List of works - Philippe G. Frank

A Western-type diet accelerates tumor progression in an autochthonous mouse model of prostate cancer

scientific article published on 18 November 2010

A biphasic response of hepatobiliary cholesterol metabolism to dietary fat at the onset of obesity in the mouse

scientific article published in April 2005

ATR/TEM8 is highly expressed in epithelial cells lining Bacillus anthracis' three sites of entry: implications for the pathogenesis of anthrax infection

scientific article

Ablation of calcineurin Aβ reveals hyperlipidemia and signaling cross-talks with phosphodiesterases

scientific article published on 20 December 2012

Adenovirus-mediated expression of caveolin-1 in mouse liver increases plasma high-density lipoprotein levels

scientific article

Alterations in membrane caveolae and BKCa channel activity in skin fibroblasts in Smith-Lemli-Opitz syndrome

scientific article published on 27 May 2011

Altered emotionality, spatial memory and cholinergic function in caveolin-1 knock-out mice

scientific article

Apolipoprotein A-I conformation in reconstituted discoidal lipoproteins varying in phospholipid and cholesterol content

scientific article published on 01 November 1995

Caveolin, caveolae, and endothelial cell function

scientific article

Caveolin-1 (P132L), a common breast cancer mutation, confers mammary cell invasiveness and defines a novel stem cell/metastasis-associated gene signature

scientific article published on May 2009

Caveolin-1 Null (−/−) Mice Show Dramatic Reductions in Life Span†

scientific article published on 01 December 2003

Caveolin-1 and caveolae in atherosclerosis: differential roles in fatty streak formation and neointimal hyperplasia

scientific article

Caveolin-1 and regulation of cellular cholesterol homeostasis

scientific journal article

Caveolin-1 deficiency stimulates neointima formation during vascular injury

scientific article

Caveolin-1 expression negatively regulates cell cycle progression by inducing G(0)/G(1) arrest via a p53/p21(WAF1/Cip1)-dependent mechanism.

scientific article

Caveolin-1 promotes tumor progression in an autochthonous mouse model of prostate cancer: genetic ablation of Cav-1 delays advanced prostate tumor development in tramp mice

scientific article

Caveolin-1 regulates the anti-atherogenic properties of macrophages

scientific article published on 17 October 2014

Caveolin-1-/- null mammary stromal fibroblasts share characteristics with human breast cancer-associated fibroblasts

scientific article published on March 2009

Caveolin-1-deficient aortic smooth muscle cells show cell autonomous abnormalities in proliferation, migration, and endothelin-based signal transduction

scientific article published on 13 January 2006

Caveolin-1-deficient mice are lean, resistant to diet-induced obesity, and show hypertriglyceridemia with adipocyte abnormalities

scientific article published on 5 December 2001

Caveolin-1-deficient mice show accelerated mammary gland development during pregnancy, premature lactation, and hyperactivation of the Jak-2/STAT5a signaling cascade.

scientific article

Caveolin-1-deficient mice show defects in innate immunity and inflammatory immune response during Salmonella enterica serovar Typhimurium infection

scientific article

Caveolin-1/3 double-knockout mice are viable, but lack both muscle and non-muscle caveolae, and develop a severe cardiomyopathic phenotype.

scientific article published on June 2002

Caveolin-2-deficient mice show increased sensitivity to endotoxemia

scientific article

Celecoxib combined with atorvastatin prevents progression of atherosclerosis

scientific article published on 31 March 2010

Characterization of human apolipoprotein A-I expressed in Escherichia coli.

scientific article

Cholesterol and breast cancer development.

