List of works - Dimitar Efremov

ABT-199 (Venetoclax), a BH3-mimetic Bcl-2 inhibitor, does not cause Ca2+ -signalling dysregulation or toxicity in pancreatic acinar cells

article

Association between molecular lesions and specific B-cell receptor subsets in chronic lymphocytic leukemia.

scientific article published in May 2013

Autoimmune hemolytic anemia during bendamustine plus rituximab treatment in CLL patients: multicenter experience

scientific article published on 27 January 2016

B cell receptors in TCL1 transgenic mice resemble those of aggressive, treatment-resistant human chronic lymphocytic leukemia

scholarly article

B-cell receptor pathway inhibitors affect CD20 levels and impair antitumor activity of anti-CD20 monoclonal antibodies

scientific article published on 10 January 2014

B-cell receptor, clinical course and prognosis in chronic lymphocytic leukaemia: the growing saga of the IGHV3 subgroup gene usage

scientific article published on 08 February 2011

BCR signaling contributes to autophagy regulation in chronic lymphocytic leukemia

scientific article published on 28 August 2019

BCR signaling inhibitors differ in their ability to overcome Mcl-1-mediated resistance of CLL B cells to ABT-199.

scientific article published on 19 April 2016

Bendamustine in combination with rituximab for elderly patients with previously untreated B-cell chronic lymphocytic leukemia: A retrospective analysis of real-life practice in Italian hematology departments

scientific article published on 26 July 2015

Bruton's tyrosine kinase (BTK) function is important to the development and expansion of chronic lymphocytic leukemia (CLL).

scientific article published on 05 December 2013

CD38 and ZAP-70 are functionally linked and mark CLL cells with high migratory potential

scientific article published on 15 August 2007

CTLA-4 exon 1 polymorphism in patients with autoimmune blood disorders

scientific article

Characterization of a second secreted IgE isoform and identification of an asymmetric pathway of IgE assembly.

scientific article published on April 1996

Chic adaptor regulates apoptosis in CLL

scientific article published on 01 May 2010

Chlorambucil plus Rituximab as Front-Line Therapy in Elderly/Unfit Patients Affected by B-Cell Chronic Lymphocytic Leukemia: Results of a Single-Centre Experience

scientific article published on 2 May 2013

Chlorambucil plus rituximab as front-line therapy for elderly and/or unfit chronic lymphocytic leukemia patients: correlation with biologically-based risk stratification

scientific article published on 8 June 2017

Chronic Lymphocytic Leukemia With Eyelid Involvement Responding to Alemtuzumab

scientific article published on 14 October 2008

Chronic lymphocytic leukemia patients with a V1-69 gene rearrangement do not have inferior survival with respect to patients that express other unmutated VH genes

article

Chronic lymphocytic leukemia: a tale of one or two signals?

scientific article published on 13 November 2012

Clonal B-cell expansions in peripheral blood of HCV-infected patients

scientific article published on 01 July 1995

Comparison between oral and intravenous fludarabine plus cyclophosphamide regime as front-line therapy in patients affected by chronic lymphocytic leukaemia: influence of biological parameters on the clinical outcome

scientific article published on 13 July 2010

Comparison of ZAP-70/Syk mRNA levels with immunoglobulin heavy-chain gene mutation status and disease progression in chronic lymphocytic leukemia

scientific article published in November 2005

Comprehensive characterization of IGHV3-21-expressing B-cell chronic lymphocytic leukemia: an Italian multicenter study

article

Constitutive IP signaling underlies the sensitivity of B-cell cancers to the Bcl-2/IP receptor disruptor BIRD-2

scientific article published on 13 June 2018

Cytomegalovirus reactivation during alemtuzumab therapy for chronic lymphocytic leukemia: incidence and treatment with oral ganciclovir

scientific article published in October 2004

Efficacy and safety of low-dose alemtuzumab as treatment of autoimmune hemolytic anemia in pretreated B-cell chronic lymphocytic leukemia

scientific article published on 19 April 2007

Ethnic difference in the prevalence of monoclonal B-cell proliferation in patients affected by hepatitis C virus chronic liver disease

scientific article published in June 1999

Expression of Mutated IGHV3-23 Genes in Chronic Lymphocytic Leukemia Identifies a Disease Subset with Peculiar Clinical and Biological Features

article

FOXO discriminates tonic from chronic in DLBCL.

