List of works - Thoas Fioretos

A glioma classification scheme based on coexpression modules of EGFR and PDGFRA.

scientific article published on 18 February 2014

A novel gene, MSI2, encoding a putative RNA-binding protein is recurrently rearranged at disease progression of chronic myeloid leukemia and forms a fusion gene with HOXA9 as a result of the cryptic t(7;17)(p15;q23).

scientific article

A novelSERPINE1-FOSBfusion gene results in transcriptional up-regulation ofFOSBin pseudomyogenic haemangioendothelioma

article

Abberant cytogenetic evolution pattern of Philadelphia-positive chronic myeloid leukemia treated with interferon-alpha

scientific article published on 01 July 1996

Activation of human telomerase reverse transcriptase through gene fusion in clear cell sarcoma of the kidney

scientific article

Acute myelomonocytic leukemia with inv(16)(p13q22) complicating Philadelphia chromosome positive chronic myeloid leukemia

scientific article published in March 1992

An EcoRI polymorphism at the insulin receptor locus on a fragment comprising exons 4 to 8.

scientific article

An improved method for detecting and delineating genomic regions with altered gene expression in cancer

scientific article

Antibodies targeting human IL1RAP (IL1R3) show therapeutic effects in xenograft models of acute myeloid leukemia.

scientific article

BCR/ABL-negative chronic myeloid leukemia with ETV6/ABL fusion

scientific article published on 01 November 1997

BRAF mutations are very rare in B- and T-cell pediatric acute lymphoblastic leukemias

scientific article published on 14 February 2008

CRK proto-oncogene maps to human chromosome band 17p13

scientific article

Clinical and genetic studies of ETV6/ABL1-positive chronic myeloid leukaemia in blast crisis treated with imatinib mesylate

scientific article

Clinical impact of breakpoint position within M-bcr in chronic myeloid leukemia

scientific article published on 01 August 1993

Clinical impact of internal tandem duplications and activating point mutations in FLT3 in acute myeloid leukemia in elderly patients.

scientific article published in May 2004

Combined high-resolution array-based comparative genomic hybridization and expression profiling of ETV6/RUNX1-positive acute lymphoblastic leukemias reveal a high incidence of cryptic Xq duplications and identify several putative target genes within

scientific article published on 09 August 2007

Cross-platform classification in microarray-based leukemia diagnostics

scientific article published on 01 June 2006

Cytogenetic and molecular genetic evolution of chronic myeloid leukemia.

scientific article

Cytogenetic evolution patterns in CML post-SCT

scientific article published on 08 January 2007

Cytogenetic polyclonality in hematologic malignancies

scientific article published on 01 March 1999

Deep sequencing and SNP array analyses of pediatric T-cell acute lymphoblastic leukemia reveal NOTCH1 mutations in minor subclones and a high incidence of uniparental isodisomies affecting CDKN2A

scientific article published on 24 April 2015

Deregulation of cyclin D2 by juxtaposition with T-cell receptor alpha/delta locus in t(12;14)(p13;q11)-positive childhood T-cell acute lymphoblastic leukemia.

scientific article

Deregulation of the Wilms' tumour gene 1 protein (WT1) by BCR/ABL1 mediates resistance to imatinib in human leukaemia cells.

scientific article published on 30 August 2007

Diagnosis of acute promyelocytic leukaemia by RT-PCR: detection of PML-RARA and RARA-PML fusion transcripts

scientific article published on 01 November 1992

ETV6/ABL fusion is rare in Ph-negative chronic myeloid disorders

scientific article

Ebf1 heterozygosity results in increased DNA damage in pro-B cells and their synergistic transformation by Pax5 haploinsufficiency

scientific article published on 2 April 2015

Establishment and phenotypic characterization of human U937 cells with inducible P210 BCR/ABL expression reveals upregulation of CEACAM1 (CD66a).

scientific article

Evidence for a single-step mechanism in the origin of hyperdiploid childhood acute lymphoblastic leukemia.

