List of works by Heinrich Kovar

A Detailed Analysis Of Duplications Appearing During Early, High Multiplicity Infections With Polyoma Virus

scientific article published on August 1, 1991

A molecular function map of Ewing's sarcoma

scientific article published on 30 April 2009

AURKA inhibitors: right in time

scientific article published on 01 July 2010

Abstract 61: A mouse model for small round cell tumors induced by the Ewing sarcoma oncogene EWS/FLI1

article published in 2014

Acute leukemias express a functional receptor for the human growth hormone

scientific article published in June 1997

Among genes involved in the RB dependent cell cycle regulatory cascade, the p16 tumor suppressor gene is frequently lost in the Ewing family of tumors.

scientific article published on October 1997

An integrated chemical biology approach identifies specific vulnerability of Ewing's sarcoma to combined inhibition of Aurora kinases A and B.

scientific article published on 18 July 2011

Blocking the road, stopping the engine or killing the driver? Advances in targeting EWS/FLI-1 fusion in Ewing sarcoma as novel therapy.

scientific article

C/EBPβ-1 promotes transformation and chemoresistance in Ewing sarcoma cells

scientific article

CD133 expression in chemo-resistant Ewing sarcoma cells

scientific article

CD99 positivity and EWS-FLI1 gene rearrangement identify a breast tumor in a 60-year-old patient with attributes of the Ewing family of neoplasms

scientific article published on 01 September 1999

CD99 regulates neural differentiation of Ewing sarcoma cells through miR-34a-Notch-mediated control of NF-κB signaling

scientific article published on 30 November 2015

CD99-positive "Ewing's sarcoma" from mouse-bone marrow-derived mesenchymal progenitor cells?

scientific article published on 01 October 2006

Caveolin-1 (CAV1) is a target of EWS/FLI-1 and a key determinant of the oncogenic phenotype and tumorigenicity of Ewing's sarcoma cells.

scientific article published on October 2006

Cloning of a novel human ELF-1-related ETS transcription factor, ELFR, its characterization and chromosomal assignment relative to ELF-1

scientific article

Co-amplification of a novel gene, NAG, with the N-myc gene in neuroblastoma.

scientific article published in January 1999

Combinatorial Drug Screening Identifies Ewing Sarcoma-specific Sensitivities

scientific article published on 15 November 2016

Combined experience of six independent laboratories attempting to create an Ewing sarcoma mouse model

scientific article

Common variants near TARDBP and EGR2 are associated with susceptibility to Ewing sarcoma

scientific article (publication date: 12 February 2012)

Constitutive and DNA damage inducible activation of pig3 and MDM2 genes by tumor-derived p53 mutant C277Y.

scientific article

Context matters: the hen or egg problem in Ewing's sarcoma.

scientific article

Correction: Increased survival and cell cycle progression pathways are required for EWS/FLI1-induced malignant transformation

Cryptic exons as a source of increased diversity of Ewing tumor-associated EWS-FLI1 chimeric products

scientific article published in September 1999

Cytogenetic and molecular genetic changes in malignant primary bone tumors

scientific article

DNA methylation heterogeneity defines a disease spectrum in Ewing sarcoma.

scientific article

Detection and clinical relevance of genetic abnormalities in pediatric acute lymphoblastic leukemia: a comparison between cytogenetic and polymerase chain reaction analyses.

scientific article published in May 1993

Detection of tumour cells in peripheral blood and bone marrow from Ewing tumour patients by RT-PCR.

scientific article published in April 1995

Development of curative therapies for Ewing sarcomas by interdisciplinary cooperative groups in Europe

scientific article published on 18 May 2015

Does expression of different EWS chimeric transcripts define clinically distinct risk groups of Ewing tumor patients?

scientific article published in April 1996

Downstream EWS/FLI1 - upstream Ewing's sarcoma

scientific article published on 28 January 2010

Dr. Jekyll and Mr. Hyde: The Two Faces of the FUS/EWS/TAF15 Protein Family.

