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List of works by Tim U. Krohne

Apical-to-basolateral transcytosis of photoreceptor outer segments induced by lipid peroxidation products in human retinal pigment epithelial cells

scientific article

Astrocyte hypoxic response is essential for pathological but not developmental angiogenesis of the retina

scientific article published on August 2010

Astrocyte pVHL and HIF-α isoforms are required for embryonic-to-adult vascular transition in the eye

scientific article published on November 2011

Complement Component C5a Primes Retinal Pigment Epithelial Cells for Inflammasome Activation by Lipofuscin-mediated Photooxidative Damage

scientific article published on 12 November 2015

Concentrations of unbound bevacizumab in the aqueous of untreated fellow eyes after a single intravitreal injection in humans

scientific article published on 16 February 2010

Current therapeutic options in retinopathy of prematurity

scientific article

Diabetic maculopathy - classification and therapy

scientific article

Diabetic retinopathy. Pathophysiology and therapy of hypoxia-induced inflammation

scientific article published in May 2003

Effect of 308 nm excimer laser irradiation on retinal pigment epithelium cell viability in vitro

scientific article

Effects of Lipid Peroxidation-Related Protein Modifications on RPE Lysosomal Functions and POS Phagocytosis

scientific article published on 01 March 2007

Effects of lipid peroxidation products on lipofuscinogenesis and autophagy in human retinal pigment epithelial cells

scientific article

Efficacy of novel selective NLRP3 inhibitors in human and murine retinal pigment epithelial cells

scientific article published on 10 February 2019

Geldanamycin treatment reduces neovascularization in a mouse model of retinopathy of prematurity

scientific article published on 01 February 2007

Gene therapy of hepatocellular carcinoma in vitro and in vivo in nude mice by adenoviral transfer of the Escherichia coli purine nucleoside phosphorylase gene

scientific article published in March 2000

Generation of retinal pigment epithelial cells from small molecules and OCT4 reprogrammed human induced pluripotent stem cells

scientific article published in February 2012

High-resolution optical coherence tomography of subpigment epithelial structures in patients with pigment epithelium detachment secondary to age-related macular degeneration

scientific article published on 13 June 2012

ICAM-1 depletion does not alter retinal vascular development in a model of oxygen-mediated neovascularization.

scientific article published on 29 May 2009

INFLUENCE OF OCULAR VOLUME AND LENS STATUS ON PHARMACOKINETICS AND DURATION OF ACTION OF INTRAVITREAL VASCULAR ENDOTHELIAL GROWTH FACTOR INHIBITORS

scientific article published on 01 January 2015

INTRAOCULAR PHARMACOKINETICS AFTER A SINGLE INTRAVITREAL INJECTION OF 1.5 mg VERSUS 3.0 mg OF BEVACIZUMAB IN HUMANS

scientific article published on 01 October 2011

Immunotherapy directed against α-fetoprotein results in autoimmune liver disease during liver regeneration in mice

scientific article published on 01 October 2001

In-depth mass spectrometric mapping of the human vitreous proteome

scientific article published on 20 May 2013

Incidence of retinopathy of prematurity in Germany: evaluation of current screening criteria

scientific article published on 28 September 2020

Inflammasome priming increases retinal pigment epithelial cell susceptibility to lipofuscin phototoxicity by changing the cell death mechanism from apoptosis to pyroptosis

scientific article published on 21 May 2016

Intraocular pharmacokinetics of bevacizumab after a single intravitreal injection in humans

scientific article published on 17 July 2008

Intraocular pharmacokinetics of ranibizumab following a single intravitreal injection in humans

scientific article published on 19 July 2012

Juvenile neuronal ceroid lipofuscinosis. Ophthalmologic findings and differential diagnosis

scientific article published in July 2010

Klassifikation biomedizinischer Forschungsberichte als Grundlage evidenzbasierter Medizin in der Augenheilkunde

scientific article published on 01 December 2005

Light induces NLRP3 inflammasome activation in retinal pigment epithelial cells via lipofuscin-mediated photooxidative damage

scientific article published on 18 March 2015

Lipid metabolites in the pathogenesis and treatment of neovascular eye disease

scientific article published on 18 March 2011

Lipid peroxidation products reduce lysosomal protease activities in human retinal pigment epithelial cells via two different mechanisms of action

scientific article

Mechanisms of cell death induced by suicide genes encoding purine nucleoside phosphorylase and thymidine kinase in human hepatocellular carcinoma cells in vitro.

scientific article

Mechanisms of cell death induced by the suicide genes encoding purine nucleoside phosphorylase and thymidine kinase in human hepatocellular carcinoma cells in vitro

article

Modulation of three key innate immune pathways for the most common retinal degenerative diseases

scientific article published on 01 October 2018

Mouse alpha-fetoprotein-specific DNA-based immunotherapy of hepatocellular carcinoma leads to tumor regression in mice

scientific article

New pharmacologic approaches to therapy for age-related macular degeneration

scientific article

No Evidence to Support the Use of Plasmapheresis for Age-Related Macular Degeneration

scientific article published on 29 October 2010

Okuläre Pharmakokinetik

scientific article published on 01 February 2014

Optical coherence tomography angiography (OCT-A) in an animal model of laser-induced choroidal neovascularization

scientific article published on 16 April 2019

Pathogenesis of choroidal neovascularization. Old concepts, new questions

scientific article

Pathogenesis of diabetic macular oedema

scientific article published in August 2003

Pathological but not physiological retinal neovascularization is altered in TNF-Rp55-receptor-deficient mice.

scientific article

Pharmacokinetics and safety of intravitreally delivered etanercept

scientific article published on 17 March 2004

Pharmakokinetik intravitreal applizierter VEGF-Inhibitoren

scientific article published on 01 February 2014

Plasmapheresis for Dry Age-Related Macular Degeneration—Evidence Based?

article

Retinal Vascular Occlusion after COVID-19 Vaccination: More Coincidence than Causal Relationship? Data from a Retrospective Multicentre Study

scientific article published in 2022

Retinopathy of prematurity - pathophysiologic mechanisms and new treatment options

scientific article

Silicone oil tamponade for persistent macular holes

scientific article published on 21 October 2020

Statement of the German Ophthalmological Society, the Retina Society and the Professional Association of German Ophthalmologists: endophthalmitis prophylaxis intravitreal operative medications input (IVOM) (July 2013)

scientific article published on 15 November 2013

Stemming vision loss with stem cells

scientific article published on September 2010

The German ROP Registry: data from 90 infants treated for retinopathy of prematurity

scientific article

The long dystrophin gene product Dp427 modulates retinal function and vascular morphology in response to age and retinal ischemia

scientific article published on 11 June 2019

Unilateral blurred vision associated with combined macular and papillary edema: a 34-year-old male patient

scientific article published on December 2010

Unilateral visual impairment in the presence of retinal hemorrhages in a 35-year old female patient

scientific article published in June 2005

Using flow cytometry to compare the dynamics of photoreceptor outer segment phagocytosis in iPS-derived RPE cells

scientific article

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