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List of works by Keigo Machida

"Second hit" models of alcoholic liver disease.

scientific article

A super TLR agonist to improve efficacy of dendritic cell vaccine in induction of anti-HCV immunity

scientific article published on 7 November 2012

Alcohol and hepatitis C virus--interactions in immune dysfunctions and liver damage

scientific article published on 20 January 2010

Alcohol, TLR4-TGF-β antagonism, and liver cancer.

scientific article published on 27 December 2013

Association of hepatitis C virus replication complexes with microtubules and actin filaments is dependent on the interaction of NS3 and NS5A

scientific article

HCV core expression in hepatocytes protects against autoimmune liver injury and promotes liver regeneration in mice

scientific article published in October 2006

HCV infection enhances Th17 commitment, which could affect the pathogenesis of autoimmune diseases

scientific article

Hepatitis C Virus (HCV)-Induced Immunoglobulin Hypermutation Reduces the Affinity and Neutralizing Activities of Antibodies against HCV Envelope Protein

scientific article

Hepatitis C Virus Causes Uncoupling of Mitotic Checkpoint and Chromosomal Polyploidy through the Rb Pathway

scientific article

Hepatitis C Virus Inhibits DNA Damage Repair through Reactive Oxygen and Nitrogen Species and by Interfering with the ATM-NBS1/Mre11/Rad50 DNA Repair Pathway in Monocytes and Hepatocytes ⬇️

scientific article published on October 25, 2010

Hepatitis C Virus Triggers Mitochondrial Permeability Transition with Production of Reactive Oxygen Species, Leading to DNA Damage and STAT3 Activation

scientific article

Hepatitis C virus E2-CD81 interaction induces hypermutation of the immunoglobulin gene in B cells

scientific article

Hepatitis C virus NS3/4A protein interacts with ATM, impairs DNA repair and enhances sensitivity to ionizing radiation.

scientific article

Hepatitis C virus and disrupted interferon signaling promote lymphoproliferation via type II CD95 and interleukins

scientific article

Hepatitis C virus egress and release depend on endosomal trafficking of core protein

scientific article

Hepatitis C virus has a genetically determined lymphotropism through co-receptor B7.2.

scientific article

Hepatitis C virus induces a mutator phenotype: enhanced mutations of immunoglobulin and protooncogenes

scholarly article

Hepatitis C virus induces toll-like receptor 4 expression, leading to enhanced production of beta interferon and interleukin-6

scientific article

Hepatitis C virus infection activates the immunologic (type II) isoform of nitric oxide synthase and thereby enhances DNA damage and mutations of cellular genes

scientific article published on August 2004

Hepatitis C virus infection of T cells inhibits proliferation and enhances fas-mediated apoptosis by down-regulating the expression of CD44 splicing variant 6.

scientific article

Hepatitis C virus infects T cells and affects interferon-gamma signaling in T cell lines

scientific article published on 18 December 2006

Hepatitis C virus translation preferentially depends on active RNA replication

scientific article

Hepatitis C virus-related lymphomagenesis in a mouse model.

scientific article

Isolation of RNA aptamers specific to the NS3 protein of hepatitis C virus from a pool of completely random RNA.

scientific article published on October 1997

Lymphotropic HCV strain can infect human primary naïve CD4+ cells and affect their proliferation and IFN-γ secretion activity.

scientific article

Mitochondrial GSH determines the toxic or therapeutic potential of superoxide scavenging in steatohepatitis.

scientific article

Morphogens and hepatic stellate cell fate regulation in chronic liver disease.

scientific article published in March 2012

Mouse intragastric infusion (iG) model.

scientific article

NUMB phosphorylation destabilizes p53 and promotes self-renewal of tumor-initiating cells by a NANOG-dependent mechanism in liver cancer.

scientific article

Oncogenic signaling pathways and origins of tumor-initiating stem-like cells of hepatocellular carcinomas induced by hepatitis C virus, alcohol and/or obesity.

scientific article published on 20 June 2014

Osteopontin deficiency does not prevent but promotes alcoholic neutrophilic hepatitis in mice.

scientific article

PPARs and Liver Disease

scientific article published on 5 February 2013

Polo-like kinase 1 is involved in hepatitis C virus replication by hyperphosphorylating NS5A

scientific article

SYNCRIP (synaptotagmin-binding, cytoplasmic RNA-interacting protein) is a host factor involved in hepatitis C virus RNA replication

scientific article

Smad7 regulates compensatory hepatocyte proliferation in damaged mouse liver and positively relates to better clinical outcome in human hepatocellular carcinoma

scientific article

TLR4-dependent tumor-initiating stem cell-like cells (TICs) in alcohol-associated hepatocellular carcinogenesis

scientific article

TLRs, Alcohol, HCV, and Tumorigenesis ⬇️

scientific article published on January 1, 2010

The TBC1D15 oncoprotein controls stem cell self-renewal through destabilization of the Numb-p53 complex

scientific article

Toll-like receptor signaling in liver diseases

scientific article published on January 2010

Transient activation of the PI3K-AKT pathway by hepatitis C virus to enhance viral entry

scientific article

Truncating mutation in the autophagy gene UVRAG confers oncogenic properties and chemosensitivity in colorectal cancers

scientific article published on 3 August 2015

Tumor-initiating stem-like cells and drug resistance: carcinogenesis through Toll-like receptors, environmental factors, and virus.

scientific article published on April 2013

c-Jun mediates hepatitis C virus hepatocarcinogenesis through signal transducer and activator of transcription 3 and nitric oxide-dependent impairment of oxidative DNA repair.

scientific article

p53 destabilizing protein skews asymmetric division and enhances NOTCH activation to direct self-renewal of TICs

scientific article published on 17 June 2020

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