scientific article published in February 2016

FOXO1 promotes resistance of non-Hodgkin lymphomas to anti-CD20-based therapy

scientific article published on 25 January 2018

Genetic evidence of PTPN22 effects on chronic lymphocytic leukemia--author's response to Hebbring

scientific article published in January 2013

HDAC6 inhibition upregulates CD20 levels and increases the efficacy of anti-CD20 monoclonal antibodies

scientific article

Hepatitis C virus, mixed cryoglobulinaemia and non-Hodgkin's lymphoma.

scientific article published in August 1998

IGHD3-3fails to behave as unfavourable prognostic marker in chronic lymphocytic leukaemia

IGHV gene mutational status and 17p deletion are independent molecular predictors in a comprehensive clinical-biological prognostic model for overall survival prediction in chronic lymphocytic leukemia

scientific article published on 30 January 2012

IL-4 regulates B-cell receptor signaling in CLL.

scientific article published in July 2016

IgM-producing chronic lymphocytic leukemia cells undergo immunoglobulin isotype-switching without acquiring somatic mutations.

scientific article

Immunophenotypic characterization of IgVH3-72 B-cell chronic lymphocytic leukaemia (B-CLL).

scientific article

Inhibition of constitutive and BCR-induced Syk activation downregulates Mcl-1 and induces apoptosis in chronic lymphocytic leukemia B cells

scientific article published on 18 December 2008

Inhibitors of SRC kinases impair antitumor activity of anti-CD20 monoclonal antibodies.

scientific article

Intrinsic and extrinsic factors influencing the clinical course of B-cell chronic lymphocytic leukemia: prognostic markers with pathogenetic relevance

scientific article published on 28 August 2009

Lamivudine treatment for acute hepatitis B virus infection during allogeneic peripheral blood stem cell transplantation

scientific article published in March 2003

Long-term follow up of frontline therapy with fludarabine and cyclophosphamide in chronic lymphocytic leukemia: impact of biological parameters on clinical outcome

scientific article

Low prevalence of chronic hepatitis C virus infection in B-cell non-Hodgkin's lymphoma patients from a population with a high prevalence of healthy hepatitis c virus carriers.

scientific article published in April 2000

Low-dose intravenous alemtuzumab therapy in pretreated patients affected by chronic lymphocytic leukemia. A single center experience.

scientific article published in August 2005

Low-dose thalidomide in combination with oral fludarabine and cyclophosphamide is ineffective in heavily pre-treated patients with chronic lymphocytic leukemia

scientific article published on 03 July 2006

Mechanisms of B Cell Receptor Activation and Responses to B Cell Receptor Inhibitors in B Cell Malignancies

scientific article published on 28 May 2020

Microenvironmental interactions in chronic lymphocytic leukemia: hints for pathogenesis and identification of targets for rational therapy

scientific article published on January 2012

Mild and severe beta-thalassemia among homozygotes from Turkey: identification of the types by hybridization of amplified DNA with synthetic probes.

scientific article published in January 1988

Molecular analysis of IgE H-chain transcripts expressed in vivo by peripheral blood lymphocytes from normal and atopic individuals

scientific article published on August 1993

Molecular and clinical features of chronic lymphocytic leukaemia with stereotyped B cell receptors: results from an Italian multicentre study

article

Molecular and clinical features of chronic lymphocytic leukemia with stereotyped B-cell receptors in a Ukrainian cohort

scientific article

Multicentre validation of a prognostic index for overall survival in chronic lymphocytic leukaemia

scientific article

Multiple distinct sets of stereotyped antigen receptors indicate a role for antigen in promoting chronic lymphocytic leukemia

scientific article

Multiple transcripts of the murine immunoglobulin epsilon membrane locus are generated by alternative splicing and differential usage of two polyadenylation sites

