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List of works by José A. Melero

A primer vector system that allows temperature dependent gene amplification and expression in mammalian cells: regulation of the influenza virus NS1 gene expression

scientific article

Analysis of genetic variability in human respiratory syncytial virus by the RNase A mismatch cleavage method: subtype divergence and heterogeneity

scientific article published on January 1990

Antibody-Induced Internalization of the Human Respiratory Syncytial Virus Fusion Protein

scientific article published on 3 May 2017

Antigenic structure of the human respiratory syncytial virus G glycoprotein and relevance of hypermutation events for the generation of antigenic variants

scientific article published in October 1997

Apoptosis, Toll-like, RIG-I-like and NOD-like Receptors Are Pathways Jointly Induced by Diverse Respiratory Bacterial and Viral Pathogens

scientific article published on March 2017

Binding of human respiratory syncytial virus to cells: implication of sulfated cell surface proteoglycans.

scientific article

Characterization in vitro and in vivo of a pandemic H1N1 influenza virus from a fatal case.

scientific article

Characterization of a Prefusion-Specific Antibody That Recognizes a Quaternary, Cleavage-Dependent Epitope on the RSV Fusion Glycoprotein

scientific article published on 10 July 2015

Characterization of a human astrovirus serotype 2 structural protein (VP26) that contains an epitope involved in virus neutralization.

scientific article published on June 1994

Chimeric Pneumoviridae fusion proteins as immunogens to induce cross-neutralizing antibody responses

scientific article published on 7 December 2017

Cleavage of the human respiratory syncytial virus fusion protein at two distinct sites is required for activation of membrane fusion

scientific article

Clinical response to pandemic H1N1 influenza virus from a fatal and mild case in ferrets.

scientific article

Conformational constraints of conserved neutralizing epitopes from a major antigenic area of human respiratory syncytial virus fusion glycoprotein.

scientific article

Conservation of G-Protein Epitopes in Respiratory Syncytial Virus (Group A) Despite Broad Genetic Diversity: Is Antibody Selection Involved in Virus Evolution?

scientific article published on 20 May 2015

Construction of cell lines that regulate by temperature the amplification and expression of influenza virus non-structural protein genes

scientific article published on September 1986

Coordinate expression of the 48K host nuclear phosphoprotein and SV40 T Ag upon primary infection of mouse cells ⬇️

scientific article published on April 30, 1980

Corrigendum: Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state

scientific article published on 29 November 2017

Cytoplasmic inclusions of respiratory syncytial virus-infected cells: formation of inclusion bodies in transfected cells that coexpress the nucleoprotein, the phosphoprotein, and the 22K protein

scientific article published on July 1993

Deoxyribinucleic acid-binding proteins in virus-transformed cell lines ⬇️

scientific article published on May 25, 1975

Effect of proteolytic processing at two distinct sites on shape and aggregation of an anchorless fusion protein of human respiratory syncytial virus and fate of the intervening segment.

scientific article published in July 2002

Electron microscopy of the human respiratory syncytial virus fusion protein and complexes that it forms with monoclonal antibodies

scientific article published in May 2000

Eliminating a region of respiratory syncytial virus attachment protein allows induction of protective immunity without vaccine-enhanced lung eosinophilia.

scientific article

Engineering, Structure and Immunogenicity of the Human Metapneumovirus F Protein in the Postfusion Conformation.

scientific article

Enhanced neutralization of human respiratory syncytial virus by mixtures of monoclonal antibodies to the attachment (G) glycoprotein

scientific article published in September 1998

Entry of enveloped viruses into host cells: membrane fusion

scientific article published on January 2013

Evaluation of the antibody specificities of human convalescent-phase sera against the attachment (G) protein of human respiratory syncytial virus: influence of strain variation and carbohydrate side chains

scientific article published in April 2000

Evolution of the G and P genes of human respiratory syncytial virus (subgroup A) studied by the RNase A mismatch cleavage method

scientific article published in September 1991

Exogenous, TAP-independent lysosomal presentation of a respiratory syncytial virus CTL epitope

scientific article published on 28 August 2012

Frame shift mutations as a novel mechanism for the generation of neutralization resistant mutants of human respiratory syncytial virus.

scientific article published on December 1990

Generation and Characterization of ALX-0171, a Potent Novel Therapeutic Nanobody for the Treatment of Respiratory Syncytial Virus Infection

scientific article

Generation of monoclonal antibodies specific of the postfusion conformation of the Pneumovirinae fusion (F) protein.

scientific article published on 12 August 2015

High level expression of soluble glycoproteins in the allantoic fluid of embryonated chicken eggs using a Sendai virus minigenome system

scientific article

Host nuclear proteins expressed in simian virus 40-transformed and -infected cells

scientific article

Human respiratory syncytial virus infects and induces activation markers in mouse B lymphocytes

scientific article published on 20 January 2009

ISG15 Is Upregulated in Respiratory Syncytial Virus Infection and Reduces Virus Growth through Protein ISGylation.

scientific article published on 13 January 2016

Identification of the glucose/glycosylation‐regulated proteins as those which accumulate in the temperature‐sensitive cell line K12 ⬇️

scientific article published on October 1, 1981

Influence of Respiratory Syncytial Virus F Glycoprotein Conformation on Induction of Protective Immune Responses.

scientific article published on 23 March 2016

Influence of antigen conformation and mode of presentation on the antibody and protective responses against human respiratory syncytial virus: relevance for vaccine development

scientific article published on 7 April 2016

Intensified-Fenton process for the treatment of phenol aqueous solutions

scientific article

Isolation and cell cycle analysis of temperature-sensitive mutants from Chinese hamster cells

scientific article published on January 1, 1979

Llama-derived single domain antibodies to build multivalent, superpotent and broadened neutralizing anti-viral molecules

scientific article (publication date: April 2011)

