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List of works by Michael S. Roberts

'Massive' metformin overdose

scientific article published on 17 April 2018

2-Methyl-4-chlorophenoxyacetic acid (MCPA) and bromoxynil herbicide ingestion

scientific article

2-Methyl-4-chlorophenoxyacetic acid and bromoxynil herbicide death

scientific article

A Comparison of the Penetration and Permeation of Caffeine into and through Human Epidermis after Application in Various Vesicle Formulations

scientific article published on 06 November 2015

A comparison of hepatic ischemia/hypoxia-reperfusion injury models

scientific article published on 19 March 2013

A compartmental model of hepatic disposition kinetics: 1. Model development and application to linear kinetics

scientific article published in April 2002

A dispersion model of hepatic elimination: 1. Formulation of the model and bolus considerations

scientific article published in June 1986

A dispersion model of hepatic elimination: 2. Steady-state considerations-influence of hepatic blood flow, binding within blood, and hepatocellular enzyme activity

scientific article published on 01 June 1986

A dispersion model of hepatic elimination: 3. Application to metabolite formation and elimination kinetics

scientific article published in June 1986

A model to study intestinal and hepatic metabolism of propranolol in the dog.

scientific article published in February 2004

A multicenter study on the effect of continuous hemodiafiltration intensity on antibiotic pharmacokinetics

scientific article published on 13 March 2015

A novel way to investigate the effects of plasma exchange on antibiotic levels: use of microdialysis

scientific article published on 4 December 2007

A physiological pharmacokinetic model for solute disposition in tissues below a topical below a topical application site

scientific article published in September 1999

A physiologically based kinetic model for elucidating the in vivo distribution of administered mesenchymal stem cells.

scientific article published on 29 February 2016

A preliminary study of atorvastatin plasma concentrations in critically ill patients with sepsis.

scientific article published on 26 November 2008

A special issue on skin nanotechnology

scientific article published on 01 October 2010

Absorption of sunscreens across human skin: an evaluation of commercial products for children and adults

scientific article

Acute human self-poisoning with bispyribac-containing herbicide Nominee: a prospective observational study

scientific article

Adequacy of high-dose cefepime regimen in febrile neutropenic patients with hematological malignancies

scientific article

Aging and the response of the isolated perfused rat liver to vasoactive drugs.

scientific article

Altered pharmacokinetics of piperacillin in febrile neutropenic patients with hematological malignancy

scientific article

Alternative methods to animal studies for the evaluation of topical/transdermal drug delivery systems

scientific article published on 12 April 2018

An Optimized Model for Rat Liver Perfusion Studies

scientific article published on 01 November 1996

An analysis of solute structure-human epidermal transport relationships in epidermal iontophoresis using the ionic mobility: pore model.

scientific article

An improved nonlinear model describing the hepatic pharmacokinetics of digoxin: evidence for two functionally different uptake systems and saturable binding

scientific article published on 13 July 2010

An improved survival model of hypoxia/ischaemia in the piglet suitable for neuroprotection studies

scientific article

An international, multicentre survey of β-lactam antibiotic therapeutic drug monitoring practice in intensive care units

scientific article published on 16 January 2014

An isolated in-situ rat head perfusion model for pharmacokinetic studies

scientific article published on 01 February 2000

An isolated perfused human placental lobule model for multiple indicator dilution studies

scientific article published on 01 September 1997

Analysis of the metabolic deterioration of ex vivo skin from ischemic necrosis through the imaging of intracellular NAD(P)H by multiphoton tomography and fluorescence lifetime imaging microscopy

scientific article published on 01 July 2010

Anionic Long-Circulating Quantum Dots for Long-Term Intravital Vascular Imaging

scientific article published on 20 November 2018

Antibiotic dosing in the 'at risk' critically ill patient: Linking pathophysiology with pharmacokinetics/pharmacodynamics in sepsis and trauma patients

scientific article

Antioxidative function of L-FABP in L-FABP stably transfected Chang liver cells

scientific article

Applications of multiphoton tomographs and femtosecond laser nanoprocessing microscopes in drug delivery research.

scientific article

Are standard doses of piperacillin sufficient for critically ill patients with augmented creatinine clearance?

scientific article

Assessment of feasibility of maillard reaction between baclofen and lactose by liquid chromatography and tandem mass spectrometry, application to pre formulation studies.

scientific article published on 20 May 2009

Availability of isosorbide dinitrate, diazepam and chlormethiazole, from i.v. delivery systems

scientific article published in February 1981

Availability predictions by hepatic elimination models for Michaelis-Menten kinetics

scientific article published on December 1989

Axial tissue diffusion can account for the disparity between current models of hepatic elimination for lipophilic drugs

scientific article published in February 1992

Background free imaging of upconversion nanoparticle distribution in human skin

scientific article published in June 2013

Baclofen in the treatment of alcohol dependence with or without liver disease: multisite, randomised, double-blind, placebo-controlled trial

scientific article published on 02 May 2018

Bathing Does Not Facilitate Human Skin Penetration or Adverse Cellular Effects of Nanoparticulate Zinc Oxide Sunscreens after Topical Application

scientific article published on 21 January 2020

Blood flow measurements in skin and underlying tissues by microsphere method: application to dermal pharmacokinetics of polar nonelectrolytes

scientific article published in September 1993

Bovine-serum-albumin-containing receptor phase better predicts transdermal absorption parameters for lipophilic compounds.