scientific article

ESF-EMBO Symposium "Molecular Biology and Innovative Therapies in Sarcomas of Childhood and Adolescence" Sept 29-Oct 4, Polonia Castle Pultusk, Poland

scientific article published on 4 June 2013

ETS Proteins Bind with Glucocorticoid Receptors: Relevance for Treatment of Ewing Sarcoma

scientific article published on 01 October 2019

EWS-FLI1 and EWS-ERG gene fusions are associated with similar clinical phenotypes in Ewing's sarcoma.

scientific article

EWS-FLI1 confers exquisite sensitivity to NAMPT inhibition in Ewing sarcoma cells

scientific article published on February 2017

EWS-FLI1 employs an E2F switch to drive target gene expression.

scientific article

EWS-FLI1 impairs aryl hydrocarbon receptor activation by blocking tryptophan breakdown via the kynurenine pathway

scientific article published on 9 June 2016

EWS-FLI1 in Ewing's sarcoma: real targets and collateral damage

scientific article

EWS-FLI1 modulated alternative splicing of ARID1A reveals novel oncogenic function through the BAF complex

scientific article published on 01 October 2019

EWS-FLI1 suppresses NOTCH-activated p53 in Ewing's sarcoma

scientific article published on September 2008

EWS-FLI1 target genes recovered from Ewing's sarcoma chromatin

scientific article

EZH2 is a mediator of EWS/FLI1 driven tumor growth and metastasis blocking endothelial and neuro-ectodermal differentiation

scholarly article

Epigenome mapping reveals distinct modes of gene regulation and widespread enhancer reprogramming by the oncogenic fusion protein EWS-FLI1.

scientific article

Ewing Sarcoma: Current Management and Future Approaches Through Collaboration

scientific article published on 24 August 2015

Ewing sarcoma

scientific article published in July 2018

Ewing tumor biology: perspectives for innovative treatment approaches

scientific article

Ewing's sarcoma and peripheral primitive neuroectodermal tumors after their genetic union

scientific article published in July 1998

Ewing's sarcoma family of tumors: current management

scientific article (publication date: May 2006)

Expression of identical E2A/PBX1 fusion transcripts occurs in both pre-B and early pre-B immunological subtypes of childhood acute lymphoblastic leukemia

scientific article published in December 1993

Fas- and activation-induced apoptosis are reduced in human T cells preactivated in the presence of TGF-beta 1.

scientific article published in January 1996

Fine-mapping of cytogenetically undetectable EWS/ERG fusions on DNA fibers of Ewing tumors

scientific article published in January 2001

Frequent low level expression in Ewing sarcoma family tumors and widespread absence of the metastasis suppressor KAI1/CD82 in neuroblastoma

scientific article published in August 2002

Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours

scientific article

Genome-wide association study identifies multiple new loci associated with Ewing sarcoma susceptibility

scientific article published in Nature Communications

Heterogeneity of the T-cell receptor delta gene indicating subclone formation in acute precursor B-cell leukemias.

scientific article published in May 1995

High nm23-H1/NDPK-A expression in Ewing tumors: paradoxical immunohistochemical reactivity and lack of prognostic significance

scientific article published in April 1995

High-throughput RNAi screen in Ewing sarcoma cells identifies leucine rich repeats and WD repeat domain containing 1 (LRWD1) as a regulator of EWS-FLI1 driven cell viability.

scientific article published on 16 October 2016

Homologous recombination of polyoma virus DNA in mouse cells

scientific article published in January 1985

Homotypic and heterotypic interactions of EWS, FLI1 and their oncogenic fusion protein

scientific article published in October 2003

Hypoxia modulates EWS-FLI1 transcriptional signature and enhances the malignant properties of Ewing's sarcoma cells in vitro

scientific article

Identifying the druggable interactome of EWS-FLI1 reveals MCL-1 dependent differential sensitivities of Ewing sarcoma cells to apoptosis inducers