scientific article

Expression of NUP98/TOP1, but not of TOP1/NUP98, in a treatment-related myelodysplastic syndrome with t(10;20;11)(q24;q11;p15)

scientific article published on 01 June 2002

Expression of P190 and P210 BCR/ABL1 in normal human CD34(+) cells induces similar gene expression profiles and results in a STAT5-dependent expansion of the erythroid lineage.

scientific article published on 9 January 2009

Expression patterns of the human sarcoma-associated genes FUS and EWS and the genomic structure of FUS

scientific article

FLT3 mutations in a 10 year consecutive series of 177 childhood acute leukemias and their impact on global gene expression patterns

scientific article published in January 2008

Formation of der(19)t(1;19)(q23;p13) in acute lymphoblastic leukemia

scientific article published on 01 February 2005

Formation of trisomies and their parental origin in hyperdiploid childhood acute lymphoblastic leukemia

scientific article published on 26 June 2003

Fusion gene-mediated truncation of RUNX1 as a potential mechanism underlying disease progression in the 8p11 myeloproliferative syndrome

scientific article published on 01 July 2007

Fusion of the BCR and the fibroblast growth factor receptor-1 (FGFR1) genes as a result of t(8;22)(p11;q11) in a myeloproliferative disorder: the first fusion gene involving BCR but not ABL.

scientific article published in December 2001

Fusion of the FUS gene with ERG in acute myeloid leukemia with t(16;21)(p11;q22)

scientific article published on 01 December 1994

Fusion of the MORF and CBP genes in acute myeloid leukemia with the t(10;16)(q22;p13)

scientific journal article

Fusions involving protein kinase C and membrane-associated proteins in benign fibrous histiocytoma

scientific article published on 08 April 2014

Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among subtypes with specific genetic aberrations.

scientific article

Gene expression signatures in childhood acute leukemias are largely unique and distinct from those of normal tissues and other malignancies.

scientific article

Genetic analysis of dasatinib-treated chronic myeloid leukemia rapidly developing into acute myeloid leukemia with monosomy 7 in Philadelphia-negative cells

scientific article published in June 2010

High-resolution genome-wide array-based comparative genome hybridization reveals cryptic chromosome changes in AML and MDS cases with trisomy 8 as the sole cytogenetic aberration

scientific article published on 01 May 2006

IFN-alpha treatment of p190 bcr abl transgenic mice

scientific article published on 01 July 1994

IL1RAP expression as a measure of leukemic stem cell burden at diagnosis of chronic myeloid leukemia predicts therapy outcome.

scientific article published on 12 June 2015

Identification of a commonly amplified 4.3 Mb region with overexpression of C8FW, but not MYC in MYC-containing double minutes in myeloid malignancies

scientific article published on 26 May 2004

Identification of cryptic aberrations and characterization of translocation breakpoints using array CGH in high hyperdiploid childhood acute lymphoblastic leukemia

scientific article published on 14 September 2006

Identification of genes differentially regulated by the P210 BCR/ABL1 fusion oncogene using cDNA microarrays

scientific article

Impact of malignant stem cell burden on therapy outcome in newly diagnosed chronic myeloid leukemia patients

scientific article

Integrative analysis of gene expression and copy number alterations using canonical correlation analysis

scientific article

Intratumoral genome diversity parallels progression and predicts outcome in pediatric cancer

scientific article published on 27 January 2015

Isochromosome 17q in blast crisis of chronic myeloid leukemia and in other hematologic malignancies is the result of clustered breakpoints in 17p11 and is not associated with coding TP53 mutations

scientific article published on 01 July 1999

Isodicentric 7p, idic(7)(q11.2), in acute myeloid leukemia associated with older age and favorable response to induction chemotherapy: a new clinical entity?

