List of works - Aimin Liu

A Pitcher-and-Catcher Mechanism Drives Endogenous Substrate Isomerization by a Dehydrogenase in Kynurenine Metabolism

scientific article

A catalytic di-heme bis-Fe(IV) intermediate, alternative to an Fe(IV)=O porphyrin radical

scholarly article

A single EF-hand isolated from STIM1 forms dimer in the absence and presence of Ca2+

scientific article

Adapting to oxygen: 3-Hydroxyanthrinilate 3,4-dioxygenase employs loop dynamics to accommodate two substrates with disparate polarities

scientific article published in Journal of Biological Chemistry

Alpha-amino-beta-carboxymuconic-epsilon-semialdehyde decarboxylase (ACMSD) is a new member of the amidohydrolase superfamily

scientific article published on May 2006

Alternative reactivity of an alpha-ketoglutarate-dependent iron(II) oxygenase: enzyme self-hydroxylation

scientific article published in May 2001

Amidohydrolase Superfamily

An Iron Reservoir to the Catalytic Metal: THE RUBREDOXIN IRON IN AN EXTRADIOL DIOXYGENASE.

scientific article published on 27 April 2015

An engineered CuA Amicyanin capable of intermolecular electron transfer reactions

scientific article

An unexpected copper catalyzed 'reduction' of an arylazide to amine through the formation of a nitrene intermediate

scientific article published on June 2013

Backbone Dehydrogenation in Pyrrole-Based Pincer Ligands

scientific article published on 24 July 2018

Biocatalytic Carbon-Hydrogen and Carbon-Fluorine Bond Cleavage through Hydroxylation Promoted by a Histidyl-Ligated Heme Enzyme

scientific article published on 11 April 2019

Biochemical and spectroscopic studies on (S)-2-hydroxypropylphosphonic acid epoxidase: a novel mononuclear non-heme iron enzyme

scientific article published in October 2003

Bis-Fe(IV): nature's sniper for long-range oxidation

scientific article published on 11 April 2014

Carbon-fluorine bond cleavage mediated by metalloenzymes

scientific article published on 08 June 2020

Characterization of the non-heme iron center of cysteamine dioxygenase and its interaction with substrates

scientific article published on 28 June 2020

Chemical Rescue of the Distal Histidine Mutants of Tryptophan 2,3-Dioxygenase ⬇️

article by Jiafeng Geng et al published 13 July 2012 in Journal of the American Chemical Society

Chemical reduction of the diferric/radical center in protein R2 from mouse ribonucleotide reductase is independent of the proposed radical transfer pathway

Cleavage of a carbon-fluorine bond by an engineered cysteine dioxygenase

scholarly article by Jiasong Li published in September 2018

Cofactor Biogenesis in Cysteamine Dioxygenase: C-F Bond Cleavage with Genetically Incorporated Unnatural Tyrosine

scholarly article by Yifan Wang et al published 2 July 2018 in Angewandte Chemie International Edition

Cofactor Biogenesis in Cysteamine Dioxygenase: C−F Bond Cleavage with Genetically Incorporated Unnatural Tyrosine

Control of carotenoid biosynthesis through a heme-based cis-trans isomerase

scientific article published on 15 June 2015

Cross-linking of dicyclotyrosine by the cytochrome P450 enzyme CYP121 from Mycobacterium tuberculosis proceeds through a catalytic shunt pathway

scientific article published on 30 June 2017

Crystal Structures of L-DOPA Dioxygenase from Streptomyces sclerotialus

scientific article published on 25 June 2019

Crystal structure of alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase: insight into the active site and catalytic mechanism of a novel decarboxylation reaction

scientific article published in 2006

Crystallographic and spectroscopic snapshots reveal a dehydrogenase in action

scientific article

Decarboxylation mechanisms in biological system

scientific article published on 02 April 2012

Defining the Role of the Axial Ligand of the Type 1 Copper Site in Amicyanin by Replacement of Methionine with Leucine

scientific article

Detection of Transient Intermediates in the Metal-Dependent Nonoxidative Decarboxylation Catalyzed by α-Amino-β-Carboxymuconate-ε-Semialdehyde Decarboxylase

article

Determination of the substrate binding mode to the active site iron of (S)-2-hydroxypropylphosphonic acid epoxidase using 17O-enriched substrates and substrate analogues

scientific article

Development of a CZE-ESI-MS assay with a sulfonated capillary for profiling picolinic acid and quinolinic acid formation in multienzyme system

scientific article

Diflunisal Derivatives as Modulators of ACMS Decarboxylase Targeting the Tryptophan-Kynurenine Pathway

