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List of works by Alessandra Ghigo

A novel protective role for activating transcription factor 3 in the cardiac response to metabolic stress.

scientific article published on 12 January 2017

Ablation of calcineurin Aβ reveals hyperlipidemia and signaling cross-talks with phosphodiesterases

scientific article published on 20 December 2012

Anchoring proteins as regulators of signaling pathways.

scientific article

Antineoplastic Drug-Induced Cardiotoxicity: A Redox Perspective

scientific article published on 7 March 2018

Autophagy and cancer therapy cardiotoxicity: From molecular mechanisms to therapeutic opportunities

scientific article published on 22 June 2019

Cell-specific roles of p110β in myocardial ischaemia

scientific article published on 01 July 2019

Combined inhibition of PI3Kβ and PI3Kγ reduces fat mass by enhancing α-MSH-dependent sympathetic drive

scientific article published on 18 November 2014

Contractile Function During Angiotensin-II Activation: Increased Nox2 Activity Modulates Cardiac Calcium Handling via Phospholamban Phosphorylation.

scientific article published in July 2015

Crossroads of PI3K and Rac pathways.

scientific article published on April 2015

Data demonstrating the anti-oxidant role of hemopexin in the heart.

scientific article

Data demonstrating the role of peroxiredoxin 2 as important anti-oxidant system in lung homeostasis.

scientific article published on 30 September 2017

Dietary ω-3 fatty acids protect against vasculopathy in a transgenic mouse model of sickle cell disease.

scientific article published on May 2015

Different inhibition of Gβγ-stimulated class IB phosphoinositide 3-kinase (PI3K) variants by a monoclonal antibody. Specific function of p101 as a Gβγ-dependent regulator of PI3Kγ enzymatic activity

scientific article

Disruption of ArhGAP15 results in hyperactive Rac1, affects the architecture and function of hippocampal inhibitory neurons and causes cognitive deficits

scientific article published on 7 October 2016

Distinct effects of leukocyte and cardiac phosphoinositide 3-kinase γ activity in pressure overload-induced cardiac failure

scientific article published on 17 January 2011

Elastin degradation and ensuing inflammation as emerging keys to atherosclerosis.

scientific article

Hemopexin counteracts systolic dysfunction induced by heme-driven oxidative stress.

scientific article

Hemopexin therapy improves cardiovascular function by preventing heme-induced endothelial toxicity in mouse models of hemolytic diseases

scientific article published on 27 February 2013

Hyperactivity of Rac1-GTPase pathway impairs neuritogenesis of cortical neurons by altering actin dynamics.

scientific article

Inhaled Biologicals for the Treatment of Cystic Fibrosis

scientific article published on 01 January 2019

Inhibition of aquaporin-1 prevents myocardial remodeling by blocking the transmembrane transport of hydrogen peroxide

scientific article published on 01 October 2020

Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110γ.

scientific article published on April 2011

Isoform selective phosphoinositide 3-kinase gamma and delta inhibitors and their therapeutic potential

scientific article

Lack of kinase-independent activity of PI3Kγ in locus coeruleus induces ADHD symptoms through increased CREB signaling.

scientific article published on 16 April 2015

Mechanisms underlying the cross-talk between heart and cancer

scientific article published on 06 July 2019

Metabolic Alterations in a Slow-Paced Model of Pancreatic Cancer-Induced Wasting.

scientific article published on 26 February 2018

Mitotic Spindle Assembly and Genomic Stability in Breast Cancer Require PI3K-C2α Scaffolding Function

scientific article published in October 2017

Models of Heart Failure Based on the Cardiotoxicity of Anticancer Drugs.

scientific article published on 18 April 2016

Molecular mechanism of action of Pelargonidin-3-O-glucoside, the main anthocyanin responsible for the anti-inflammatory effect of strawberry fruits.

scientific article published on 7 December 2017

Myocyte signalling in leucocyte recruitment to the heart

scientific article published on 05 February 2014

NADPH oxidases in heart failure: poachers or gamekeepers?

scientific article

New avenues in cardio-oncology

scientific article published on 01 February 2019

New signal transduction paradigms in anthracycline-induced cardiotoxicity.

scientific article published on 29 January 2016

PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation

scientific article published on 10 December 2021

PI3K and Calcium Signaling in Cardiovascular Disease

scientific article

PI3K in cancer-stroma interactions: bad in seed and ugly in soil.

scientific article published on 29 July 2013

PI3K inhibition in inflammation: Toward tailored therapies for specific diseases.

scientific article published on March 2010

PI3K signaling in chronic obstructive pulmonary disease: mechanisms, targets, and therapy.

scientific article published on 20 March 2018

Peroxiredoxin-2 plays a pivotal role as multimodal cytoprotector in the early phase of pulmonary hypertension

scientific article published on 08 August 2017

Phosphoinositide 3-Kinase Gamma Inhibition Protects from Anthracycline Cardiotoxicity and Reduces Tumor Growth.

scientific article published on 18 January 2018

Phosphoinositide 3-kinase γ protects against catecholamine-induced ventricular arrhythmia through protein kinase A-mediated regulation of distinct phosphodiesterases

scientific journal article

Phosphoinositide 3-kinase: friend and foe in cardiovascular disease

scientific article

Phosphoinositide 3-kinases in health and disease

scientific article published on January 2012

Phosphoinositides and cardiovascular diseases.

scientific article published on January 2012

Pi3ks In Diabetic Cardiomyopathy.

scientific article published on 22 June 2017

Pulmonary-derived phosphoinositide 3-kinase gamma (PI3Kγ) contributes to ventilator-induced lung injury and edema

scientific article published on 19 August 2010

Rac signal adaptation controls neutrophil mobilization from the bone marrow.

scientific article

Taming the PI3K team to hold inflammation and cancer at bay.

scientific article published on 05 March 2008

The novel butyrate derivative phenylalanine-butyramide protects from doxorubicin-induced cardiotoxicity

scientific article published on 06 March 2019

Therapeutic Targeting of PDEs and PI3K in Heart Failure with Preserved Ejection Fraction (HFpEF).

scientific article

Tregs restrain dendritic cell autophagy to ameliorate autoimmunity.

scientific article published on 05 June 2017

Understanding the common mechanisms of heart and skeletal muscle wasting in cancer cachexia

scientific article published on 08 January 2021

cAMP/PKA signaling compartmentalization in cardiomyocytes: Lessons from FRET-based biosensors

scientific article published on 24 April 2019

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