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List of works by Thavendran Govender

(1R,3S)-Methyl 2-benzyl-6,7-dimeth-oxy-1-phenyl-1,2,3,4-tetra-hydro-isoquinoline-3-carboxyl-ate.

scientific article

(1R,3S)-Methyl 6,7-dimeth-oxy-1-(4-meth-oxy-phen-yl)-1,2,3,4-tetra-hydro-isoquinoline-3-carboxyl-ate

scientific article

(1R,3S)-N-Benzhydryl-2-benzyl-6,7-dimeth-oxy-1-phenyl-1,2,3,4-tetra-hydro-isoquinoline-3-carbothio-amide

scientific article published on 25 November 2011

(1S,3S)-Methyl 2-benzyl-6,7-dimeth-oxy-1-phenyl-1,2,3,4-tetra-hydro-isoquinoline-3-carboxyl-ate.

scientific article

(1S,3S)-Methyl 6,7-dimeth-oxy-1-phenyl-1,2,3,4-tetra-hydro-isoquinoline-3-carboxyl-ate

scientific article

(2-(Benzo[d]thia-zol-2yl-meth-oxy)-5-chloro-phen-yl)(phen-yl)methanone.

scientific article

(3S)-2-Benzyl-3-carb-oxy-1,2,3,4-tetra-hydro-isoquinolinium chloride monohydrate.

scientific article

(68)Ga-NOTA-functionalized Ubiquicidin: Cytotoxicity, Biodistribution, Radiation Dosimetry and First-in-Human Positron Emission Tomography/Computed Tomography Imaging of Infections.

scientific article published on 19 October 2017

(S)-2-Benzyl-N-(2,6-diisopropyl-phen-yl)-1,2,3,4-tetra-hydro-isoquinoline-3-carboxamide.

scientific article

(S)-Benzyl 3-phenyl-carbamoyl-1,2,3,4-tetra-hydro-isoquinoline-2-carboxyl-ate.

scientific article published on 29 February 2012

(S)-Methyl 2-benzamido-3-(3,4-dimeth-oxy-phen-yl)propano-ate.

scientific article published on 21 December 2011

(S)-Methyl 3-(3,4-dimethoxyphenyl)-2-[2-(diphenylphosphanyl)benzamido]propanoate ⬇️

scientific article published on November 12, 2011

1,7-Dimethyl-penta-cyclo-[5.4.0.0.0.0]undecane-8,11-dione.

scientific article

2-(3,5-Dimethyl-1,1-dioxo-2H-1λ(6),2,6-thia-diazin-4-yl)benzoic acid.

scientific article

2-(4-Chloro-3-nitro-phen-yl)-4-(4-chloro-phen-yl)-1,3-thia-zole.

scientific article

2-(Tricyclo[3.3.1.1]dec-2-ylamino)ethanol hemihydrate.

scientific article

2-Methyltetrahydrofuran and cyclopentyl methyl ether for green solid-phase peptide synthesis

scientific article published on 24 September 2015

2-[(1R,3S)-6,7-Dimeth-oxy-1-phenyl-1,2,3,4-tetra-hydro-isoquinolin-3-yl]-4-phenyl-1,3-thia-zole.

scientific article

3-(2-Amino-1,3-thia-zol-4-yl)-6-bromo-2H-chromen-2-one

scientific article

6,7-Dimeth-oxy-3-meth-oxy-carbonyl-1-(2-meth-oxy-phen-yl)-3,4-dihydro-isoquinoline 2-oxide.

scientific article

6-(Bromomaleimido)hexanoic acid as a connector for the construction of multiple branched peptide platforms.

scientific article

A comparative modeling and molecular docking study on Mycobacterium tuberculosis targets involved in peptidoglycan biosynthesis.

scientific article

A novel and more efficient biosynthesis approach for human insulin production in Escherichia coli (E. coli)

scientific article published on 10 March 2020

A sensitive WST-8-based bioassay for PEGylated granulocyte colony stimulating factor using the NFS-60 cell line

scientific article

An efficient solid-phase strategy for total synthesis of naturally occurring amphiphilic marine siderophores: amphibactin-T and moanachelin ala-B.