Location of the epitope recognized by monoclonal antibody 63G on the primary structure of human respiratory syncytial virus G glycoprotein and the ability of synthetic peptides containing this epitope to induce neutralizing antibodies

scientific article published in October 1992

Low-pH-induced membrane fusion mediated by human metapneumovirus F protein is a rare, strain-dependent phenomenon

scientific article published on 2 July 2008

Major changes in the G protein of human respiratory syncytial virus isolates introduced by a duplication of 60 nucleotides.

scientific article published in November 2003

Membrane permeability changes induced in Escherichia coli by the SH protein of human respiratory syncytial virus.

scientific article published in September 1997

Mutant forms of the F protein of human respiratory syncytial (RS) virus induce a cytotoxic T lymphocyte response but not a neutralizing antibody response and only transient resistance to RS virus infection

scientific article published in June 1996

Nuclear transport of influenza virus polymerase PA protein.

scientific article

Nucleotide sequence of the fusion and phosphoprotein genes of human respiratory syncytial (RS) virus Long strain: evidence of subtype genetic heterogeneity

scientific article

Participation of cytoskeletal intermediate filaments in the infectious cycle of human respiratory syncytial virus (RSV).

scientific article

Polyclonal and monoclonal antibodies specific for the six-helix bundle of the human respiratory syncytial virus fusion glycoprotein as probes of the protein post-fusion conformation.

scientific article published on 29 May 2014

Polylactide-co-glycolide (PLG) microparticles modify the immune response to DNA vaccination

article

Possible transcriptional control of three polypeptides which accumulate in a temperature-sensitive mammalian cell line

scientific article published in Nature

Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state.

scientific article published on 13 February 2017

Progress in understanding and controlling respiratory syncytial virus: still crazy after all these years

scientific article published on 22 September 2011

Rapid profiling of RSV antibody repertoires from the memory B cells of naturally infected adult donors

scientific article published on 09 December 2016

Recombinant Soluble Respiratory Syncytial Virus F Protein That Lacks Heptad Repeat B, Contains a GCN4 Trimerization Motif and Is Not Cleaved Displays Prefusion-Like Characteristics.

scientific article published on 24 June 2015

Reduced innate immune response, apoptosis, and virus release in cells cured of respiratory syncytial virus persistent infection.

scientific article published on 18 November 2010

Relevance of viral context and diversity of antigen-processing routes for respiratory syncytial virus cytotoxic T-lymphocyte epitopes

scientific article

Respiratory syncytial virus and other pneumoviruses: a review of the international symposium--RSV 2003.

scientific article

Respiratory syncytial virus infection of gene gun vaccinated mice induces Th2-driven pulmonary eosinophilia even in the absence of sensitisation to the fusion (F) or attachment (G) protein

scientific article published in December 2000

Roflumilast inhibits respiratory syncytial virus infection in human differentiated bronchial epithelial cells

scientific article

Selection and characterization of human respiratory syncytial virus escape mutants resistant to a polyclonal antiserum raised against the F protein

scientific article published on 14 March 2012

Social, economic, and health impact of the respiratory syncytial virus: a systematic search

scientific article

Structural, antigenic and immunogenic features of respiratory syncytial virus glycoproteins relevant for vaccine development

scientific article published on 27 September 2016

Structure and immunogenicity of pre-fusion-stabilized human metapneumovirus F glycoprotein.

scientific article published on 16 November 2017

Subcellular distribution of DNA-binding proteins from cultured hamster fibroblasts

scientific article published in July 1976

Ten years of global evolution of the human respiratory syncytial virus BA genotype with a 60-nucleotide duplication in the G protein gene

scientific article published on 26 May 2010

The Complexity of Antibody Responses Elicited against the Respiratory Syncytial Virus Glycoproteins in Hospitalized Children Younger than 2 Years

scientific article published on 22 November 2017

The Effect of Heat-inactivated Murine Cytomegalovirus on Host DNA Synthesis of Different Cells

scientific article published on June 1, 1978

The G protein of human respiratory syncytial virus: significance of carbohydrate side-chains and the C-terminal end to its antigenicity

scientific article published on March 1991

The Pneumovirinae fusion (F) protein: A common target for vaccines and antivirals

scientific article

The cysteine-rich region of respiratory syncytial virus attachment protein inhibits innate immunity elicited by the virus and endotoxin

scientific article

The main allergen of Olea europaea (Ole e I) is also present in other species of the Oleaceae family

scientific article published in April 1993

The respiratory syncytial virus vaccine landscape: lessons from the graveyard and promising candidates

scholarly article by Natalie I Mazur et al published October 2018 in Lancet Infectious Diseases

The three C-terminal residues of human respiratory syncytial virus G glycoprotein (Long strain) are essential for integrity of multiple epitopes distinguishable by antiidiotypic antibodies

scientific article published in January 1995

The use of monoclonal antibodies and lectins to identify changes in viral glycoproteins that are influenced by glycosylation: the case of human respiratory syncytial virus attachment (G) glycoprotein.

scientific article published on January 2007

Thermostability of the human respiratory syncytial virus fusion protein before and after activation: implications for the membrane-fusion mechanism

scientific article published in December 2004

Trivalency of a Nanobody Specific for the Human Respiratory Syncytial Virus Fusion Glycoprotein Drastically Enhances Virus Neutralization and Impacts Escape Mutant Selection

scientific article published on 22 August 2016

Unusual antigenic and genetic characteristics of human respiratory syncytial viruses isolated in Cuba.

scientific article

Venous Collector in a Case of Partial Anomalous Pulmonary Venous Drainage

scientific article published on 01 June 2015

Xylose isomerization with zeolites in a two-step alcohol-water process.

scientific article

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