scientific article published on 28 December 2020

Diradical intermediate within the context of tryptophan tryptophylquinone biosynthesis

scientific article

EPR and Mössbauer spectroscopy show inequivalent hemes in tryptophan dioxygenase

scientific article

EPR evidence of two structurally different diferric sites in Mycobacterium tuberculosis R2-2 ribonucleotide reductase protein

article

Effects of the loss of the axial tyrosine ligand of the low-spin heme of MauG on its physical properties and reactivity

scientific article published on 2 November 2012

Electron Paramagnetic Resonance (EPR) in Enzymology

Electron Paramagnetic Resonance Evidence for a Novel Interconversion of [3Fe-4S]+and [4Fe-4S]+Clusters with Endogenous Iron and Sulfide in Anaerobic Ribonucleotide Reductase Activasein Vitro

scientific article published in Journal of Biological Chemistry

Enzymatic mechanism of Fe-only hydrogenase: density functional study on H-H making/breaking at the diiron cluster with concerted proton and electron transfers

scientific article published in February 2004

Enzyme reactivation by hydrogen peroxide in heme-based tryptophan dioxygenase

scientific article

Evidence for a Dual Role of an Active Site Histidine in α-Amino-β-carboxymuconate-ε-semialdehyde Decarboxylase

scientific article

Formation of Monofluorinated Radical Cofactor in Galactose Oxidase through Copper-Mediated C-F Bond Scission

scientific article published on 22 October 2020

Heme iron nitrosyl complex of MauG reveals an efficient redox equilibrium between hemes with only one heme exclusively binding exogenous ligands

scientific article published on December 2009

Heme-dependent dioxygenases in tryptophan oxidation

scientific article published on December 2013

Heterogeneity of the Local Electrostatic Environment of the Tyrosyl Radical inMycobacterium tuberculosisRibonucleotide Reductase Observed by High-Field Electron Paramagnetic Resonance

scholarly article by Aimin Liu et al published March 2000 in Journal of the American Chemical Society

Heterolytic OO bond cleavage: Functional role of Glu113 during bis-Fe(IV) formation in MauG.

scientific article published on 9 November 2016

High-Frequency/High-Field Electron Paramagnetic Resonance and Theoretical Studies of Tryptophan-Based Radicals.

scientific article

Human α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase (ACMSD): a structural and mechanistic unveiling

scientific journal article

Hypertryptophanemia due to tryptophan 2,3-dioxygenase deficiency

scientific article published in March 2017

Improved separation and detection of picolinic acid and quinolinic acid by capillary electrophoresis-mass spectrometry: application to analysis of human cerebrospinal fluid

scientific article published on 2 October 2013

Interconversion of two oxidized forms of taurine/alpha-ketoglutarate dioxygenase, a non-heme iron hydroxylase: evidence for bicarbonate binding

scholarly article

Kinetic and physical evidence that the diheme enzyme MauG tightly binds to a biosynthetic precursor of methylamine dehydrogenase with incompletely formed tryptophan tryptophylquinone

scientific article published on 26 January 2008

Kinetic and spectroscopic characterization of ACMSD from Pseudomonas fluorescens reveals a pentacoordinate mononuclear metallocofactor

scientific article published in September 2005

MauG, a novel diheme protein required for tryptophan tryptophylquinone biogenesis

scientific article

Mutagenesis of tryptophan199 suggests that hopping is required for MauG-dependent tryptophan tryptophylquinone biosynthesis

scientific article

Mutagenic analysis of Cox11 of Rhodobacter sphaeroides: insights into the assembly of Cu(B) of cytochrome c oxidase

scientific article published on July 2010

Mutual synergy between catalase and peroxidase activities of the bifunctional enzyme KatG is facilitated by electron hole-hopping within the enzyme

scientific article

New paramagnetic species formed at the expense of the transient tyrosyl radical in mutant protein R2 F208Y of Escherichia coli ribonucleotide reductase.

