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List of works by Andrew K Sewell

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one

scientific article (publication date: November 2016)

A Molecular Switch Abrogates Glycoprotein 100 (gp100) T-cell Receptor (TCR) Targeting of a Human Melanoma Antigen.

scientific article

A Novel Approach to Antigen-Specific Deletion of CTL with Minimal Cellular Activation Using α3 Domain Mutants of MHC Class I/Peptide Complex

scientific article published on 01 May 2001

A distinct immunogenic region of glutamic acid decarboxylase 65 is naturally processed and presented by human islet cells to cytotoxic CD8 T cells.

scientific article published on January 2015

A molecular switch in immunodominant HIV-1-specific CD8 T-cell epitopes shapes differential HLA-restricted escape

scientific article

A single autoimmune T cell receptor recognizes more than a million different peptides

scientific article published on 18 November 2011

A structural voyage toward an understanding of the MHC‐I‐restricted immune response: lessons learned and much to be learned ⬇️

scientific article published on November 1, 2012

Activation of heat shock transcription factor in yeast is not influenced by the levels of expression of heat shock proteins.

scientific article

Adenosine and cAMP signalling skew human dendritic cell differentiation towards a tolerogenic phenotype with defective CD8(+) T-cell priming capacity

scientific article published on 01 April 2013

Adoptive T-cell therapy for cancer in the United kingdom: a review of activity for the British Society of Gene and Cell Therapy annual meeting 2015.

scientific article published on May 2015

Advances in T-cell epitope engineering

scientific article published on 5 June 2013

Agr interference between clinical Staphylococcus aureus strains in an insect model of virulence.

scientific article published on 25 August 2006

Analysis of CD8+ T-cell-mediated inhibition of hepatitis C virus replication using a novel immunological model

scientific article

Analysis of copper-induced metallothionein expression using autonomously replicating plasmids in Candida glabrata

article

Antagonism of cytotoxic T lymphocyte-mediated lysis by natural HIV-1 altered peptide ligands requires simultaneous presentation of agonist and antagonist peptides.

scientific article published in September 1997

Antagonism of cytotoxic T-lymphocyte activation by soluble CD8.

scientific article published in April 1999

Anti-CD8 antibodies can trigger CD8+ T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining

scientific article

Anti-coreceptor antibodies profoundly affect staining with peptide-MHC class I and class II tetramers

scientific article published on July 2006

Antibody stabilization of peptide-MHC multimers reveals functional T cells bearing extremely low-affinity TCRs

scientific article

Antigen-specific release of beta-chemokines by anti-HIV-1 cytotoxic T lymphocytes

scientific article

Author Correction: Genome-wide CRISPR-Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1

scientific article published on 02 March 2020

Autoreactive T effector memory differentiation mirrors β cell function in type 1 diabetes.

scientific article published on 16 July 2018

Availability of a diversely avid CD8+ T cell repertoire specific for the subdominant HLA-A2-restricted HIV-1 Gag p2419-27 epitope

scientific article published on June 2007

Avidity for antigen shapes clonal dominance in CD8+ T cell populations specific for persistent DNA viruses

scientific article

Bioactivity of Metallothionein-3 Correlates with Its Novel .beta. Domain Sequence Rather Than Metal Binding Properties

scientific article published on 01 April 1995

Breaking the kinetic window of T-cell activation

scientific article published on 01 February 2002

CD8 controls T cell cross-reactivity

scientific article published on 15 September 2010

CD8 exerts differential effects on the deployment of cytotoxic T lymphocyte effector functions

scientific article published on April 2007

CD8(+) T cell cross-reactivity profiles and HIV-1 immune escape towards an HLA-B35-restricted immunodominant Nef epitope

scientific article

CRISPR-mediated TCR replacement generates superior anticancer transgenic T cells

scientific article published on 9 November 2017

CTLs are targeted to kill ? cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope.

