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List of works by Roger G Linington

"Function-first" lead discovery: mode of action profiling of natural product libraries using image-based screening

scientific article

A Cutibacterium acnes antibiotic modulates human skin microbiota composition in hair follicles ⬇️

scientific article published on 01 November 2020

A selective genome-guided method for environmental Burkholderia isolation

scientific article published on 24 January 2019

A systematic analysis of biosynthetic gene clusters in the human microbiome reveals a common family of antibiotics.

scientific article

Abyssomicin 2 reactivates latent HIV-1 by a PKC- and HDAC-independent mechanism ⬇️

scientific article published on 5 January 2015

Almiramides A-C: discovery and development of a new class of leishmaniasis lead compounds ⬇️

scientific article published on May 2010

An NF-κB-based high-throughput screen identifies piericidins as inhibitors of the Yersinia pseudotuberculosis type III secretion system ⬇️

scientific article published on 02 December 2013

An image-based 384-well high-throughput screening method for the discovery of biofilm inhibitors in Vibrio cholerae.

scientific article

An isotopic labeling approach linking natural products with biosynthetic gene clusters

scientific article published on 30 December 2021

Antimalarial linear lipopeptides from a Panamanian strain of the marine cyanobacterium Lyngbya majuscula. ⬇️

scientific article

Antimalarial peptides from marine cyanobacteria: isolation and structural elucidation of gallinamide A. ⬇️

scientific article published on January 2009

Artificial intelligence for natural product drug discovery ⬇️

scientific article from 2023

Bastimolide A, a Potent Antimalarial Polyhydroxy Macrolide from the Marine Cyanobacterium Okeania hirsuta

scientific article

Biofilm Formation and Detachment in Gram-Negative Pathogens Is Modulated by Select Bile Acids

scientific article

Borrelidin B: isolation, biological activity, and implications for nitrile biosynthesis

scientific article

Caminoside A, an antimicrobial glycolipid isolated from the marine sponge Caminus sphaeroconia

scientific article published on 01 November 2002

Caminosides B-D, antimicrobial glycolipids isolated from the marine sponge Caminus sphaeroconia

scientific article published on 01 February 2006

Connecting phenotype and chemotype: high-content discovery strategies for natural products research.

scientific article published on 2 March 2015

Correction of F508del-CFTR trafficking by the sponge alkaloid latonduine is modulated by interaction with PARP.

scientific article

Correction: Sloth Hair as a Novel Source of Fungi with Potent Anti-Parasitic, Anti-Cancer and Anti-Bacterial Bioactivity

Correction: The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research

scientific article published on 23 November 2018

Data-analysis strategies for image-based cell profiling.

scientific article published on August 2017

De Novo terpenoid biosynthesis by the dendronotid nudibranch Melibe leonina

scientific article published in November 2002

Dereplication and de novo sequencing of nonribosomal peptides

scientific article published on 13 July 2009

Development of a Custom MALDI-TOF Mass Spectrometric Database for Identification of Environmental Burkholderia and Related Genera

scientific article published on 03 April 2020

Development of an NMR-Based Platform for the Direct Structural Annotation of Complex Natural Products Mixtures

scientific article published in 2021

Development of antibiotic activity profile screening for the classification and discovery of natural product antibiotics.

scientific article

Development of benzo[1,4]oxazines as biofilm inhibitors and dispersal agents against Vibrio cholerae

scientific article published on January 2015

Development of quinoline-based disruptors of biofilm formation against Vibrio cholerae.

scientific article

Discovery and biological characterization of the auromomycin chromophore as an inhibitor of biofilm formation in Vibrio cholerae

scientific article

Discovery of anabaenopeptin 679 from freshwater algal bloom material: Insights into the structure-activity relationship of anabaenopeptin protease inhibitors.

scientific article published on 6 September 2016

Dragonamide E, a modified linear lipopeptide from Lyngbya majuscula with antileishmanial activity ⬇️

scientific article

Erratum for Duncan et al., An NF-κB-Based High-Throughput Screen Identifies Piericidins as Inhibitors of the Yersinia pseudotuberculosis Type III Secretion System

scientific article published on 20 June 2016

Evaluation of Ion Mobility Spectrometry for Improving Constitutional Assignment in Natural Product Mixtures

scientific article published in 2022

Examination of the mode of action of the almiramide family of natural products against the kinetoplastid parasite Trypanosoma brucei

scientific article

Examining the fish microbiome: vertebrate-derived bacteria as an environmental niche for the discovery of unique marine natural products

scientific article

Expansion of Gamma-Butyrolactone Signaling Molecule Biosynthesis to Phosphotriester Natural Products

scientific article published on 24 November 2020

Expedient synthesis of α,α-dimethyl-β-hydroxy carbonyl scaffolds via Evans' aldol reaction with a tertiary enolate

scientific article published on June 2011

Genome-Directed Lead Discovery: Biosynthesis, Structure Elucidation, and Biological Evaluation of Two Families of Polyene Macrolactams against Trypanosoma brucei

scientific article published on 13 August 2015

Highlights of marine invertebrate-derived biosynthetic products: their biomedical potential and possible production by microbial associants

scientific article

Hit-to-lead development of the chamigrane endoperoxide merulin A for the treatment of African sleeping sickness

scientific article

Identification and characterization of a phosphodiesterase that inversely regulates motility and biofilm formation in Vibrio cholerae

scientific article published on 9 July 2010

Image-based 384-well high-throughput screening method for the discovery of skyllamycins A to C as biofilm inhibitors and inducers of biofilm detachment in Pseudomonas aeruginosa.