scientific article published in April 2003

Bromoxynil and 2-methyl-4-chlorophenoxyacetic acid (MCPA) poisoning could be a bad combination.

scientific article

Can increasing the viscosity of formulations be used to reduce the human skin penetration of the sunscreen oxybenzone?

scientific article published in July 2001

Can therapeutic drug monitoring optimize exposure to piperacillin in febrile neutropenic patients with haematological malignancies? A randomized controlled trial

scientific article published on 7 May 2015

Cardiovascular toxicity with levetiracetam overdose.

scientific article

Catheter effects in organ perfusion experiments

scientific article published in January 2002

Cationic drug pharmacokinetics in diseased livers determined by fibrosis index, hepatic protein content, microsomal activity, and nature of drug

scientific article published in June 2002

Cellular metabolism and pore lifetime of human skin following microprojection array mediation

scientific article published on 21 May 2019

Challenges and innovations of drug delivery in older age

scientific article published on 11 September 2018

Changes in antibiotic distribution due to pancreatitis

scientific article

Changes in the redox state and endogenous fluorescence of in vivo human skin due to intrinsic and photo-aging, measured by multiphoton tomography with fluorescence lifetime imaging

scientific article published in June 2013

Characterization of optical properties of ZnO nanoparticles for quantitative imaging of transdermal transport

scientific article published on 15 November 2011

Characterization of the physiological spaces and distribution of tolbutamide in the perfused rat pancreas

scientific article published in March 2007

Chloroform ingestion causing severe gastrointestinal injury, hepatotoxicity and dermatitis confirmed with plasma chloroform concentrations.

scientific article

Clinical applicability of current pharmacokinetic models: splanchnic elimination of 5-fluorouracil in cancer patients

scientific article

Clinical pharmacokinetics of high dose mebendazole in patients treated for cystic hydatid disease

scientific article published on 01 January 1982

Commentary: using the convection-dispersion model and transit time density functions in the analysis of organ distribution kinetics

scientific article published in December 2000

Compartmental modeling of skin transport

scientific article published on 19 July 2018

Compatibility studies of acyclovir and lactose in physical mixtures and commercial tablets.

scientific article published on 23 July 2009

CompoundAstragalusandSalvia miltiorrhizaextract inhibits cell invasion by modulating transforming growth factor-β/Smad in HepG2 cell

scientific article published on 27 September 2009

Computational strategies unravel and trace how liver disease changes hepatic drug disposition

scientific article published on 23 October 2008

Concentration dependency in nicotine skin penetration flux from aqueous solutions reflects vehicle induced changes in nicotine stratum corneum retention.

scientific article

Concise Review: Quantitative Detection and Modeling the In Vivo Kinetics of Therapeutic Mesenchymal Stem/Stromal Cells.

scientific article published on 6 December 2017

Continuation of Statin Therapy in Patients with Presumed Infection

scientific article published on 19 October 2010

Convective transport of highly plasma protein bound drugs facilitates direct penetration into deep tissues after topical application.

scientific article

Defining a Model to Predict the Distribution of Topically Applied Growth Factors and Other Solutes in Excisional Full-Thickness Wounds

scientific article published on 01 January 1999

Dermal and underlying tissue pharmacokinetics of lidocaine after topical application

scientific article published in June 1994

Dermal and underlying tissue pharmacokinetics of salicylic acid after topical application

scientific article published in August 1993

Designer artificial membrane binding proteins to direct stem cells to the myocardium

scientific article published on 03 July 2019

Designing inorganic light-protective skin nanotechnology products

scientific article published on October 1, 2010

Determination of aspirin and its major metabolites in plasma by high-performance liquid chromatography without solvent extraction ⬇️

scientific article published on September 11, 1981

Determination of benzylpenicillin in plasma and urine by high-performance liquid chromatography

Determination of the effect of lipophilicity on the in vitro permeability and tissue reservoir characteristics of topically applied solutes in human skin layers.

scientific article published in May 2003

Determination of trovafloxacin and marbofloxacin in sheep plasma samples by HPLC using UV detection

scientific article published on 15 January 2012

Development and Evaluation of Lipid Nanoparticles Containing Natural Botanical Oil for Sun Protection: Characterization and in vitro and in vivo Human Skin Permeation and Toxicity.

scientific article published on 4 November 2017

Development and validation of a reversed-phase high-performance liquid chromatographic method for quantification of peptide dendrimers in human skin permeation experiments

scientific article published on 29 August 2009

Development and validation of the patients' attitudes towards deprescribing (PATD) questionnaire

scientific article published on 09 October 2012

Development of a Sensitive and Specific Radioimmunoassay for Benztropine

article

Development of a quality use of medicines coding system to rate clinical pharmacists' medication review recommendations.

scientific article published on October 2003

Dialysis-assisted fiber optic spectroscopy for in situ biomedical sensing

scientific article

Diffusion Modelling of Percutaneous Absorption Kinetics: 4. Effects of a Slow Equilibration Process Within Stratum Corneum on Absorption and Desorption Kinetics

scientific article published on 01 February 2009

Diffusion modeling of percutaneous absorption kinetics. 1. Effects of flow rate, receptor sampling rate, and viable epidermal resistance for a constant donor concentration

scientific article published in November 1999

Diffusion modeling of percutaneous absorption kinetics. 1. Effects of flow rate, receptor sampling rate, and viable epidermal resistance for a constant donor concentration.