scientific article published in September 2009

CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope

scientific article published on October 2008

Ca2+ release from the endoplasmic reticulum of NY-ESO-1-specific T cells is modulated by the affinity of TCR and by the use of the CD8 coreceptor

scientific article

Cellular-level versus receptor-level response threshold hierarchies in T-cell activation

scientific article published on 05 September 2013

Circulating β cell-specific CD8+ T cells restricted by high-risk HLA class I molecules show antigen experience in children with and at risk of type 1 diabetes

scientific article published on 10 November 2019

Clonotypically similar hybrid αβ T cell receptors can exhibit markedly different surface expression, antigen specificity and cross-reactivity.

scientific article published on June 2015

Comparison of peptide-major histocompatibility complex tetramers and dextramers for the identification of antigen-specific T cells

scientific article

Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor

scientific article published on 9 November 2008

Copresentation of natural HIV-1 agonist and antagonist ligands fails to induce the T cell receptor signaling cascade.

scientific article

Coreceptor CD8-driven modulation of T cell antigen receptor specificity.

scientific article published on 8 August 2007

Coreceptor scanning by the T cell receptor provides a mechanism for T cell tolerance

scientific article published on 2 October 2014

Cross-staining of cytotoxic T lymphocyte populations with peptide-MHC class I multimers of natural HIV-1 variant antigens

article

Crystallization and preliminary X-ray structural studies of a Melan-A pMHC-TCR complex

scientific article

Cytotoxic T lymphocyte responses to human immunodeficiency virus: control and escape.

scientific article

Defining the directionality and quality of influenza virus-specific CD8+ T cell cross-reactivity in individuals infected with hepatitis C virus

scientific article

Defining the directionality and quality of influenza virus?specific CD8+ T cell cross-reactivity in individuals infected with hepatitis C virus.

scientific article published in March 2011

Design of soluble recombinant T cell receptors for antigen targeting and T cell inhibition

scientific article

Design, synthesis and evaluation of β-lactam antigenic peptide hybrids; unusual opening of the β-lactam ring in acidic media ⬇️

scientific article published on October 7, 2010

Designer T-cells and T-cell receptors for customized cancer immunotherapies

scientific article published on 29 May 2018

Detection of low avidity CD8(+) T cell populations with coreceptor-enhanced peptide-major histocompatibility complex class I tetramers

scientific article published on 31 July 2008

Different T Cell Receptor Affinity Thresholds and CD8 Coreceptor Dependence Govern Cytotoxic T Lymphocyte Activation and Tetramer Binding Properties

scientific article published in Journal of Biological Chemistry

Differential clade-specific HLA-B*3501 association with HIV-1 disease outcome is linked to immunogenicity of a single Gag epitope

scientific article published on 12 September 2012

Differential processing of HLA A2-restricted HIV type 1 cytotoxic T lymphocyte epitopes

scientific article

Disease etiology and diagnosis by TCR repertoire analysis goes viral.

scientific article published on November 2016

Distortion of the Major Histocompatibility Complex Class I Binding Groove to Accommodate an Insulin-derived 10-Mer Peptide

scientific article published on 17 June 2015

Dominance of metallothionein in metal ion buffering in yeast capable of synthesis of (gamma EC)nG isopeptides

scientific article published in Journal of Biological Chemistry

Dual Molecular Mechanisms Govern Escape at Immunodominant HLA A2-Restricted HIV Epitope.

scientific article published on 10 November 2017

Dyslipidemia due to retroviral protease inhibitors

scientific article

ELISPOT and functional T cell analyses using HLA mono-specific target cells.

scientific article published in September 2009

Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8+ and CD4+ T lymphocytes

scientific article

Effects of retroviral protease inhibitors on proteasome function and processing of HIV-derived MHC class I-restricted cytotoxic T lymphocyte epitopes.

scientific article published in July 2001

Engineering of Isogenic Cells Deficient for MR1 with a CRISPR/Cas9 Lentiviral System: Tools To Study Microbial Antigen Processing and Presentation to Human MR1-Restricted T Cells

scientific article published on 15 June 2016

Enhanced Detection of Antigen-Specific CD4+ T Cells Using Altered Peptide Flanking Residue Peptide-MHC Class II Multimers

scientific article published on 9 November 2015

Enhanced immunogenicity of CTL antigens through mutation of the CD8 binding MHC class I invariant region

scientific article published on May 2007

Enhanced neurotrophic activity in Alzheimer's disease cortex is not associated with down-regulation of metallothionein-III (GIF).

