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List of works by Anne Lingford-Hughes

11C-PBR28 and 18F-PBR111 Detect White Matter Inflammatory Heterogeneity in Multiple Sclerosis

scientific article

A [11C]Ro15 4513 PET study suggests that alcohol dependence in man is associated with reduced α5 benzodiazepine receptors in limbic regions

scientific article published on 24 September 2010

A dose-finding design for dual-agent trials with patient-specific doses for one agent with application to an opiate detoxification trial

scientific article published on 10 December 2021

A feasibility study of an intervention for structured preparation before detoxification in alcohol dependence: the SPADe trial protocol

scientific article published on 27 April 2019

A feasibility trial of an intervention in alcohol dependence for structured preparation before detoxification versus usual care: the SPADe trial results

A pilot study of the effectiveness of D-cycloserine during cue-exposure therapy in abstinent alcohol-dependent subjects

scientific article published on 12 February 2011

A pilot study on the effects of treatment with acamprosate on craving for alcohol in alcohol-dependent patients

scientific article

A proof-of-concept study using [11C]flumazenil PET to demonstrate that pagoclone is a partial agonist

scientific article

A transdiagnostic dimensional approach towards a neuropsychological assessment for addiction: an international Delphi consensus study

scientific article published on 05 October 2018

Acute D3 Antagonist GSK598809 Selectively Enhances Neural Response During Monetary Reward Anticipation in Drug and Alcohol Dependence

scientific article

Acute acetate administration increases endogenous opioid levels in the human brain: A [<sup>11</sup>C]carfentanil molecular imaging study

scientific article published on 06 January 2021

Acute increases in synaptic GABA detectable in the living human brain: a [¹¹C]Ro15-4513 PET study

scientific article published on 17 May 2014

Acute naltrexone does not remediate fronto-striatal disturbances in alcoholic and alcoholic polysubstance-dependent populations during a monetary incentive delay task

scientific article published on 6 September 2016

Addiction.

scientific article published in January 2003

Addiction: the clinical interface

scientific article published on 14 April 2008

Addressing unmet needs in opiate dependence: supporting detoxification and advances in relapse prevention

Adjunctive Ketamine With Relapse Prevention–Based Psychological Therapy in the Treatment of Alcohol Use Disorder

Alcohol Hangover: Underlying Biochemical, Inflammatory and Neurochemical Mechanisms

scientific article published on 01 May 2019

Alcohol and Alzheimer's Disease-Does Alcohol Dependence Contribute to Beta-Amyloid Deposition, Neuroinflammation and Neurodegeneration in Alzheimer's Disease?

scientific article published on 3 December 2016

Alcohol and Alzheimer's Disease-Does Alcohol Dependence Contribute to Beta-Amyloid Deposition, Neuroinflammation and Neurodegeneration in Alzheimer's Disease?

scientific article published in March 2017

Alcohol and the Brain

Alcohol-related brain damage: report from a Medical Council on Alcohol Symposium, June 2010.

scientific article published on 16 February 2012

Amphetamine induced endogenous opioid release in the human brain detected with [¹¹C]carfentanil PET: replication in an independent cohort

scientific article

Antidepressant treatment response: 'I want it all, and I want it now!'†.

scientific article published in February 2016

Are prescribed benzodiazepines likely to affect the availability of the 18 kDa translocator protein (TSPO) in PET studies?

scientific article

Assessment of GABAA benzodiazepine receptor (GBzR) sensitivity in patients with alcohol dependence

scientific article published on 27 June 2008

Association between the serotonin transporter gene and alcohol consumption in social drinkers

scientific article

Attentional bias for alcohol-related information in adolescents with alcohol-dependent parents

scientific article published on 19 April 2006

Authors' reply

scientific article published on 01 September 2019

BAP guidelines on the management of weight gain, metabolic disturbances and cardiovascular risk associated with psychosis and antipsychotic drug treatment.

scientific article published on 4 May 2016

BAP updated guidelines: evidence-based guidelines for the pharmacological management of substance abuse, harmful use, addiction and comorbidity: recommendations from BAP.

scientific article

Baclofen for the treatment of alcohol use disorder: the Cagliari Statement

Biomarkers for detecting thiamine deficiency--improving confidence and taking a comprehensive history are also important

scientific article published in November 2009

Blockade of alcohol's amnestic activity in humans by an alpha5 subtype benzodiazepine receptor inverse agonist

scientific article published on 16 August 2007

Blunted Endogenous Opioid Release Following an Oral Amphetamine Challenge in Pathological Gamblers

scientific article published on 10 November 2015

Blunted endogenous opioid release following an oral dexamphetamine challenge in abstinent alcohol-dependent individuals

scientific article published on 25 June 2018

Boosting the diagnostic power of amyloid-β PET using a data-driven spatially informed classifier for decision support