scientific article published on 03 August 2012

Clinical and translational implications of the caveolin gene family: lessons from mouse models and human genetic disorders

scientific article published on 30 March 2009

Deletion of central alpha-helices in human apolipoprotein A-I: effect on phospholipid association

scientific article published on 01 February 1997

Deletion of the C-terminal domain of apolipoprotein A-I impairs cell surface binding and lipid efflux in macrophage

scientific article published on 01 November 1999

Development of a Novel High-Performance Thin Layer Chromatography-Based Method for the Simultaneous Quantification of Clinically Relevant Lipids from Cells and Tissue Extracts

scientific article published on 18 May 2020

Distinct central amphipathic alpha-helices in apolipoprotein A-I contribute to the in vivo maturation of high density lipoprotein by either activating lecithin-cholesterol acyltransferase or binding lipids

scientific article

EPA and DHA Fatty Acids Induce a Remodeling of Tumor Vasculature and Potentiate Docetaxel Activity

scientific article published on 14 July 2020

Effect of apolipoprotein A-I lipidation on the formation and function of pre-beta and alpha-migrating LpA-I particles

scientific article published on 01 February 1999

Effect of the surface lipid composition of reconstituted LPA-I on apolipoprotein A-I structure and lecithin: cholesterol acyltransferase activity

scientific article published on 01 February 1998

Endothelial caveolae and caveolin-1 as key regulators of atherosclerosis

scientific article published on 25 June 2010

Endothelial cells isolated from caveolin-2 knockout mice display higher proliferation rate and cell cycle progression relative to their wild-type counterparts

scientific article

Evolutionarily conserved role of calcineurin in phosphodegron-dependent degradation of phosphodiesterase 4D

scientific article

Genetic ablation of caveolin-1 confers protection against atherosclerosis

scientific article published on 16 October 2003

Genetic ablation of caveolin-1 drives estrogen-hypersensitivity and the development of DCIS-like mammary lesions

scientific article published on April 2009

Heteronuclear NMR studies of human serum apolipoprotein A-I. Part I. Secondary structure in lipid-mimetic solution

scientific article

ICAM-1: role in inflammation and in the regulation of vascular permeability

scientific article published on 8 August 2008

Impaired phagocytosis in caveolin-1 deficient macrophages

scientific article

Importance of central alpha-helices of human apolipoprotein A-I in the maturation of high-density lipoproteins

scientific article published on 01 September 1998

Ketones and lactate "fuel" tumor growth and metastasis: Evidence that epithelial cancer cells use oxidative mitochondrial metabolism

scientific article

Loss of caveolin-1 causes the hyper-proliferation of intestinal crypt stem cells, with increased sensitivity to whole body gamma-radiation

scientific article

Loss of caveolin-3 induces a lactogenic microenvironment that is protective against mammary tumor formation

scientific journal article

Loss of stromal caveolin-1 leads to oxidative stress, mimics hypoxia and drives inflammation in the tumor microenvironment, conferring the "reverse Warburg effect": a transcriptional informatics analysis with validation

scientific article published in June 2010

Microvascular hyperpermeability in caveolin-1 (-/-) knock-out mice. Treatment with a specific nitric-oxide synthase inhibitor, L-NAME, restores normal microvascular permeability in Cav-1 null mice

scientific article published on 7 August 2002

Muscle-specific interaction of caveolin isoforms: differential complex formation between caveolins in fibroblastic vs. muscle cells

scientific article

Oxidized Products of α-Linolenic Acid Negatively Regulate Cellular Survival and Motility of Breast Cancer Cells

scientific article published on 28 December 2019

Proteasome inhibitor (MG-132) treatment of mdx mice rescues the expression and membrane localization of dystrophin and dystrophin-associated proteins

scientific article published on October 2003

Role of caveolin-1 in the regulation of lipoprotein metabolism

scientific article published on 28 May 2008

Role of caveolin-1 in the regulation of the vascular shear stress response

scientific article published on May 2006

Role of cholesterol in the development and progression of breast cancer

scientific article

SCN4B acts as a metastasis-suppressor gene preventing hyperactivation of cell migration in breast cancer

scientific article published on 05 December 2016

SR-BI: Linking Cholesterol and Lipoprotein Metabolism with Breast and Prostate Cancer

scientific article

Seminal plasma choline phospholipid-binding proteins stimulate cellular cholesterol and phospholipid efflux

scientific article published on 01 April 1999

Stabilization of caveolin-1 by cellular cholesterol and scavenger receptor class B type I.