scientific article published in February 1997

New and Old Monoclonal Antibodies for the Treatment of Chronic Lymphocytic Leukemia

scientific article published on 01 June 2011

New developments in the management of chronic lymphocytic leukemia: role of ofatumumab

scientific article

Novel Agents and Emerging Strategies for Targeting the B-Cell Receptor Pathway in CLL

scientific article

Oral fludarabine and cyclophosphamide as front-line chemotherapy in patients with chronic lymphocytic leukemia. The impact of biological parameters in the response duration

scientific article published on 28 June 2008

Overexpression of the autoimmunity-associated phosphatase PTPN22 promotes survival of antigen-stimulated CLL cells by selectively activating AKT.

scientific article

Pathogen-specific B-cell receptors drive chronic lymphocytic leukemia by light-chain-dependent cross-reaction with autoantigens

scientific article published on 12 September 2017

Phosphorylation of the activation loop tyrosines is required for sustained Syk signaling and growth factor-independent B-cell proliferation

scientific article published on 16 March 2009

Prevalence, characteristics and management of occult hepatitis B virus infection in patients with chronic lymphocytic leukemia: a single center experience

scientific article published on 16 February 2015

Prognostic value of immunoglobulin variable heavy chain gene mutation status: long term follow-up in a series of chronic lymphocytic leukemia patients.

scientific article published on December 2006

Rare hemoglobin variants: Hb G-Szuhu (HBB: c.243C>G), Hb G-Coushatta (HBB: c.68A>C) and Hb Mizuho (HBB: c.206T>C) in Sri Lankan families

scientific article published on 9 January 2015

Recent advances in the pathogenesis and treatment of chronic lymphocytic leukemia

scientific article published on January 2014

Reduced expression of the tumor suppressor PHLPP1 enhances the antiapoptotic B-cell receptor signal in chronic lymphocytic leukemia B-cells.

scientific article published on 23 September 2010

Regression of monoclonal B-cell expansion in patients affected by mixed cryoglobulinemia responsive to alpha-interferon therapy

scientific article published on June 1996

Restricted immunoglobulin VH region repertoire in chronic lymphocytic leukemia patients with autoimmune hemolytic anemia

scientific article published on 01 May 1996

Role of ETS1 in the Transcriptional Network of Diffuse Large B Cell Lymphoma of the Activated B Cell-Like Type

scientific article published on 15 July 2020

Signal-dependent and signal-independent functions of the B-cell receptor in chronic lymphocytic leukemia

scientific article published on November 2014

Signaling pathways activated by antigen-receptor engagement in chronic lymphocytic leukemia B-cells

scientific article published on 28 March 2007

Somatic hypermutation, clonal diversity, and preferential expression of the VH 51p1/VL kv325 immunoglobulin gene combination in hepatitis C virus-associated immunocytomas.

scientific article published on April 1998

Sustained signaling through the B-cell receptor induces Mcl-1 and promotes survival of chronic lymphocytic leukemia B cells.

scientific article published on 22 February 2005

Synovial B cells of rheumatoid arthritis express ZAP-70 which increases the survival and correlates with the inflammatory and autoimmune phenotype

scientific article

TLR9 signaling defines distinct prognostic subsets in CLL.

scientific article published on January 2013

Targeting transcription-coupled nucleotide excision repair overcomes resistance in chronic lymphocytic leukemia.

scientific article

The -158 (C-->T) promoter mutation is responsible for the increased transcription of the 3' gamma gene in the Atlanta type of hereditary persistence of fetal hemoglobin.

scientific article published in June 1994

The Akt signaling pathway determines the different proliferative capacity of chronic lymphocytic leukemia B-cells from patients with progressive and stable disease.

scientific article

The Akt/Mcl-1 pathway plays a prominent role in mediating antiapoptotic signals downstream of the B-cell receptor in chronic lymphocytic leukemia B cells

scientific article

The Aurora A and B kinases are up-regulated in bone marrow-derived chronic lymphocytic leukemia cells and represent potential therapeutic targets

scientific article

The SIRT1/TP53 axis is activated upon B-cell receptor triggering via miR-132 up-regulation in chronic lymphocytic leukemia cells.

