List of works - Maria Bertolotto

6-amino-4-oxo-1,3-diphenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonyl derivatives as a new class of potent inhibitors of Interleukin-8-induced neutrophil chemotaxis.

scientific article published on 11 April 2009

A novel role of the CX3CR1/CX3CL1 system in the cross-talk between chronic lymphocytic leukemia cells and tumor microenvironment.

scientific article

Acipimox reduces circulating levels of insulin and associated neutrophilic inflammation in metabolic syndrome.

scientific article published on 25 January 2011

Activation of neutrophil respiratory burst by cytokines and chemoattractants. Regulatory role of extracellular matrix glycoproteins

scientific article published on 01 August 1998

Anti-Apolipoprotein A-1 auto-antibodies are active mediators of atherosclerotic plaque vulnerability

Anti-apolipoprotein A-1 auto-antibodies as active modulators of atherothrombosis.

scientific article

Antiproliferative and proapoptotic activities of a new class of pyrazole derivatives in HL-60 cells.

scientific article published on October 2009

Baseline hs-CRP predicts hypertension remission in metabolic syndrome

scientific article published on 03 June 2019

CB(2) cannabinoid receptor activation is cardioprotective in a mouse model of ischemia/reperfusion

scientific article published on 7 January 2009

CCL3 (MIP-1α) induces in vitro migration of GM-CSF-primed human neutrophils via CCR5-dependent activation of ERK 1/2

CX3CR1 is expressed by human B lymphocytes and mediates [corrected] CX3CL1 driven chemotaxis of tonsil centrocytes

scientific article

Chlorhexidine prevents hypochlorous acid-induced inactivation of alpha1-antitrypsin

scientific article published on 4 August 2009

Coronary artery calcification and cardiovascular risk: the role of RANKL/OPG signalling

scientific article published on 23 May 2010

Delayed apoptosis of human monocytes exposed to immune complexes is reversed by oxaprozin: role of the Akt/IkappaB kinase/nuclear factor kappaB pathway

scientific article published on 26 March 2009

Early reduction of matrix metalloproteinase-8 serum levels is associated with leptin drop and predicts diabetes remission after bariatric surgery

scientific article published on 13 July 2017

Effect of different cytokines on mammaglobin and maspin gene expression in normal leukocytes: possible relevance to the assays for the detection of micrometastatic breast cancer.

scientific article published in May 2005

Endothelial and smooth muscle cells from abdominal aortic aneurysm have increased oxidative stress and telomere attrition

scientific article

Exocytosis of azurophil and arginase 1-containing granules by activated polymorphonuclear neutrophils is required to inhibit T lymphocyte proliferation.

scientific article

Human mesenchymal stem cells inhibit neutrophil apoptosis: a model for neutrophil preservation in the bone marrow niche

scientific article published on 11 October 2007

Immune complexes induce monocyte survival through defined intracellular pathways.

scientific article published in January 2007

Induction of Neutrophil Chemotaxis by Leptin: Crucial Role for p38 and Src Kinases

scientific article published on 01 June 2006

Inhibition of nicotinamide phosphoribosyltransferase reduces neutrophil-mediated injury in myocardial infarction

scientific article published on 14 May 2012

Insulin Primes Human Neutrophils for CCL3-Induced Migration: Crucial Role for JNK 1/2

scientific article published on 01 December 2006

Intraplaque Expression of C-Reactive Protein Predicts Cardiovascular Events in Patients with Severe Atherosclerotic Carotid Artery Stenosis

scientific article published on 21 September 2016

Leptin as a uremic toxin interferes with neutrophil chemotaxis.

scientific article

Leptin/adiponectin ratio predicts poststroke neurological outcome

scientific article published on 18 September 2015

Neutrophil migration towards C5a and CXCL8 is prevented by non-steroidal anti-inflammatory drugs via inhibition of different pathways

scientific article

Nicotinamide phosphoribosyltransferase inhibition reduces intraplaque CXCL1 production and associated neutrophil infiltration in atherosclerotic mice

scientific article published on 7 November 2013

Nonleukoreduced red blood cell transfusion induces a sustained inhibition of neutrophil chemotaxis by stimulating in vivo production of transforming growth factor-beta1 by neutrophils: role of the immunoglobulinlike transcript 1, sFasL, and sHLA-I.

scientific article published in August 2007

Oxaprozin-induced apoptosis on CD40 ligand-treated human primary monocytes is associated with the modulation of defined intracellular pathways

scientific article published on 10 August 2009

Platelet-to-lymphocyte ratio at the time of carotid endarterectomy is associated with acute coronary syndrome occurrence

scientific article published on 20 September 2019

Receptor activator of NF- κB ligand (RANKL) increases the release of neutrophil products associated with coronary vulnerability.