scientific article

Functional and biophysical characterization of an HLA-A*6801-restricted HIV-specific T cell receptor

scientific article

Functional discrepancies in HIV-specific CD8+ T-lymphocyte populations are related to plasma virus load

scientific article published in November 2002

Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination

scientific article published on 29 August 2016

Generation of a functional, soluble tapasin protein from an alternatively spliced mRNA.

scientific article published on March 2004

Generation of robust CD8+ T-cell responses against subdominant epitopes in conserved regions of HIV-1 by repertoire mining with mimotopes

scientific article

Genetic and Structural Basis for Selection of a Ubiquitous T Cell Receptor Deployed in Epstein-Barr Virus Infection

scientific article

Genome-wide CRISPR-Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1

scientific article published on 20 January 2020

Germ Line-governed Recognition of a Cancer Epitope by an Immunodominant Human T-cell Receptor

scientific article

HLA-A*0201 presents TAP-dependent peptide epitopes to cytotoxic T lymphocytes in the absence of tapasin.

scientific article published on October 1998

Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity

scientific article published on 16 May 2016

Human TCR-binding affinity is governed by MHC class restriction

scientific article

Human TRAV1-2-negative MR1-restricted T cells detect S. pyogenes and alternatives to MAIT riboflavin-based antigens

scientific article published on 16 August 2016

Human leucocyte antigen class I-redirected anti-tumour CD4+ T cells require a higher T cell receptor binding affinity for optimal activity than CD8+ T cells

scientific article published on 20 June 2016

Human leukocyte antigen (HLA) class II peptide flanking residues tune the immunogenicity of a human tumor-derived epitope

scientific article published on 16 October 2019

Human β-cell killing by autoreactive preproinsulin-specific CD8 T cells is predominantly granule-mediated with the potency dependent upon T-cell receptor avidity

scientific article

Hydrophobic CDR3 residues promote the development of self-reactive T cells

scientific article published on 27 June 2016

IFN-gamma exposes a cryptic cytotoxic T lymphocyte epitope in HIV-1 reverse transcriptase

scientific article (publication date: 15 June 1999)

Identification of human viral protein-derived ligands recognized by individual MHCI-restricted T-cell receptors

scientific article published on 5 February 2016

In Silico and Structural Analyses Demonstrate That Intrinsic Protein Motions Guide T Cell Receptor Complementarity Determining Region Loop Flexibility.

scientific article published on 11 April 2018

Induction of influenza-specific local CD8 T-cells in the respiratory tract after aerosol delivery of vaccine antigen or virus in the Babraham inbred pig.

scientific article

Interaction between the CD8 coreceptor and major histocompatibility complex class I stabilizes T cell receptor-antigen complexes at the cell surface

scientific article published on 18 April 2005

LILRB1 Blockade Enhances Bispecific T Cell Engager Antibody-Induced Tumor Cell Killing by Effector CD8+ T Cells

scientific article published on 28 June 2019

MHC class I molecules with Superenhanced CD8 binding properties bypass the requirement for cognate TCR recognition and nonspecifically activate CTLs.

scientific article published on 26 February 2010

Macrophage-tropic HIV induces and exploits dendritic cell chemotaxis

scientific article

Major TCR Repertoire Perturbation by Immunodominant HLA-B44:03-Restricted CMV-Specific T Cells

Metabolic Adaptation of Human CD4+ and CD8+ T-Cells to T-Cell Receptor-Mediated Stimulation

scientific article published on 9 November 2017

Mixed Cu+ and Zn2+ coordination in the DNA-binding domain of the AMT1 transcription factor from Candida glabrata.

scientific article

Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T cell recognition

scientific article

Modification of the carboxy-terminal flanking region of a universal influenza epitope alters CD4⁺ T-cell repertoire selection

scientific article published on 7 February 2012

Molecular Basis of a Dominant T Cell Response to an HIV Reverse Transcriptase 8-mer Epitope Presented by the Protective Allele HLA-B*51:01

scientific article

Monoclonal TCR-redirected tumor cell killing.

scientific article

Monocytes and γδ T cells control the acute-phase response to intravenous zoledronate: insights from a phase IV safety trial.