scientific article published on October 2002

The autophagic tumor stroma model of cancer: Role of oxidative stress and ketone production in fueling tumor cell metabolism

scientific article

The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stroma

scientific article

The reverse Warburg effect: glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts

scientific article

Towards a new "stromal-based" classification system for human breast cancer prognosis and therapy

scientific article published in June 2009

Transcriptional evidence for the "Reverse Warburg Effect" in human breast cancer tumor stroma and metastasis: similarities with oxidative stress, inflammation, Alzheimer's disease, and "Neuron-Glia Metabolic Coupling"

scientific article

List of works by Philippe G. Frank

A Western-type diet accelerates tumor progression in an autochthonous mouse model of prostate cancer

A biphasic response of hepatobiliary cholesterol metabolism to dietary fat at the onset of obesity in the mouse

ATR/TEM8 is highly expressed in epithelial cells lining Bacillus anthracis' three sites of entry: implications for the pathogenesis of anthrax infection

Ablation of calcineurin Aβ reveals hyperlipidemia and signaling cross-talks with phosphodiesterases

Adenovirus-mediated expression of caveolin-1 in mouse liver increases plasma high-density lipoprotein levels

Alterations in membrane caveolae and BKCa channel activity in skin fibroblasts in Smith-Lemli-Opitz syndrome

Altered emotionality, spatial memory and cholinergic function in caveolin-1 knock-out mice

Apolipoprotein A-I conformation in reconstituted discoidal lipoproteins varying in phospholipid and cholesterol content

Caveolin, caveolae, and endothelial cell function

Caveolin-1 (P132L), a common breast cancer mutation, confers mammary cell invasiveness and defines a novel stem cell/metastasis-associated gene signature

Caveolin-1 Null (−/−) Mice Show Dramatic Reductions in Life Span†

Caveolin-1 and caveolae in atherosclerosis: differential roles in fatty streak formation and neointimal hyperplasia

Caveolin-1 and regulation of cellular cholesterol homeostasis

Caveolin-1 deficiency stimulates neointima formation during vascular injury

Caveolin-1 expression negatively regulates cell cycle progression by inducing G(0)/G(1) arrest via a p53/p21(WAF1/Cip1)-dependent mechanism.

Caveolin-1 promotes tumor progression in an autochthonous mouse model of prostate cancer: genetic ablation of Cav-1 delays advanced prostate tumor development in tramp mice

Caveolin-1 regulates the anti-atherogenic properties of macrophages

Caveolin-1-/- null mammary stromal fibroblasts share characteristics with human breast cancer-associated fibroblasts

Caveolin-1-deficient aortic smooth muscle cells show cell autonomous abnormalities in proliferation, migration, and endothelin-based signal transduction

Caveolin-1-deficient mice are lean, resistant to diet-induced obesity, and show hypertriglyceridemia with adipocyte abnormalities

Caveolin-1-deficient mice show accelerated mammary gland development during pregnancy, premature lactation, and hyperactivation of the Jak-2/STAT5a signaling cascade.

Caveolin-1-deficient mice show defects in innate immunity and inflammatory immune response during Salmonella enterica serovar Typhimurium infection

Caveolin-1/3 double-knockout mice are viable, but lack both muscle and non-muscle caveolae, and develop a severe cardiomyopathic phenotype.

Caveolin-2-deficient mice show increased sensitivity to endotoxemia

Celecoxib combined with atorvastatin prevents progression of atherosclerosis

Characterization of human apolipoprotein A-I expressed in Escherichia coli.

Cholesterol and breast cancer development.