scientific article published on 24 November 2011

Recombinant Tissue Plasminogen Activator (r-tPA) Induces In-Vitro Human Neutrophil Migration via Low Density Lipoprotein Receptor-Related Protein 1 (LRP-1)

scientific article published on 23 September 2020

Resistin exerts a beneficial role in atherosclerotic plaque inflammation by inhibiting neutrophil migration

scientific article published on 24 July 2018

Serum PCSK9 levels predict the occurrence of acute coronary syndromes in patients with severe carotid artery stenosis

scientific article published on 01 July 2018

Serum adiponectin levels predict acute coronary syndrome (ACS) in patients with severe carotid stenosis

scientific article published on 2 January 2018

Serum levels of anti-apolipoprotein A-1 auto-antibodies and myeloperoxidase as predictors of major adverse cardiovascular events after carotid endarterectomy

scholarly article by Giovanni Spinella et al published 2013 in Thrombosis and Haemostasis

Serum levels of osteopontin predict major adverse cardiovascular events in patients with severe carotid artery stenosis

scientific article published on 5 January 2018

Serum lipoprotein (a) predicts acute coronary syndromes in patients with severe carotid stenosis

scientific article

Statin treatment is associated with reduction in serum levels of receptor activator of NF-κB ligand and neutrophil activation in patients with severe carotid stenosis.

scientific article

Sulphasalazine accelerates apoptosis in neutrophils exposed to immune complex: Role of caspase pathway.

scientific article published on 19 May 2009

Synthesis and Biological Evaluation ofN-Pyrazolyl-N‘-alkyl/benzyl/phenylureas: a New Class of Potent Inhibitors of Interleukin 8-Induced Neutrophil Chemotaxis

Synthesis and biological evaluation of novel heterocyclic ionone-like derivatives as anti-inflammatory agents

scientific article published on 08 May 2006

Systemic and intraplaque mediators of inflammation are increased in patients symptomatic for ischemic stroke

scientific article

The activation of the cannabinoid receptor type 2 reduces neutrophilic protease-mediated vulnerability in atherosclerotic plaques.

scientific article

Treatment with Angiotensin-(1–7) reduces inflammation in carotid atherosclerotic plaques

scientific article published on 06 February 2014

Treatment with KLEPTOSE® CRYSMEB reduces mouse atherogenesis by impacting on lipid profile and Th1 lymphocyte response

scientific article published on 25 April 2015

Treatment with recombinant tissue plasminogen activator (r-TPA) induces neutrophil degranulation in vitro via defined pathways

scientific article published on 18 December 2014

Treatment with sulphated galactan inhibits macrophage chemotaxis and reduces intraplaque macrophage content in atherosclerotic mice

scientific article

Tumor necrosis factor-alpha (TNF-α) induces integrin CD11b/CD18 (Mac-1) up-regulation and migration to the CC chemokine CCL3 (MIP-1α) on human neutrophils through defined signalling pathways

article

Vitamin D receptor is expressed within human carotid plaques and correlates with pro-inflammatory M1 macrophages

scientific article published on 20 August 2016

List of works by Maria Bertolotto

6-amino-4-oxo-1,3-diphenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonyl derivatives as a new class of potent inhibitors of Interleukin-8-induced neutrophil chemotaxis.

A novel role of the CX3CR1/CX3CL1 system in the cross-talk between chronic lymphocytic leukemia cells and tumor microenvironment.

Acipimox reduces circulating levels of insulin and associated neutrophilic inflammation in metabolic syndrome.

Activation of neutrophil respiratory burst by cytokines and chemoattractants. Regulatory role of extracellular matrix glycoproteins

Anti-Apolipoprotein A-1 auto-antibodies are active mediators of atherosclerotic plaque vulnerability

Anti-apolipoprotein A-1 auto-antibodies as active modulators of atherothrombosis.

Antiproliferative and proapoptotic activities of a new class of pyrazole derivatives in HL-60 cells.

Baseline hs-CRP predicts hypertension remission in metabolic syndrome

CB(2) cannabinoid receptor activation is cardioprotective in a mouse model of ischemia/reperfusion

CCL3 (MIP-1α) induces in vitro migration of GM-CSF-primed human neutrophils via CCR5-dependent activation of ERK 1/2

CX3CR1 is expressed by human B lymphocytes and mediates [corrected] CX3CL1 driven chemotaxis of tonsil centrocytes

Chlorhexidine prevents hypochlorous acid-induced inactivation of alpha1-antitrypsin

Coronary artery calcification and cardiovascular risk: the role of RANKL/OPG signalling

Delayed apoptosis of human monocytes exposed to immune complexes is reversed by oxaprozin: role of the Akt/IkappaB kinase/nuclear factor kappaB pathway

Early reduction of matrix metalloproteinase-8 serum levels is associated with leptin drop and predicts diabetes remission after bariatric surgery

Effect of different cytokines on mammaglobin and maspin gene expression in normal leukocytes: possible relevance to the assays for the detection of micrometastatic breast cancer.