scientific article

MYC is not overexpressed in a case of chronic myelomonocytic leukemia with MYC-containing double minutes

scientific article published on 01 April 2003

MYC-containing double minutes in hematologic malignancies: evidence in favor of the episome model and exclusion of MYC as the target gene

article

Microarray-based classification of a consecutive series of 121 childhood acute leukemias: prediction of leukemic and genetic subtype as well as of minimal residual disease status

scientific article published on 5 April 2007

Modeling chronic myeloid leukemia in immunodeficient mice reveals expansion of aberrant mast cells and accumulation of pre-B cells.

scientific article

Modeling the human 8p11-myeloproliferative syndrome in immunodeficient mice.

scientific article published on 16 June 2010

Molecular analysis of Philadelphia-positive childhood chronic myeloid leukemia

scientific article published on July 1, 1992

Molecular analysis of simple variant translocations in acute promyelocytic leukemia

scientific article published on 01 April 1994

Molecular characterization of early-stage bladder carcinomas by expression profiles, FGFR3 mutation status, and loss of 9q.

scientific article published in April 2006

Molecular signatures in childhood acute leukemia and their correlations to expression patterns in normal hematopoietic subpopulations.

scholarly article

Multicolor COBRA-FISH analysis of chronic myeloid leukemia reveals novel cryptic balanced translocations during disease progression.

scientific article published on October 2002

Mutations of FLT3, NRAS, KRAS, and PTPN11 are frequent and possibly mutually exclusive in high hyperdiploid childhood acute lymphoblastic leukemia.

scientific article published in January 2008

Myeloid malignancies with acquired trisomy 21 as the sole cytogenetic change are clinically highly variable and display a heterogeneous pattern of copy number alterations and mutations

scientific article published on 17 November 2011

New chromosomal rearrangement, t(12;22)(p13;q12), in acute nonlymphocytic leukemia

scientific article published on 01 February 1991

New oncogenic subtypes in pediatric B-cell precursor acute lymphoblastic leukemia

scientific article published on 4 August 2017

No evidence for genomic imprinting of the human BCR gene

scientific article published on 01 June 1994

Paired multiplex reverse-transcriptase polymerase chain reaction (PMRT-PCR) analysis as a rapid and accurate diagnostic tool for the detection of MLL fusion genes in hematologic malignancies

scientific article published on 01 August 2001

Pancreatic carcinoma cell lines with SMAD4 inactivation show distinct expression responses to TGFB1.

scientific article

Poor survival in t(8;21) (q22;q22)-associated acute myeloid leukaemia with leukocytosis

scientific article published in July 1997

Prognostic implications of BCL6 rearrangement in uniformly treated patients with diffuse large B-cell lymphoma--a Nordic Lymphoma Group study.

scientific article published in January 2002

RNA-seq identifies clinically relevant fusion genes in leukemia including a novel MEF2D/CSF1R fusion responsive to imatinib

scientific article

RT-PCR analysis of acute myeloid leukemia with t(8;16)(p11;p13): identification of a novel MOZ/CBP transcript and absence of CBP/MOZ expression

scientific article published on 01 December 2002

RT-PCR analysis of the MOZ-CBP and CBP-MOZ chimeric transcripts in acute myeloid leukemias with t(8;16)(p11;p13).

scientific article

Rearrangement of the transcription factor gene CHOP in myxoid liposarcomas with t(12;16)(q13;p11)

scientific article (publication date: November 1992)

Recurrent and multiple bladder tumors show conserved expression profiles

scientific article

Regional localization and developmental expression of the BCR gene in rodent brain

scientific article published on January 1995

Relapsed childhood high hyperdiploid acute lymphoblastic leukemia: presence of preleukemic ancestral clones and the secondary nature of microdeletions and RTK-RAS mutations.

scientific article published on 18 March 2010

Remarkably long survival of a patient with Ph1-positive chronic myeloid leukemia and 5' bcr rearrangement

scientific article published on 01 June 1990

SOCS2 is dispensable for BCR/ABL1-induced chronic myeloid leukemia-like disease and for normal hematopoietic stem cell function ⬇️

scientific article published on June 22, 2012

Selective killing of candidate AML stem cells by antibody targeting of IL1RAP.