scientific article

An improved synthesis of Fmoc-N-methyl-alpha-amino acids

scientific article published in August 2005

An insight to the molecular interactions of the FDA approved HIV PR drugs against L38L↑N↑L PR mutant

scientific article

Analysis of Current Pulses in HeLa-Cell Permeabilization Due to High Voltage DC Corona Discharge.

scientific article published in September 2016

Applied Enantioselective Aminocatalysis: α-Heteroatom Functionalization Reactions on the Carbapenem (β-Lactam Antibiotic) Core

Artificial Intelligence vs. Statistical Modeling and Optimization of Continuous Bead Milling Process for Bacterial Cell Lysis

scientific article published on 22 November 2016

Asymmetric conjugate addition of thioglycolate to a range of chalcones using tetrahydroisoquinoline (TIQ) N,N′-dioxide ligands

article

Binding Free Energy Calculations of Nine FDA-approved Protease Inhibitors Against HIV-1 Subtype C I36T↑T Containing 100 Amino Acids Per Monomer

scientific article

Brain penetration of ketamine: Intranasal delivery VS parenteral routes of administraion

scientific article published on 20 February 2019

Chemical Platforms for Peptide Vaccine Constructs

scientific article published on 27 April 2015

Chemical speciation of copper(II) diaminediamide derivative of pentacycloundecane--a potential anti-inflammatory agent

scientific article published on 8 February 2007

Chiral Hetero- and Carbocyclic Compounds from the Asymmetric Hydrogenation of Cyclic Alkenes

scientific article published on 24 April 2012

Clofazimine protects against mycobacterium tuberculosis dissemination in the CNS following an aerosol challenge in a murine model.

scientific article

Comparison of the molecular dynamics and calculated binding free energies for nine FDA-approved HIV-1 PR drugs against subtype B and C-SA HIV PR.

scientific article published on 19 November 2012

Complete NMR elucidation of a novel trishomocubane hydantoin and its mono- and bis-t-Boc protected derivatives

scientific article

Concerted hydrolysis mechanism of HIV-1 natural substrate against subtypes B and C-SA PR: insight through molecular dynamics and hybrid QM/MM studies

scientific article published on 16 January 2020

Cu(OAc)2-Catalysed Oxidative Dual C-H/N-H Activation of Terminal Alkynes andN-Deprotected Sulfonimidamides: An Easy Access toN-Alkynylated Sulfonimidamides

article by Ganesh Chandra Nandi et al published 17 March 2015 in European Journal of Organic Chemistry

Design and study of peptide-based inhibitors of amylin cytotoxicity

scientific article published on 11 January 2010

Design, synthesis, characterization, and antibacterial activity of {5-chloro-2-[(3-substitutedphenyl-1,2,4-oxadiazol-5-yl)-methoxy]-phenyl}-(phenyl)-methanones

scientific article published on 12 February 2010

Determination of the antitubercular drug PA-824 in rat plasma, lung and brain tissues by liquid chromatography tandem mass spectrometry: application to a pharmacokinetic study.

scientific article published on 9 March 2015

Development and validation of a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the quantification of tigecycline in rat brain tissues.

scientific article published on 17 September 2015

Differential flap dynamics in l,d-transpeptidase2 from mycobacterium tuberculosis revealed by molecular dynamics.

scientific article published on 8 May 2017

Efficient Purification of rhG-CSF and its PEGylated Forms and Evaluation for In Vitro Activities.

scientific article published in January 2015

Enantioselective Organocatalyzed Transformations of β-Ketoesters.

scientific article

Enantioselective Synthesis of Chiral Sulfones by Ir-Catalyzed Asymmetric Hydrogenation: A Facile Approach to the Preparation of Chiral Allylic and Homoallylic Compounds

scientific article published on 07 August 2012

Enhanced brain penetration of pretomanid by intranasal administration of an oil-in-water nanoemulsion

scientific article published on 23 May 2018

Erratum: Tetra-kis-μ-l-alanine-κO:O'-bis-[tetra-aqua-terbium(III)] hexa-perchlorate. Corrigendum.