Brain dopamine response in human opioid addiction.

scientific article

Brain opioid receptor binding in early abstinence from alcohol dependence and relationship to craving: an [11C]diprenorphine PET study.

scientific article

Brain opioid receptor binding in early abstinence from opioid dependence: positron emission tomography study.

scientific article

Brief intervention for alcohol misuse in people attending sexual health clinics: study protocol for a randomized controlled trial.

scientific article

British Association for Psychopharmacology consensus guidance on the use of psychotropic medication preconception, in pregnancy and postpartum 2017.

scientific article published in March 2017

COVID-19 and substance use disorders: a review of international guidelines for frontline healthcare workers of addiction services

Cannabis use and risk of psychotic or affective mental health outcomes: a systematic review

scientific article (publication date: 28 July 2007)

Central noradrenergic responsiveness to a clonidine challenge in Generalized Anxiety Disorder: a Single Photon Emission Computed Tomography study

scientific article published on 17 September 2011

Cerebral blood flow predicts differential neurotransmitter activity.

scientific article published on 6 March 2018

Challenges the addiction field must overcome to avert being the Cinderella of medicine

scientific article

Characterisation of the contribution of the GABA-benzodiazepine α1 receptor subtype to [(11)C]Ro15-4513 PET images

scientific article published on 4 January 2012

Chronic ethanol and pentobarbital administration in the rat: effects on GABAA receptor function and expression in brain

scientific article

Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study

Comparison of cannabinoids in hair with self-reported cannabis consumption in heavy, light and non-cannabis users

scientific article

Comparison of ethyl glucuronide in hair with self-reported alcohol consumption

scientific article published on 14 February 2012

Correction to: Service Users' Views and Experiences of Alcohol Relapse Prevention Treatment and Adherence: New Role for Pharmacists?

correction of a scholarly article

Corrigendum to “Prevention of suicide and reduction of self-harm among people with substance use disorder: A systematic review and meta-analysis of randomised controlled trials” [Comprehensive Psychiatry, volume 96 (2020)]

correction of a scholarly article

D-Cycloserine and performance under different states of anxiety in healthy volunteers.

scientific article published on 18 May 2007

Decreased GABA-A Receptor Binding in Association With β-Lactam Antibiotic Use

scientific article published on 01 December 2019

Decreased hippocampal translocator protein (18 kDa) expression in alcohol dependence: a [11C]PBR28 PET study

scientific article published on 10 January 2017

Differences between magnetoencephalographic (MEG) spectral profiles of drugs acting on GABA at synaptic and extrasynaptic sites: a study in healthy volunteers

scientific article published on 4 September 2014

Does alcohol increase the risk of overdose death: the need for a translational approach

scientific article published on 7 April 2008

Does human presynaptic striatal dopamine function predict social conformity?

scientific article published on 20 November 2013

Effects of acute tyrosine/phenylalanine depletion on the selective processing of smoking-related cues and the relative value of cigarettes in smokers

scientific article published on 25 November 2007

Effects of cannabis use on outcomes of psychotic disorders: systematic review

scientific article

Effects of naltrexone are influenced by childhood adversity during negative emotional processing in addiction recovery

scientific article

Elevating endogenous GABA levels with GAT-1 blockade modulates evoked but not induced responses in human visual cortex

scientific article published on 9 January 2013

Endogenous opioid release in the human brain reward system induced by acute amphetamine administration

scientific article

Erratum: Acute D3 Antagonist GSK598809 Selectively Enhances Neural Response During Monetary Reward Anticipation in Drug and Alcohol Dependence

correction of an scholarly article

Erratum: Acute D3 Antagonist GSK598809 Selectively Enhances Neural Response During Monetary Reward Anticipation in Drug and Alcohol Dependence

correction of a scholarly article

Ethanol Reversal of Tolerance to the Respiratory Depressant Effects of Morphine

scientific article

Evidence for GABA-A receptor dysregulation in gambling disorder: correlation with impulsivity

scientific article published on 13 October 2016

Evidence-based guidelines for the pharmacological management of substance misuse, addiction and comorbidity: recommendations from the British Association for Psychopharmacology

scientific article published in September 2004

Evidence-based guidelines for the pharmacological treatment of schizophrenia: Updated recommendations from the British Association for Psychopharmacology

scientific article published on 12 December 2019

FORWARDS-1: an adaptive, single-blind, placebo-controlled ascending dose study of acute baclofen on safety parameters in opioid dependence during methadone-maintenance treatment-a pharmacokinetic-pharmacodynamic study

Functional connectivity analysis of the neural circuits of opiate craving: "more" rather than "different"?

scientific article

Functional evaluation of NK antagonism on cue reactivity in opiate dependence; An fMRI study

Future directions in substance dependence research.