scientific article

The Syk inhibitor fostamatinib disodium (R788) inhibits tumor growth in the Eμ- TCL1 transgenic mouse model of CLL by blocking antigen-dependent B-cell receptor signaling

scientific article published on 17 August 2010

The Syk kinase as a therapeutic target in leukemia and lymphoma

scientific article published on 26 March 2011

The detection of β-globin gene mutations in β-thalassemia using oligonucleotide probes and amplified DNA

article

The leukemic cells of chronic lymphocytic leukemia patients with autoimmune hemolytic anemia produce isotype-switched immunoglobulins that are preferentially encoded by the 51p1 and DP-50 VH genes

scientific article published on April 1997

The miR-17∼92 family regulates the response to Toll-like receptor 9 triggering of CLL cells with unmutated IGHV genes.

scientific article published on 20 February 2012

The pathologic significance of the immunoglobulins expressed by chronic lymphocytic leukemia B-cells in the development of autoimmune hemolytic anemia

scientific article published on January 1998

The proliferative response to CpG-ODN stimulation predicts PFS, TTT and OS in patients with chronic lymphocytic leukemia

scientific article published on 13 January 2010

The relative levels of βAand βSmRNAs in Hb S heterozygotes and in patients with Hb S-β+-thalassaemia or Hb S-β+-HPFH combinations

scientific article published on 01 June 1994

The two membrane isoforms of human IgE assemble into functionally distinct B cell antigen receptors

scientific article

The use of low-dose alemtuzumab in pretreated B-cell chronic lymphocytic leukemia

scientific article published on 21 January 2010

The use of monoclonal antibodies in the treatment of autoimmune complications of chronic lymphocytic leukemia

scientific article

Therapeutic Targets in Chronic Lymphocytic Leukemia

scientific article published on 04 November 2020

Treatment approach for elderly and unfit patients with chronic lymphocytic leukemia

scientific article published on 30 October 2017

Two types of BCR interactions are positively selected during leukemia development in the Eμ-TCL1 transgenic mouse model of CLL.

scientific article

ZAP-70 enhances B-cell-receptor signaling despite absent or inefficient tyrosine kinase activation in chronic lymphocytic leukemia and lymphoma B cells

scientific article published on 12 October 2006

List of works by Dimitar Efremov

ABT-199 (Venetoclax), a BH3-mimetic Bcl-2 inhibitor, does not cause Ca2+ -signalling dysregulation or toxicity in pancreatic acinar cells

Association between molecular lesions and specific B-cell receptor subsets in chronic lymphocytic leukemia.

Autoimmune hemolytic anemia during bendamustine plus rituximab treatment in CLL patients: multicenter experience

B cell receptors in TCL1 transgenic mice resemble those of aggressive, treatment-resistant human chronic lymphocytic leukemia

B-cell receptor pathway inhibitors affect CD20 levels and impair antitumor activity of anti-CD20 monoclonal antibodies

B-cell receptor, clinical course and prognosis in chronic lymphocytic leukaemia: the growing saga of the IGHV3 subgroup gene usage

BCR signaling contributes to autophagy regulation in chronic lymphocytic leukemia

BCR signaling inhibitors differ in their ability to overcome Mcl-1-mediated resistance of CLL B cells to ABT-199.

Bendamustine in combination with rituximab for elderly patients with previously untreated B-cell chronic lymphocytic leukemia: A retrospective analysis of real-life practice in Italian hematology departments

Bruton's tyrosine kinase (BTK) function is important to the development and expansion of chronic lymphocytic leukemia (CLL).

CD38 and ZAP-70 are functionally linked and mark CLL cells with high migratory potential

CTLA-4 exon 1 polymorphism in patients with autoimmune blood disorders

Characterization of a second secreted IgE isoform and identification of an asymmetric pathway of IgE assembly.