scientific article published on 17 July 2010

Ethyl 2-(3,5-dimethyl-1,1-dioxo-2H-1λ(6),2,6-thia-diazin-4-yl)benzoate

scientific article

Ethyl 4-(1,3-benzodioxol-5-yl)-6-methyl-2-sulfanylidene-1,2,3,4-tetra-hydro-pyrimidine-5-carboxyl-ate

scientific article published on 29 October 2011

Ethyl 4-(4-hydroxy-phen-yl)-6-methyl-2-oxo-1,2,3,4-tetra-hydro-pyrimidine-5-carboxyl-ate monohydrate

scientific article

Ethyl 6-methyl-2-sulfanyl-idene-4-[4-(trifluoro-meth-yl)phen-yl]-1,2,3,4-tetra-hydro-pyrimidine-5-carboxyl-ate.

scientific article

Evaluation of MALDI Biotyping for Rapid Subspecies Identification of Carbapenemase-Producing Bacteria via Protein Profiling

Evidence for the presence of clofazimine and its distribution in the healthy mouse brain.

scientific article published on 25 July 2015

Exploring the concerted mechanistic pathway for HIV-1 PR-substrate revealed by umbrella sampling simulation

scientific article published on 19 October 2020

Exploring the flap dynamics of the South African HIV subtype C protease in presence of FDA-approved inhibitors: MD study

scientific article published on 24 September 2018

Facile synthesis of Fmoc-N-methylated α- and β-amino acids

Fast and efficient detection of tuberculosis antigens using liposome encapsulated secretory proteins of Mycobacterium tuberculosis.

scientific article published on 8 July 2015

Highly chemoselective ligation of thiol- and amino-peptides on a bromomaleimide core

scientific article

I36T↑T mutation in South African subtype C (C-SA) HIV-1 protease significantly alters protease-drug interactions

scientific article published on 19 May 2017

Identification of potent L,D-transpeptidase 5 inhibitors for Mycobacterium tuberculosis as potential anti-TB leads: virtual screening and molecular dynamics simulations

scientific article published on 28 October 2019

Immobilized coupling reagents: synthesis of amides/peptides.

scientific article

In vitro ADMET and physicochemical investigations of poly-N-methylated peptides designed to inhibit Abeta aggregation

scientific article published on July 2010

In vitro evaluation of metal chelators as potential metallo- β -lactamase inhibitors

scientific article published on 5 February 2016

Inhibition mechanism of L,D-transpeptidase 5 in presence of the β-lactams using ONIOM method

scientific article published on 28 November 2018

Integrated approach to structure-based enzymatic drug design: molecular modeling, spectroscopy, and experimental bioactivity

scientific article published on 11 September 2013

Interaction of beta-amyloid interactions with peptide functionalized gold nanoparticles.

scientific article

Investigating time dependent brain distribution of nevirapine via mass spectrometric imaging

scientific article published on 04 November 2019

Investigation of the binding free energies of FDA approved drugs against subtype B and C-SA HIV PR: ONIOM approach.

scientific article

Kinetic and thermodynamic characterisation of HIV-protease inhibitors against E35D↑G↑S mutant in the South African HIV-1 subtype C protease

scientific article published on 01 December 2019

Lansoprazole-sulfide, pharmacokinetics of this promising anti-tuberculous agent.

scientific article

Linear and cyclic glycopeptide as HIV protease inhibitors

scientific article published on 29 November 2012

MALDI MSI and LC-MS/MS: Towards preclinical determination of the neurotoxic potential of fluoroquinolones.

scientific article published on 18 September 2015

Mass Spectrometry Imaging Demonstrates the Regional Brain Distribution Patterns of Three First-Line Antiretroviral Drugs

scientific article published on 05 December 2019

Mass spectrometric investigations into the brain delivery of abacavir, stavudine and didanosine in a rodent model

scientific article published on 29 August 2019

Mechanistic investigation of the uncatalyzed esterification reaction of acetic acid and acid halides with methanol: a DFT study.