scientific article

O2- and alpha-ketoglutarate-dependent tyrosyl radical formation in TauD, an alpha-keto acid-dependent non-heme iron dioxygenase

scientific article published in February 2003

Observing 3-hydroxyanthranilate-3,4-dioxygenase in action through a crystalline lens

scientific article published on 30 July 2020

Optimal group symmetric localized molecular orbitals

Pirin is an iron-dependent redox regulator of NF-κB ⬇️

scientific article published on May 28, 2013

Probing Ligand Exchange in the P450 Enzyme CYP121 from Mycobacterium tuberculosis: Dynamic Equilibrium of the Distal Heme Ligand as a Function of pH and Temperature

scientific article published in November 2017

Probing bis-Fe(IV) MauG: experimental evidence for the long-range charge-resonance model

scientific article

Probing the Cys-Tyr Cofactor Biogenesis in Cysteine Dioxygenase by the Genetic Incorporation of Fluorotyrosine

scientific article published on 4 April 2019

Proline 107 Is a Major Determinant in Maintaining the Structure of the Distal Pocket and Reactivity of the High-Spin Heme of MauG

scientific article

Proline 96 of the Copper Ligand Loop of Amicyanin Regulates Electron Transfer from Methylamine Dehydrogenase by Positioning Other Residues at the Protein−Protein Interface

scientific article

Purification and characterization of the epoxidase catalyzing the formation of fosfomycin from Pseudomonas syringae

scientific article

Quaternary structure of α-amino-β-carboxymuconate-ϵ-semialdehyde decarboxylase (ACMSD) controls its activity

scientific article published on 12 June 2019

Radical Trapping Study of the Relaxation of bis-Fe(IV) MauG

Reassignment of the human aldehyde dehydrogenase ALDH8A1 (ALDH12) to the kynurenine pathway in tryptophan catabolism

scientific article published in Journal of Biological Chemistry

Reduction of Escherichia coli ribonucleotide reductase subunit R2 with eight water-soluble ferrocene derivatives

article

Resonance Raman studies of the iron(II)--alpha-keto acid chromophore in model and enzyme complexes

scientific article published in May 2001

Role of calcium in metalloenzymes: effects of calcium removal on the axial ligation geometry and magnetic properties of the catalytic diheme center in MauG.

scientific article published on 16 February 2012

Site-directed mutagenesis and spectroscopic studies of the iron-binding site of (S)-2-hydroxypropylphosphonic acid epoxidase

scientific article

Stepwise O-Atom Transfer in Heme-Based Tryptophan Dioxygenase: Role of Substrate Ammonium in Epoxide Ring Opening.

scientific article

Substrate radical intermediates in soluble methane monooxygenase

scientific article published on 7 September 2005

Substrate-Assisted Hydroxylation and O-Demethylation in the Peroxidase-like Cytochrome P450 Enzyme CYP121

scientific article published on 20 December 2019

Synthesis, characterization, and preliminary in vitro studies of vanadium(IV) complexes with a Schiff base and thiosemicarbazones as mixed-ligands

scientific article published on February 2012

The Power of Two: ARGININE 51 AND ARGININE 239* FROM A NEIGHBORING SUBUNIT ARE ESSENTIAL FOR CATALYSIS IN -AMINO- -CARBOXYMUCONATE- -SEMIALDEHYDE DECARBOXYLASE

scientific article

The anaerobic (class III) ribonucleotide reductase from Lactococcus lactis. Catalytic properties and allosteric regulation of the pure enzyme system.

scientific article published on January 2000

The mechanism of inactivation of 3-hydroxyanthranilate-3,4-dioxygenase by 4-chloro-3-hydroxyanthranilate

scientific article published in May 2005

The roles of Rhodobacter sphaeroides copper chaperones PCu(A)C and Sco (PrrC) in the assembly of the copper centers of the aa(3)-type and the cbb(3)-type cytochrome c oxidases

scientific article published on 8 January 2012

The tightly bound calcium of MauG is required for tryptophan tryptophylquinone cofactor biosynthesis

scientific article published on 13 December 2010

The tyrosyl free radical of recombinant ribonucleotide reductase from Mycobacterium tuberculosis is located in a rigid hydrophobic pocket

scientific article published in November 1998

Transition metal-catalyzed nonoxidative decarboxylation reactions

scientific article published in 2006

Tryptophan tryptophylquinone biosynthesis: A radical approach to posttranslational modification ⬇️

scientific article published on January 28, 2012

Tryptophan-mediated charge-resonance stabilization in the bis -Fe(IV) redox state of MauG ⬇️

scientific article published on May 29, 2013

What is the tryptophan kynurenine pathway and why is it important to neurotherapeutics?

scientific article published on 24 May 2015

Yeast ribonucleotide reductase has a heterodimeric iron-radical-containing subunit

scientific article

List of works by Aimin Liu

A Pitcher-and-Catcher Mechanism Drives Endogenous Substrate Isomerization by a Dehydrogenase in Kynurenine Metabolism

A catalytic di-heme bis-Fe(IV) intermediate, alternative to an Fe(IV)=O porphyrin radical

A single EF-hand isolated from STIM1 forms dimer in the absence and presence of Ca2+

Adapting to oxygen: 3-Hydroxyanthrinilate 3,4-dioxygenase employs loop dynamics to accommodate two substrates with disparate polarities

Alpha-amino-beta-carboxymuconic-epsilon-semialdehyde decarboxylase (ACMSD) is a new member of the amidohydrolase superfamily

Alternative reactivity of an alpha-ketoglutarate-dependent iron(II) oxygenase: enzyme self-hydroxylation

Amidohydrolase Superfamily

An Iron Reservoir to the Catalytic Metal: THE RUBREDOXIN IRON IN AN EXTRADIOL DIOXYGENASE.

