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List of works by Ewa C Ellis

A liver‐humanized mouse model of carbamoyl phosphate synthetase 1‐deficiency

scientific article published on 02 April 2019

A novel bile acid-activated vitamin D receptor signaling in human hepatocytes

scientific article

ATPase Class I Type 8B Member 1 and protein kinase C zeta induce the expression of the canalicular bile salt export pump in human hepatocytes

scientific article

Addition of Dexamethasone Alters the Bile Acid Composition by Inducing CYP8B1 in Primary Cultures of Human Hepatocytes.

scientific article published on 10 February 2016

Aging and Caloric Restriction Modulate the DNA Methylation Profile of the Ribosomal RNA Locus in Human and Rat Liver

scientific article published on 21 January 2020

Assay of Bile Acid Conjugation and Excretion in Human Hepatocytes

scientific article published on 01 January 2015

Author Correction: Liver macrophages regulate systemic metabolism through non-inflammatory factors

scientific article published on 01 April 2019

Bigger may not be better when it comes to hepatocytes

scientific article published in 2005

Bile acid signaling pathways increase stability of Small Heterodimer Partner (SHP) by inhibiting ubiquitin-proteasomal degradation

scientific article published on April 2009

Bile acid synthesis in cultured human hepatocytes: support for an alternative biosynthetic pathway to cholic acid

scientific article published in June 2000

Bile acid synthesis in primary cultures of rat and human hepatocytes

scientific article published in February 1998

Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity-implications for therapeutic targeting of Nrf2.

scientific article

Changes in gluconeogenesis and intracellular lipid accumulation characterize uremic human hepatocytes ex vivo

scientific article published on 7 April 2016

Characterisation of the NRF2 transcriptional network and its response to chemical insult in primary human hepatocytes: implications for prediction of drug-induced liver injury

Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease

scientific article

Chenodeoxycholic Acid Modulates Bile Acid Synthesis Independent of Fibroblast Growth Factor 19 in Primary Human Hepatocytes

scientific article published on 01 January 2020

Circulating Fibroblast Growth Factor 19 in Portal and Systemic Blood

scientific article published on 28 July 2017

Comparison of culture media for bile Acid transport studies in primary human hepatocytes

scientific article published on 16 December 2012

Composition and functionality of the intrahepatic innate lymphoid cell-compartment in human nonfibrotic and fibrotic livers

scientific article published on 14 June 2017

Cutting edge: identification and characterization of human intrahepatic CD49a+ NK cells.

scientific article published on 11 February 2015

De Novo Donor-Specific HLA Antibody Formation in Two Patients With Crigler-Najjar Syndrome Type I Following Human Hepatocyte Transplantation With Partial Hepatectomy Preconditioning

scientific article

Development and application of purified tissue dissociation enzyme mixtures for human hepatocyte isolation

scientific article

Differentiation and transplantation of human embryonic stem cell-derived hepatocytes

scientific article

Diiodothyronines regulate metabolic homeostasis in primary human hepatocytes by modulating mTORC1 and mTORC2 activity

scientific article published on 30 September 2019

Ethanol stimulates bile acid formation in primary human hepatocytes

scientific article published on 15 October 2007

Evaluation of organic anion-transporting polypeptide 1B1 and CYP3A4 activities in primary human hepatocytes and HepaRG cells cultured in a dynamic three-dimensional bioreactor system

scientific article published on 12 July 2012

Feedback regulation of bile acid synthesis in human liver: importance of HNF-4alpha for regulation of CYP7A1.

scientific article published in May 2005

Feedback regulation of bile acid synthesis in primary human hepatocytes: evidence that CDCA is the strongest inhibitor

scientific article published in October 2003

From brain to bile. Evidence that conjugation and omega-hydroxylation are important for elimination of 24S-hydroxycholesterol (cerebrosterol) in humans

scientific article published on 19 July 2001

GH is a regulator of IGF2 promoter-specific transcription in human liver

scientific article published in March 2002

GPS2-dependent corepressor/SUMO pathways govern anti-inflammatory actions of LRH-1 and LXRbeta in the hepatic acute phase response

scientific article

Guide to the Assessment of Mature Liver Gene Expression in Stem Cell-Derived Hepatocytes

scientific article published on 01 July 2019

Hepatic differentiation of amniotic epithelial cells

scientific article

Hepatobiliary disposition of 17-OHPC and taurocholate in fetal human hepatocytes: a comparison with adult human hepatocytes

scientific article published on 5 November 2012

Hepatocyte growth factor signaling pathway inhibits cholesterol 7alpha-hydroxylase and bile acid synthesis in human hepatocytes

scientific article published in December 2007

Hepatocyte transplantation ameliorates the metabolic abnormality in a mouse model of acute intermittent porphyria

scientific article published in January 2014

Hepatocyte transplantation for inherited metabolic diseases of the liver.

scientific article published on 20 August 2012

Hepatocyte transplantation improves phenotype and extends survival in a murine model of intermediate maple syrup urine disease

scientific article published on 12 May 2009

Hepatocyte transplantation: clinical experience and potential for future use.

scientific article published on January 2006

Human pregnane X receptor activation and CYP3A4/CYP2B6 induction by 2,3-oxidosqualene:lanosterol cyclase inhibition

scientific article published on 21 January 2009

Hypothermic storage of human hepatocytes for transplantation

scientific article published on January 2014

Identification of oxysterol 7alpha-hydroxylase (Cyp7b1) as a novel retinoid-related orphan receptor alpha (RORalpha) (NR1F1) target gene and a functional cross-talk between RORalpha and liver X receptor (NR1H3)

scientific journal article

Imbalance of Genes Encoding Natural Killer Immunoglobulin-Like Receptors and Human Leukocyte Antigen in Patients With Biliary Cancer

scientific article published on 21 June 2019

Improved cryopreservation of human hepatocytes using a new xeno free cryoprotectant solution

scientific article

Improving the techniques for human hepatocyte transplantation: report from a consensus meeting in London.

