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List of works by Frank Beier

A new prescription for growth? Statins, cholesterol and cartilage homeostasis.

scientific article

A top-notch dilemma: The complex role of NOTCH signaling in osteoarthritis

scientific article

ADAMTS-7 forms a positive feedback loop with TNF-α in the pathogenesis of osteoarthritis

scientific article

Activating transcription factor 2 controls Bcl-2 promoter activity in growth plate chondrocytes.

scientific article published in May 2007

Activating transcription factor 2 is necessary for maximal activity and serum induction of the cyclin A promoter in chondrocytes

scientific article published on 01 April 2000

Adult cartilage-specific peroxisome proliferator-activated receptor gamma knockout mice exhibit the spontaneous osteoarthritis phenotype

scientific article published on 30 January 2013

An approach towards accountability: suggestions for increased reproducibility in surgical destabilization of medial meniscus (DMM) models.

scientific article

An in vivo investigation of the initiation and progression of subchondral cysts in a rodent model of secondary osteoarthritis.

scientific article published on 3 February 2012

Atrx deficiency induces telomere dysfunction, endocrine defects, and reduced life span.

scientific article published on 8 April 2013

Biology and pathology of Rho GTPase, PI-3 kinase-Akt, and MAP kinase signaling pathways in chondrocytes.

scientific article published on June 2010

C-type natriuretic peptide regulates cellular condensation and glycosaminoglycan synthesis during chondrogenesis

scientific article published on 19 July 2007

C-type natriuretic peptide regulates endochondral bone growth through p38 MAP kinase-dependent and -independent pathways

scientific article published on 20 March 2007

C57BL/6 mice are resistant to joint degeneration induced by whole-body vibration.

scientific article published on 6 October 2016

CCN2 is necessary for adhesive responses to transforming growth factor-beta1 in embryonic fibroblasts

scientific article published on 16 February 2006

CXC chemokine ligand 12a enhances chondrocyte proliferation and maturation during endochondral bone formation.

scientific article

Cartilage biology in osteoarthritis--lessons from developmental biology

scientific article published on 27 September 2011

Cartilage-specific deletion of Mig-6 results in osteoarthritis-like disorder with excessive articular chondrocyte proliferation

scientific article published on 03 February 2014

Cell cycle control in growth plate chondrocytes.

scientific article

Cell cycle genes in chondrocyte proliferation and differentiation.

scientific article

Characterization of human type X procollagen and its NC-1 domain expressed as recombinant proteins in HEK293 cells.

scientific article

Choline kinase beta is required for normal endochondral bone formation

scientific article

Chondrocyte hypertrophy in skeletal development, growth, and disease.

scientific article published on March 2014

Context-specific protection of TGFα null mice from osteoarthritis.

scientific article published on 26 July 2016

Control of chondrocyte gene expression by actin dynamics: a novel role of cholesterol/Ror-alpha signalling in endochondral bone growth

scientific article published on September 2009

Correction: Forced mobilization accelerates pathogenesis: characterization of a preclinical surgical model of osteoarthritis.

scientific article published on 22 September 2008

Deletion of Dual Specificity Phosphatase 1 Does Not Predispose Mice to Increased Spontaneous Osteoarthritis

scientific article (publication date: 2015)

Deletion of Panx3 Prevents the Development of Surgically Induced Osteoarthritis

scientific article

Deletion of glycogen synthase kinase-3β in cartilage results in up-regulation of glycogen synthase kinase-3α protein expression.

scientific article

Determination of 5' ends of specific mRNAs by DNA ligase-dependent amplification

scientific article published on 01 October 1993

Developmental biology: Is there such a thing as a cartilage-specific knockout mouse?

scientific article published on 30 September 2014

Dexamethasone stimulates expression of C-type Natriuretic Peptide in chondrocytes

scientific article

Dicam promotes proliferation and maturation of chondrocyte through Indian hedgehog signaling in primary cilia.

scientific article published on 24 April 2018

Disturbed cartilage and joint homeostasis resulting from a loss of mitogen-inducible gene 6 in a mouse model of joint dysfunction

scientific article published on October 2014

EGFR Signaling: Friend or Foe for Cartilage?

Early Changes of Articular Cartilage and Subchondral Bone in The DMM Mouse Model of Osteoarthritis

scientific article published on 12 February 2018

Editorial: changes in messenger RNA stability in chondrocytes: there's more to osteoarthritis than transcription

scientific article published on 01 November 2014

Elevated expression of periostin in human osteoarthritic cartilage and its potential role in matrix degradation via matrix metalloproteinase-13.

scientific article

Endothelial nitric oxide synthase deficiency in mice results in reduced chondrocyte proliferation and endochondral bone growth

scientific article published on 01 July 2010

Exposure to the RXR Agonist SR11237 in Early Life Causes Disturbed Skeletal Morphogenesis in a Rat Model

scientific article published on 20 October 2019

Expression profiling of Dexamethasone-treated primary chondrocytes identifies targets of glucocorticoid signalling in endochondral bone development

scientific article

F-spondin deficient mice have a high bone mass phenotype

scientific article

F-spondin, a neuroregulatory protein, is up-regulated in osteoarthritis and regulates cartilage metabolism via TGF-beta activation.