scientific article published on 02 December 2013

Insights into secondary metabolism from a global analysis of prokaryotic biosynthetic gene clusters ⬇️

scientific article published in July 2014

Integration of high-content screening and untargeted metabolomics for comprehensive functional annotation of natural product libraries

scientific article

Interlaboratory Comparison of Untargeted Mass Spectrometry Data Uncovers Underlying Causes for Variability

scientific article published in 2021

Interpretation of tandem mass spectra obtained from cyclic nonribosomal peptides

scientific article published on June 2009

Isolation, Structure Elucidation, and Total Synthesis of Dolichovespulide, a Sesquiterpene from Dolichovespula Yellowjackets

scientific article published on 18 June 2019

Latonduines A and B, New Alkaloids Isolated from the Marine Sponge Stylissa carteri: Structure Elucidation, Synthesis, and Biogenetic Implications. ⬇️

scientific article published on 30 June 2005

Latonduines A and B, new alkaloids isolated from the marine sponge Stylissa carteri: structure elucidation, synthesis, and biogenetic implications

scientific article published on 01 July 2003

Living in the matrix: assembly and control of Vibrio cholerae biofilms.

scientific article published on May 2015

MIBiG 2.0: a repository for biosynthetic gene clusters of known function

scientific article published on 01 January 2020

MIBiG 3.0: a community-driven effort to annotate experimentally validated biosynthetic gene clusters

scientific article published on 18 November 2022

MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration

scientific article published on 9 December 2024

MS/MS-based networking and peptidogenomics guided genome mining revealed the stenothricin gene cluster in Streptomyces roseosporus ⬇️

scientific article published on 23 October 2013

Maculatic Acids-Sex Attractant Pheromone Components of Bald-Faced Hornets

scientific article published on 28 June 2018

Marine Mammal Microbiota Yields Novel Antibiotic with Potent Activity Against Clostridium difficile. ⬇️

scientific article published on 18 October 2017

Mechanism of action-based classification of antibiotics using high-content bacterial image analysis ⬇️

scientific article published on April 23, 2013

Microbial natural product databases: moving forward in the multi-omics era

scientific article published on 28 August 2020

Molecular networking as a dereplication strategy

scientific article published on 11 September 2013

NP Analyst: An Open Online Platform for Compound Activity Mapping

scientific article published on 24 January 2022

NP-MRD: the Natural Products Magnetic Resonance Database

scientific article published on 01 January 2022

New innovations for an old infection: antimalarial lead discovery from marine natural products during the period 2003-2008.

scientific article published on July 2009

New methods for isolation and structure determination of natural products

scientific article published on 28 June 2019

On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds

scientific article

Optimized quinoline amino alcohols as disruptors and dispersal agents of Vibrio cholerae biofilms

scientific article published on July 2015

Phenotype-Guided Natural Products Discovery Using Cytological Profiling.

scientific article published on 21 August 2015

Piericidin A1 Blocks Yersinia Ysc Type III Secretion System Needle Assembly

scientific article published on January 2017

Reply to Skinnider and Magarvey: Rates of novel natural product discovery remain high

scientific article published on 14 July 2017

Retrospective analysis of natural products provides insights for future discovery trends

scientific article

Salinipostins A-K, long-chain bicyclic phosphotriesters as a potent and selective antimalarial chemotype

scientific article published on 13 January 2015

Sansanmycin natural product analogues as potent and selective anti-mycobacterials that inhibit lipid I biosynthesis

scientific article published on March 2017

Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking

scientific article (publication date: 9 August 2016)

Sloth hair as a novel source of fungi with potent anti-parasitic, anti-cancer and anti-bacterial bioactivity

scientific article published in 2014

Special Issue in Honor of Professor Phil Crews

scientific article published in March 2017

Stereochemical assignment in acyclic lipids across long distance by circular dichroism: absolute stereochemistry of the aglycone of caminoside A.

scientific article published in November 2004

Symplocamide A, a potent cytotoxin and chymotrypsin inhibitor from the marine Cyanobacterium Symploca sp ⬇️

scientific article

Synthesis and evaluation of analogues of the glycinocin family of calcium-dependent antibiotics

scientific article published in 2018

Synthetic Studies Toward the Skyllamycins: Total Synthesis and Generation of Simplified Analogues

scientific article published on 25 May 2018

The Antimalarial Natural Product Salinipostin A Identifies Essential α/β Serine Hydrolases Involved in Lipid Metabolism in P. falciparum Parasites

scientific article published on 23 January 2020

The Natural Product N-Palmitoyl-l-leucine Selectively Inhibits Late Assembly of Human Spliceosomes

scientific article published on 25 September 2015

The Natural Products Atlas 2.0: a database of microbially-derived natural products

scientific article published on 04 October 2021

The Natural Products Atlas: An Open Access Knowledge Base for Microbial Natural Products Discovery

scientific article published on 14 November 2019

The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research

article by James B. McAlpine et al published 13 July 2018 in Natural Product Reports

Total Synthesis of Glycinocins A-C.

scientific article

Total Synthesis of Skyllamycins A-C.

scientific article published on 14 September 2017

Total Synthesis of Teixobactin.

scientific article

Total synthesis, stereochemical assignment, and antimalarial activity of gallinamide A.

scientific article published on 18 October 2011

Venturamides A and B: antimalarial constituents of the panamanian marine Cyanobacterium Oscillatoria sp.

scientific article published on March 2007

Versatile method for the detection of covalently bound substrates on solid supports by DART mass spectrometry

scientific article published on 24 June 2011

Watery Saliva Secreted by the Grain Aphid Sitobion avenae Stimulates Aphid Resistance in Wheat

scientific article

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