scientific article published in March 2013

More tricks with tetramers: a practical guide to staining T cells with peptide-MHC multimers

scientific article

Mutated yeast heat shock transcription factor exhibits elevated basal transcriptional activation and confers metal resistance

scientific article published on October 1995

Naive CD8⁺ T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamics

scientific article

Nonstimulatory peptide-MHC enhances human T-cell antigen-specific responses by amplifying proximal TCR signaling.

scientific article published on 13 July 2018

Novel CD8+ T cell antagonists based on beta 2-microglobulin.

scientific article published on 25 March 2002

Oligoclonal expansions of CD8(+) T cells in chronic HIV infection are antigen specific.

scientific article published on August 1998

On the path to TCR-directed therapeutics

scientific article published in June 2006

Optimized Peptide-MHC Multimer Protocols for Detection and Isolation of Autoimmune T-Cells

P16-56 LB. Novel tetramer technology for the detection of high affinity CD8 T cells

PD-1+ Polyfunctional T Cells Dominate the Periphery after Tumor-Infiltrating Lymphocyte Therapy for Cancer

scientific article published on 5 July 2017

Paediatric non-progression following grandmother-to-child HIV transmission

scientific article published on 08 September 2016

Patterns of immunodominance in HIV-1-specific cytotoxic T lymphocyte responses in two human histocompatibility leukocyte antigens (HLA)-identical siblings with HLA-A*0201 are influenced by epitope mutation.

scientific article

Peptide Super-Agonist Enhances T-Cell Responses to Melanoma

article

Peptide cargo tunes a network of correlated motions in human leucocyte antigens

scientific article published on 05 March 2020

Peptide length determines the outcome of TCR/peptide-MHCI engagement

scientific article

Peptide mimic for influenza vaccination using nonnatural combinatorial chemistry.

scientific article published on 12 March 2018

Peptide-MHC Class I Tetramers Can Fail To Detect Relevant Functional T Cell Clonotypes and Underestimate Antigen-Reactive T Cell Populations.

scientific article published on 26 February 2018

Peptide-major histocompatibility complex dimensions control proximal kinase-phosphatase balance during T cell activation

scientific article published on 23 July 2009

Polypropylene Sulfide Nanoparticle p24 Vaccine Promotes Dendritic Cell-Mediated Specific Immune Responses against HIV-1.

scientific article

Positive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infection

scientific article

Profound inhibition of antigen-specific T-cell effector functions by dasatinib

scientific article published in April 2008

Protein kinase inhibitors substantially improve the physical detection of T-cells with peptide-MHC tetramers

scientific article

Real time detection of peptide-MHC dissociation reveals that improvement of primary MHC-binding residues can have a minimal, or no, effect on stability.

scientific article

Recognition of nonpeptide antigens by human V gamma 9V delta 2 T cells requires contact with cells of human origin

scientific article

Recurrence of melanoma following T cell treatment: continued antigen expression in a tumor that evades T cell recruitment

scientific article published on 3 November 2014

Regulation of metallothionein genes by the ACE1 and AMT1 transcription factors

scientific article published in Journal of Biological Chemistry

Reversed-polarity T(reg) cell TCRs provide a shock

scientific article published on October 2015

Reversible Oligonucleotide Chain Blocking Enables Bead Capture and Amplification of T-Cell Receptor α and β Chain mRNAs.

scientific article published on August 2016

Simultaneous Aerosol and Intramuscular Immunization with Influenza Vaccine Induces Powerful Protective Local T Cell and Systemic Antibody Immune Responses in Pigs

scientific article published on 16 December 2020

Soluble T cell receptors: novel immunotherapies.

scientific article

Specific T-cell activation in an unspecific T-cell repertoire.

scientific article published on January 2011

Specificity of CTL interactions with peptide-MHC class I tetrameric complexes is temperature dependent

scientific article published on 01 October 1999

Structural Mechanism Underpinning Cross-reactivity of a CD8+ T-cell Clone That Recognizes a Peptide Derived from Human Telomerase Reverse Transcriptase.