scientific article published on 09 September 2008

Focal adhesion kinase/Src suppresses early chondrogenesis: central role of CCN2.

scientific article

Forced mobilization accelerates pathogenesis: characterization of a preclinical surgical model of osteoarthritis

scientific article published on January 2007

GSK-3β function in bone regulates skeletal development, whole-body metabolism, and male life span

scientific article published on 31 July 2013

GSK3787-Loaded Poly(Ester Amide) Particles for Intra-Articular Drug Delivery

scientific article published on 26 March 2020

Genetic ablation of Rac1 in cartilage results in chondrodysplasia.

scientific article

Genome-wide analyses of gene expression during mouse endochondral ossification

scientific article

Genomic organization and full-length cDNA sequence of human collagen X

scientific article (publication date: 26 October 1992)

Global analyses of gene expression in early experimental osteoarthritis

scientific article published on 01 June 2007

Global deletion of Panx3 produces multiple phenotypic effects in mouse humeri and femora.

scientific article published on 7 January 2016

Human stanniocalcin-1 or -2 expressed in mice reduces bone size and severely inhibits cranial intramembranous bone growth

scientific article published on 20 February 2010

Identification of the cyclin D1 gene as a target of activating transcription factor 2 in chondrocytes.

scientific article

Identification of the putative collagen X gene from the pufferfish Fugu rubripes.

scientific article published in November 2004

Inactivation of hepatic ATRX in Atrx Foxg1cre mice prevents reversal of aging-like phenotypes by thyroxine.

scientific article published in June 2018

Inducible nitric oxide synthase-nitric oxide signaling mediates the mitogenic activity of Rac1 during endochondral bone growth.

scientific article published on 29 September 2011

Interplay between genetics and epigenetics in osteoarthritis

scientific article published on 09 April 2020

Liver X Receptor activation delays chondrocyte hypertrophy during endochondral bone growth.

scientific article published on 20 May 2014

Loss of ATRX does not confer susceptibility to osteoarthritis

scientific journal article

Loss of ATRX in chondrocytes has minimal effects on skeletal development

scientific article

Loss of bone sialoprotein leads to impaired endochondral bone development and mineralization

scientific journal article

Loss of the mammalian DREAM complex deregulates chondrocyte proliferation

scientific article

MAP kinases in chondrocyte differentiation.

scientific article published on November 2003

Microarray analyses of gene expression during chondrocyte differentiation identifies novel regulators of hypertrophy

scientific article

Molecular and histological analysis of a new rat model of experimental knee osteoarthritis

scientific article published on 23 July 2007

Mosaic expression of Atrx in the mouse central nervous system causes memory deficits.

scientific article published on 12 January 2017

Mouse models of osteoarthritis: modelling risk factors and assessing outcomes.

scientific article published on 25 March 2014

NFATs are good for your cartilage!

scientific article published on 25 April 2014

Nitric oxide, C-type natriuretic peptide and cGMP as regulators of endochondral ossification.

scientific article published on 03 May 2008

Novel Insights into Osteoarthritis Joint Pathology from Studies in Mice.

scientific article published on August 2015

Nuclear receptors regulate lipid metabolism and oxidative stress markers in chondrocytes

scientific article published on 9 January 2017

Osteoarthritis year in review 2014: mechanics--basic and clinical studies in osteoarthritis

scientific article

Osteopontin mediates mineralization and not osteogenic cell development in vitro

scientific article published in December 2014

Overexpression of MIG-6 in the cartilage induces an osteoarthritis-like phenotype in mice

scientific article published on 19 May 2020

PPARgamma2 expression in growth plate chondrocytes is regulated by p38 and GSK-3.

scientific article published on January 2010

Peroxisome proliferator-activated receptor δ promotes the progression of posttraumatic osteoarthritis in a mouse model.

scientific article

Poly(ester amide) particles for controlled delivery of celecoxib

scientific article published on 22 February 2019

Rac1 Dosage Is Crucial for Normal Endochondral Bone Growth

scientific article published in October 2017

Rac1 activation induces tumour necrosis factor-α expression and cardiac dysfunction in endotoxemia

scientific article published on 26 May 2010

Rac1 signaling regulates CTGF/CCN2 gene expression via TGFbeta/Smad signaling in chondrocytes.

scientific article

Rac1 signaling stimulates N-cadherin expression, mesenchymal condensation, and chondrogenesis

scientific article

Rac1/Cdc42 and RhoA GTPases antagonistically regulate chondrocyte proliferation, hypertrophy, and apoptosis

scientific article

Raf signaling stimulates and represses the human collagen X promoter through distinguishable elements.

scientific article published on March 1999

Recent developments in emerging therapeutic targets of osteoarthritis

scientific article published on January 2017

Reduced EGFR signaling enhances cartilage destruction in a mouse osteoarthritis model

scientific article published on 5 August 2014

Reduced chondrocyte proliferation, earlier cell cycle exit and increased apoptosis in neuronal nitric oxide synthase-deficient mice.