scientific article

Diffusion modeling of percutaneous absorption kinetics: 2. Finite vehicle volume and solvent deposited solids

scientific article published in April 2001

Diffusion modeling of percutaneous absorption kinetics: 3. Variable diffusion and partition coefficients, consequences for stratum corneum depth profiles and desorption kinetics.

scientific article

Diffusion modelling of percutaneous absorption kinetics. Predicting urinary excretion from in vitro skin permeation tests (IVPT) for an infinite dose

scientific article published on 01 February 2020

Disposition and measured toxicity of zinc oxide nanoparticles and zinc ions against keratinocytes in cell culture and viable human epidermis

scientific article published on 31 January 2020

Disposition kinetics of propranolol isomers in the perfused rat liver.

scientific article

Distribution kinetics of diazepam, lidocaine and antipyrine in the isolated perfused rat hindlimb

scientific article published in November 1997

Distribution kinetics of solutes in the isolated in-situ perfused rat head using the multiple indicator dilution technique and a physiological two-barrier model

scientific article published in March 2002

Does Beta-lactam Pharmacokinetic Variability in Critically Ill Patients Justify Therapeutic Drug Monitoring? A Systematic Review

scientific article

Drug structure-transport relationships

scientific article

Dry-coated microprojection array patches for targeted delivery of immunotherapeutics to the skin

article

Effect of Obesity on the Population Pharmacokinetics of Fluconazole in Critically Ill Patients

scientific article published on 22 August 2016

Effect of Obesity on the Population Pharmacokinetics of Meropenem in Critically Ill Patients

scientific article published on 16 May 2016

Effect of adjuvant-induced systemic inflammation in rats on hepatic disposition kinetics of taurocholate.

scientific article published on 28 October 2010

Effect of flexing and massage on in vivo human skin penetration and toxicity of zinc oxide nanoparticles

scientific article published on 22 April 2016

Effect of posture and sleep on pharmacokinetics

scientific article published on 01 August 1980

Effect of vehicle pretreatment on the flux, retention, and diffusion of topically applied penetrants in vitro.

scientific article published in September 2003

Effect of vehicles on the maximum transepidermal flux of similar size phenolic compounds

scientific article

Effects of hypoxia/reperfusion injury on drug disposition in the rat isolated perfused liver

scientific article published in April 2007

Effects of magnesium deficiency--more than skin deep.

scientific article

Effects of vasoconstriction on dermal pharmacokinetics and local tissue distribution of compounds

scientific article published in June 1994

Enhanced sonophoretic delivery of 5-aminolevulinic acid: preliminary human ex vivo permeation data

scientific article

Enhanced transdermal delivery of 5-aminolevulinic acid and a dipeptide by iontophoresis

scientific article published on 01 January 2011

Epidermal iontophoresis: I. Development of the ionic mobility-pore model

scientific article published in October 1998

Epidermal iontophoresis: II. Application of the ionic mobility-pore model to the transport of local anesthetics

scientific article published in October 1998

Estimating Maximal In Vitro Skin Permeation Flux from Studies Using Non-sink Receptor Phase Conditions.

scientific article published on 16 June 2016

Estimation of sinusoidal flow heterogeneity in normal and diseased rat livers from tracer dilution data using a fractal model.

scientific article

Evaluation of Medication-Related Problems in Medication Reviews: A Comparative Perspective ⬇️

scientific article published on July 10, 2012

Evaluation of Quantum Dot Skin Penetration in Porcine Skin: Effect of Age and Anatomical Site of Topical Application

scientific article published on 14 May 2019

Explicit evidence-based prescribing criteria - an important step in achieving quality therapeutics in nursing homes

article

Expression and antioxidant function of liver fatty acid binding protein in normal and bile-duct ligated rats

scientific article published on 19 January 2007

Factors affecting the formation of a skin reservoir for topically applied solutes

scientific article published on January 2004

Factors influencing PRN medication use in nursing homes

scientific article published on 01 June 2004

Feasibility of a patient-centered deprescribing process to reduce inappropriate use of proton pump inhibitors.

scientific article

Feasibility of multiphoton microscopy-based quantification of antibiotic uptake into neutrophil granulocytes

scientific article published on 01 July 2013

First-dose and steady-state population pharmacokinetics and pharmacodynamics of piperacillin by continuous or intermittent dosing in critically ill patients with sepsis

scientific article published on 16 December 2009

Fluorescence recovery after photo-bleaching as a method to determine local diffusion coefficient in the stratum corneum

scientific article published on 2 February 2012

Follicular Penetration of Caffeine from Topically Applied Nanoemulsion Formulations Containing Penetration Enhancers: In vitro Human Skin Studies

scientific article published on 12 July 2018

Functional and structural characterization of isolated perfused stingray liver including effects of ischaemia/reperfusion

scientific article published on 01 April 1998

Functional characterization of hepatic transporters using intravital microscopy

scientific article published on 18 June 2013

Gold Nanoparticle Penetration and Reduced Metabolism in Human Skin by Toluene

article

Grey goo on the skin? Nanotechnology, cosmetic and sunscreen safety.

scientific article published on March 2007

Hair follicles contribute significantly to penetration through human skin only at times soon after application as a solvent deposited solid in man.

scientific article published on November 2011

Has drug therapy gone to the dogs?

scientific article published on 01 July 2003

Hepatic disposition and metabolite kinetics of a homologous series of diflunisal esters.