Chic adaptor regulates apoptosis in CLL

Chlorambucil plus Rituximab as Front-Line Therapy in Elderly/Unfit Patients Affected by B-Cell Chronic Lymphocytic Leukemia: Results of a Single-Centre Experience

Chlorambucil plus rituximab as front-line therapy for elderly and/or unfit chronic lymphocytic leukemia patients: correlation with biologically-based risk stratification

Chronic Lymphocytic Leukemia With Eyelid Involvement Responding to Alemtuzumab

Chronic lymphocytic leukemia patients with a V1-69 gene rearrangement do not have inferior survival with respect to patients that express other unmutated VH genes

Chronic lymphocytic leukemia: a tale of one or two signals?

Clonal B-cell expansions in peripheral blood of HCV-infected patients

Comparison between oral and intravenous fludarabine plus cyclophosphamide regime as front-line therapy in patients affected by chronic lymphocytic leukaemia: influence of biological parameters on the clinical outcome

Comparison of ZAP-70/Syk mRNA levels with immunoglobulin heavy-chain gene mutation status and disease progression in chronic lymphocytic leukemia

Comprehensive characterization of IGHV3-21-expressing B-cell chronic lymphocytic leukemia: an Italian multicenter study

Constitutive IP signaling underlies the sensitivity of B-cell cancers to the Bcl-2/IP receptor disruptor BIRD-2

Cytomegalovirus reactivation during alemtuzumab therapy for chronic lymphocytic leukemia: incidence and treatment with oral ganciclovir

Efficacy and safety of low-dose alemtuzumab as treatment of autoimmune hemolytic anemia in pretreated B-cell chronic lymphocytic leukemia

Ethnic difference in the prevalence of monoclonal B-cell proliferation in patients affected by hepatitis C virus chronic liver disease

Expression of Mutated IGHV3-23 Genes in Chronic Lymphocytic Leukemia Identifies a Disease Subset with Peculiar Clinical and Biological Features

FOXO discriminates tonic from chronic in DLBCL.

FOXO1 promotes resistance of non-Hodgkin lymphomas to anti-CD20-based therapy

Genetic evidence of PTPN22 effects on chronic lymphocytic leukemia--author's response to Hebbring

HDAC6 inhibition upregulates CD20 levels and increases the efficacy of anti-CD20 monoclonal antibodies

Hepatitis C virus, mixed cryoglobulinaemia and non-Hodgkin's lymphoma.

IGHD3-3fails to behave as unfavourable prognostic marker in chronic lymphocytic leukaemia

IGHV gene mutational status and 17p deletion are independent molecular predictors in a comprehensive clinical-biological prognostic model for overall survival prediction in chronic lymphocytic leukemia

IL-4 regulates B-cell receptor signaling in CLL.

IgM-producing chronic lymphocytic leukemia cells undergo immunoglobulin isotype-switching without acquiring somatic mutations.

Immunophenotypic characterization of IgVH3-72 B-cell chronic lymphocytic leukaemia (B-CLL).

Inhibition of constitutive and BCR-induced Syk activation downregulates Mcl-1 and induces apoptosis in chronic lymphocytic leukemia B cells

Inhibitors of SRC kinases impair antitumor activity of anti-CD20 monoclonal antibodies.

Intrinsic and extrinsic factors influencing the clinical course of B-cell chronic lymphocytic leukemia: prognostic markers with pathogenetic relevance

Lamivudine treatment for acute hepatitis B virus infection during allogeneic peripheral blood stem cell transplantation

Long-term follow up of frontline therapy with fludarabine and cyclophosphamide in chronic lymphocytic leukemia: impact of biological parameters on clinical outcome

Low prevalence of chronic hepatitis C virus infection in B-cell non-Hodgkin's lymphoma patients from a population with a high prevalence of healthy hepatitis c virus carriers.

Low-dose intravenous alemtuzumab therapy in pretreated patients affected by chronic lymphocytic leukemia. A single center experience.