scientific article

GABA-A receptor differences in schizophrenia: a positron emission tomography study using [11C]Ro154513

scientific article published on 15 April 2020

GABA-benzodiazepine receptor function in alcohol dependence: a combined 11C-flumazenil PET and pharmacodynamic study

scientific article published on 28 April 2005

GABAA receptor availability is not altered in adults with autism spectrum disorder or in mouse models

article

GABAB receptors in addiction and its treatment

scientific article published on January 2010

Gender equality in academic publishing: action from the BJPsych

scientific article published on 25 November 2020

History of cannabis use is not associated with alterations in striatal dopamine D2/D3 receptor availability

scientific article published on 2 September 2011

History of cigarette smoking is associated with higher limbic GABAA receptor availability

scientific article published on 14 December 2012

Human brain imaging and substance abuse

scientific article

Human functional neuroimaging connectivity research in dependence

scientific article

Imaging alcohol cue exposure in alcohol dependence using a PET 15O-H2O paradigm: results from a pilot study

scientific article published on March 2006

Imaging synaptic microstructure and synaptic loss in vivo in early Alzheimer’s Disease

Imaging the GABA-benzodiazepine receptor subtype containing the alpha5-subunit in vivo with [11C]Ro15 4513 positron emission tomography

scientific article

Impact of COVID-19 on mental health research: is this the breaking point?

Impact of COVID-19 restrictions on alcohol consumption behaviours

Improving GHB withdrawal with baclofen: study protocol for a feasibility study for a randomised controlled trial

scientific article published on 27 September 2016

Impulsivity in abstinent alcohol and polydrug dependence: a multidimensional approach

scientific article published on 25 February 2016

In vivo imaging of GABAA receptors using sequential whole-volume iodine-123 iomazenil single-photon emission tomography

scientific article published on 01 January 1995

In vivo imaging of cerebral dopamine D3 receptors in alcoholism.

scientific article

Infecting the brain to stop addiction?

scholarly article

Influence of agonist induced internalization on [3H]Ro15-4513 binding-an application to imaging fluctuations in endogenous GABA with positron emission tomography

scientific article published on 19 September 2014

Initial evaluation of123I-5-I-R91150, a selective 5-HT2A ligand for single-photon emission tomography, in healthy human subjects

Interdisciplinary working in public health research: a proposed good practice checklist

scientific article published on 14 March 2017

Intravenous immunoglobulin and rituximab versus placebo treatment of antibody-associated psychosis: study protocol of a randomised phase IIa double-blinded placebo-controlled trial (SINAPPS2)

scientific article published on 07 June 2019

Introduction to Horizons Review series on neuroimaging

scientific article published in February 2017

Investigating expectation and reward in human opioid addiction with [(11) C]raclopride PET

scientific article

Is socioeconomic status in early life associated with drug use? A systematic review of the evidence

scientific article

Is there cognitive impairment in clinically 'healthy' abstinent alcohol dependence?

scientific article published on 26 September 2005

Joint BAP NAPICU evidence-based consensus guidelines for the clinical management of acute disturbance: De-escalation and rapid tranquillisation

scientific article published on 08 June 2018

Low sensitivity of the positron emission tomography ligand [11C]diprenorphine to agonist opiates

scientific article

Measurement of GABA using J-difference edited1H-MRS following modulation of synaptic GABA concentration with tiagabine

scientific article published on 02 May 2014

Measurement of brain GABA-benzodiazepine receptor levels in vivo using emission tomography.

scientific article

Minocycline reduces chronic microglial activation after brain trauma but increases neurodegeneration

scientific article published on 19 December 2017

Nalmefene Reduces Reward Anticipation in Alcohol Dependence: An Experimental Functional Magnetic Resonance Imaging Study.

scientific article

Naltrexone ameliorates functional network abnormalities in alcohol-dependent individuals

scientific article

Naltrexone differentially modulates the neural correlates of motor impulse control in abstinent alcohol-dependent and poly-substance dependent individuals

scientific article published on 26 November 2018

Nature or nurture? Determining the heritability of human striatal dopamine function: an [18F]-DOPA PET study

scientific article

Neural and neurocognitive markers of vulnerability to gambling disorder: a study of unaffected siblings

scientific article published on 09 October 2019

Neural substrates of cue reactivity and craving in gambling disorder

scientific article published on 3 January 2017

Neurobiology of addiction and implications for treatment

scientific article

Neuroimaging

2007 scholarly article by Rothwell

Neuropharmacology of addiction and how it informs treatment

scientific article

Noradrenergic function in generalized anxiety disorder: impact of treatment with venlafaxine on the physiological and psychological responses to clonidine challenge

article

Opioid Imaging

scientific article published in January 2007

Opioid imaging.

scientific article published on November 2006

Opioids and anxiety.

scientific article published on 08 June 2010

Prehabilitation in Alcohol Dependence as a Treatment Model for Sustainable Outcomes. A Narrative Review of Literature on the Risks Associated With Detoxification, From Animal Models to Human Translational Research.