scientific article published in August 1998

Hepatic interaction between quinidine and digoxin: Role of inhibition of sinusoidal Na+/K+ ATPase digoxin binding

scientific article published on 17 July 2012

Hepatic pharmacokinetics of cationic drugs in a high-fat emulsion-induced rat model of nonalcoholic steatohepatitis

scientific article

Hepatic pharmacokinetics of propranolol in rats with adjuvant-induced systemic inflammation

scientific journal article

Hepatic pharmacokinetics of taurocholate in the normal and cholestatic rat liver

scientific article

Hepatic structure-pharmacokinetic relationships: the hepatic disposition and metabolite kinetics of a homologous series of O-acyl derivatives of salicylic acid.

scientific article

Hepatocellular necrosis, fibrosis and microsomal activity determine the hepatic pharmacokinetics of basic drugs in right-heart-failure-induced liver damage

scientific article published in June 2012

Hepatocyte [3H]-palmitate uptake: effect of albumin surface charge modification

scientific article published in October 2001

Herb-drug interactions: in vivo and in vitro effect of Shenmai injection, a herbal preparation, on the metabolic activities of hepatic cytochrome P450 3A1/2, 2C6, 1A2, and 2E1 in rats

scientific article published on 11 September 2009

High lethality and minimal variation after acute self-poisoning with carbamate insecticides in Sri Lanka - implications for global suicide prevention

scientific article published on 02 June 2016

High-performance liquid chromatographic assay for common sunscreening agents in cosmetic products, bovine serum albumin solution and human plasma

scientific article published on 01 June 1996

High-performance liquid chromatographic assay for the measurement of melphalan and its hydrolysis products in perfusate and plasma and melphalan in tissues from human and rat isolated limb perfusions

scientific article published on 01 November 1995

High-performance liquid chromatographic determination of phenol, 4-nitrophenol, β-naphthol and a number of their glucuronide and sulphate conjugates in organ perfusate

scientific article published on 01 February 1996

How to measure pharmacokinetics in critically ill patients?

scientific article published on December 2011

Human skin penetration and local effects of topical nano zinc oxide after occlusion and barrier impairment

scientific article published on 27 April 2016

Human skin penetration of sunscreen nanoparticles: in-vitro assessment of a novel micronized zinc oxide formulation

scientific article published on 17 January 2007

Human skin penetration of the major components of Australian tea tree oil applied in its pure form and as a 20% solution in vitro

scientific article published on 5 October 2007

Imaging of zinc oxide nanoparticle penetration in human skin in vitro and in vivo

scientific article

Imaging the penetration and distribution of zinc and zinc species after topical application of zinc pyrithione to human skin

scientific article published on 19 February 2018

Impact of Age on Risk of Lymph Node Positivity in Patients with Colon Cancer.

scientific article published on 12 May 2019

In Vivo Microdialysis To Determine Subcutaneous Interstitial Fluid Penetration and Pharmacokinetics of Fluconazole in Intensive Care Unit Patients with Sepsis

scientific article published on 23 November 2015

In vitro and in vivo evaluation in rabbits of a controlled release 5-fluorouracil subconjunctival implant based on poly(D,L-lactide-co-glycolide)

scientific article published on 01 July 1996

In vitro human epidermal and polyethylene membrane penetration and retention of the sunscreen benzophenone-3 from a range of solvents

scientific article published on 01 December 1998

Inadequate antimicrobial prophylaxis during surgery: a study of beta-lactam levels during burn debridement

scientific article published on 15 May 2007

Increased platelet-derived microparticles in the coronary circulation of percutaneous transluminal coronary angioplasty patients

scientific article

Indocyanine green-incorporating nanoparticles for cancer theranostics.

scientific article published on 2 February 2018

Influence of perfusate composition on drug disposition in the in-situ perfused rat lung.

scientific article published on 28 August 2009

Influence of physicochemical parameters and perfusate flow rate on the distribution of solutes in the isolated perfused rat hindlimb determined by the impulse-response technique

scientific article published on 01 August 1995

Influence of sustained low-efficiency diafiltration (SLED-f) on interstitial fluid concentrations of fluconazole in a critically ill patient: Use of microdialysis

scientific article published on 28 March 2015

Inhibition of platelet function by a controlled release acetylsalicylic acid formulation--single and chronic dosing studies

scientific article published on 01 January 1984

Inter- and intralaboratory variation of in vitro diffusion cell measurements: an international multicenter study using quasi-standardized methods and materials.

scientific article published in March 2005

Interconnected-tubes model of hepatic elimination.

scientific article published in September 1997

Interconnected-tubes model of hepatic elimination: steady-state considerations.

scientific article published in August 1999

Intravital multiphoton imaging of the selective uptake of water-dispersible quantum dots into sinusoidal liver cells.

scientific article published on 15 December 2014

Intravital multiphoton microscopy can model uptake and excretion of fluorescein in hepatic ischemia-reperfusion injury

scientific article published in October 2013

Ion-trapping, microsomal binding, and unbound drug distribution in the hepatic retention of basic drugs

scientific article published on 17 October 2003

Iontophoresis-mediated transdermal permeation of peptide dendrimers across human epidermis

scientific article published on 21 March 2013

Iontophoretic skin permeation of peptides: an investigation into the influence of molecular properties, iontophoretic conditions and formulation parameters

scientific article published on 01 June 2014

Is there tissue penetration after application of topical salicylate formulations?

