List of works by Patrick Deelen

A Functional Genomics Approach to Understand Variation in Cytokine Production in Humans.

scientific article published on November 2016

A GWAS meta-analysis suggests roles for xenobiotic metabolism and ion channel activity in the biology of stool frequency

scientific article published on 29 July 2016

A high-quality human reference panel reveals the complexity and distribution of genomic structural variants

scientific article published on 06 October 2016

A proteomics and transcriptomics approach to identify leukemic stem cell (LSC) markers

scientific article published on 11 December 2012

Associations of autozygosity with a broad range of human phenotypes

scientific article published on 31 October 2019

Author Correction: Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

scientific article

Author Correction: Individual variations in cardiovascular-disease-related protein levels are driven by genetics and gut microbiome

scholarly article published in Nature Genetics

CNV-association meta-analysis in 191,161 European adults reveals new loci associated with anthropometric traits

scientific article published on 29 September 2017

Calling genotypes from public RNA-sequencing data enables identification of genetic variants that affect gene-expression levels

scientific article

Cohort profile: LifeLines DEEP, a prospective, general population cohort study in the northern Netherlands: study design and baseline characteristics

scientific article

Common and rare variant association analyses in Amyotrophic Lateral Sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

preprint

Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

scholarly article

Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps

scientific article published on 26 September 2016

Disease variants alter transcription factor levels and methylation of their binding sites

scientific article published on 5 December 2016

Exome sequencing in a family segregating for celiac disease

scientific article

Fine mapping of the celiac disease-associated LPP locus reveals a potential functional variant

scientific article

Functional and Genomic Architecture of Borrelia burgdorferi-Induced Cytokine Responses in Humans.

scientific article published on November 2016

Genetic and epigenetic regulation of gene expression in fetal and adult human livers

scientific article

Genome of The Netherlands population-specific imputations identify an ABCA6 variant associated with cholesterol levels

scientific article

Genotype harmonizer: automatic strand alignment and format conversion for genotype data integration

scientific article published on 11 December 2014

Identification of context-dependent expression quantitative trait loci in whole blood

scientific article published on 5 December 2016

Improved imputation quality of low-frequency and rare variants in European samples using the 'Genome of The Netherlands'.

scientific article published on 4 June 2014

Improving the diagnostic yield of exome- sequencing by predicting gene-phenotype associations using large-scale gene expression analysis

scientific article published on 28 June 2019

Improving the diagnostic yield of exome-sequencing, by predicting gene-phenotype associations using large-scale gene expression analysis

article

Individual variations in cardiovascular-disease-related protein levels are driven by genetics and gut microbiome

Inter-individual variability and genetic influences on cytokine responses to bacteria and fungi

scientific article published on 4 July 2016

Lessons learned from whole exome sequencing in multiplex families affected by a complex genetic disorder, intracranial aneurysm

scientific article

Multi-omics strategies for detecting gene-environment interactions ⬇️

PhD thesis of Patrick Deelen

Multi-omics strategies for detecting gene-environment interactions ⬇️

Electronic edition of PhD thesis of Patrick Deelen

Pooled Resequencing of 122 Ulcerative Colitis Genes in a Large Dutch Cohort Suggests Population-Specific Associations of Rare Variants in MUC2

scientific article

Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity

scientific article

Population-specific genotype imputations using minimac or IMPUTE2.

scientific article published on 30 July 2015

Refined mapping of autoimmune disease associated genetic variants with gene expression suggests an important role for non-coding RNAs

scientific article

Single-cell RNA sequencing identifies celltype-specific cis-eQTLs and co-expression QTLs.

scientific article published on 2 April 2018

TMEM258 Is a Component of the Oligosaccharyltransferase Complex Controlling ER Stress and Intestinal Inflammation

scientific article published in December 2016

The Genome of the Netherlands: design, and project goals

scientific article (publication date: February 2014)

The effect of host genetics on the gut microbiome

scientific article published on 03 October 2016

Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLA

scientific article

Unraveling the regulatory mechanisms underlying tissue-dependent genetic variation of gene expression

scientific article

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