scientific article published on 11 March 2013

Smad4 binds Hoxa9 in the cytoplasm and protects primitive hematopoietic cells against nuclear activation by Hoxa9 and leukemia transformation

scientific article published on 6 April 2011

Standpoint on imprinting of BCR and ABL.

scientific article published in April 1995

The DNA methylome of pediatric acute lymphoblastic leukemia

scientific article published on 13 August 2009

The FLT3 inhibitor PKC412 in combination with cytostatic drugs in vitro in acute myeloid leukemia.

scientific article published on 25 October 2007

The breakpoint region of the most common isochromosome, i(17q), in human neoplasia is characterized by a complex genomic architecture with large, palindromic, low-copy repeats

scientific article

The emerging complexity of gene fusions in cancer

scientific article published on June 2015

The genomic landscape of high hyperdiploid childhood acute lymphoblastic leukemia

scientific article

The incidence of trisomy 8 as a sole chromosomal aberration in myeloid malignancies varies in relation to gender, age, prior iatrogenic genotoxic exposure, and morphology

scientific article published on 01 October 2001

The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias

scientific article

The t(X;7)(q22;q34) in paediatric T-cell acute lymphoblastic leukaemia results in overexpression of the insulin receptor substrate 4 gene through illegitimate recombination with the T-cell receptor beta locus.

scientific article

Threshold-free high-power methods for the ontological analysis of genome-wide gene-expression studies

scientific article published on January 2007

Tiling resolution array comparative genomic hybridization, expression and methylation analyses of dup(1q) in Burkitt lymphomas and pediatric high hyperdiploid acute lymphoblastic leukemias reveal clustered near-centromeric breakpoints and overexpres

scientific article

Trisomy 8 as the sole chromosomal aberration in myelocytic malignancies: a multicolor and locus-specific fluorescence in situ hybridization study

scientific article published on January 2003

Whole-exome sequencing of pediatric acute lymphoblastic leukemia.

scientific article published on 18 November 2011

t(3;21)(q26;q22) with AML1 rearrangement in a de novo childhood acute monoblastic leukaemia

scientific article published on 01 February 1996

List of works by Thoas Fioretos

A glioma classification scheme based on coexpression modules of EGFR and PDGFRA.

A novel gene, MSI2, encoding a putative RNA-binding protein is recurrently rearranged at disease progression of chronic myeloid leukemia and forms a fusion gene with HOXA9 as a result of the cryptic t(7;17)(p15;q23).

A novelSERPINE1-FOSBfusion gene results in transcriptional up-regulation ofFOSBin pseudomyogenic haemangioendothelioma

Abberant cytogenetic evolution pattern of Philadelphia-positive chronic myeloid leukemia treated with interferon-alpha

Activation of human telomerase reverse transcriptase through gene fusion in clear cell sarcoma of the kidney

Acute myelomonocytic leukemia with inv(16)(p13q22) complicating Philadelphia chromosome positive chronic myeloid leukemia

An EcoRI polymorphism at the insulin receptor locus on a fragment comprising exons 4 to 8.

An improved method for detecting and delineating genomic regions with altered gene expression in cancer

Antibodies targeting human IL1RAP (IL1R3) show therapeutic effects in xenograft models of acute myeloid leukemia.

BCR/ABL-negative chronic myeloid leukemia with ETV6/ABL fusion

BRAF mutations are very rare in B- and T-cell pediatric acute lymphoblastic leukemias

CRK proto-oncogene maps to human chromosome band 17p13

Clinical and genetic studies of ETV6/ABL1-positive chronic myeloid leukaemia in blast crisis treated with imatinib mesylate

Clinical impact of breakpoint position within M-bcr in chronic myeloid leukemia

Clinical impact of internal tandem duplications and activating point mutations in FLT3 in acute myeloid leukemia in elderly patients.

