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List of works by Dougald M. Monroe

A high affinity, antidote-controllable prothrombin and thrombin-binding RNA aptamer inhibits thrombin generation and thrombin activity.

scientific article

A mouse bleeding model to study oral anticoagulants.

scientific article

A novel one-step purification of mouse factor IX.

scientific article published on 26 January 2016

A rationally designed heparin, M118, has anticoagulant activity similar to unfractionated heparin and different from Lovenox in a cell-based model of thrombin generation.

scientific article published in August 2009

A unique protein kinase C-dependent pathway for tissue factor downregulation in pericytes

scientific article published on 01 March 2019

Abnormal hemostasis in a knock-in mouse carrying a variant of factor IX with impaired binding to collagen type IV.

scientific article published on 6 July 2009

Abnormal joint and bone wound healing in hemophilia mice is improved by extending factor IX activity after hemarthrosis.

scientific article published on 30 December 2016

Activated protein C cleaves factor Va more efficiently on endothelium than on platelet surfaces

scientific article published on 01 July 2002

Activation of protease-activated receptors 3 and 4 accelerates tissue factor-induced thrombin generation on the surface of vascular smooth muscle cells

scientific article published on 7 October 2010

Adding some muscle to blood coagulation

scientific article published on October 2016

An activated factor VII variant with enhanced tissue factor-independent activity speeds wound healing in a mouse hemophilia B model.

scientific article published on 8 March 2016

An anticoagulant RNA aptamer that inhibits proteinase-cofactor interactions within prothrombinase

scientific article

Anticoagulation increases alveolar hemorrhage in mice infected with influenza A.

scientific article published on December 2016

Bleeding risk in warfarinized patients with a therapeutic international normalized ratio: the effect of low factor IX levels.

scientific article published in June 2013

Celecoxib does not delay cutaneous wound healing in haemophilia B mice

scientific article

Characterization of IXINITY® (Trenonacog Alfa), a Recombinant Factor IX with Primary Sequence Corresponding to the Threonine-148 Polymorph.

scientific article published on 21 February 2016

Characterization of the glycosaminoglycan-binding region of lactoferrin

scientific article published on 01 February 1995

Circulating tissue factor accumulates in thrombi, but not in hemostatic plugs

scientific article published on 01 September 2006

Coagulation 2006: a modern view of hemostasis.

scientific article

Coagulation factor XI is a contaminant in intravenous immunoglobulin preparations

scientific article published on 01 September 2000

Coated platelet assay: a feasible approach to a complicated science

scientific article

Coated platelets and severe haemophilia A bleeding phenotype: Is there a connection?

scientific article published on 11 November 2015

Comparison of the behavior of normal factor IX and the factor IX Bm variant Hilo in the prothrombin time test using tissue factors from bovine, human, and rabbit sources

scientific article published in July 1993

Current concepts of hemostasis: implications for therapy.

scientific article published on March 2004

Cutaneous wound healing is impaired in hemophilia B.

scientific article published on 6 July 2006

Cystamine preparations exhibit anticoagulant activity

scientific article

Deencryption of cellular tissue factor is independent of its cytoplasmic domain.

scientific article

Differential contribution of FXa and thrombin to vascular inflammation in a mouse model of sickle cell disease.

scientific article published on 21 January 2014

Dysregulation of hemostasis by cancer.

scientific article published on January 2009

Effects of codon optimization on coagulation factor IX translation and structure: Implications for protein and gene therapies

scientific article published on 29 October 2019

Elevated prothrombin results in clots with an altered fiber structure: a possible mechanism of the increased thrombotic risk

scientific article published on 27 December 2002

Excessive breakthrough bleeding in haemophilia B patients on factor IX-albumin fusion protein prophylactic therapy: A single centre case series

scientific article published on 27 November 2019

FVIIa as used pharmacologically is not TF dependent in hemophilia B mice

scientific article published on 14 January 2014

Factor VIIa: on its own and loving it

scientific article published on 01 July 2012

Factor XI promotes hemostasis in factor IX-deficient mice

scientific article published on 16 August 2018

Further understanding of recombinant activated factor VII mode of action.

scientific article published on April 2008

Harold Ross Roberts, MD, 1930-2017.

scientific article published on 27 November 2017

High dose factor VIIa improves clot structure and stability in a model of haemophilia B.

scientific article published in December 2005

High-dose factor VIIa increases initial thrombin generation and mediates faster platelet activation in thrombocytopenia-like conditions in a cell-based model system.

scientific article

Impact of procoagulant concentration on rate, peak and total thrombin generation in a model system

scientific article published in March 2004

In vitro activation of coagulation by human neutrophil DNA and histone proteins but not neutrophil extracellular traps.

scientific article published on 5 December 2016

In vitro characterization of MOD-5014, a novel long-acting carboxy-terminal peptide (CTP)-modified activated FVII.

