast cancer

scientific article published in March 2006

Structures composing protein domains ⬇️

scientific article published on April 10, 2013

Superoxide Dismutase and Nicotinamide Adenine Dinucleotide Phosphate

article

THE ENVIRONMENTAL POLLUTANT AND CARCINOGEN 3-NITROBENZANTHRONE AND ITS HUMAN METABOLITE 3-AMINOBENZANTHRONE ARE POTENT INDUCERS OF RAT HEPATIC CYTOCHROMES P450 1A1 AND -1A2 AND NAD(P)H:QUINONE OXIDOREDUCTASE

scientific article published on 19 May 2006

Targeted Sequencing of Pancreatic Adenocarcinomas from Patients with Metachronous Pulmonary Metastases

scientific article published on 24 November 2020

The CHEK2 gene I157T mutation and other alterations in its proximity increase the risk of sporadic colorectal cancer in the Czech population

scientific article published on 06 November 2008

The association between glutathione S-transferase gene polymorphisms and pancreatic cancer in a central European Slavonic population

scientific article published on 26 September 2009

The association between the expression of solute carrier transporters and the prognosis of pancreatic cancer.

scientific article published on 11 August 2013

The association of taxane resistance genes with the clinical course of ovarian carcinoma.

scientific article published on 28 March 2013

The effect of flavonoid derivatives on doxorubicin transport and metabolism.

scientific article published on 4 November 2007

The expression profile of ATP-binding cassette transporter genes in breast carcinoma

scientific article published on 01 April 2013

The modulation of carbonyl reductase 1 by polyphenols

scientific article published on 29 September 2015

The oxidative metabolism of dimemorfan by human cytochrome P450 enzymes.

scientific article published in February 2010

The role of ABC transporters in progression and clinical outcome of colorectal cancer.

scientific article published in March 2012

The role of CYP2E1 and 2B1 in metabolic activation of benzene derivatives

scientific article published on January 1996

The role of cytochromes p450 and aldo-keto reductases in prognosis of breast carcinoma patients

scientific article

The role of membrane transporters in ovarian cancer chemoresistance and prognosis.

scientific article published on 16 May 2017

The role of various biomarkers in the evaluation of styrene genotoxicity

scientific article published on 01 January 2003

Variation in the vitamin D receptor gene is not associated with risk of colorectal cancer in the Czech Republic.

scientific article

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