scientific article published in January 2012

In situ characterization of intrahepatic non-parenchymal cells in PSC reveals phenotypic patterns associated with disease severity.

scientific article

In vitro evaluation of major in vivo drug metabolic pathways using primary human hepatocytes and HepaRG cells in suspension and a dynamic three-dimensional bioreactor system

scientific article

Insights From Liver-Humanized Mice on Cholesterol Lipoprotein Metabolism and LXR-Agonist Pharmacodynamics in Humans

scientific article published on 30 November 2019

Insulin regulation of cholesterol 7alpha-hydroxylase expression in human hepatocytes: roles of forkhead box O1 and sterol regulatory element-binding protein 1c.

scientific article

Isolation of Amniotic Epithelial Stem Cells

scientific article published in November 2007

Isolation of Amniotic Mesenchymal Stem Cells

scientific article published in March 2010

Isolation of amniotic epithelial stem cells.

scientific article published in January 2010

Isolation of mouse hepatocytes for transplantation: a comparison between antegrade and retrograde liver perfusion

scientific article published in January 2007

Lipidomic analysis of human primary hepatocytes following LXR activation with GW3965 identifies AGXT2L1 as a main target associated to changes in phosphatidylethanolamine

scientific article published on 26 November 2019

Liver X receptor agonist downregulates growth hormone signaling in the liver

scientific article published in January 2011

Liver macrophages inhibit the endogenous antioxidant response in obesity-associated insulin resistance

scientific article published on 01 February 2020

Liver macrophages regulate systemic metabolism through non-inflammatory factors

scientific article published on 25 March 2019

Long term cultures of primary human hepatocytes as an alternative to drug testing in animals.

scientific article published in January 2009

Long-term culture of genome-stable bipotent stem cells from adult human liver

scientific article

Maintenance of Hepatic Functions in Primary Human Hepatocytes Cultured on Xeno-Free and Chemical Defined Human Recombinant Laminins

scientific article

Marked induction of sterol 27-hydroxylase activity and mRNA levels during differentiation of human cultured monocytes into macrophages

scientific article

Massive rearrangements of cellular MicroRNA signatures are key drivers of hepatocyte dedifferentiation

scientific article published on 17 August 2016

Metabolism of 17alpha-hydroxyprogesterone caproate, an agent for preventing preterm birth, by fetal hepatocytes.

scientific article

Metabolism of 4 beta -hydroxycholesterol in humans.

scientific article published on 20 June 2002

Mice with chimeric livers are an improved model for human lipoprotein metabolism

scientific article

Molecular Aging of Human Liver: An Epigenetic/Transcriptomic Signature

scientific article published on 15 March 2018

Mouse Model of Alagille Syndrome and Mechanisms of Jagged1 Missense Mutations.

scientific article

New potential cell source for hepatocyte transplantation: discarded livers from metabolic disease liver transplants.

scientific article

Overexpression of cholesterol 7α-hydroxylase promotes hepatic bile acid synthesis and secretion and maintains cholesterol homeostasis

scientific article published on 11 February 2011

Physiological differences between human and rat primary hepatocytes in response to liver X receptor activation by 3-[3-[N-(2-chloro-3-trifluoromethylbenzyl)-(2,2-diphenylethyl)amino]propyloxy]phenylacetic acid hydrochloride (GW3965).

scientific article published on 12 July 2007

Positive and Negative Regulation of Human Hepatic Hydroxysteroid Sulfotransferase (SULT2A1) Gene Transcription by Rifampicin: Roles of Hepatocyte Nuclear Factor 4 and Pregnane X Receptor

scientific article published on 23 August 2007

Potency of individual bile acids to regulate bile acid synthesis and transport genes in primary human hepatocyte cultures

scientific article

Present status and perspectives of cell-based therapies for liver diseases

scientific article

Primary cultures of human hepatocytes but not HepG2 hepatoblastoma cells are suitable for the study of glycosidic conjugation of bile acids.

scientific article

Production of hepatocyte-like cells from human amnion.

scientific article published on January 2009

Rapid and Sensitive Assessment of Human Hepatocyte Functions

scientific article published in December 2014

Regulation of CYP3A4 and CYP2B6 expression by liver X receptor agonists

scientific article

Regulation of bile acid metabolism in biliary atresia: reduction of FGF19 by Kasai portoenterostomy and possible relation to early outcome

scientific article published on 24 January 2020

Robust expansion of human hepatocytes in Fah-/-/Rag2-/-/Il2rg-/- mice

scientific article

Serum apolipoprotein E as a marker to monitor graft function after hepatocyte transplantation in a clinically relevant mouse model

scientific article published in June 2013

Spatial Transcriptomics to define transcriptional patterns of zonation and structural components in the mouse liver

scientific article published on 02 December 2021

Strategies for short-term storage of hepatocytes for repeated clinical infusions

scientific article published in January 2014

Successful treatment of severe unconjugated hyperbilirubinemia via induction of UGT1A1 by rifampicin

scientific article published in January 2006

Systemic modified messenger RNA for replacement therapy in alpha 1-antitrypsin deficiency

scientific article published on 27 April 2020

The human ADFP gene is a direct liver-X-receptor (LXR) target gene and differentially regulated by synthetic LXR ligands

scientific article published on 20 October 2009

The use of human hepatocytes to investigate bile acid synthesis

scientific article published in January 2010

Transport, Metabolism, and Hepatotoxicity of Flutamide, Drug–Drug Interaction with Acetaminophen Involving Phase I and Phase II Metabolites

scientific article (publication date: October 2007)

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