scientific article published on 7 September 2016

Metabolic Imaging of Infection.

scientific article published on 17 August 2017

Methyl 1-cyclo-hexyl-6,7-dimeth-oxy-3,4-dihydro-isoquinoline-3-carboxyl-ate. ⬇️

scientific article

Methyl 2-(2,3,5-trimethyl-1,1-dioxo-2H-1λ(6),2,6-thia-diazin-4-yl)benzoate

scientific article published on 17 November 2012

Microreactors for peptide synthesis: looking through the eyes of twenty first century !!!

scientific article published on 25 June 2014

Microwave assisted SPPS of amylin and its toxicity of the pure product to RIN-5F cells

scientific article

Microwave-Assisted Synthesis of Antimicrobial Peptides.

scientific article

Microwave-Assisted Synthesis of Guanidine Organocatalysts Bearing a Tetrahydroisoquinoline Framework and Their Evaluation in Michael Addition Reactions

article

Microwave-assisted synthesis of meso-carboxyalkyl-BODIPYs and an application to fluorescence imaging

scientific article published on 28 September 2020

Molecular Modeling of T. rangeli, T. brucei gambiense, and T. evansi Sialidases in Complex with the DANA Inhibitor

scientific article published on 13 April 2012

Molecular insight on the non-covalent interactions between carbapenems and l,d-transpeptidase 2 from Mycobacterium tuberculosis: ONIOM study

scientific article published on 29 May 2018

N-(2-Hydroxy-ethyl)-N-(tricyclo-[3.3.1.1]dec-2-yl)benzamide.

scientific article

N-(Adamantan-1-yl)-2-chloro-acetamide

scientific article

N-Trifluoromethylthiolated Sulfonimidamides and Sulfoximines: Anti-microbial, Anti-mycobacterial, and Cytotoxic Activity

scientific article published on 11 September 2019

NMR elucidation of a novel (S)-pentacyclo-undecane bis-(4-phenyloxazoline) ligand and related derivatives

scientific article

NOTA: a potent metallo-β-lactamase inhibitor.

scientific article published on 6 January 2015

Neuroprotective potential of Linezolid: a quantitative and distribution study via mass spectrometry.

scientific article published on 21 June 2016

Novel PCU cage diol peptides as potential targets against wild-type CSA HIV-1 protease: synthesis, biological screening and molecular modelling studies

article

Novel polycyclic 'cage'-1,2-diamines as potential anti-tuberculosis agents.

scientific article published on 4 April 2012

Novel tetrahydroisoquinoline based organocatalysts for asymmetric Diels–Alder reactions: insight into the catalytic mode using ROESY NMR and DFT studies

On-Water Synthesis of Biaryl Sulfonyl Fluorides

scientific article published on 29 February 2016

Optically active diaryl tetrahydroisoquinoline derivatives

scientific article published on 08 February 2011

Optimized Microwave Assisted Synthesis of LL37, a Cathelicidin Human Antimicrobial Peptide

Organocatalytic Mannich Reactions on a Carbapenem Core - Synthesis of Mannich Bases and Bicyclic Diazanonanes

Organocatalytic synthesis of chiral benzopyrans

Organocatalyzed stereospecific C-C bond formation of β-lactams

scientific article published on 11 November 2013

Oxyma-B, an excellent racemization suppressor for peptide synthesis

scientific article published in November 2014

Pd-catalyzed C–N coupling of vinylbromides and sulfonimidamides: a facile synthesis of N′-vinylsulfonimidamides

scholarly article in RSC Advances, vol. 5 no. 76, 2015

Pentacycloundecane derived hydroxy acid peptides: a new class of irreversible non-scissile ether bridged type isoster as potential HIV-1 wild type C-SA protease inhibitors

scientific article published on 16 August 2011

Pentacycloundecane lactam vs lactone norstatine type protease HIV inhibitors: binding energy calculations and DFT study