An engineered CuA Amicyanin capable of intermolecular electron transfer reactions

An unexpected copper catalyzed 'reduction' of an arylazide to amine through the formation of a nitrene intermediate

Backbone Dehydrogenation in Pyrrole-Based Pincer Ligands

Biocatalytic Carbon-Hydrogen and Carbon-Fluorine Bond Cleavage through Hydroxylation Promoted by a Histidyl-Ligated Heme Enzyme

Biochemical and spectroscopic studies on (S)-2-hydroxypropylphosphonic acid epoxidase: a novel mononuclear non-heme iron enzyme

Bis-Fe(IV): nature's sniper for long-range oxidation

Carbon-fluorine bond cleavage mediated by metalloenzymes

Characterization of the non-heme iron center of cysteamine dioxygenase and its interaction with substrates

Chemical Rescue of the Distal Histidine Mutants of Tryptophan 2,3-Dioxygenase ⬇️

Chemical reduction of the diferric/radical center in protein R2 from mouse ribonucleotide reductase is independent of the proposed radical transfer pathway

Cleavage of a carbon-fluorine bond by an engineered cysteine dioxygenase

Cofactor Biogenesis in Cysteamine Dioxygenase: C-F Bond Cleavage with Genetically Incorporated Unnatural Tyrosine

Cofactor Biogenesis in Cysteamine Dioxygenase: C−F Bond Cleavage with Genetically Incorporated Unnatural Tyrosine

Control of carotenoid biosynthesis through a heme-based cis-trans isomerase

Cross-linking of dicyclotyrosine by the cytochrome P450 enzyme CYP121 from Mycobacterium tuberculosis proceeds through a catalytic shunt pathway

Crystal Structures of L-DOPA Dioxygenase from Streptomyces sclerotialus

Crystal structure of alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase: insight into the active site and catalytic mechanism of a novel decarboxylation reaction

Crystallographic and spectroscopic snapshots reveal a dehydrogenase in action

Decarboxylation mechanisms in biological system

Defining the Role of the Axial Ligand of the Type 1 Copper Site in Amicyanin by Replacement of Methionine with Leucine

Detection of Transient Intermediates in the Metal-Dependent Nonoxidative Decarboxylation Catalyzed by α-Amino-β-Carboxymuconate-ε-Semialdehyde Decarboxylase

Determination of the substrate binding mode to the active site iron of (S)-2-hydroxypropylphosphonic acid epoxidase using 17O-enriched substrates and substrate analogues

Development of a CZE-ESI-MS assay with a sulfonated capillary for profiling picolinic acid and quinolinic acid formation in multienzyme system

Diflunisal Derivatives as Modulators of ACMS Decarboxylase Targeting the Tryptophan-Kynurenine Pathway

Diradical intermediate within the context of tryptophan tryptophylquinone biosynthesis

EPR and Mössbauer spectroscopy show inequivalent hemes in tryptophan dioxygenase

EPR evidence of two structurally different diferric sites in Mycobacterium tuberculosis R2-2 ribonucleotide reductase protein

Effects of the loss of the axial tyrosine ligand of the low-spin heme of MauG on its physical properties and reactivity

Electron Paramagnetic Resonance (EPR) in Enzymology

Electron Paramagnetic Resonance Evidence for a Novel Interconversion of [3Fe-4S]+and [4Fe-4S]+Clusters with Endogenous Iron and Sulfide in Anaerobic Ribonucleotide Reductase Activasein Vitro

Enzymatic mechanism of Fe-only hydrogenase: density functional study on H-H making/breaking at the diiron cluster with concerted proton and electron transfers

Enzyme reactivation by hydrogen peroxide in heme-based tryptophan dioxygenase

Evidence for a Dual Role of an Active Site Histidine in α-Amino-β-carboxymuconate-ε-semialdehyde Decarboxylase

Formation of Monofluorinated Radical Cofactor in Galactose Oxidase through Copper-Mediated C-F Bond Scission

Heme iron nitrosyl complex of MauG reveals an efficient redox equilibrium between hemes with only one heme exclusively binding exogenous ligands

Heme-dependent dioxygenases in tryptophan oxidation

Heterogeneity of the Local Electrostatic Environment of the Tyrosyl Radical inMycobacterium tuberculosisRibonucleotide Reductase Observed by High-Field Electron Paramagnetic Resonance

Heterolytic OO bond cleavage: Functional role of Glu113 during bis-Fe(IV) formation in MauG.