scientific article

Prevention of suicide and reduction of self-harm among people with substance use disorder: A systematic review and meta-analysis of randomised controlled trials

scientific article published on 10 October 2019

Psychiatry and the global drugs debate: what every psychiatrist needs to know

scientific article published on 01 April 2020

Reduced thalamic grey matter volume in opioid dependence is influenced by degree of alcohol use: a voxel-based morphometry study

scientific article

Reframing the science and policy of nicotine, illegal drugs and alcohol - conclusions of the ALICE RAP Project.

scientific article

Resting state synchrony in anxiety-related circuits of abstinent alcohol-dependent patients

scientific article published in November 2013

Selective D3 receptor antagonism modulates neural response during negative emotional processing in substance dependence

Serotonin release measured in the human brain: a PET study with [11C]CIMBI-36 and d-amphetamine challenge

scientific article published on 12 November 2019

Service Users' Views and Experiences of Alcohol Relapse Prevention Treatment and Adherence: New Role for Pharmacists?

scholarly article

Significant decreases in frontal and temporal [11C]-raclopride binding after THC challenge

scientific article published on 6 May 2010

Significant reductions in human visual gamma frequency by the gaba reuptake inhibitor tiagabine revealed by robust peak frequency estimation.

scientific article

Socio-economic status in childhood and later alcohol use: a systematic review.

scientific article

Striatal dopamine D₂/D₃ receptor binding in pathological gambling is correlated with mood-related impulsivity

scientific article

Substance abuse disorders

scientific article published on January 2012

Substitution treatment in addiction: there is more than one way...

scientific article published on 23 February 2016

The ICCAM platform study: An experimental medicine platform for evaluating new drugs for relapse prevention in addiction. Part B: fMRI description

scientific article published on 04 October 2016

The Imperial College Cambridge Manchester (ICCAM) platform study: An experimental medicine platform for evaluating new drugs for relapse prevention in addiction. Part A: Study description

scientific article

The Use of Baclofen as a Treatment for Alcohol Use Disorder: A Clinical Practice Perspective

The brain GABA-benzodiazepine receptor alpha-5 subtype in autism spectrum disorder: a pilot [(11)C]Ro15-4513 positron emission tomography study

scientific article published on 21 April 2012

The clinical and cost-effectiveness of brief advice for excessive alcohol consumption among people attending sexual health clinics: a randomised controlled trial.

scientific article

The clinical effectiveness and cost-effectiveness of brief intervention for excessive alcohol consumption among people attending sexual health clinics: a randomised controlled trial (SHEAR).

scientific article

The clinical pharmacology of acamprosate ⬇️

scientific article published on February 1, 2014

The dopamine theory of addiction: 40 years of highs and lows

scientific article

The effect of nicotine on striatal dopamine release in man: A [11C]raclopride PET study

scientific article

The effects of elevated endogenous GABA levels on movement-related network oscillations

scientific article published on 27 October 2012

The role of central noradrenergic dysregulation in anxiety disorders: evidence from clinical studies

scientific article published on 08 June 2010

There is more to dopamine than just pleasure. Commentary on Volkow et al. 'Role of dopamine in drug reinforcement and addiction in humans: results from imaging studies'.

scientific article published in September 2002

Through a glass darkly: can we improve clarity about mechanism and aims of medications in drug and alcohol treatments?

Treatment interventions to maintain abstinence from alcohol in primary care: systematic review and network meta-analysis

scientific article published on 25 November 2020

UNDERSTANDING CAUSAL PATHWAYS: A RESPONSE TO THE COMMENTARIES

Unleashing talent in mental health sciences: gender equality at the top

article

Using Baclofen to Explore GABA-B Receptor Function in Alcohol Dependence: Insights From Pharmacokinetic and Pharmacodynamic Measures

Using [(11)C]Ro15 4513 PET to characterise GABA-benzodiazepine receptors in opiate addiction: Similarities and differences with alcoholism

scientific article

Using [11C]diprenorphine to image opioid receptor occupancy by methadone in opioid addiction: clinical and preclinical studies

scientific article published on 3 September 2004

Validated Method for the Quantification of Baclofen in Human Plasma Using Solid-Phase Extraction and Liquid Chromatography-Tandem Mass Spectrometry

scientific article published on 4 November 2015

Widespread cell stress and mitochondrial dysfunction in early Alzheimer’s Disease

Widespread cell stress and mitochondrial dysfunction occur in patients with early Alzheimer’s disease

Αlpha 5 subunit-containing GABA receptors in temporal lobe epilepsy with normal MRI

scholarly article

γ-aminobutyric acid as a metabolite: Interpreting magnetic resonance spectroscopy experiments

scientific article published on 22 March 2016

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