scientific article

Pentacycloundecane-based inhibitors of wild-type C-South African HIV-protease

scientific article published on March 2011

Pentacycloundecane-diol-based HIV-1 protease inhibitors: biological screening, 2D NMR, and molecular simulation studies

scientific article published on 27 April 2012

Peptide synthesis beyond DMF: THF and ACN as excellent and friendlier alternatives

scientific article published in February 2015

Phototriggerable peptidomimetics for the inhibition of Mycobacterium tuberculosis ribonucleotide reductase by targeting protein-protein binding

scientific article published on March 2015

Poly-N-methylated Aβ-Peptide C-Terminal fragments (MEPTIDES) reverse the deleterious effects of amyloid-β in rats

scientific article

Poly-N-methylated amyloid beta-peptide (Abeta) C-terminal fragments reduce Abeta toxicity in vitro and in Drosophila melanogaster

scientific article published in December 2009

Polycyclic Cage Structures as Lipophilic Scaffolds for Neuroactive Drugs ⬇️

scientific article published on 03 February 2012

Pore formation in phospholipid bilayers by amphiphilic cavitands

scientific article published on 20 April 2011

Post heroin dose tissue distribution of 6-monoacetylmorphine (6-MAM) with MALDI imaging

scientific article

Potential inhibition of HIV-1 encapsidation by oligoribonucleotide-dendrimer nanoparticle complexes.

scientific article published on 04 January 2017

Preclinical evaluation of 68Ga-labeled 1,4,7-triazacyclononane-1,4,7-triacetic acid-ubiquicidin as a radioligand for PET infection imaging

scientific article published on 16 January 2014

Proline N-oxides: modulators of the 3D conformation of linear peptides through "NO-turns".

scientific article

Purification and characterization of naturally occurring HIV-1 (South African subtype C) protease mutants from inclusion bodies.

scientific article

Rapid and widespread distribution of doxycycline in rat brain: a mass spectrometric imaging study.

scientific article

Rilpivirine as a potential candidate for the treatment of HIV-associated neurocognitive disorders (HAND)

scientific article published on 22 April 2019

Short AntiMicrobial Peptides (SAMPs) as a class of extraordinary promising therapeutic agents.

scientific article published on July 2016

Simulating the inhibition reaction of Mycobacterium tuberculosis L,D-transpeptidase 2 by carbapenems.

scientific article

Small molecule distribution in rat lung: a comparison of various cryoprotectants as inflation media and their applicability to MSI.

scientific article published on 13 January 2016

Solid-Phase Synthesis of Pyrrole Derivatives through a Multicomponent Reaction Involving Lys-Containing Peptides.

scientific article published on 14 February 2018

Solid-phase peptide synthesis (SPPS), C-terminal vs. side-chain anchoring: a reality or a myth.

scientific article published on 26 April 2014

Spatial distribution of elvitegravir and tenofovir in rat brain tissue: Application of matrix-assisted laser desorption/ionization mass spectrometry imaging and liquid chromatography/tandem mass spectrometry

scientific article published on 01 November 2019

Structural and functional features of enzymes of Mycobacterium tuberculosis peptidoglycan biosynthesis as targets for drug development.

scientific article

Sulfonimidamide in medizinischer Chemie und Agrochemie

Sulfonimidamides in Medicinal and Agricultural Chemistry

scientific article published on 13 December 2016

Synthesis and Biological Evaluation of a Teixobactin Analogue.