scientific article published in The Lancet

Kidney biomarkers in MCPA-induced acute kidney injury in rats: Reduced clearance enhances early biomarker performance

scientific article published on 27 January 2014

Kinetic analysis of saturable hepatic uptake of digoxin and its inhibition by rifampicin

scientific journal article

Kinetic analysis of vascular marker distribution in perfused rat livers after regeneration following partial hepatectomy

scientific article published in September 1998

Kinetics of Toxic Doses of Paraquat and the Effects of Hemoperfusion in the Dog

article

Kinetics of propranolol uptake in muscle, skin, and fat of the isolated perfused rat hindlimb

scientific article published on 01 August 2000

Lateral iontophoretic solute transport in skin.

scientific article published in January 1999

Liver fibrosis impairs hepatic pharmacokinetics of liver transplant drugs in the rat model

scientific article published on 22 September 2010

Loss of nitroglycerin from intravenous infusion sets ⬇️

scientific article published on August 12, 1978

Matching prescription claims with medication data for nursing home residents: implications for prescriber feedback, drug utilisation studies and selection of prescription claims database.

scientific article

Mathematical and pharmacokinetic modelling of epidermal and dermal transport processes.

scientific article published on 07 May 2012

Mathematical models of skin permeability: An overview ⬇️

scientific article published on February 25, 2011

Maximum transepidermal flux for similar size phenolic compounds is enhanced by solvent uptake into the skin

scientific article published on 23 April 2011

Mechanisms of transforming growth factor beta(1)/Smad signalling mediated by mitogen-activated protein kinase pathways in keloid fibroblasts.

scientific article

Mechanistic Evaluation of Enhanced Curcumin Delivery through Human Skin In Vitro from Optimised Nanoemulsion Formulations Fabricated with Different Penetration Enhancers

scientific article published on 01 December 2019

Mechanistic Evaluation of Hydration Effects on the Human Epidermal Permeation of Salicylate Esters.

scientific article published on 15 September 2016

Medication management at home: medication-related risk factors associated with poor health outcomes

scientific article published in November 2005

Meropenem dosing in critically ill patients with sepsis and without renal dysfunction: intermittent bolus versus continuous administration? Monte Carlo dosing simulations and subcutaneous tissue distribution.

scientific article published on 27 April 2009

Metabolite mean transit times in the liver as predicted by various models of hepatic elimination

scientific article published on 01 August 1997

Methimazole and propylthiouracil equally cross the perfused human term placental lobule

scientific article published on 01 September 1997

Microdialysis and response during regional chemotherapy by isolated limb infusion of melphalan for limb malignancies

scientific article

Microneedle enhanced delivery of cosmeceutically relevant peptides in human skin.

scientific article

Microprojection arrays to immunise at mucosal surfaces.

scientific article published on 5 October 2014

Minoxidil Skin Delivery from Nanoemulsion Formulations Containing Eucalyptol or Oleic Acid: Enhanced Diffusivity and Follicular Targeting

scientific article published on 25 January 2018

Model representation of salicylate pharmacokinetics using unbound plasma salicylate concentrations and metabolite urinary excretion rates following a single oral dose

scientific article published in October 1991

Modeling and simulation of hepatic drug disposition using a physiologically based, multi-agent in silico liver.

scientific article

Modeling of subcutaneous absorption kinetics of infusion solutions in the elderly using technetium

scientific article published on 01 February 1997

Modeling solute sorption into plastic tubing during organ perfusion and intravenous infusions

scientific article published in June 1996

Modeling the human skin barrier--towards a better understanding of dermal absorption.

scientific article published on 14 April 2012

Modelling dermal drug distribution after topical application in human

scientific article published on 27 April 2011

Modelling drug transport within the viable skin - a review

scientific article published on 05 October 2020

Modelling of the SDF-1/CXCR4 regulated homing of therapeutic mesenchymal stem/stromal cells in mice

scientific article published on 06 December 2018

Models of hepatic elimination: Comparison of stochastic models to describe residence time distributions and to predict the influence of drug distribution, enzyme heterogeneity, and systemic recycling on hepatic elimination

scientific article published in February 1988

Molecular mechanism of recombinant liver fatty acid binding protein's antioxidant activity.

scientific article published on 27 May 2009

Molecular size as the main determinant of solute maximum flux across the skin.

scientific article published in April 2004

Multidisciplinary case conference reviews: improving outcomes for nursing home residents, carers and health professionals

scientific article

Multiphoton microscopy can visualize zonal damage and decreased cellular metabolic activity in hepatic ischemia-reperfusion injury in rats

scientific article published on 01 November 2011

Multiphoton microscopy in defining liver function.

scientific article published on September 2014

Nanoparticles and microparticles for skin drug delivery.

scientific article published on 23 February 2011

Nanopatch-targeted skin vaccination against West Nile Virus and Chikungunya virus in mice

scientific article published on August 2010

Nanotechnology, cosmetics and the skin: is there a health risk?

scientific article published on 03 June 2008

Nitric oxide induced sinusoidal relaxation after a propranolol priming dose in the perfused rat liver reduces propranolol availability on subsequent dosing.

scientific article published on October 2010

Nitroglycerin disposition in human blood

scientific article published on 01 January 1985

Non-animal models of epithelial barriers (skin, intestine and lung) in research, industrial applications and regulatory toxicology.