Low-dose thalidomide in combination with oral fludarabine and cyclophosphamide is ineffective in heavily pre-treated patients with chronic lymphocytic leukemia

Mechanisms of B Cell Receptor Activation and Responses to B Cell Receptor Inhibitors in B Cell Malignancies

Microenvironmental interactions in chronic lymphocytic leukemia: hints for pathogenesis and identification of targets for rational therapy

Mild and severe beta-thalassemia among homozygotes from Turkey: identification of the types by hybridization of amplified DNA with synthetic probes.

Molecular analysis of IgE H-chain transcripts expressed in vivo by peripheral blood lymphocytes from normal and atopic individuals

Molecular and clinical features of chronic lymphocytic leukaemia with stereotyped B cell receptors: results from an Italian multicentre study

Molecular and clinical features of chronic lymphocytic leukemia with stereotyped B-cell receptors in a Ukrainian cohort

Multicentre validation of a prognostic index for overall survival in chronic lymphocytic leukaemia

Multiple distinct sets of stereotyped antigen receptors indicate a role for antigen in promoting chronic lymphocytic leukemia

Multiple transcripts of the murine immunoglobulin epsilon membrane locus are generated by alternative splicing and differential usage of two polyadenylation sites

New and Old Monoclonal Antibodies for the Treatment of Chronic Lymphocytic Leukemia

New developments in the management of chronic lymphocytic leukemia: role of ofatumumab

Novel Agents and Emerging Strategies for Targeting the B-Cell Receptor Pathway in CLL

Oral fludarabine and cyclophosphamide as front-line chemotherapy in patients with chronic lymphocytic leukemia. The impact of biological parameters in the response duration

Overexpression of the autoimmunity-associated phosphatase PTPN22 promotes survival of antigen-stimulated CLL cells by selectively activating AKT.

Pathogen-specific B-cell receptors drive chronic lymphocytic leukemia by light-chain-dependent cross-reaction with autoantigens

Phosphorylation of the activation loop tyrosines is required for sustained Syk signaling and growth factor-independent B-cell proliferation

Prevalence, characteristics and management of occult hepatitis B virus infection in patients with chronic lymphocytic leukemia: a single center experience

Prognostic value of immunoglobulin variable heavy chain gene mutation status: long term follow-up in a series of chronic lymphocytic leukemia patients.

Rare hemoglobin variants: Hb G-Szuhu (HBB: c.243C>G), Hb G-Coushatta (HBB: c.68A>C) and Hb Mizuho (HBB: c.206T>C) in Sri Lankan families

Recent advances in the pathogenesis and treatment of chronic lymphocytic leukemia

Reduced expression of the tumor suppressor PHLPP1 enhances the antiapoptotic B-cell receptor signal in chronic lymphocytic leukemia B-cells.

Regression of monoclonal B-cell expansion in patients affected by mixed cryoglobulinemia responsive to alpha-interferon therapy

Restricted immunoglobulin VH region repertoire in chronic lymphocytic leukemia patients with autoimmune hemolytic anemia

Role of ETS1 in the Transcriptional Network of Diffuse Large B Cell Lymphoma of the Activated B Cell-Like Type

Signal-dependent and signal-independent functions of the B-cell receptor in chronic lymphocytic leukemia

Signaling pathways activated by antigen-receptor engagement in chronic lymphocytic leukemia B-cells

Somatic hypermutation, clonal diversity, and preferential expression of the VH 51p1/VL kv325 immunoglobulin gene combination in hepatitis C virus-associated immunocytomas.

Sustained signaling through the B-cell receptor induces Mcl-1 and promotes survival of chronic lymphocytic leukemia B cells.

Synovial B cells of rheumatoid arthritis express ZAP-70 which increases the survival and correlates with the inflammatory and autoimmune phenotype

TLR9 signaling defines distinct prognostic subsets in CLL.

Targeting transcription-coupled nucleotide excision repair overcomes resistance in chronic lymphocytic leukemia.

The -158 (C-->T) promoter mutation is responsible for the increased transcription of the 3' gamma gene in the Atlanta type of hereditary persistence of fetal hemoglobin.

The Akt signaling pathway determines the different proliferative capacity of chronic lymphocytic leukemia B-cells from patients with progressive and stable disease.