Combined high-resolution array-based comparative genomic hybridization and expression profiling of ETV6/RUNX1-positive acute lymphoblastic leukemias reveal a high incidence of cryptic Xq duplications and identify several putative target genes within

Cross-platform classification in microarray-based leukemia diagnostics

Cytogenetic and molecular genetic evolution of chronic myeloid leukemia.

Cytogenetic evolution patterns in CML post-SCT

Cytogenetic polyclonality in hematologic malignancies

Deep sequencing and SNP array analyses of pediatric T-cell acute lymphoblastic leukemia reveal NOTCH1 mutations in minor subclones and a high incidence of uniparental isodisomies affecting CDKN2A

Deregulation of cyclin D2 by juxtaposition with T-cell receptor alpha/delta locus in t(12;14)(p13;q11)-positive childhood T-cell acute lymphoblastic leukemia.

Deregulation of the Wilms' tumour gene 1 protein (WT1) by BCR/ABL1 mediates resistance to imatinib in human leukaemia cells.

Diagnosis of acute promyelocytic leukaemia by RT-PCR: detection of PML-RARA and RARA-PML fusion transcripts

ETV6/ABL fusion is rare in Ph-negative chronic myeloid disorders

Ebf1 heterozygosity results in increased DNA damage in pro-B cells and their synergistic transformation by Pax5 haploinsufficiency

Establishment and phenotypic characterization of human U937 cells with inducible P210 BCR/ABL expression reveals upregulation of CEACAM1 (CD66a).

Evidence for a single-step mechanism in the origin of hyperdiploid childhood acute lymphoblastic leukemia.

Expression of NUP98/TOP1, but not of TOP1/NUP98, in a treatment-related myelodysplastic syndrome with t(10;20;11)(q24;q11;p15)

Expression of P190 and P210 BCR/ABL1 in normal human CD34(+) cells induces similar gene expression profiles and results in a STAT5-dependent expansion of the erythroid lineage.

Expression patterns of the human sarcoma-associated genes FUS and EWS and the genomic structure of FUS

FLT3 mutations in a 10 year consecutive series of 177 childhood acute leukemias and their impact on global gene expression patterns

Formation of der(19)t(1;19)(q23;p13) in acute lymphoblastic leukemia

Formation of trisomies and their parental origin in hyperdiploid childhood acute lymphoblastic leukemia

Fusion gene-mediated truncation of RUNX1 as a potential mechanism underlying disease progression in the 8p11 myeloproliferative syndrome

Fusion of the BCR and the fibroblast growth factor receptor-1 (FGFR1) genes as a result of t(8;22)(p11;q11) in a myeloproliferative disorder: the first fusion gene involving BCR but not ABL.

Fusion of the FUS gene with ERG in acute myeloid leukemia with t(16;21)(p11;q22)

Fusion of the MORF and CBP genes in acute myeloid leukemia with the t(10;16)(q22;p13)

Fusions involving protein kinase C and membrane-associated proteins in benign fibrous histiocytoma

Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among subtypes with specific genetic aberrations.

Gene expression signatures in childhood acute leukemias are largely unique and distinct from those of normal tissues and other malignancies.

Genetic analysis of dasatinib-treated chronic myeloid leukemia rapidly developing into acute myeloid leukemia with monosomy 7 in Philadelphia-negative cells

High-resolution genome-wide array-based comparative genome hybridization reveals cryptic chromosome changes in AML and MDS cases with trisomy 8 as the sole cytogenetic aberration

IFN-alpha treatment of p190 bcr abl transgenic mice

IL1RAP expression as a measure of leukemic stem cell burden at diagnosis of chronic myeloid leukemia predicts therapy outcome.

