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List of works by Lars Tönges

AAV.shRNA-mediated downregulation of ROCK2 attenuates degeneration of dopaminergic neurons in toxin-induced models of Parkinson's disease in vitro and in vivo

scientific article published on 2 October 2014

Acute axonal degeneration in vivo is attenuated by inhibition of autophagy in a calcium-dependent manner

scientific article published on July 2010

Alpha-Synuclein affects neurite morphology, autophagy, vesicle transport and axonal degeneration in CNS neurons.

scientific article

Alpha-synuclein mutations impair axonal regeneration in models of Parkinson's disease.

scientific article published on 10 September 2014

Altered Expression of Growth Associated Protein-43 and Rho Kinase in Human Patients with Parkinson's Disease

scientific article published on 8 January 2016

Antibody-based immunotherapies for Parkinsonian syndromes

scientific article published on 01 November 2019

Association of Blood Pressure With Outcomes in Acute Stroke Thrombectomy

scientific article published on 13 January 2020

Axonal degeneration as a therapeutic target in the CNS.

scientific article published on 06 March 2012

BAG1 promotes axonal outgrowth and regeneration in vivo via Raf-1 and reduction of ROCK activity.

scientific article published on 29 August 2008

Blood Contamination in CSF and Its Impact on Quantitative Analysis of Alpha-Synuclein

scientific article published on 05 February 2020

Brainstem Encephalitis With Low-Titer Acetylcholine Receptor Antibodies Mimicking Myasthenia Gravis

scientific article published on 02 August 2019

Brainstem Raphe Alterations in TCS: A Biomarker for Depression and Apathy in Parkinson's Disease Patients

scholarly article by Daniel Richter et al published 2018 in Frontiers in Neurology

Building a Parkinson-Network-Experiences from Germany

scientific article published on 25 August 2020

CSF Sample Preparation for Data-Independent Acquisition

scientific article published on 01 January 2019

Calpain-mediated cleavage of collapsin response mediator protein-2 drives acute axonal degeneration

scientific article

Charakteristika und Dynamik der stationären Behandlung von Parkinson-Patienten in Deutschland

scholarly article by Lars Tönges et al published 6 August 2018 in Der Nervenarzt

Classification of advanced stages of Parkinson's disease: translation into stratified treatments

scientific article published on 24 March 2017

Clinical testing and spinal cord removal in a mouse model for amyotrophic lateral sclerosis (ALS)

scientific article published on 17 March 2012

Combined inhibition of Cdk5 and ROCK additively increase cell survival, but not the regenerative response in regenerating retinal ganglion cells

scientific article published on 25 September 2009

Comment on: A 57-Year-Old Woman With Progressive Left Hand Clumsiness and Falls

scientific article published on 15 May 2020

Coronal Transcranial Sonography and M-Mode Tremor Frequency Determination in Parkinson's Disease and Essential Tremor

scientific article published on 20 April 2017

Correlates of polyneuropathy in Parkinson's disease

scientific article published on 17 September 2020

Das idiopathische Parkinsonsyndrom und Schmerz – diagnostische und therapeutische Ansätze für ein herausforderndes nicht-motorisches Symptom

Deferiprone Rescues Behavioral Deficits Induced by Mild Iron Exposure in a Mouse Model of Alpha-Synuclein Aggregation

scientific article published on 16 June 2017

Dynamics of Parkinson's Disease Multimodal Complex Treatment in Germany from 2010⁻2016: Patient Characteristics, Access to Treatment, and Formation of Regional Centers

article

Dynamics of device-based treatments for Parkinson's disease in Germany from 2010 to 2017: application of continuous subcutaneous apomorphine, levodopa-carbidopa intestinal gel, and deep brain stimulation

scientific article published on 20 June 2019

Dyskinesia in multiple system atrophy and progressive supranuclear palsy

scientific article published on 13 May 2019

Elemental fingerprint as a cerebrospinal fluid biomarker for the diagnosis of Parkinson's disease

scientific article published in February 2018

Elemental fingerprint: Reassessment of a cerebrospinal fluid biomarker for Parkinson's disease

scientific article published on 13 November 2019

Emergence of Bruxism after Reducing Left Pallidal Stimulation in a Patient with Huntington's Disease

scientific article published on 16 July 2020

Emerging Immunotherapies for Parkinson Disease.

scientific article

Epidemiology of Parkinson's Disease and Current Concepts of Outpatient Care in Germany

scientific article published on 23 June 2017

Fasudil attenuates aggregation of α-synuclein in models of Parkinson's disease

scientific article published on 22 April 2016

Fingolimod for Irradiation-Induced Neurodegeneration

scientific article published on 09 July 2019

GluN2D-containing NMDA receptors-mediate synaptic currents in hippocampal interneurons and pyramidal cells in juvenile mice

scientific article published on 25 March 2015

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Hematopoietic cytokines--on the verge of conquering neurology

scientific article published on March 2007

Hepatocyte growth factor protects retinal ganglion cells by increasing neuronal survival and axonal regeneration in vitro and in vivo.

scientific article published on 26 April 2011

High-Resolution Nerve Ultrasound and Electrophysiological Findings in Restless Legs Syndrome