scientific article published on 14 March 2018

Inflammation does not predispose to bleeding in hemophilia

scientific article published in November 2010

Low intensity laser therapy speeds wound healing in hemophilia by enhancing platelet procoagulant activity.

scientific article

Major burn injury is not associated with acute traumatic coagulopathy.

scientific article

Manipulation of prothrombin concentration improves response to high-dose factor VIIa in a cell-based model of haemophilia

scientific article published on 20 June 2006

Mechanism of action of high-dose factor VIIa: points of agreement and disagreement

scientific article published in January 2003

Models for assessing immunogenicity and efficacy of new therapeutics for the treatment of haemophilia

scientific article

Nontoxic irreversible inhibitors of factors IXa, Xa, and thrombin: potential therapeutic agents for the in vivo regulation of thrombin generation and activity

scientific article published on 01 January 1986

Novel mouse hemostasis model for real-time determination of bleeding time and hemostatic plug composition.

scientific article

Perivascular tissue factor is down-regulated following cutaneous wounding: implications for bleeding in hemophilia

scientific article published on 30 November 2007

Plasmin Activation of Glial Cells through Protease-Activated Receptor 1.

scientific article

Platelet Heterogeneity

scientific article published on 13 January 2005

Platelet activation and its patient-specific consequences

scientific article published on 22 October 2007

Platelet activation in patients with thrombotic thrombocytopenic purpura.

scientific article

Platelet binding and activity of a factor VIIa variant with enhanced tissue factor independent activity.

scientific article published in April 2011

Polyphosphates rock! A role in thrombosis?

scientific article published in September 2015

Potent anticoagulant aptamer directed against factor IXa blocks macromolecular substrate interaction.

scientific article published on 13 February 2012

Progressive improvement in wound healing with increased therapy in haemophilia B mice

scientific article published on 23 July 2013

Prophylactic efficacy of BeneFIX vs Alprolix in hemophilia B mice.

scientific article published on 22 April 2016

Protease: Serpin complexes to assess contact system and intrinsic pathway activation

scientific article published on 25 June 2020

Prothrombin times on deficient plasma reconstituted with factors IX and X

scientific article published on 01 November 1994

RNA aptamers as reversible antagonists of coagulation factor IXa.

scientific article

Recombinant activated factor VII and the anaesthetist.

scientific article

Recombinant human factor VIIa (rFVIIa) can activate factor FIX on activated platelets.

scientific article

Restoring hemostatic thrombin generation at the time of cutaneous wounding does not normalize healing in hemophilia B.

scientific article published in August 2007

Reversal of dabigatran effects in models of thrombin generation and hemostasis by factor VIIa and prothrombin complex concentrate.

scientific article published on February 2015

Reversing targeted oral anticoagulants

scientific article

Role of the gamma-carboxyglutamic acid domain of activated factor X in the presence of calcium during inhibition by antithrombin-heparin

scientific article

Single synonymous mutation in factor IX alters protein properties and underlies haemophilia B.

scientific article published on 22 December 2016

Soluble phosphatidylserine binds to two sites on human factor IXa in a Ca2+ dependent fashion to specifically regulate structure and activity

scientific article

Structure/function analyses of recombinant variants of human factor Xa: factor Xa incorporation into prothrombinase on the thrombin-activated platelet surface is not mimicked by synthetic phospholipid vesicles.

scientific article published on April 1998

Studies on the mechanism of action of the aptamer BAX499, an inhibitor of tissue factor pathway inhibitor.

scientific article

The Coagulation Cascade in Cirrhosis

scientific article published on 01 February 2009

The Effect of Temperature and pH on the Activity of Factor VIIa: Implications for the Efficacy of High-Dose Factor VIIa in Hypothermic and Acidotic Patients

scientific article published on 01 November 2003

The action of high-dose factor Vlla (FVIIa) in a cell-based model of hemostasis

scientific article published on 01 January 2003

The clotting system - a major player in wound healing

scientific article

The tissue factor-factor VIIa complex: procoagulant activity, regulation, and multitasking.

scientific article published on June 2007

The use of recombinant factor VIIa in the treatment of bleeding disorders.

scientific article

Thrombin generation and cell-dependent hypercoagulability in sickle cell disease

scientific article published on 19 July 2016

Thrombin generation in vascular tissue.

scientific article

Tissue factor around dermal vessels has bound factor VII in the absence of injury

scientific article published on 09 April 2007

Tissue factor in brain is not saturated with factor VIIa: implications for factor VIIa dosing in intracerebral hemorrhage

scientific article

VWF (von Willebrand Factor) Is Not Required for Red Blood Cell Retention in Clots in Mice

scientific article published on 25 June 2020

Variability in platelet procoagulant activity in healthy volunteers

article

What is wrong with the allosteric disulfide bond hypothesis?

scientific article published on December 2009

Wound healing in haemophilia--breaking the vicious cycle.

scientific article published on May 2010

Wound healing in hemophilia B mice and low tissue factor mice

scientific article published on 19 February 2010

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