scientific article

Non-invasive imaging of skin physiology and percutaneous penetration using fluorescence spectral and lifetime imaging with multiphoton and confocal microscopy

scientific article

Non-invasive metabolic imaging of melanoma progression.

scientific article published on 19 December 2016

Noninvasive in vivo human multiphoton microscopy: a key method in proving nanoparticulate zinc oxide sunscreen safety ⬇️

scientific article published on 01 January 2020

Novel Nanocarriers for Targeted Topical Skin Delivery of the Antioxidant Resveratrol

scientific article published on 29 January 2020

Novel direct high-performance liquid chromatographic method for determination of salicylate glucuronide conjugates in human urine

scientific article

On the relation between extended forms of the sinusoidal perfusion and of the convection-dispersion models of hepatic elimination

scientific article

Optical Characterization of Zinc Pyrithione

scientific article published on 22 April 2019

Pathway and kinetics of prednisolone metabolism in the human placenta

scientific article published on 01 March 1993

Patient Barriers to and Enablers of Deprescribing: a Systematic Review ⬇️

scientific article published on October 1, 2013

Penetration of nanoparticles into human skin.

scientific article published on January 2013

People's attitudes, beliefs, and experiences regarding polypharmacy and willingness to Deprescribe.

scientific article published on 26 August 2013

Percutaneous Absorption of Steroids: Determination of in vitro Permeability and Tissue Reservoir Characteristics in Human Skin Layers

scientific article published on 23 August 2006

Percutaneous Absorption of Sunscreen Agents from Liquid Paraffin: Self-Association of Octyl Salicylate and Effects on Skin Flux

scientific article published on 01 July 1997

Percutaneous absorption of steroids: relative contributions of epidermal penetration and dermal clearance

scientific article

Permeability of solutes through biological membranes measured by a desorption technique

scientific article published in Nature

Permeation Mechanism of Caffeine and Naproxen through in vitro Human Epidermis: Effect of Vehicles and Penetration Enhancers

scientific article published on 25 March 2019

Permeation of topically applied Magnesium ions through human skin is facilitated by hair follicles

scientific article published on June 2016

Pharmacokinetic evaluation of fluconazole in critically ill patients

scientific article published on 02 September 2011

Pharmacokinetics and pharmacodynamics of melphalan in isolated limb infusion for recurrent localized limb malignancy

scientific article published on 01 August 2001

Pharmacokinetics of aspirin and salicylate in elderly subjects and in patients with alcoholic liver disease

scientific article published on 01 January 1983

Physiological pharmacokinetics of solutes in the isolated perfused rat hindlimb: characterization of the physiology with changing perfusate flow, protein content, and temperature using statistical moment analysis

scientific article published in December 1993

Physiologically Based Pharmacokinetic Model for Long-Circulating Inorganic Nanoparticles.

scientific article

Physiologically based synthetic models of hepatic disposition

scientific article

Piperacillin penetration into tissue of critically ill patients with sepsis--bolus versus continuous administration?

scientific article published in March 2009

Plasma acetate, gluconate and interleukin-6 profiles during and after cardiopulmonary bypass: a comparison of Plasma-Lyte 148 with a bicarbonate-balanced solution.

scientific article published on 14 January 2011

Plasma and target-site subcutaneous tissue population pharmacokinetics and dosing simulations of cefazolin in post-trauma critically ill patients

scientific article published on 20 January 2015

Plasma and tissue pharmacokinetics of cefazolin in patients undergoing elective and semielective abdominal aortic aneurysm open repair surgery

scientific article

Population Pharmacokinetic Model for Tramadol and O-desmethyltramadol in Older Patients

scientific article published on 15 February 2022

Population Pharmacokinetics of Piperacillin in Nonobese, Obese, and Morbidly Obese Critically Ill Patients

scientific article published on 4 January 2017

Potent immunity to low doses of influenza vaccine by probabilistic guided micro-targeted skin delivery in a mouse model

scientific article (publication date: 2010)

Potential therapeutic effects of a traditional Chinese formulation, BJ-JN, on liver fibrosis induced by carbon tetrachloride in rats

scientific article

Pramipexole Overdose Associated with Visual Hallucinations, Agitation and Myoclonus

scientific article published on 25 May 2017

Predicting skin penetration of actives from complex cosmetic formulations: an evaluation of inter formulation and inter active effects during formulation optimization for transdermal delivery

scientific article published on 11 October 2012

Prediction of organophosphorus insecticide-induced intermediate syndrome with stimulated concentric needle single fibre electromyography

scientific article published in PLoS ONE

Prediction of paraquat exposure and toxicity in clinically ill poisoned patients: a model based approach.

scientific article

Prevalence and Factors Associated with Analgesic Prescribing in Poly-Medicated Elderly Patients

scientific article published on 01 April 2020

Pro Re Nata Medication for Psychoses: An Audit of Practice in Two Metropolitan Hospitals

scientific article published on 01 October 2002

Pro re nata medication for psychoses: the knowledge and beliefs of doctors and nurses

scientific article published in October 2002

Probing the effect of vehicles on topical delivery: understanding the basic relationship between solvent and solute penetration using silicone membranes

scientific article

Providing community-based health practitioners with timely and accurate discharge medicines information

scientific article

Qualitative and quantitative comparison of heat separated epidermis and dermatomed skin in percutaneous absorption studies

scientific article published on 28 September 2007

Quantitative determination of ophiopogonin d by liquid chromatography/electrospray ionization mass spectrometry and its pharmacokinetics in rat.