Clinical and translational implications of the caveolin gene family: lessons from mouse models and human genetic disorders

Deletion of central alpha-helices in human apolipoprotein A-I: effect on phospholipid association

Deletion of the C-terminal domain of apolipoprotein A-I impairs cell surface binding and lipid efflux in macrophage

Development of a Novel High-Performance Thin Layer Chromatography-Based Method for the Simultaneous Quantification of Clinically Relevant Lipids from Cells and Tissue Extracts

Distinct central amphipathic alpha-helices in apolipoprotein A-I contribute to the in vivo maturation of high density lipoprotein by either activating lecithin-cholesterol acyltransferase or binding lipids

EPA and DHA Fatty Acids Induce a Remodeling of Tumor Vasculature and Potentiate Docetaxel Activity

Effect of apolipoprotein A-I lipidation on the formation and function of pre-beta and alpha-migrating LpA-I particles

Effect of the surface lipid composition of reconstituted LPA-I on apolipoprotein A-I structure and lecithin: cholesterol acyltransferase activity

Endothelial caveolae and caveolin-1 as key regulators of atherosclerosis

Endothelial cells isolated from caveolin-2 knockout mice display higher proliferation rate and cell cycle progression relative to their wild-type counterparts

Evolutionarily conserved role of calcineurin in phosphodegron-dependent degradation of phosphodiesterase 4D

Genetic ablation of caveolin-1 confers protection against atherosclerosis

Genetic ablation of caveolin-1 drives estrogen-hypersensitivity and the development of DCIS-like mammary lesions

Heteronuclear NMR studies of human serum apolipoprotein A-I. Part I. Secondary structure in lipid-mimetic solution

ICAM-1: role in inflammation and in the regulation of vascular permeability

Impaired phagocytosis in caveolin-1 deficient macrophages

Importance of central alpha-helices of human apolipoprotein A-I in the maturation of high-density lipoproteins

Ketones and lactate "fuel" tumor growth and metastasis: Evidence that epithelial cancer cells use oxidative mitochondrial metabolism

Loss of caveolin-1 causes the hyper-proliferation of intestinal crypt stem cells, with increased sensitivity to whole body gamma-radiation

Loss of caveolin-3 induces a lactogenic microenvironment that is protective against mammary tumor formation

Loss of stromal caveolin-1 leads to oxidative stress, mimics hypoxia and drives inflammation in the tumor microenvironment, conferring the "reverse Warburg effect": a transcriptional informatics analysis with validation

Microvascular hyperpermeability in caveolin-1 (-/-) knock-out mice. Treatment with a specific nitric-oxide synthase inhibitor, L-NAME, restores normal microvascular permeability in Cav-1 null mice

Muscle-specific interaction of caveolin isoforms: differential complex formation between caveolins in fibroblastic vs. muscle cells

Oxidized Products of α-Linolenic Acid Negatively Regulate Cellular Survival and Motility of Breast Cancer Cells

Proteasome inhibitor (MG-132) treatment of mdx mice rescues the expression and membrane localization of dystrophin and dystrophin-associated proteins

Role of caveolin-1 in the regulation of lipoprotein metabolism

Role of caveolin-1 in the regulation of the vascular shear stress response

Role of cholesterol in the development and progression of breast cancer

SCN4B acts as a metastasis-suppressor gene preventing hyperactivation of cell migration in breast cancer

SR-BI: Linking Cholesterol and Lipoprotein Metabolism with Breast and Prostate Cancer

Seminal plasma choline phospholipid-binding proteins stimulate cellular cholesterol and phospholipid efflux

Stabilization of caveolin-1 by cellular cholesterol and scavenger receptor class B type I.

The autophagic tumor stroma model of cancer: Role of oxidative stress and ketone production in fueling tumor cell metabolism

The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stroma

The reverse Warburg effect: glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts

Towards a new "stromal-based" classification system for human breast cancer prognosis and therapy

Transcriptional evidence for the "Reverse Warburg Effect" in human breast cancer tumor stroma and metastasis: similarities with oxidative stress, inflammation, Alzheimer's disease, and "Neuron-Glia Metabolic Coupling"