Impact of EWS-ETS fusion type on disease progression in Ewing's sarcoma/peripheral primitive neuroectodermal tumor: prospective results from the cooperative Euro-E.W.I.N.G. 99 trial

scientific article published on 22 March 2010

Increased survival and cell cycle progression pathways are required for EWS/FLI1-induced malignant transformation

scientific article published on 13 October 2016

Interaction of the EWS NH2 terminus with BARD1 links the Ewing's sarcoma gene to a common tumor suppressor pathway

scientific article (publication date: 15 August 2002)

Intercohort gene expression co-analysis reveals chemokine receptors as prognostic indicators in Ewing's sarcoma

scientific article

Intratumoural heterogeneity of 1p deletions and MYCN amplification in neuroblastomas

scientific article published in January 2001

Low incidence of molecular evidence for tumour in PBPC harvests from patients with high risk Ewing tumours

scientific article published in August 1999

Low-frequency variation near common germline susceptibility loci are associated with risk of Ewing sarcoma

scientific article published on 03 September 2020

Lysine-specific demethylase 1 (LSD1/KDM1A/AOF2/BHC110) is expressed and is an epigenetic drug target in chondrosarcoma, Ewing's sarcoma, osteosarcoma, and rhabdomyosarcoma

scientific article published on 13 January 2012

MIC2 is a specific marker for ewing's sarcoma and peripheral primitive neuroectodermal tumors. Evidence for a common histogenesis of ewing's sarcoma and peripheral primitive neuroectodermal tumors from MIC2 expression and specific chromosome aberrati

article

Metastatic extraosseous Ewing tumor: Association of the additional translocation der(16)t(1;16) with the variant EWS/ERG rearrangement in a case of cytogenetically inconspicuous chromosome 22

scientific article published on 01 April 1996

Mobilization of tumour cells during biopsy in an infant with Ewing sarcoma

scientific article published on May 1996

NPM/ALK gene fusion transcripts identify a distinct subgroup of null type Ki-1 positive anaplastic large cell lymphomas

scientific article published on 01 March 1996

Narrow spectrum of infrequent p53 mutations and absence of MDM2 amplification in Ewing tumours.

scientific article published in October 1993

Neuroblastoma cells can actively eliminate supernumerary MYCN gene copies by micronucleus formation--sign of tumour cell revertance?

scientific article published on October 1997

Notch is active in Langerhans cell histiocytosis and confers pathognomonic features on dendritic cells.

scientific article published on 16 October 2012

Notch signalling is off and is uncoupled from HES1 expression in Ewing's sarcoma

scientific article published on 24 August 2011

O-GlcNAcylation is involved in the transcriptional activity of EWS-FLI1 in Ewing's sarcoma

scientific article published on 19 January 2009

Oncogenic ETS fusions deregulate E2F3 target genes in Ewing sarcoma and prostate cancer

scientific article published on 12 August 2013

Oncogenic EWS-Fli1 interacts with hsRPB7, a subunit of human RNA polymerase II.

scientific article published on August 1998

Overexpression of HOX genes is prevalent in Ewing sarcoma and is associated with altered epigenetic regulation of developmental transcription programs.

scientific article

Paul Ehrlich (1854-1915) and His Contributions to the Foundation and Birth of Translational Medicine.

scientific article

Potentials for RNAi in sarcoma research and therapy: Ewing's sarcoma as a model.

scientific article published on August 2003

Predictive potential of testing for bone marrow involvement in Ewing tumor patients by RT-PCR: a preliminary evaluation

scientific article published in February 1998

Progress in the molecular biology of ewing tumors.

scientific article

Redirecting T cells to Ewing's sarcoma family of tumors by a chimeric NKG2D receptor expressed by lentiviral transduction or mRNA transfection

scientific article

Regression and progression in neuroblastoma. Does genetics predict tumour behaviour?