scientific article

Quantitative evaluation of altered hepatic spaces and membrane transport in fibrotic rat liver

scientific article published in November 2002

Quantum dot penetration into viable human skin

scientific article

Rationale and evidence for the incorporation of heparin into the diclofenac epolamine medicated plaster

scientific article published on 20 December 2018

Real-time histology in liver disease using multiphoton microscopy with fluorescence lifetime imaging.

scientific article

Reduced hepatic extraction of palmitate in steatosis correlated to lower level of liver fatty acid binding protein

scientific article published on 2 September 2004

Relative Dispersions of Intra-albumin Transit Times across Rat and Elasmobranch Perfused Livers, and Implications for Intra- and Inter-species Scaling of Hepatic Clearance using Microsomal Data ⬇️

scientific article published on August 1, 1998

Relative Penetration of Zinc Oxide and Zinc Ions into Human Skin after Application of Different Zinc Oxide Formulations

scientific article published on 7 January 2016

Relative dispersion of intravascular transit times during isolated human limb perfusions for recurrent melanoma ⬇️

scientific article published on October 1, 1997

Relative uptake of minoxidil into appendages and stratum corneum and permeation through human skin in vitro.

scientific article published in February 2010

Removing physiological motion from intravital and clinical functional imaging data

scientific article published on 09 July 2018

Renal biomarkers predict nephrotoxicity after paraquat.

scientific article

Residence time distributions of solutes in the perfused rat liver using a dispersion model of hepatic elimination: 2. Effect of pharmacological agents, retrograde perfusions, and enzyme inhibition on evans blue, sucrose, water, and taurocholate

scientific article published in June 1990

Response to 'Comment on ''Massive' metformin overdose' by Chiew et al.'

scientific article published on 02 October 2018

Response to β-blockers in maternal and fetal rat hearts in vitro

scientific article published on 01 January 1991

Review of deprescribing processes and development of an evidence-based, patient-centred deprescribing process.

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Role of Conductivity in Iontophoresis. 2. Anodal Iontophoretic Transport of Phenylethylamine and Sodium across Excised Human Skin

scientific article published on 01 March 1994

SLOW-RELEASE ASPIRIN AND PROSTAGLANDIN INHIBITION

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SaMpling Antibiotics in Renal Replacement Therapy (SMARRT): an observational pharmacokinetic study in critically ill patients

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Saturable dose–response relationships for melphalan in melanoma treatment by isolated limb infusion in the nude rat

scientific article published on 01 December 2001

Severe Hypertension and Bradycardia Secondary to Midodrine Overdose.

scientific article published on 14 July 2016

Short- and Long-Term Tracking of Anionic Ultrasmall Nanoparticles in Kidney.

scientific article published on 8 January 2016

Simple and sensitive liquid chromatography–tandem mass spectrometry methods for quantification of paraquat in plasma and urine: Application to experimental and clinical toxicological studies

scientific article published on 10 September 2011

Simple rules defining the potential of compounds for transdermal delivery or toxicity

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Skin delivery--to Scheuplein and beyond. Preface.

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Skin models for the testing of transdermal drugs

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Skin solubility determines maximum transepidermal flux for similar size molecules

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Solute-Vehicle-Skin Interactions in Percutaneous Absorption: The Principles and the People ⬇️

scientific article published on July 29, 2013

Space- and time-resolved investigation on diffusion kinetics of human skin following macromolecule delivery by microneedle arrays

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Structure-hepatic disposition relationships for phenolic compounds

scientific article published in July 1999

Sulphonylurea physicochemical-pharmacokinetic relationships in the pancreas and liver.

scientific article published in August 2009

Sunscreen penetration of human skin and related keratinocyte toxicity after topical application

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Support for the Safe Use of Zinc Oxide Nanoparticle Sunscreens: Lack of Skin Penetration or Cellular Toxicity after Repeated Application in Volunteers

scientific article published on 15 November 2018

Surfactant protein expression in human skin: evidence and implications

scientific article published on 28 September 2006

Synergistic Skin Penetration Enhancer and Nanoemulsion Formulations Promote the Human Epidermal Permeation of Caffeine and Naproxen.

scientific article published on 10 November 2015

Systemic absorption of sunscreen after topical application.

scientific article published in September 1997

Targeted Topical Delivery of Retinoids in the Management of Acne Vulgaris: Current Formulations and Novel Delivery Systems

scientific article published on 24 September 2019

The Antioxidant Activity of Recombinant Rat Hepatic Fatty Acid Binding Protein T94A Variant

scientific article published on 01 January 2018

The Effect of Occlusion on Epidermal Penetration of Parabens from a Commercial Allergy Test Ointment, Acetone and Ethanol Vehicles

scientific article published on 01 November 2000

The Human Stratum Corneum Prevents Small Gold Nanoparticle Penetration and Their Potential Toxic Metabolic Consequences

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The application of molecular structural predictors of intestinal absorption to screening of compounds for transdermal penetration.

scientific article published on June 2010

The back diffusion of glucose across human skin in vitro.

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The effect of formulation on the penetration of coated and uncoated zinc oxide nanoparticles into the viable epidermis of human skin in vivo.