Endothelial and smooth muscle cells from abdominal aortic aneurysm have increased oxidative stress and telomere attrition

Exocytosis of azurophil and arginase 1-containing granules by activated polymorphonuclear neutrophils is required to inhibit T lymphocyte proliferation.

Human mesenchymal stem cells inhibit neutrophil apoptosis: a model for neutrophil preservation in the bone marrow niche

Immune complexes induce monocyte survival through defined intracellular pathways.

Induction of Neutrophil Chemotaxis by Leptin: Crucial Role for p38 and Src Kinases

Inhibition of nicotinamide phosphoribosyltransferase reduces neutrophil-mediated injury in myocardial infarction

Insulin Primes Human Neutrophils for CCL3-Induced Migration: Crucial Role for JNK 1/2

Intraplaque Expression of C-Reactive Protein Predicts Cardiovascular Events in Patients with Severe Atherosclerotic Carotid Artery Stenosis

Leptin as a uremic toxin interferes with neutrophil chemotaxis.

Leptin/adiponectin ratio predicts poststroke neurological outcome

Neutrophil migration towards C5a and CXCL8 is prevented by non-steroidal anti-inflammatory drugs via inhibition of different pathways

Nicotinamide phosphoribosyltransferase inhibition reduces intraplaque CXCL1 production and associated neutrophil infiltration in atherosclerotic mice

Nonleukoreduced red blood cell transfusion induces a sustained inhibition of neutrophil chemotaxis by stimulating in vivo production of transforming growth factor-beta1 by neutrophils: role of the immunoglobulinlike transcript 1, sFasL, and sHLA-I.

Oxaprozin-induced apoptosis on CD40 ligand-treated human primary monocytes is associated with the modulation of defined intracellular pathways

Platelet-to-lymphocyte ratio at the time of carotid endarterectomy is associated with acute coronary syndrome occurrence

Receptor activator of NF- κB ligand (RANKL) increases the release of neutrophil products associated with coronary vulnerability.

Recombinant Tissue Plasminogen Activator (r-tPA) Induces In-Vitro Human Neutrophil Migration via Low Density Lipoprotein Receptor-Related Protein 1 (LRP-1)

Resistin exerts a beneficial role in atherosclerotic plaque inflammation by inhibiting neutrophil migration

Serum PCSK9 levels predict the occurrence of acute coronary syndromes in patients with severe carotid artery stenosis

Serum adiponectin levels predict acute coronary syndrome (ACS) in patients with severe carotid stenosis

Serum levels of anti-apolipoprotein A-1 auto-antibodies and myeloperoxidase as predictors of major adverse cardiovascular events after carotid endarterectomy

Serum levels of osteopontin predict major adverse cardiovascular events in patients with severe carotid artery stenosis

Serum lipoprotein (a) predicts acute coronary syndromes in patients with severe carotid stenosis

Statin treatment is associated with reduction in serum levels of receptor activator of NF-κB ligand and neutrophil activation in patients with severe carotid stenosis.

Sulphasalazine accelerates apoptosis in neutrophils exposed to immune complex: Role of caspase pathway.

Synthesis and Biological Evaluation ofN-Pyrazolyl-N‘-alkyl/benzyl/phenylureas: a New Class of Potent Inhibitors of Interleukin 8-Induced Neutrophil Chemotaxis

Synthesis and biological evaluation of novel heterocyclic ionone-like derivatives as anti-inflammatory agents

Systemic and intraplaque mediators of inflammation are increased in patients symptomatic for ischemic stroke

The activation of the cannabinoid receptor type 2 reduces neutrophilic protease-mediated vulnerability in atherosclerotic plaques.

Treatment with Angiotensin-(1–7) reduces inflammation in carotid atherosclerotic plaques

Treatment with KLEPTOSE® CRYSMEB reduces mouse atherogenesis by impacting on lipid profile and Th1 lymphocyte response

Treatment with recombinant tissue plasminogen activator (r-TPA) induces neutrophil degranulation in vitro via defined pathways

Treatment with sulphated galactan inhibits macrophage chemotaxis and reduces intraplaque macrophage content in atherosclerotic mice

Tumor necrosis factor-alpha (TNF-α) induces integrin CD11b/CD18 (Mac-1) up-regulation and migration to the CC chemokine CCL3 (MIP-1α) on human neutrophils through defined signalling pathways

Vitamin D receptor is expressed within human carotid plaques and correlates with pro-inflammatory M1 macrophages