scientific article published in January 1995

Relation of neurological marker expression and EWS gene fusion types in MIC2/CD99-positive tumors of the Ewing family.

scientific article published in September 1999

Response of Ewing tumor cells to forced and activated p53 expression

scientific article published on May 2003

Retraction Note: Increased survival and cell cycle progression pathways are required for EWS/FLI1-induced malignant transformation

scientific article published on 13 August 2019

SLFN11: Achilles' Heel or Troublemaker

scientific article published in June 2015

Screening for neuroblastoma

scientific article published in The Lancet

Selective enhancer changes in osteosarcoma lung metastasis

scientific article published in February 2018

Single-chain antibodies to the EWS NH(2) terminus structurally discriminate between intact and chimeric EWS in Ewing's sarcoma and interfere with the transcriptional activity of EWS in vivo

scientific article

Suppression of FOXO1 is responsible for a growth regulatory repressive transcriptional sub-signature of EWS-FLI1 in Ewing sarcoma.

scientific article published on 2 September 2013

Suppression of KCMF1 by constitutive high CD99 expression is involved in the migratory ability of Ewing's sarcoma cells

scientific article published on 01 May 2006

Suppression of deacetylase SIRT1 mediates tumor-suppressive NOTCH response and offers a novel treatment option in metastatic Ewing sarcoma

scientific article published on 3 October 2014

Synthetic lethality between the cohesin subunits STAG1 and STAG2 in diverse cancer contexts

scientific article published on 10 July 2017

Targeted therapies in bone sarcomas.

scientific article

The ENCCA-WP7/EuroSarc/EEC/PROVABES/EURAMOS 3rd European Bone Sarcoma Networking Meeting/Joint Workshop of EU Bone Sarcoma Translational Research Networks; Vienna, Austria, September 24-25, 2015. Workshop Report

scientific article published on 16 March 2016

The EWS gene rearrangement in Ewing tumors: key to the disease

scientific article published in July 1994

The EWS protein is dispensable for Ewing tumor growth.

scientific article published in August 2001

The Ewing family of tumors and the search for the Achilles' heel.

scientific article

The YAP/TAZ Pathway in Osteogenesis and Bone Sarcoma Pathogenesis

scientific article published on 15 April 2020

The first European interdisciplinary ewing sarcoma research summit ⬇️

scientific article

The molecular basis of sarcoma

scientific article

The role of miR-17-92 in the miRegulatory landscape of Ewing sarcoma

scientific article

The second European interdisciplinary Ewing sarcoma research summit--A joint effort to deconstructing the multiple layers of a complex disease

scientific article

Two-dimensional DNA electrophoresis identifies novel CpG islands frequently coamplified withMYCN in neuroblastoma

article

Unexpected heterogeneity in E2A/PBX1 fusion messenger RNA detected by the polymerase chain reaction in pediatric patients with acute lymphoblastic leukemia.

scientific article published in September 1992

Use of transcription reporters with novel p53 binding sites to target tumour cells expressing endogenous or virally transduced p53 mutants with altered sequence-specificity

scientific article

Variability in functional p53 reactivation by PRIMA-1(Met)/APR-246 in Ewing sarcoma.

scientific article published on 15 October 2013

Variability of nm23-H1/NDPK-A expression in human lymphomas and its relation to tumour aggressiveness

scientific article

Workshop Report on the European Bone Sarcoma Networking Meeting: Integration of Clinical Trials with Tumor Biology

scientific article published in September 2011

Workshop report on the 2nd Joint ENCCA/EuroSARC European bone sarcoma network meeting: integration of clinical trials with tumour biology

scientific article published in May 2014

YAP/TAZ inhibition reduces metastatic potential of Ewing sarcoma cells

scientific article published on 08 January 2021

YK-4-279 effectively antagonizes EWS-FLI1 induced leukemia in a transgenic mouse model

scientific article published on 8 October 2015

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