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The effect of posture on the pharmacokinetics of intravenous benzylpenicillin

scientific article published on 01 January 1986

The effects of posture on the pharmacokinetics of intramuscular benzylpenicillin

scientific article published in January 1988

The influence of the Pharmaceutical Benefits Scheme (PBS) on inappropriate prescribing in Australian nursing homes

scientific article published on February 2007

The pharmacokinetics and pharmacodynamics of cisatracurium in critically ill patients with severe sepsis ⬇️

scientific article published on May 1, 2012

The pharmacokinetics of cefazolin in patients undergoing elective & semi-elective abdominal aortic aneurysm open repair surgery

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The pharmacokinetics of tetrabenazine and its hydroxy metabolite in patients treated for involuntary movement disorders

scientific article published in January 1986

The prediction of the hepatic clearance of tanshinone IIA in rat liver subcellular fractions: accuracy improvement

scientific article published in January 2008

The role of cellular reactive oxygen species in cancer chemotherapy

scientific article published in November 2018

Therapeutic drug monitoring of beta-lactams in critically ill patients: proof of concept

scientific article published on 3 August 2010

Therapeutic effects and possible mechanisms of a snake venom preparation in the fibrotic rat liver

scientific article published in April 2005

Therapeutic modulators of hepatic stellate cells for hepatocellular carcinoma

scientific article published on 03 February 2020

Time-correlated single photon counting for simultaneous monitoring of zinc oxide nanoparticles and NAD(P)H in intact and barrier-disrupted volunteer skin.

scientific article published on 30 June 2011

Tissue accumulation of cephalothin in burns: a comparative study by microdialysis of subcutaneous interstitial fluid cephalothin concentrations in burn patients and healthy volunteers

scientific article published on 27 October 2008

Topical Nano and Microemulsions for Skin Delivery.

scientific article published on 21 September 2017

Topical and Transdermal Drug Delivery: From Simple Potions to Smart Technologies

scientific article published on 01 January 2019

Topical and cutaneous delivery using nanosystems

scientific article published on 23 December 2016

Topical penetration of commercial salicylate esters and salts using human isolated skin and clinical microdialysis studies ⬇️

scientific article published on July 1, 1998

Tracing multiscale mechanisms of drug disposition in normal and diseased livers

scientific article published on 20 April 2010

Transdermal patches: history, development and pharmacology.

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Transdermal penetration of vasoconstrictors--present understanding and assessment of the human epidermal flux and retention of free bases and ion-pairs

scientific article published in February 2003

Two-photon dual imaging platform for in vivo monitoring cellular oxidative stress in liver injury.

scientific article published on 28 March 2017

Unbound cephalothin pharmacokinetics in adult burn patients are related to the elapsed time after injury

scientific article published on 14 September 2009

Unexpected clobetasol propionate profile in human stratum corneum after topical application in vitro.

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Unidirectional inversion of ibuprofen in Caco-2 cells: developing a suitable model for presystemic chiral inversion study

scientific article published in April 2005

Uptake and metabolism of ginsenoside Rh2 and its aglycon protopanaxadiol by Caco-2 cells.

scientific article published on February 2005

Use of In Vitro Human Skin Membranes to Model and Predict the Effect of Changing Blood Flow on the Flux and Retention of Topically Applied Solutes

scientific article published on 01 August 2008

Use of a glyphosate-based herbicide-induced nephrotoxicity model to investigate a panel of kidney injury biomarkers.

scientific article published on 19 December 2013

Use of multiphoton tomography and fluorescence lifetime imaging to investigate skin pigmentation in vivo.

scientific article published on February 2013

Using Population Pharmacokinetic Modeling and Monte Carlo Simulations To Determine whether Standard Doses of Piperacillin in Piperacillin-Tazobactam Regimens Are Adequate for the Management of Febrile Neutropenia

scientific article published on 14 August 2017

Using a simple equation to predict the microporation-enhanced transdermal drug flux.

scientific article published on 31 January 2018

Using deconvolution to understand the mechanism for variable plasma concentration-time profiles after intramuscular injection

scientific article published on 27 January 2015

Using in vivo multiphoton fluorescence lifetime imaging to unravel disease-specific changes in the liver redox state

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Using pharmacokinetics and pharmacodynamics to optimise dosing of antifungal agents in critically ill patients: a systematic review

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Using skin for drug delivery and diagnosis in the critically ill.

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Variability of antibiotic concentrations in critically ill patients receiving continuous renal replacement therapy: a multicentre pharmacokinetic study

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Varying the morphology of silver nanoparticles results in differential toxicity against micro-organisms, HaCaT keratinocytes and affects skin deposition

scientific article published on 16 September 2016

Vasoplegic Shock Treated with Methylene Blue Complicated by Severe Serotonin Syndrome

scientific article published on 13 November 2017

Veterinary drug delivery: potential for skin penetration enhancement

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Visualization and Modeling of the In Vivo Distribution of Mesenchymal Stem Cells.

scientific article published on 15 November 2017

Visualizing liver anatomy, physiology and pharmacology using multiphoton microscopy.

scientific article published on 17 June 2016

What is the effect of obesity on piperacillin and meropenem trough concentrations in critically ill patients?

scientific article published on 24 December 2015

Zinc oxide nanoparticle removal from wounded human skin

scientific article published on 7 March 2013

ZnO:SBA-15 Nanocomposites for Potential Use in Sunscreen: Preparation, Properties, Human Skin Penetration and Toxicity

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β-lactam pharmacokinetics and pharmacodynamics in critically ill patients and strategies for dose optimization: a structured review

scientific article published on June 2012

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