High-Frequency/High-Field Electron Paramagnetic Resonance and Theoretical Studies of Tryptophan-Based Radicals.

Human α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase (ACMSD): a structural and mechanistic unveiling

Hypertryptophanemia due to tryptophan 2,3-dioxygenase deficiency

Improved separation and detection of picolinic acid and quinolinic acid by capillary electrophoresis-mass spectrometry: application to analysis of human cerebrospinal fluid

Interconversion of two oxidized forms of taurine/alpha-ketoglutarate dioxygenase, a non-heme iron hydroxylase: evidence for bicarbonate binding

Kinetic and physical evidence that the diheme enzyme MauG tightly binds to a biosynthetic precursor of methylamine dehydrogenase with incompletely formed tryptophan tryptophylquinone

Kinetic and spectroscopic characterization of ACMSD from Pseudomonas fluorescens reveals a pentacoordinate mononuclear metallocofactor

MauG, a novel diheme protein required for tryptophan tryptophylquinone biogenesis

Mutagenesis of tryptophan199 suggests that hopping is required for MauG-dependent tryptophan tryptophylquinone biosynthesis

Mutagenic analysis of Cox11 of Rhodobacter sphaeroides: insights into the assembly of Cu(B) of cytochrome c oxidase

Mutual synergy between catalase and peroxidase activities of the bifunctional enzyme KatG is facilitated by electron hole-hopping within the enzyme

New paramagnetic species formed at the expense of the transient tyrosyl radical in mutant protein R2 F208Y of Escherichia coli ribonucleotide reductase.

O2- and alpha-ketoglutarate-dependent tyrosyl radical formation in TauD, an alpha-keto acid-dependent non-heme iron dioxygenase

Observing 3-hydroxyanthranilate-3,4-dioxygenase in action through a crystalline lens

Optimal group symmetric localized molecular orbitals

Pirin is an iron-dependent redox regulator of NF-κB ⬇️

Probing Ligand Exchange in the P450 Enzyme CYP121 from Mycobacterium tuberculosis: Dynamic Equilibrium of the Distal Heme Ligand as a Function of pH and Temperature

Probing bis-Fe(IV) MauG: experimental evidence for the long-range charge-resonance model

Probing the Cys-Tyr Cofactor Biogenesis in Cysteine Dioxygenase by the Genetic Incorporation of Fluorotyrosine

Proline 107 Is a Major Determinant in Maintaining the Structure of the Distal Pocket and Reactivity of the High-Spin Heme of MauG

Proline 96 of the Copper Ligand Loop of Amicyanin Regulates Electron Transfer from Methylamine Dehydrogenase by Positioning Other Residues at the Protein−Protein Interface

Purification and characterization of the epoxidase catalyzing the formation of fosfomycin from Pseudomonas syringae

Quaternary structure of α-amino-β-carboxymuconate-ϵ-semialdehyde decarboxylase (ACMSD) controls its activity

Radical Trapping Study of the Relaxation of bis-Fe(IV) MauG

Reassignment of the human aldehyde dehydrogenase ALDH8A1 (ALDH12) to the kynurenine pathway in tryptophan catabolism

Reduction of Escherichia coli ribonucleotide reductase subunit R2 with eight water-soluble ferrocene derivatives

Resonance Raman studies of the iron(II)--alpha-keto acid chromophore in model and enzyme complexes

Role of calcium in metalloenzymes: effects of calcium removal on the axial ligation geometry and magnetic properties of the catalytic diheme center in MauG.

Site-directed mutagenesis and spectroscopic studies of the iron-binding site of (S)-2-hydroxypropylphosphonic acid epoxidase

Stepwise O-Atom Transfer in Heme-Based Tryptophan Dioxygenase: Role of Substrate Ammonium in Epoxide Ring Opening.

Substrate radical intermediates in soluble methane monooxygenase

Substrate-Assisted Hydroxylation and O-Demethylation in the Peroxidase-like Cytochrome P450 Enzyme CYP121

Synthesis, characterization, and preliminary in vitro studies of vanadium(IV) complexes with a Schiff base and thiosemicarbazones as mixed-ligands