scientific article

Structural and biophysical determinants of αβ T-cell antigen recognition

scientific article published on January 2012

Structural and kinetic basis for heightened immunogenicity of T cell vaccines

scientific article

Structural basis for ineffective T-cell responses to MHC anchor residue-improved "heteroclitic" peptides

scientific article

Structural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes

scientific article

T cell Receptor Alpha Variable 12-2 bias in the immunodominant response to Yellow fever virus

scientific article published on 3 October 2017

T cell receptor binding affinity governs the functional profile of cancer-specific CD8+ T cells

scientific article published on May 2015

T cell receptor engagement of peptide-major histocompatibility complex class I does not modify CD8 binding

scientific article published on 19 February 2008

T cell sensitivity and the outcome of viral infection.

scientific article published on December 2009

T-cell Receptor (TCR)-Peptide Specificity Overrides Affinity-enhancing TCR-Major Histocompatibility Complex Interactions

scientific article

T-cell Receptor-optimized Peptide Skewing of the T-cell Repertoire Can Enhance Antigen Targeting

scientific article

T-cell libraries allow simple parallel generation of multiple peptide-specific human T-cell clones

scientific article published on 27 January 2016

T-cell responses directed against multiple HLA-A*0201-restricted epitopes derived from Wilms' tumor 1 protein in patients with leukemia and healthy donors: identification, quantification, and characterization

scientific article published on December 2005

TCR-induced alteration of primary MHC peptide anchor residue

scientific article published on 27 May 2019

TCR/pMHC Optimized Protein crystallization Screen

scientific article published on 15 June 2012

Targeting the T cell receptor β-chain constant region for immunotherapy of T cell malignancies

scientific article published on 13 November 2017

Techniques to improve the direct ex vivo detection of low frequency antigen-specific CD8+ T cells with peptide-major histocompatibility complex class I tetramers

scientific article published on November 2008

The CD8 T cell coreceptor exhibits disproportionate biological activity at extremely low binding affinities

scientific article published on 15 April 2003

The HLA A*0201-restricted hTERT(540-548) peptide is not detected on tumor cells by a CTL clone or a high-affinity T-cell receptor

scientific article

The Staphyloccous aureus Eap protein activates expression of proinflammatory cytokines.

scientific article published on 10 March 2008

The T cell antigen receptor: the Swiss army knife of the immune system.

scientific article

The human CD8 coreceptor effects cytotoxic T cell activation and antigen sensitivity primarily by mediating complete phosphorylation of the T cell receptor zeta chain.

scientific article

The influence of antigenic variation on cytotoxic T lymphocyte responses in HIV-1 infection

article

The molecular determinants of CD8 co-receptor function

scientific article published on October 2012

The multiple roles of the CD8 coreceptor in T cell biology: opportunities for the selective modulation of self-reactive cytotoxic T cells

scientific article

The nucleocapsid protein of Rift Valley fever virus is a potent human CD8+ T cell antigen and elicits memory responses

scientific article

The promise of γδ T cells and the γδ T cell receptor for cancer immunotherapy

scientific article

The versatility of the αβ T-cell antigen receptor

scientific article published on 28 January 2014

Thermal Stability of Heterotrimeric pMHC Proteins as Determined by Circular Dichroism Spectroscopy.

scientific article

Tracking the repertoire of human adult and neonatal T cells during ex vivo amplification

scientific article

Transmission and accumulation of CTL escape variants drive negative associations between HIV polymorphisms and HLA.

scientific article

Tricks with tetramers: how to get the most from multimeric peptide-MHC.

scientific article published on February 2009

Use of peptide-major histocompatibility complex tetramer technology to study interactions between Staphylococcus aureus proteins and human cells

scientific article published on 15 October 2007

Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens.

scientific article

VDJdb in 2019: database extension, new analysis infrastructure and a T-cell receptor motif compendium

scientific article published on 01 January 2020

VDJdb: a curated database of T-cell receptor sequences with known antigen specificity

scientific article published on September 2017

Why must T cells be cross-reactive?

scientific article published in September 2012

αβ T cell receptors as predictors of health and disease

scientific article

β-cell-specific CD8 T cell phenotype in type 1 diabetes reflects chronic autoantigen exposure

scientific article

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