Identification of a commonly amplified 4.3 Mb region with overexpression of C8FW, but not MYC in MYC-containing double minutes in myeloid malignancies

Identification of cryptic aberrations and characterization of translocation breakpoints using array CGH in high hyperdiploid childhood acute lymphoblastic leukemia

Identification of genes differentially regulated by the P210 BCR/ABL1 fusion oncogene using cDNA microarrays

Impact of malignant stem cell burden on therapy outcome in newly diagnosed chronic myeloid leukemia patients

Integrative analysis of gene expression and copy number alterations using canonical correlation analysis

Intratumoral genome diversity parallels progression and predicts outcome in pediatric cancer

Isochromosome 17q in blast crisis of chronic myeloid leukemia and in other hematologic malignancies is the result of clustered breakpoints in 17p11 and is not associated with coding TP53 mutations

Isodicentric 7p, idic(7)(q11.2), in acute myeloid leukemia associated with older age and favorable response to induction chemotherapy: a new clinical entity?

MYC is not overexpressed in a case of chronic myelomonocytic leukemia with MYC-containing double minutes

MYC-containing double minutes in hematologic malignancies: evidence in favor of the episome model and exclusion of MYC as the target gene

Microarray-based classification of a consecutive series of 121 childhood acute leukemias: prediction of leukemic and genetic subtype as well as of minimal residual disease status

Modeling chronic myeloid leukemia in immunodeficient mice reveals expansion of aberrant mast cells and accumulation of pre-B cells.

Modeling the human 8p11-myeloproliferative syndrome in immunodeficient mice.

Molecular analysis of Philadelphia-positive childhood chronic myeloid leukemia

Molecular analysis of simple variant translocations in acute promyelocytic leukemia

Molecular characterization of early-stage bladder carcinomas by expression profiles, FGFR3 mutation status, and loss of 9q.

Molecular signatures in childhood acute leukemia and their correlations to expression patterns in normal hematopoietic subpopulations.

Multicolor COBRA-FISH analysis of chronic myeloid leukemia reveals novel cryptic balanced translocations during disease progression.

Mutations of FLT3, NRAS, KRAS, and PTPN11 are frequent and possibly mutually exclusive in high hyperdiploid childhood acute lymphoblastic leukemia.

Myeloid malignancies with acquired trisomy 21 as the sole cytogenetic change are clinically highly variable and display a heterogeneous pattern of copy number alterations and mutations

New chromosomal rearrangement, t(12;22)(p13;q12), in acute nonlymphocytic leukemia

New oncogenic subtypes in pediatric B-cell precursor acute lymphoblastic leukemia

No evidence for genomic imprinting of the human BCR gene

Paired multiplex reverse-transcriptase polymerase chain reaction (PMRT-PCR) analysis as a rapid and accurate diagnostic tool for the detection of MLL fusion genes in hematologic malignancies

Pancreatic carcinoma cell lines with SMAD4 inactivation show distinct expression responses to TGFB1.

Poor survival in t(8;21) (q22;q22)-associated acute myeloid leukaemia with leukocytosis

Prognostic implications of BCL6 rearrangement in uniformly treated patients with diffuse large B-cell lymphoma--a Nordic Lymphoma Group study.

RNA-seq identifies clinically relevant fusion genes in leukemia including a novel MEF2D/CSF1R fusion responsive to imatinib

RT-PCR analysis of acute myeloid leukemia with t(8;16)(p11;p13): identification of a novel MOZ/CBP transcript and absence of CBP/MOZ expression

RT-PCR analysis of the MOZ-CBP and CBP-MOZ chimeric transcripts in acute myeloid leukemias with t(8;16)(p11;p13).

Rearrangement of the transcription factor gene CHOP in myxoid liposarcomas with t(12;16)(q13;p11)

Recurrent and multiple bladder tumors show conserved expression profiles

Regional localization and developmental expression of the BCR gene in rodent brain

Relapsed childhood high hyperdiploid acute lymphoblastic leukemia: presence of preleukemic ancestral clones and the secondary nature of microdeletions and RTK-RAS mutations.