scientific article published on 10 December 2015

Synthesis and NMR elucidation of novel penta-cycloundecane amine derivatives as potential antituberculosis agents

scientific article

Synthesis and NMR elucidation of novel pentacycloundecane-based peptides

scientific article published in June 2010

Synthesis and NMR elucidation of novel tetrapeptides

scientific article published on 11 November 2011

Synthesis and evaluation of SQ109 analogues as potential anti-tuberculosis candidates

scientific article published on 28 January 2010

Synthesis and structural studies of pentacycloundecane-based HIV-1 PR inhibitors: a hybrid 2D NMR and docking/QM/MM/MD approach

scientific article published on 7 June 2011

Synthesis of novel 1,2,4-thiadiazinane 1,1-dioxides via three component SuFEx type reaction

scholarly article in RSC Advances, vol. 8 no. 65, 2018

Synthesis, 2D-NMR and molecular modelling studies of pentacycloundecane lactam-peptides and peptoids as potential HIV-1 wild type C-SA protease inhibitors

scientific article

Synthesis, 68Ga-radiolabeling, and preliminary in vivo assessment of a depsipeptide-derived compound as a potential PET/CT infection imaging agent

scientific article

Synthesis, in vitro evaluation, and 68 Ga-radiolabeling of CDP1 toward PET/CT imaging of bacterial infection.

scientific article published on 22 March 2017

Synthesis, screening and computational investigation of pentacycloundecane-peptoids as potent CSA-HIV PR inhibitors

article

Synthetic approaches to radiochemical probes for imaging of bacterial infections.

scientific article published on 29 March 2017

TOMBU and COMBU as Novel Uronium-type peptide coupling reagents derived from Oxyma-B.

scientific article published on 18 November 2014

Targeting the cell wall of Mycobacterium tuberculosis: a molecular modeling investigation of the interaction of imipenem and meropenem with L,D-transpeptidase 2.

scientific article published on 12 March 2015

Tetra-kis-μ-l-alanine-κO:O'-bis-[tetra-aqua-terbium(III)] hexa-perchlorate.

scientific article

Tetrahydroisoquinoline-Based N-Oxides as Chiral Organocatalysts for the Asymmetric Allylation of Aldehydes

The Driving Force for the Acylation of β-Lactam Antibiotics by L,D-Transpeptidase 2: Quantum Mechanics/Molecular Mechanics (QM/MM) Study

scientific article published on 10 April 2019

The catalytic role of water in the binding site of l,d-transpeptidase 2 within acylation mechanism: A QM/MM (ONIOM) modelling

scientific article published on 19 October 2018

The downfall of TBA-354 - a possible explanation for its neurotoxicity via mass spectrometric imaging.

scientific article published in September 2017

The effect of N-methylation of amino acids (Ac-X-OMe) on solubility and conformation: a DFT study.

scientific article published on 20 August 2015

The impact of active site mutations of South African HIV PR on drug resistance: Insight from molecular dynamics simulations, binding free energy and per-residue footprints

scientific article published on April 2014

Theoretical Model for HIV-1 PR That Accounts for Substrate Recognition and Preferential Cleavage of Natural Substrates

scientific article published on 22 July 2019

Time-dependent regional brain distribution of methadone and naltrexone in the treatment of opioid addiction.

scientific article published on 14 February 2018

Tissue distribution of pretomanid in rat brain via mass spectrometry imaging

scientific article published on 24 July 2015

Total synthesis of a depsidomycin analogue by convergent solid-phase peptide synthesis and macrolactonization strategy for antitubercular activity.

scientific article published on 18 July 2011

Towards a stereoselective synthesis of α,α-disubstituted proline analogues

Trishomocubane Amino Acid as a β-turn scaffold

Visualization of Time-Dependent Distribution of Rifampicin in Rat Brain Using MALDI MSI and Quantitative LCMS/MS.

scientific article published on 12 June 2015

Zidovudine and Lamivudine as Potential Agents to Combat HIV-Associated Neurocognitive Disorder

scientific article published on 01 October 2019

l-Proline organocatalyzed Michael synthesis of monobactam and carbapenem β-lactam cores

{(1R,3S)-2-Benzyl-6,7-dimeth-oxy-1-phenyl-1,2,3,4-tetra-hydro-isoquinolin-3-yl}diphenyl-methanol.

scientific article

{2-[(1,3-Benzo-thia-zol-2-yl)meth-oxy]-5-fluoro-phen-yl}(4-chloro-phen-yl)methanone

scientific article published on 08 June 2013

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