Hospitalization Rates and Comorbidities in Patients with Progressive Supranuclear Palsy in Germany from 2010 to 2017

scientific article published on 31 July 2020

Imaging of rat optic nerve axons in vivo

scientific article

Impairment of Motor Function Correlates with Neurometabolite and Brain Iron Alterations in Parkinson's Disease

scholarly article by Beate Pesch et al published 29 January 2019 in Cells

Inhibition of rho kinase enhances survival of dopaminergic neurons and attenuates axonal loss in a mouse model of Parkinson's disease

scientific article

Interventional Influence of the Intestinal Microbiome Through Dietary Intervention and Bowel Cleansing Might Improve Motor Symptoms in Parkinson's Disease

scientific article published on 06 February 2020

JNK isoforms differentially regulate neurite growth and regeneration in dopaminergic neurons in vitro.

scientific article

Landscape of pain in Parkinson's disease: impact of gender differences

scientific article published on 12 October 2018

Lentiform Nucleus Hyperechogenicity in Parkinsonian Syndromes: A Systematic Review and Meta-Analysis with Consideration of Molecular Pathology

scientific article published on 18 December 2019

Letter to the editor: risk comorbidities of COVID-19 in Parkinson's disease patients in Germany

scientific article published on 11 August 2020

Mechanisms of acute axonal degeneration in the optic nerve in vivo

scientific article

Modulation of Microglial Activity by Rho-Kinase (ROCK) Inhibition as Therapeutic Strategy in Parkinson's Disease and Amyotrophic Lateral Sclerosis

scientific article published on 04 April 2017

Motor, cognitive and mobility deficits in 1000 geriatric patients: protocol of a quantitative observational study before and after routine clinical geriatric treatment - the ComOn-study

scientific article published on 06 February 2020

Novel Immunotherapeutic Approaches to Target Alpha-Synuclein and Related Neuroinflammation in Parkinson's Disease

scientific article published on 31 January 2019

Parkinson's Disease Multimodal Complex Treatment (PD-MCT): Analysis of Therapeutic Effects and Predictors for Improvement

scientific article published on 16 June 2020

Parkinson's Disease Multimodal Complex Treatment improves motor symptoms, depression and quality of life

scientific article published on 03 December 2019

Parkinson-Erkrankung und Neuroinflammation – Zelluläre Pathologie, Mechanismen und therapeutische Optionen

scholarly article by Lars Tönges et al published 17 July 2018 in Fortschritte der Neurologie, Psychiatrie

Praktische Anwendung der kontinuierlichen Apomorphin-Pumpentherapie

Propionic Acid and Fasudil as Treatment Against Rotenone Toxicity in an In Vitro Model of Parkinson's Disease

scientific article published on 28 May 2020

ROCK inhibition and CNTF interact on intrinsic signalling pathways and differentially regulate survival and regeneration in retinal ganglion cells

scientific article published on 5 December 2007

ROCK inhibition in models of neurodegeneration and its potential for clinical translation

scientific article published on 2 April 2018

ROCK2 is a major regulator of axonal degeneration, neuronal death and axonal regeneration in the CNS.

scientific article

ROCKing Regeneration: Rho Kinase Inhibition as Molecular Target for Neurorestoration.

scientific article

Reversible Immuno-Infrared Sensor for the Detection of Alzheimer's Disease Related Biomarkers

scientific article published on 10 July 2019

Rho Kinase Inhibition with Fasudil in the SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis-Symptomatic Treatment Potential after Disease Onset

scientific article published on 31 January 2017

Rho kinase inhibition by fasudil in the striatal 6-hydroxydopamine lesion mouse model of Parkinson disease

scientific article published in August 2014

Rho kinase inhibition modulates microglia activation and improves survival in a model of amyotrophic lateral sclerosis.

scientific article published on 6 December 2013

Selenium speciation analysis in the cerebrospinal fluid of patients with Parkinson's disease

scientific article published on 24 September 2019

Septic embolic encephalitis after Staphylococcus aureus endocarditis of a prosthetic valve in a 57-year-old woman: a case report

scientific article published on 31 July 2009

Specialized Staff for the Care of People with Parkinson's Disease in Germany: An Overview

scientific article published on 10 August 2020

Stearylated octaarginine and artificial virus-like particles for transfection of siRNA into primary rat neurons

scientific article published on 12 May 2006

TAT-Hsp70-mediated neuroprotection and increased survival of neuronal precursor cells after focal cerebral ischemia in mice

scientific article published on 22 April 2009

TDP-43 as structure-based biomarker in amyotrophic lateral sclerosis

scientific article published on 02 December 2020

TGF-beta 1 enhances neurite outgrowth via regulation of proteasome function and EFABP.

scientific article published on 6 March 2010

Tat-Hsp70 protects dopaminergic neurons in midbrain cultures and in the substantia nigra in models of Parkinson's disease.

scientific article published on 24 December 2007

The rho kinase inhibitor Y-27632 improves motor performance in male SOD1(G93A) mice

scientific article

The spinal muscular atrophy disease protein SMN is linked to the Rho-kinase pathway via profilin.

scientific article published on 14 September 2011

Transduction of neural precursor cells with TAT-heat shock protein 70 chaperone: therapeutic potential against ischemic stroke after intrastriatal and systemic transplantation

scientific article published on June 2012

Upregulation of reggie-1/flotillin-2 promotes axon regeneration in the rat optic nerve in vivo and neurite growth in vitro.

scientific article

Viral vector-mediated downregulation of RhoA increases survival and axonal regeneration of retinal ganglion cells

scientific article

[Care of patients with Parkinson's disease in Germany]

scientific article published on 18 March 2020

[Parkinson Networks in Germany: Future or Utopia?]

scientific article published on 06 April 2020

miR-182-5p and miR-183-5p Act as GDNF Mimics in Dopaminergic Midbrain Neurons.

scientific article

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