scientific article published on 30 November 2011

Reduction in disease progression by inhibition of transforming growth factor α-CCL2 signaling in experimental posttraumatic osteoarthritis

scientific article published on 2 July 2015

Regulation of chondrocyte differentiation by the actin cytoskeleton and adhesive interactions

scientific article published on October 2007

Regulation of gene expression by PI3K in mouse growth plate chondrocytes

scientific article

Regulator of G-protein signaling (RGS) proteins differentially control chondrocyte differentiation

scientific article published on June 2006

Repeated exposure to high-frequency low-amplitude vibration induces degeneration of murine intervertebral discs and knee joints

scientific article published on May 2015

Rho-ROCK signaling differentially regulates chondrocyte spreading on fibronectin and bone sialoprotein

scientific article

Rho/ROCK and MEK/ERK activation by transforming growth factor-alpha induces articular cartilage degradation

scientific article published on 12 October 2009

RhoA/ROCK signaling regulates Sox9 expression and actin organization during chondrogenesis.

scientific article published on 21 January 2005

RhoA/ROCK signaling regulates chondrogenesis in a context-dependent manner.

scientific article published on 24 March 2006

RhoA/ROCK signaling suppresses hypertrophic chondrocyte differentiation.

scientific article published on 15 January 2004

Role of c-fos in the regulation of type X collagen gene expression by PTH and PTHrP: localization of a PTH/PTHrP-responsive region in the human COL10A1 enhancer

scientific article

Role of interleukin-10 in endochondral bone formation in mice: anabolic effect via the bone morphogenetic protein/Smad pathway

scientific article published in December 2013

Sequence analysis of regulatory regions of the human collagen X gene

article

Src kinase inhibition promotes the chondrocyte phenotype.

scientific article

TGF-β and osteoarthritis--the good and the bad.

scientific article published in June 2013

TGFbeta and PTHrP control chondrocyte proliferation by activating cyclin D1 expression.

scientific article published on December 2001

Targeted loss of the ATR-X syndrome protein in the limb mesenchyme of mice causes brachydactyly

scientific article published on 25 July 2013

Targeting oxidative stress to reduce osteoarthritis

scientific article

The ANKH ΔE490Mutation in Calcium Pyrophosphate Dihydrate Crystal Deposition Disease (CPPDD) affects tissue non-specific Alkaline Phosphatase (TNAP) activities

scientific article published on 10 April 2008

The CPPDD-associated ANKH M48T mutation interrupts the interaction of ANKH with the sodium/phosphate cotransporter PiT-1.

scientific article published on 15 April 2009

The PI3K pathway regulates endochondral bone growth through control of hypertrophic chondrocyte differentiation

scientific article

The critical role of the epidermal growth factor receptor in endochondral ossification.

scientific article published on November 2011

The cyclin D1 and cyclin A genes are targets of activated PTH/PTHrP receptors in Jansen's metaphyseal chondrodysplasia

scientific article published on 01 September 2002

The first international workshop on the epigenetics of osteoarthritis

scientific article

The retinoic acid binding protein CRABP2 is increased in murine models of degenerative joint disease

scientific article published on 28 January 2009

The role of Akt1 in terminal stages of endochondral bone formation: angiogenesis and ossification

scientific article published on 11 August 2009

The role of activating transcription factor-2 in skeletal growth control ⬇️

scientific article published on January 1, 2003

The role of bone sialoprotein in the tendon-bone insertion.

scientific article published on 27 January 2016

The transcription factor ATF3 is upregulated during chondrocyte differentiation and represses cyclin D1 and A gene transcription

scientific article

Time-series transcriptional profiling yields new perspectives on susceptibility to murine osteoarthritis

scientific article published on 01 October 2012

Transcriptional regulators of chondrocyte hypertrophy.

scientific article published on June 2008

Transforming growth factor alpha controls the transition from hypertrophic cartilage to bone during endochondral bone growth.

scientific article published in May 2012

Transforming growth factor alpha suppression of articular chondrocyte phenotype and Sox9 expression in a rat model of osteoarthritis

scientific article published on 01 November 2007

Transforming growth factor-alpha induces endothelin receptor A expression in osteoarthritis

scientific article published on 07 March 2012

Type X collagen expression and hypertrophic differentiation in chondrogenic neoplasias

scientific article published on 01 June 1997

Upregulation of type X collagen expression in osteoarthritic cartilage

scientific article published on 01 October 1995

Variability in the upstream promoter and intron sequences of the human, mouse and chick type X collagen genes

scientific article

Weight-bearing asymmetry and vertical activity differences in a rat model of post-traumatic knee osteoarthritis.

scientific article published on 12 March 2015

Whole-body vibration of mice induces articular cartilage degeneration with minimal changes in subchondral bone

scientific article published on 10 November 2016

p38 MAP kinase signaling is necessary for rat chondrosarcoma cell proliferation

scientific article

p38 MAP kinase signalling is required for hypertrophic chondrocyte differentiation

scientific article published in February 2004

p38 MAPK signaling during murine preimplantation development.

scientific article published in April 2004

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